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10 results for “evidence synthesis”
Genomic evidence for the parallel regression of melatonin synthesis and signaling pathways in placental mammals
<p><strong>Supplementary Material for:</strong></p> <p>Emerling C.A., Springer M.S., Gatesy J., Jones Z., Hamilton D., Xia-Zhu D., Collin M.A., and Delsuc F. (2021). Genomic evidence for the parallel regression of melatonin synthesis and signaling pathways in placental mammals.<strong><em> Open Research Europe</em></strong> 1:75. doi:10.12688/openreseurope.13795.1.</p> <p> </p> <p><strong>Supplementary File Legends:</strong></p> <p><strong>- Supplementary_Figure_S1.pdf:</strong> <em>AANAT</em> PAML ‘master model’ showing branch categories, corresponding to “Model 1: 24 ratio” in Supplementary Table S7.</p> <p><strong>- Supplementary_Figure_S2.pdf:</strong> <em>ASMT</em> PAML ‘master model’ showing branch categories, corresponding to “Model 2: 24 ratio” in Supplementary Table S8.</p> <p><strong>- Supplementary_Figure_S3.pdf:</strong> <em>MTNR1A</em> PAML ‘master model’ showing branch categories, corresponding to “Model 1: 27 ratio” in Supplementary Table S9.</p> <p><strong>- Supplementary_Figure_S4.pdf:</strong> <em>MTNR1B</em> PAML ‘master model’ showing branch categories, corresponding to “Model 1: 46 ratio” in Supplementary Table S10.</p> <p><strong>- Supplementary_Figure_S5.pdf:</strong> RAxML <em>AANAT</em> gene tree. Numbers at nodes correspond to bootstrap support values.</p> <p><strong>- Supplementary_Figure_S6.pdf: </strong>RAxML <em>ASMT</em> gene tree. Numbers at nodes correspond to bootstrap support values.</p> <p><strong>- Supplementary_Figure_S7.pdf: </strong>RAxML <em>MTNR1A</em>+<em>MTNR1B</em> tree. Numbers at nodes correspond to bootstrap support values.</p> <p><strong>- Supplementary_Figure_S8.pdf: </strong>Supporting data showing the inactivation of <em>MTNR1A</em> exon 2 in cetaceans. Read Supplementary Table S13 for further details.</p> <p><strong>- Supplementary_Figure_S9.pdf: </strong>Supporting data showing the inactivation of <em>ASMT</em> in spalacids and <em>Fukomys damarensis</em>. Read Supplementary Table S13 for further details.</p> <p><strong>- Supplementary_Figure_S10.pdf: </strong>Supporting data showing the inactivation of <em>MTNR1A</em> in hyracoids and <em>Cyclopes didactylus</em>. Read Supplementary Table S13 for further details.</p> <p><strong>- Supplementary_Figure_S11.pdf: </strong>Supporting data showing the inactivation of <em>MTNR1A</em> in sirenians. Read Supplementary Table S13 for further details.</p> <p><strong>- Supplementary_Figure_S12.pdf: </strong>Supporting data showing the inactivation of <em>AANAT</em> in sirenians and a polymorphic premature stop codon in exon 5 of <em>ASMT</em> in <em>Trichechus manatus</em>. Read Supplementary Table S13 for further details.</p> <p><strong>- Supplementary_Figure_S13.pdf: </strong>Supporting data showing the inactivation of <em>MTNR1A</em> in <em>Condylura cristata</em>. Read Supplementary Table S13 for further details.</p> <p><strong>- Supplementary_Figure_S14.pdf: </strong>Supporting data showing the inactivation of <em>MTNR1A</em> in <em>Phataginus tricuspis</em>. Read Supplementary Table S14 for further details.</p> <p><strong>- Supplementary_Figure_S15.pdf: </strong>PAML <em>AANAT</em> results, Model 1: 24 ratio (see Supplementary Table S7).</p> <p><strong>- Supplementary_Figure_S16.pdf: </strong>PAML <em>ASMT</em> results, Model 2: 24 ratio (see Supplementary Table S8).</p> <p><strong>- Supplementary_Figure_S17.pdf: </strong>PAML <em>MTNR1A</em> results, Model 1: 27 ratio (see Supplementary Table S9).</p> <p><strong>- Supplementary_Figure_S18.pdf: </strong>PAML <em>MTNR1B</em> results, Model 1: 46 ratio (see Supplementary Table S10).</p> <p><strong>- Supplementary_Table_S1.xlsx: </strong>List of species examined in this study and the sources of the genes. Source key: WGS: Sequences derived from NCBI's Whole Genome Shotgun database, with accession prefix provided; Whole Genome Sequencing of Short Reads: whole genomes were sequenced using short-read technologies. The methodologies varied for the species, and will be or have been published with other projects, so please contact the author(s) for information on the specific methodology and samples used (Xenarthrans, <em>Proteles cristatus</em>, <em>Otocyon megalotis</em>: Frédéric Delsuc, e-mail: Frederic.Delsuc@umontpellier.fr; Crocodylians: John Gatesy, e-mail: jgatesy@amnh.org; <em>Dugong dugon</em>: Mark Springer, e-mail: mark.springer@ucr.edu; SRA: sequences derived from NCBI's Sequence Read Archive; GenBank: sequences derived from NCBI's nucleotide collection; Bowhead Whale Genome Resource: sequences derived from http://www.bowhead-whale.org; Ensembl: sequences derived from Ensembl genome browser (www.ensembl.org)l; Discovar de novo: sequences derived genomes assembled via Discovar de novo (<a href="https://software.broadinstitute.org/software/discovar/blog/">https://software.broadinstitute.org/software/discovar/blog/</a>). Coverage: indicates coverage of the whole genome (reported in NCBI or other source) or individual genes (derived from short read mapping). Scaffold and contig N50: reported in NCBI or other source.