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143 results for “endoplasmic reticulum stress”
Data_Supplemental_Tab3_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice
<p>Data of supplemental Tab3, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice”</p> <p>The Dataset contains the original supplemental table 3 as PDF-format (PNTD-D-21-00134R2_S_T3.pdf). Related information (meta-data) are provided as one file in TXT format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_ST3_M_1.txt) and three files in PDF format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_ST3_M_1-3.pdf).</p>
Data_Supplemental_Fig4_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice
<p>Data of supplemental Fig4, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice”</p> <p>The Dataset contains the original supplemental figure 4 as PNG-format (PNTD-D-21-00134R2_SFig4.png). Corresponding raw data and subsequent data analysis obtained from RT-PCR analysis provided as four files in CSV format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF4_1_3-4_1-4.csv), all further experiment related information provided as one meta-data-file in txt format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF4_1_3-4_M_1.txt) and three meta data files in pdf format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF4_M_1-3.pdf).</p>
Data_Supplemental_Fig2_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice
<p>Data of supplemental Fig2, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice”</p> <p>The Dataset contains the original supplemental figure 2 as PNG-format (PNTD-D-21-00134R2_SFig2.png), original supp. table S1 (31003A-179400_PNTD-D-21-00134R2_FJ_MW_SS_Echinococcus_F1_M_3.pdf) and the original supplemental file S1 (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F1_M_5.pdf).</p> <p>Corresponding raw data, subsequent data analysis and all further experiment related information (meta-data) from Western Blot analysis provided as one file in TXT format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF2_2_1-26_M_1.txt) and two files in PDF format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF2_M_2-3.pdf).</p>
Data_Supplemental_Fig3_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice
<p>Data of supplemental Fig3, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice”</p> <p>The Dataset contains the original supplemental figure 3 as PNG-format (PNTD-D-21-00134R2_SFig3.png). Corresponding raw data and subsequent data analysis obtained from RT-PCR analysis provided as two files in CSV format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF3_1_1-2_1-2.csv), all further experiment related information provided as one meta-data-file in txt format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF3_1_1-2_M_1.txt) and seven meta data files in pdf format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF3_1_1-2_M_2-4.pdf and 31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF3_M_1-3.pdf).</p>
Data_Supplemental_Fig1_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice
<p>Data of supplemental Fig1, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice”</p> <p> </p> <p>The Dataset contains the original supplemental figure 1 as PNG-format (PNTD-D-21-00134R2_SFig1.png). Related information (meta-data) are provided as one file in TXT format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF1_M_1.txt) and one file in PDF format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_SF1_M_2.pdf).</p>
Data_Figure4_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice
<p>Data of Fig4, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice”</p> <p>The Dataset contains the original figure 4 as PNG-format (PNTD-D-21-00134R2_Fig4.png). Related information (meta-data) are provided as one file in TXT format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_Fig4_M_1.txt).</p>
Data_Figure3_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice
<p>Data of Fig3, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice”</p> <p>The Dataset contains the original figure 3 as PNG-format (PNTD-D-21-00134R2_Fig3.png), original supp. table S1 (31003A-179400_PNTD-D-21-00134R2_FJ_MW_SS_Echinococcus_F1_M_3.pdf) and raw blots as the original supplemental file S1 (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F1_M_4.pdf). Corresponding raw data, subsequent data analysis and all further experiment related information (meta-data) from Western Blot analysis provided as one file in TXT format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F3_2_13-14_M_1.txt) and one file in PDF format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F3_M_2.pdf).</p>
Data_Figure2_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice
<p>Data of Fig2, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice”</p> <p>The Dataset contains the original figure 2 as PNG-format (PNTD-D-21-00134R2_Fig2.png). Corresponding raw data and subsequent data analysis obtained from Multiplex Luminex Cytokine measurement analysis provided as one files in CSV format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F2_22_1-2_1.csv). All further experiment related information (meta-data) provided as one file in TXT format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F2_22_1-2_M_1.txt) and one file in PDF format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F2_M_2.pdf).</p>
Data_Figure1_Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice
<p>Data of Fig1, “Albendazole reduces endoplasmic reticulum stress induced by Echinococcus multilocularis in mice”</p> <p> </p> <p>The Dataset contains the original figure 1 as PNG-format (PNTD-D-21-00134R2_Fig1.png), original supp. table S1 (31003A-179400_PNTD-D-21-00134R2_FJ_MW_SS_Echinococcus_F1_M_3.pdf), original supp. Figure S1 (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F1_M_4.pdf) and the original supplemental file S1 (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F1_M_5.pdf).</p> <p>Corresponding raw data, subsequent data analysis and all further experiment related information (meta-data) from Western Blot analysis provided as one file in TXT format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F1_2_1-26_M_1.txt) and one file in PDF format (31003A-179400_PNTD-D-21-00134R2 _FJ_MW_SS_Echinococcus_F1_M_2.pdf).</p>
Raw microscopy data from: Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers
<p>Protein folding homeostasis in the endoplasmic reticulum (ER) is regulated by a signaling network, termed the unfolded protein response (UPR). Inositol-requiring enzyme 1 (IRE1) is an ER membrane-resident kinase/RNase that mediates signal transmission in the most evolutionarily conserved branch of the UPR. Dimerization and/or higher-order oligomerization of IRE1 are thought to be important for its activation mechanism, yet the actual oligomeric states of inactive, active, and attenuated mammalian IRE1 complexes remained unknown. We developed an automated two-color single-molecule tracking approach to dissect the oligomerization of tagged endogenous human IRE1 in live cells. In contrast to previous models, our data indicate that IRE1 exists as a constitutive homodimer at baseline and assembles into small oligomers upon ER stress. We demonstrate that the formation of inactive dimers and stress-dependent oligomers is fully governed by IRE1's lumenal domain. Phosphorylation of IRE1's kinase domain occurs more slowly than oligomerization and is retained after oligomers disassemble back into dimers. Our findings suggest that assembly of IRE1 dimers into larger oligomers specifically enables trans- autophosphorylation, which in turn drives IRE1's RNase activity.</p> <p> </p>
Raw microscopy data from: Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers
Open the record for dataset details and reuse information.
