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46 results for “endocrine disruptor”
Using the Tea Bag Index to unravel how interactions between an antibiotic (Trimethoprim) and endocrine disruptor (17a-estradiol) affect aquatic microbial activity: Supporting Dataset 1
<p>The constant release of complex mixture of pharmaceuticals, including antimicrobials and endocrine disruptors, into the aquatic environment. These have the potential to affect aquatic microbial metabolism and alter biogeochemical cycling of carbon and nutrients. We used the Tea Bag Index (TBI) for decomposition within a series of contaminant exposure experiments to test how interactions between an antibiotic (trimethoprim) and endocrine disruptor (17a-estradiol) affects microbial activity in an aquatic system. The TBI is a citizen science tool used to test microbial activity by measuring the differential degradation of green and rooibos tea as proxies for labile and recalcitrant organic matter decomposition. Here we present the raw data on pharmaceutical exposures and the mass loss of the Rooibos and Green tea bags within the experiment. From Tea Bag mass loss we then calculated the Stabilisation Factor (S) and Initial Decomposition Rate of the labile organic matter fraction.</p>
Inter-Chemical Correlation results for the study: HHEARx2018-2512 (The Role of Environmental Endocrine Disruptors on the Health of Inner City Children)
Title: The Role of Environmental Endocrine Disruptors on the Health of Inner City Children <br>Species: Homo sapiens <br>Number of samples: 651 <br>Number of named analytes: 26 <br>Datasource url: https://hheardatacenter.mssm.edu/PublicFile/ViewPublicFile?projectid=62 <br>
Endocrine disruptors cause multigenerational and transgenerational epigenetic changes in fish exposed during early life
<p>The inland silverside, <i>Menidia beryllina</i>, is a euryhaline fish and a model organism in ecotoxicology. We previously showed that exposure to picomolar (ng/L) levels of endocrine disrupting chemicals (EDCs) can cause a variety of effects in <i>M. beryllina</i>, from changes in gene expression to phenotypic alterations. Here we explore the potential for early life exposure to EDCs to modify the epigenome in silversides, with a focus on multi- and transgenerational effects. EDCs included contaminants of emerging concern (the pyrethroid insecticide bifenthrin and the synthetic progestin levonorgestrel), as well as a commonly detected synthetic estrogen (ethinylestradiol), and a synthetic androgen (trenbolone) at exposure levels ranging from 3 to 10 ng/L. In a multigenerational experiment, we exposed parental silversides to EDCs from fertilization until 21 days post hatch (dph). Then we assessed DNA methylation patterns for three generations (F0, F1, and F2) in whole body larval fish using reduced representation bisulfite sequencing (RRBS). We found significant ( = 0.05) differences in promoter and/or gene body methylation in treatment fish relative to controls for all EDCs and all generations indicating that both multigenerational (F1) and transgenerational (F2) effects that were caused by strict inheritance of DNA methylation alterations and the dysregulation of epigenetic control mechanisms. Using gene ontology and pathway analyses, we found enrichment in biological processes and pathways representative of growth and development, immune function, reproduction, pigmentation, epigenetic regulation, stress response and repair (including pathways important in carcinogenesis). Further, we found that a subset of potentially EDC responsive genes (EDCRGs) were differentially methylated across all treatments and generations and included hormone receptors, genes involved in steroidogenesis, prostaglandin synthesis, sexual development, DNA methylation, protein metabolism and synthesis, cell signaling, and neurodevelopment. The analysis of EDCRGs provided additional evidence that differential methylation is inherited by the offspring of EDC-treated animals, sometimes in the F2 generation that was never exposed. These findings show that low, environmentally relevant levels of EDCs can cause altered methylation in genes that are functionally relevant to impaired phenotypes documented in EDC-exposed animals and EDC exposure has the potential to affect epigenetic regulation in fish that have not been directly exposed.</p>
TBT exposure dataset of the manuscript "Assessment of endocrine disruptors effects on zebrafish (Danio rerio) embryos by untargeted LC-HRMS metabolomic analysis"
<p><strong>Raw LC-HRMS data of the TBT exposure of zebrafish embryos (for more details see https://doi.org/10.1016/j.scitotenv.2018.03.369)</strong></p> <p>The exposure protocol involved zebrafish embryos exposed in groups of 20 to various concentrations of chemical compounds, with five replicates per treatment. The concentrations ranged from the lowest observed effect concentrations (LOECs) to control levels. After exposure, embryos were collected, washed, frozen, and stored. Metabolites were extracted from individual embryo pools using methanol and methionine sulfone. The extraction process included vortexing, sonication, and centrifugation, followed by addition of water and chloroform. The aqueous fraction was dried and reconstituted using acetonitrile-water solution. Liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS) was used for analysis. Chromatographic separations were carried out on a hydrophilic interaction liquid chromatography (HILIC) column. Mass spectrometry was performed using an Orbitrap mass spectrometer with electrospray ionization in positive and negative modes. The mass spectra were acquired at high resolution, and fragmentation scans were used for metabolite identification. The overall process aimed to analyze the metabolomic profile of zebrafish embryos exposed to different chemical concentrations.</p> <p><strong>Data files</strong></p> <blockquote> <p>TBT ESI+ (tbt_pos.rar) - CDF files</p> <p>- QC (4 replicates)</p> <p>- Control (5 replicates)</p> <p>- TBT 3 nM (5 replicates)</p> <p>- TBT 10 nM (5 replicates)</p> <p>- TBT 30 nM (5 replicates)</p> <p>- TBT 100 nM (5 replicates)</p> </blockquote> <p> </p> <blockquote> <p>TBT ESI- (tbt_neg.rar) - CDF files</p> <p>- QC (6 replicates)</p> <p>- Control (5 replicates)</p> <p>- TBT 3 nM (5 replicates)</p> <p>- TBT 10 nM (5 replicates)</p> <p>- TBT 30 nM (5 replicates)</p> <p>- TBT 100 nM (5 replicates)</p> </blockquote>
Effectiveness of a multicOmpoNent Behavioural intervenTion to Reduce endocrINe disrUptor Exposure During pErinatal Period (CONTINUE)
ClinicalTrials.gov study NCT07142447. IPD Sharing: NO. Countries: 1. Publications: 3.
