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ShareScore release 0.7.1
Dataset results
30 results for “drug culture”
Second-line drug resistance markers as proxy indicators of sputum culture conversion for samples tested in Uganda
<p>Increased TB disease burden arises as a result of low treatment success rates stemming from the emergence of second-line drug (SLD) resistance. We aimed at determining the usefulness of SLD resistance markers as proxy indicators of time to sputum culture conversion; a renowned predictor of Tuberculosis (TB) treatment outcome, among SLD-resistant TB patients tested at the Uganda National TB Reference Laboratory (NTRL). A cross-sectional study was conducted on 72 bacteriologically confirmed SLDR TB patients with datasets including culture conversion time and second-line probe assay mutation profiles between 01/06/2017 and 31/12/2019. The data were then imported into STATA v15 for descriptive statistical analysis, Univariate cox proportional hazard model analysis and Kaplan-Meier survival curves at a 5% level of significance; p-value ≤ 0.05. Results indicate the median time was achieved at 3 (0–12) months across the studied patients. The <em>rrs</em> G1484T mutation associated with conferring drug resistance to aminoglycosides was observed to have the shortest median conversion time of 1.5 months and the longest by the <em>gryB</em> E540D at 5 months. A single mutation in the <em>gryA</em> gene locus showed higher converted proportions 70.8% (58.9–81.0) than those that had two 8.3% (3.1–17.3) or three 2.7% (0.3–10.0) mutations. We conclude that the studied second-line drug resistance markers had no statistically significant association with the time to sputum culture conversion, although increased drug resistance levels reduced the converted proportions and stressed the need to utilize molecular diagnostics data to better comprehend proxy indicators of SLD-resistant tuberculosis management.</p>
The Culture of Advanced or Recurrent Ovarian Cancer Organoids and Drug Screening
ClinicalTrials.gov study NCT05290961. IPD Sharing: NO. Countries: 1. Publications: 14.
The Culture of Advanced/Recurrent/Metastatic Colorectal Cancer Organoids and Drug Screening
ClinicalTrials.gov study NCT05304741. IPD Sharing: NO. Countries: 1. Publications: 7.
Second-line drug resistance markers as proxy indicators of sputum culture conversion for samples tested in Uganda
Open the record for dataset details and reuse information.
Data from: Evaluating culture-free targeted next-generation sequencing for diagnosing drug-resistant tuberculosis: A multicentre clinical study of two end-to-end commercial workflows
Open the record for dataset details and reuse information.
Cultural Adaptation of Drug Treatment for DJJ Youth
ClinicalTrials.gov study NCT06003725. IPD Sharing: NO. Countries: 1. Publications: 0.
Microwell-Based Flow Culture Increases Viability and Restores Drug Response in Prostate Cancer Spheroids
<p>Data files for main manuscript figures.</p>
E2F1 mediates competition, proliferation and drug sensitivity of co-cultured resistant and sensitive ovarian cancer cells.
GEO Series GSE244626. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Fatostatin drug treatment of mouse primary microglia cultures
GEO Series GSE146864. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
A next generation three-dimensional hydrogel-based culture system for studying host-pathogen interaction and drug efficacy in tuberculosis
GEO Series GSE216503. Homo sapiens; Mycobacterium tuberculosis H37Rv. 11 samples. Type: Expression profiling by high throughput sequencing.
Spheroid culture differentially affects cancer cell sensitivity to drugs in melanoma and RCC models
GEO Series GSE190296. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Single-cell RNA-sequencing of skin, fresh blood, and cultured peripheral blood mononuclear cells from a patient with drug-induced hypersensitivity syndrome and healthy volunteers
GEO Series GSE132802. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
Gene expression in drug-resistant and circulating tumor cell cultured H460 or A549 cells
GEO Series GSE158640. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
High-throughput 3D screening reveals differences in drug sensitivities between culture models of JIMT1 breast cancer cells.
GEO Series GSE42529. Homo sapiens. 12 samples. Type: Expression profiling by array.
Transcriptional profiling of Mycobacterium tuberculosis exposed to antibiotics and drug combinations in broth culture.
GEO Series GSE292636. Mycobacterium tuberculosis. 27 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic RNAseq drug screen in cerebrocortical cultures; towards novel neurogenetic disease therapies.
GEO Series GSE110256. Mus musculus. 227 samples. Type: Expression profiling by high throughput sequencing.
Drug Use Investigation for Cell-culture Derived Influenza A (H1N1) Emulsion HA Vaccine
ClinicalTrials.gov study NCT01098786. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Ovarian Tumor Organotypic Slices Cultures for functionAl Drug Testing and Therapy Response Prediction
ClinicalTrials.gov study NCT06065358. IPD Sharing: NO. Countries: 1. Publications: 0.
Comparison of pCR Rate After Neadjuvant Chemotherapy Guided by Result of in Vitro Cell Culture Drug Sensitivity or Physician's Choice
ClinicalTrials.gov study NCT04130750. IPD Sharing: NO. Countries: 1. Publications: 0.
The Culture of Ovarian Cancer Organoids and Drug Screening
ClinicalTrials.gov study NCT04768270. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.