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314 results for “endometrium”
Comparing the effect of TGF-β receptor inhibition on human mesenchymal stem/stromal cells derived from endometrium, bone marrow and adipose tissues
<p><strong>Figure S1: Differences between bmMSC donors. A)</strong> Graph showing two groups of bmMSCs with and without effect of A83-01 treatment on % SUSD2<sup>+</sup> cells. <strong>B)</strong> Graph showing no difference in the number of cells following A83-01 treatment in the two groups of donor cells from <strong>A</strong>. Plots are median for n=3 biological samples per treatment group.</p>
Supplemental data for "Transcriptomic Profiling of the Bovine Endosalpinx and Endometrium to Identify Putative Embryokines"
<p>Supplemental data for paper describing expression of genes encoding for cell-signaling ligands in the oviduct and endometrium of cows. </p>
Papillary Serous Carcinoma of the Endometrium
ClinicalTrials.gov study NCT00515073. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of hCG on Receptivity of the Human Endometrium
ClinicalTrials.gov study NCT01786252. IPD Sharing: NO. Countries: 1. Publications: 11.
Deep immunophenotyping reveals endometriosis is marked by dysregulation of the mononuclear phagocytic system in endometrium and peripheral blood
Open the record for dataset details and reuse information.
Uterine scarring leads to adverse pregnant consequence through impairing the response of endometrium to steroids
<p>Uterine surgical scarring is an increasing risk factor for adverse pregnant consequences that threaten fetal-maternal health. The detailed molecular features of scar implantation remain largely unknown. We aim to study the pathologic features of uterine surgical scarring and the mechanisms of compromised pregnancy outcomes of scar implantation. We generated a mouse model of uterine surgical scarring with a uterine incision penetrating the myometrium to endometrium to examine the pathologic changes and transcriptome profiles of uterine scarring at various post-surgery (PS) time points, as well as features of the feto-maternal interface during scar implantation. We found that uterine surgical scar recovery was consistently poor at PS3 until PS90, as shown by a reduced number of endometrial glands, inhibition of myometrial smooth muscle cell growth but excessive collagen fiber deposition, and massive leukocyte infiltration. Transcriptome annotation indicated significant chronic inflammation at the scarring site. At the peri-implantation and postimplantation stages, abnormal expression of various steroid-responsive genes at the scarring site was in parallel with lumen epithelial cell hyperplasia, inappropriate luminal closure, and disorientation of the implanted embryo, restricted stromal cell proliferation, and defective decidualization. High embryonic lethality (around 70%) before E10.5 was observed, and the small amount of survival embryos at E10.5 exhibited restricted growth and aberrant placenta defects including overinvasion of trophoblast cells into the decidua and insufficient fetal blood vessel branching in the labyrinth. The findings indicate that chronic inflammation and compromised responses to steroids in uterine scar tissues are the pivotal molecular basis for adverse pregnancy consequences of scar implantation.</p>
Supplemental material for: The estrogen receptor α cistrome in human endometrium and epithelial organoids
<p>Endometrial health is impacted by molecular processes that underlie estrogen responses. We assessed estrogen regulation of endometrial function by integrating the estrogen receptor alpha (ESR1) cistromes and transcriptomes of endometrial biopsies taken from the proliferative and mid-secretory phases of the menstrual cycle together with hormonally stimulated endometrial epithelial organoids. The cycle stage specific ESR1 binding sites were determined by ChIPseq and then integrated with changes in gene expression from RNAseq data to infer candidate ESR1 targets in normal endometrium. Genes with ESR1 binding in whole endometrium were enriched for chromatin modification and regulation of cell proliferation. The distribution of ESR1 binding sites in organoids was more distal from gene promoters when compared to primary endometrium and was more similar to the proliferative than the mid-secretory phase ESR1 cistrome. Inferred organoid estrogen/ESR1 candidate target genes impacted formation of cellular protrusions, and chromatin modification. Comparison of signaling impacted by candidate ESR1 target genes in endometrium vs. organoids reveals enrichment of both overlapping and distinct responses. Our analysis of the ESR1 cistromes and transcriptomes from endometrium and organoids provides important resources for understanding how estrogen impacts endometrial health and function.</p>
Supplementary Figure S1 Identification the integrity of isolated endometrium and decidual tissues using quantitative PCR.