</p> <p><strong>- Supplementary_Table_S2.xlsx: </strong>Accession numbers and functionality of <em>AANAT</em> in species examined. If Accession # indicated as “New”, sequence generated for this study and can be found in Supplementary Dataset S1. Parentheses after accession number indicates coordinates for sequence on the contig / scaffold. Exon colors code for the following: green = putatively functional; yellow = missing (e.g., negative BLAST results, negative mapping results); pink = one or more inactivating mutations found. Abbreviations for mutations are as follows: del = deletion; ins = insertion; start = start codon mutation; stop = premature stop codon; ? = ambiguity whether the mutation is shared among all members of the clade. Abbreviations in brackets following an inactivating mutation indicate shared inactivating mutation. Key for each abbreviation follows: Bacu = <em>Balaenoptera acutorostrata</em>; BALA = Balaenidae; BALAEN = Balaenopteridae; Bbon = <em>Balaenoptera bonaerensis</em>; CAB = <em>Cabassous</em>; Ccap = <em>Cebus capucinus</em>; CETA = Cetacea; CHLAM = Chlamyphoridae; CHOL = <em>Choloepus</em>; Cjac = <em>Callithrix jacchus</em>; CING = Cingulata; DASY = Dasypodidae; DELP = Delphinidae; DERM = Dermoptera; Erob = <em>Eschrichtius robustus</em>; INIA = <em>Inia</em>; FOLI = Folivora; GALE = <em>Galeopterus</em>; LIPO = <em>Lipotes</em>; Lobl = <em>Lagenorhynchus obliquidens</em>; MANI = Manidae; MONO = Monodontidae; MYRM = Myrmecophagidae; MYST = Mysticeti; NPP = Not present in <em>Platanista</em> or Physeteroidea, but present in other Odontocetes; NPZ = Not present in Ziphiidae, but present in other Odontocetes; Oorc = <em>Orcinus orca</em>; PEUT = Tolypeutinae; PHOC = Phocoenidae; PHOL = Pholidota; PHOR = Chlamyphorinae; PILO = Pilosa; PHYS = Physeteroidea; PONT = <em>Pontoporia</em>; Schi = <em>Sousa chinensis</em>; SIRE = Sirenia; Tadu = <em>Tursiops aduncus</em>; TOLY = <em>Tolypeutes</em>; VERM = Vermilingua; XEN = Xenarthra.</p> <p><br> <strong>- Supplementary_Table_S3.xlsx: </strong>Accession numbers and functionality of <em>ASMT</em> in species examined. See Table S2 caption for details.</p> <p><strong>- Supplementary_Table_S4.xlsx: </strong>Accession numbers and functionality of <em>MTNR1A</em> in species examined. See Table S2 caption for details.</p> <p><strong>- Supplementary_Table_S5.xlsx: </strong>Accession numbers and functionality of <em>MTNR1B</em> in species examined. See Table S2 caption for details.</p> <p><strong>- Supplementary_Table_S6.xlsx: </strong>Codon frequency model selection. These are the results from one ratio dN/dS analyses using different codon frequency models. AIC = Akaike Information Criterion.</p> <p><strong>- Supplementary_Table_S7.xlsx: </strong>Results of <em>AANAT</em> PAML dN/dS analyses for mammals. Model: BG = branch(es) grouped with background; fixed 1 = branch(es) fixed at 1. p’-value: p-value after Holm-Bonferroni correction for multiple testing. Model Comparison: if model comparison yields statistically significant differences (p < 0.05), model comparison bolded and given green background; if model comparison is still significant after Holm-Bonferroni correction, asterisk (*) added. For most models, w only shown for branch(es) of interest. Numbers in front of taxonomic names in first row correspond to numbers in the master model shown in Supplementary Figure S1.</p> <p><strong>- Supplementary_Table_S8.xlsx: </strong>Results of <em>ASMT</em> PAML dN/dS analyses for mammals. Refer to Table S7 caption for additional details. Numbers in front of taxonomic names in first row correspond to numbers in the master model shown in Supplementary Figure S2.</p> <p><strong>- Supplementary_Table_S9.xlsx: </strong>Results of <em>MTNR1A</em> PAML dN/dS analyses for mammals. Refer to Table S7 caption for additional details. Numbers in front of taxonomic names in first row correspond to numbers in the master model shown in Supplementary Figure S3.