Processed and additional data for our publication titled "Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers"
<p>This is an updated version of our original data archive (which can be found under the doi 10.5281/zenodo.5513025) that reflects changes we've made to the manuscript over the course of the review process and incorporates the new data we've collected since the time of the initial bioRxiv submission.</p> <p>This data archive contains all raw data EXCEPT for single-particle microscopy movies (which are deposited separately due to their size) for our paper titled "Endoplasmic reticulum stress activates human IRE1a through reversible assembly of inactive dimers into small oligomers". These raw data are stored in "non_SPT_data_final_v2.zip". Additionally, full plasmid sequences for all plasmids used in this paper are stored in GenBank format in the file "plasmid_sequences_v2.zip". Finally, this repository contains processed single-particle movies in the form of dual-color tracks from the TrackMate ImageJ plugin in XML format (file: "SPT_processed_data_and_settings_final_v2.zip").</p> <p>The processed XML tracks are organized in the same way as the raw data files in the separate repository. They are sorted into subfolders by date of acquisition first, followed by experimental conditions. To recreate the figures from the paper, follow instructions in the README.md file included with the source code repository and use the JSON settings files saved here under "analysis_settings".</p>
The effect of antidepressants on genes of endoplasmic reticulum stress in human astrocyte cell line.
<p>Many central nervous system (CNS) diseases, including major depressive disorder (MDD), are underpinned by the unfolded protein response (UPR) activated under endoplasmic reticulum (ER) stress. New, more efficient, therapeutic options for MDD are needed to avoid adverse effects and drug resistance. Therefore, the aim of the work was to determine whether UPR signalling pathway activation in astrocytes may serve as a novel target for antidepressant drugs. Among the tested antidepressants (escitalopram, amitriptyline, S-ketamine), only S-ketamine induced the expression of most ER stress-responsive genes in astrocytes.</p> <p><a href="https://doi.org/10.3390/pharmaceutics14040846">https://doi.org/10.3390/pharmaceutics14040846</a></p> <p> </p>
Effect of Endoplasmic Reticulum Stress on Metabolic Function
ClinicalTrials.gov study NCT00771901. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress
<p>Eukaryotes have evolved various quality control mechanisms to promote proteostasis in the ER. Selective removal of certain ER domains via autophagy (termed as ER-phagy) has emerged as a major quality control mechanism. However, the degree to which ER-phagy is employed by other branches of ER-quality control remains largely elusive. Here, we identify a cytosolic protein, C53, that is specifically recruited to autophagosomes during ER-stress, in both plant and mammalian cells. C53 interacts with ATG8 via a distinct binding epitope, featuring a shuffled ATG8 interacting motif (sAIM). C53 senses proteotoxic stress in the ER lumen by forming a tripartite receptor complex with the ER-associated ufmylation ligase UFL1 and its membrane adaptor DDRGK1. The C53/UFL1/DDRGK1 receptor complex is activated by stalled ribosomes and induces the degradation of internal or passenger proteins in the ER. Consistently, the C53 receptor complex and ufmylation mutants are highly susceptible to ER stress. Thus, C53 forms an ancient quality control pathway that bridges selective autophagy with ribosome-associated quality control in the ER.</p>
Multi-omic Mapping of Human Pancreatic Islet Endoplasmic Reticulum and Cytokine Stress Responses Provide Type 2 Diabetes Genetic Insights
<p>The following data accompanying the manuscript can be found here:</p> <ul> <li>Expression (bulk RNA-seq & scRNA-seq) matrices</li> <li>Chromatin accessibility (bulk ATAC-seq) matrices</li> <li>TDF files for IGV browser visualization of cis-regulatory elements</li> </ul>
Study of the Expression of Endoplasmic Reticulum Stress During Extracorporeal Circulation in Humans
ClinicalTrials.gov study NCT03722979. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Relationship of Endoplasmic Reticulum Stress and Tonsillar Tissue Diseases
ClinicalTrials.gov study NCT04653376. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Involvement of Reticulum Endoplasmic Stress in the Physiopathology of Polycystic Ovary Syndrome
ClinicalTrials.gov study NCT02302326. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Relationship of Endoplasmic Reticulum Stress and Adenoid Diseases
ClinicalTrials.gov study NCT04583631. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
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