Endocrine disruptors cause multigenerational and transgenerational epigenetic changes in fish exposed during early life
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A Multimodal Study of the Relationship Between Exposure to Endocrine Disruptors and Occurrence of Hypospadias - HYPOLLUT
ClinicalTrials.gov study NCT06628375. IPD Sharing: Not stated. Countries: 1. Publications: 25.
AROPE : Early Ovarian Reserve Decreased : Impact of Exposure to Persistent Endocrine Disruptors and Organic Solvents
ClinicalTrials.gov study NCT02802397. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of an Environmental Health Education Program on Pregnant Women in Order to Reduce Endocrine Disruptor Exposition
ClinicalTrials.gov study NCT03233984. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Endocrine Disruptors, Toxic and Essential Chemical Elements and Polycystic Ovary Syndrome
ClinicalTrials.gov study NCT06968455. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Data from: An androgenic endocrine disruptor alters male mating behaviour in the guppy (Poecilia reticulata)
Hormonally active chemical pollution threatens human and wildlife populations globally. However, despite the well-established capacity of endocrine-disrupting chemicals (EDCs) to alter reproductive traits, relatively few studies have examined the impacts of EDCs on mechanisms of sexual selection. This study investigated the effects of short-term exposure to an environmentally realistic level of 17β-trenbolone—a potent anabolic steroid used in livestock production worldwide—on male mate preference, reproductive behaviour and morphology in the guppy (Poecilia reticulata). Male guppies prefer to mate with larger females because such females are generally more fecund. Hence, males gain direct fitness benefits by being choosy. Here, we found no significant effect of 17β-trenbolone exposure on male courting behaviour, with both unexposed and exposed males courting larger females more often. However, exposure to 17β-trenbolone significantly altered the amount of coercive copulatory behaviour ('sneak' matings) performed. Specifically, while both unexposed and exposed males demonstrated a preference for larger females by conducting more sneaking attempts towards these females, exposed males carried out a greater number of sneaks towards large females than did unexposed males. Further, exposure resulted in increased male condition index (i.e., mass relative to length). Together, our results show for the first time that 17β-trenbolone can alter reproductive behaviour and morphology in male fish at concentrations as low as 4 ng/L, highlighting the potential for disruption of reproductive processes in wildlife exposed to this potent agricultural contaminant.
Data from: An androgenic endocrine disruptor alters male mating behaviour in the guppy (Poecilia reticulata)
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Developmental Reprogramming of Myometrial Stem Cells by Endocrine Disruptor Linking to Risk of Uterine Fibroids [RNA-Seq]
GEO Series GSE157500. Rattus norvegicus. 2 samples. Type: Expression profiling by high throughput sequencing.
Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations
GEO Series GSE59555. Rattus norvegicus. 3 samples. Type: Methylation profiling by genome tiling array.
Transcriptomic effects of endocrine disruptors in zebrafish embryos
GEO Series GSE44263. Danio rerio. 92 samples. Type: Expression profiling by array.
Genome wide anaylsis of transcriptome modifications in rats exposed to endocrine disruptors. [RNA-Seq]
GEO Series GSE130434. Rattus norvegicus. 12 samples. Type: Expression profiling by high throughput sequencing.
The mammalian germline corrects deleterious effects of endocrine disruptors
GEO Series GSE59543. Mus musculus. 96 samples. Type: Methylation profiling by genome tiling array; Expression profiling by array.
Transcriptional profiling of developing rat ovary following intrauterine exposure to known endocrine disruptors
GEO Series GSE208545. Rattus norvegicus. 159 samples. Type: Expression profiling by high throughput sequencing.
DNA methylation changes in fetal germ cells exposed to endocrine disruptors and in the next generation [methylation set 1]
GEO Series GSE59539. Mus musculus. 32 samples. Type: Methylation profiling by genome tiling array.
Endocrine disruptor-induced epimutagenesis in vitro: Insight into molecular mechanisms [RNA-Seq]
GEO Series GSE252720. Mus musculus. 42 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
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The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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