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322 results for “endothelial dysfunction”
Dataset related to: Sirt3 deficiency promotes endothelial dysfunction and aggravates renal injury
<p>The .xlsx file contains raw data related to the article "<i><strong>Sirt3</strong></i><strong> deficiency promotes endothelial dysfunction and aggravates renal injury</strong>. <i>PLOS One</i>. 2023 Oct 10;18(10):e0291909<i>", </i>available at the following <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0291909">link</a>.</p><p> </p><p><strong>Abstract</strong></p><p>Sirtuin 3 (SIRT3), the main deacetylase of mitochondria, modulates the acetylation levels of substrates governing metabolism and oxidative stress. In the kidney, we showed that SIRT3 affects the proper functioning of high energy-demanding cells, such as tubular cells and podocytes. Less is known about the role of SIRT3 in regulating endothelial cell function and its impact on the progression of kidney disease. Here, we found that whole body <i>Sirt3</i>-deficient mice exhibited reduced renal capillary density, reflecting endothelial dysfunction, and VEGFA expression compared to wild-type mice. This was paralleled by activation of hypoxia signaling, upregulation of HIF-1α and Angiopietin-2, and oxidative stress increase. These alterations did not result in kidney disease. However, when <i>Sirt3</i>-deficient mice were exposed to the nephrotoxic stimulus Adriamycin (ADR) they developed aggravated endothelial rarefaction, altered VEGFA signaling, and higher oxidative stress compared to wild-type mice receiving ADR. As a result, ADR-treated <i>Sirt3</i>-deficient mice experienced a more severe injury with exacerbated albuminuria, podocyte loss and fibrotic lesions. These data suggest that SIRT3 is a crucial regulator of renal vascular homeostasis and its dysregulation is a predisposing factor for kidney disease. By extension, our findings indicate SIRT3 as a pharmacologic target in progressive renal disease whose treatments are still imperfect.</p>
Endothelial barrier dysfunction in systemic inflammation is mediated by soluble VE-cadherin interfering VE-PTP signalling
<p>Original dataset for publication in iScience</p>
FFA-Induced Hypertension and Endothelial Dysfunction
ClinicalTrials.gov study NCT00589888. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Green Tea Confections For Managing Postprandial Hyperglycemia-Induced Vascular Endothelial Dysfunction
ClinicalTrials.gov study NCT01857258. IPD Sharing: YES. Countries: 1. Publications: 1.
Effect of an Inhaled Glucocorticosteroid (ICS) on Endothelial Dysfunction in Cigarette Smokers
ClinicalTrials.gov study NCT01216735. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Periodontal Infection and Endothelial Dysfunction
ClinicalTrials.gov study NCT00681564. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Study to Determine Iatrogenic Hyperinsulinemia's Contribution to Insulin Resistance and Endothelial Dysfunction in Type 1 Diabetes
ClinicalTrials.gov study NCT04118374. IPD Sharing: YES. Countries: 1. Publications: 1.
Mechanisms of Endothelial Cell Dysfunction in Sleep Apnea
ClinicalTrials.gov study NCT00859950. IPD Sharing: NO. Countries: 1. Publications: 1.
The Influence of Febuxostat on Coronary Artery Endothelial Dysfunction in Participants With Chronic Stable Angina
ClinicalTrials.gov study NCT01763996. IPD Sharing: Not stated. Countries: 1. Publications: 1.
MSC Exosome Therapy for Post-Preeclampsia Endothelial Dysfunction
ClinicalTrials.gov study NCT07183384. IPD Sharing: YES. Countries: 1. Publications: 1.
Nitrite, Isoquercetin and Endothelial Dysfunction (NICE) Trial
ClinicalTrials.gov study NCT02552888. IPD Sharing: YES. Countries: 1. Publications: 2.
Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction.
ClinicalTrials.gov study NCT02836899. IPD Sharing: NO. Countries: 1. Publications: 2.
Effect of Saxagliptin on EPCs as a Cellular Biomarker for Evaluating Endothelial Dysfunction in Early T2DM Patients
ClinicalTrials.gov study NCT02024477. IPD Sharing: NO. Countries: 1. Publications: 1.
Mineralocorticoid Antagonism and Endothelial Dysfunction in Autosomal Dominant Polycystic Kidney Disease (ADPKD)
ClinicalTrials.gov study NCT01853553. IPD Sharing: NO. Countries: 1. Publications: 1.
Role of Neuraminidase Activity on Endothelial Dysfunction in Type 2 Diabetes
ClinicalTrials.gov study NCT04867707. IPD Sharing: NO. Countries: 1. Publications: 1.
Safety and Efficacy of Salsalate to Treat Endothelial Dysfunction in HIV-infected Adults
ClinicalTrials.gov study NCT01046682. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Nebivolol on Endothelial Dysfunction in African Americans With Hypertension
ClinicalTrials.gov study NCT01049009. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Molsidomine on the Endothelial (Internal Layer of Blood Vessels) Dysfunction in Patients With Angina Pectoris
ClinicalTrials.gov study NCT01363661. IPD Sharing: Not stated. Countries: 1. Publications: 2.
A Randomized Clinical Trial To Study Losartan On Endothelial Dysfunction and Insulin Resistance In Obese Patients
ClinicalTrials.gov study NCT00675987. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data for: Mitochondrial Ca2+-coupled generation of reactive oxygen species, peroxynitrite formation, and endothelial dysfunction in Cantú syndrome
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.