<p>Supplementary Figure S1 Identification the integrity of isolated endometrium and decidual tissues using quantitative PCR. The typical decidualization marker genes of <em>Dtprp</em> (A) and <em>Alpl</em> (B) were determined by qRT-PCR. (C) <em>ACTA2</em> mRNA levels of the smooth muscle maker gene was examined by qRT-PCR. Results were normalized to the housekeeping gene GAPDH and presented as the mean ± SD of three separate experiments, with different letters (a, b, c) indicating statistical difference (p < 0.05; one-way ANOVA and Tukey’s test).</p>
Endometrium Carcinoma Pipelle biopsies
<p>The dataset consists of n=91 digital pathology whole-slide images (WSI) of endometrium carcinoma Pipelle biopsies, stained with hematoxylin and eosin (H&E) at Radboud University Medical Centers, Nijmegen (The Netherlands).</p> <p>The WSIs were scanned with a 3DHistech P1000 scanners at 0.25 um/px spacing, originally stored in MRXS file format. However, the WSIs made available here have been converted to TIFF format with a maximum spacing of 0.5 um/px. This was done to make slides broadly accessible (since MRXS files are sometimes not compatible with some digital pathology viewers or APIs).</p> <p>Together with the data, we have released a web-based evaluation platform via the <a href="https://grand-challenge.org/">grand-challenge.org</a> platform, which can be found at this link: <a href="https://breastpleomorphism.grand-challenge.org/">https://breastpleomorphism.grand-challenge.org/</a>. In this way, researchers can download the WSI from Zenodo, process them with their algorithm to predict a single grading score for each slide, compile the predictions as indicated on the grand-challenge.org page, and submit them, to compare the results with the opinion of a panel of fifteen pathologists.</p> <p>The data is released under CC BY-NC 4.0 license</p>
The Study of the Relationship Between TWEAK/Fn14, JAK/STAT3 and IDO in the Immune Microenvironment of Endometrium in Repeated Implantation Failure
ClinicalTrials.gov study NCT02967419. IPD Sharing: Not stated. Countries: 1. Publications: 18.
Tamoxifen Compared With Clomiphene Citrate for Women Who Had Thin Endometrium Women Under Clomiphene in a Previous Cycle
ClinicalTrials.gov study NCT00449514. IPD Sharing: Not stated. Countries: 1. Publications: 1.
HCG (Human Chorionic Gonadotropin) Priming for Thin Endometrium in IVF (in Vitro Fertilization)
ClinicalTrials.gov study NCT01768247. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Ultrasound Appearance of the Endometrium Post Radio-Frequency Ablation
ClinicalTrials.gov study NCT02584088. IPD Sharing: NO. Countries: 1. Publications: 10.
Bariatric Surgery for Fertility-Sparing Treatment of Atypical Hyperplasia and Grade 1 Cancer of the Endometrium
ClinicalTrials.gov study NCT04008563. IPD Sharing: NO. Countries: 1. Publications: 1.
Proliferative Effects of Erythropoietin on Human Endometrium
ClinicalTrials.gov study NCT03060603. IPD Sharing: NO. Countries: 1. Publications: 6.
Preparing and Timing of the Endometrium in Modified Natural Cycle Frozen-thawed Embryo Transfers
ClinicalTrials.gov study NCT03795220. IPD Sharing: YES. Countries: 1. Publications: 3.
Transcriptomic Profile of Endometrium in Different Histological Dating of Natural Cycle
ClinicalTrials.gov study NCT03222830. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Outcome of Two Protocols Used to Prepare Endometrium for Frozen Embryo Transfer
ClinicalTrials.gov study NCT04507022. IPD Sharing: Not stated. Countries: 1. Publications: 8.
Effects of Tibolone Treatment on the Endometrium
ClinicalTrials.gov study NCT00294463. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Incidence of Non Receptive Endometrium in Obese Women
ClinicalTrials.gov study NCT02205866. IPD Sharing: Not stated. Countries: 2. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.