</p> <p><strong>- Supplementary_Table_S10.xlsx: </strong>Results of <em>MTNR1B</em> PAML dN/dS analyses for mammals. Refer to Table S7 caption for additional details. Numbers in front of taxonomic names in first row correspond to numbers in the master model shown in Supplementary Figure S4.</p> <p><strong>- Supplementary_Table_S11.xlsx: </strong>Results of PAML analyses for sauropsids.</p> <p><strong>- Supplementary_Table_S12.xlsx: </strong>Results of BLASTing and mapping short reads from <em>Alligator mississippiensis</em> RNA sequencing experiments.</p> <p><strong>- Supplementary_Table_S13.xlsx: </strong>Supporting data for validating putative inactivating mutations. Validating data came from four general sources of information: mutations shared by more than one species within a clade, mutations shared by two sources of sequencing data for the same species, mutations validated by coverage of mapped short reads and statistically elevated dN/dS ratio estimates. For additional details, see Supplementary Tables S2–S5 and S7–S10, as well as Figure 2 and Supplementary Figures S8–S18.</p> <p><strong>- Supplementary_Dataset_S1.txt:</strong><strong> </strong>Genomic alignments in fasta format used to determine the pseudogene/functional status of all four melatonin genes in different taxonomic groups.</p> <p><strong>- Supplementary_Dataset_S2.txt:</strong><strong> </strong>Alignment of <em>AANAT</em> in phylip format used in maximum likelihood phylogenetic reconstruction with RAxML. </p> <p><strong>- Supplementary_Dataset_S3.txt: </strong>Alignment of <em>ASMT</em> in phylip format used in maximum likelihood phylogenetic reconstruction with RAxML. </p> <p><strong>- Supplementary_Dataset_S4.txt: </strong>Alignment of <em>MTNR1A</em> and <em>MTNR1B</em> in phylip format used in maximum likelihood phylogenetic reconstruction with RAxML. </p> <p><strong>- Supplementary_Dataset_S5.txt:</strong><strong> </strong>Codon alignments of <em>AANAT</em> used in selection pressure analyses with PAML. </p> <p><strong>- Supplementary_Dataset_S6.txt: </strong>Codon alignments of <em>ASMT</em> used in selection pressure analyses with PAML.</p> <p><strong>- Supplementary_Dataset_S7.txt:</strong><strong> </strong>Codon alignments of <em>MTNR1A</em> used in selection pressure analyses with PAML.</p> <p><strong>- Supplementary_Dataset_S8.txt: </strong>Codon alignments of <em>MTNR1B</em> used in selection pressure analyses with PAML.</p> <p><strong>- Supplementary_Dataset_S9.txt: </strong>Tree topologies in newick format used in selection pressure analyses with PAML.</p>
Recording of workshop: Open Synthesis: Open Science in Evidence Synthesis
<p>Recording of the session "Open Synthesis: Open Science in Evidence Synthesis" chaired by Dr Elaine Toomey. Further details of the workshop can be found here: <a href="https://evidencesynthesisireland.ie/opensynthesis/">https://evidencesynthesisireland.ie/opensynthesis</a></p> <p>Dr <a href="https://evidencesynthesisireland.ie/team-member/dr-elaine-toomey/">Elaine Toomey</a> is Associate Director of <a href="https://ireland.cochrane.org/">Cochrane Ireland</a> within <a href="https://evidencesynthesisireland.ie/">Evidence Synthesis Ireland</a> based in the National University of Ireland Galway. Her research primarily focuses on methods used in the development, evaluation and implementation of health behaviour change interventions, particularly in relation to the treatment and prevention of chronic disease. She has specific expertise in implementation science, evidence synthesis, process evaluation and exploring the fidelity and adaptation of behaviour change interventions.</p> <p>Elaine is a member of the <a href="https://www.hrb.ie/">Health Research Board (HRB)</a> <a href="https://hrbopenresearch.org/advisors">Open Research National Steering Committee</a>, Co-Chair of the <a href="https://ehps.net/special-interest-groups/">European Health Psychology Society Open Science Special Interest Group</a> and a Catalyst for the Berkeley Initiative for Transparency in the Social Sciences (<a href="https://www.bitss.org/">BITSS</a>). In 2016 Elaine was awarded a Leamer-Rosenthal Prize for Open Social Science for Emerging Researchers from the University of California Berkeley for her work in fidelity and transparency of behaviour change interventions, and has been shortlisted for a <a href="https://www.esof.eu/en/news-reader/id-9th-call-for-the-2020-european-young-researchers-award-is-now-open.html">European Young Researcher Award 2020</a>.</p> <p>The presentation was part of the <a href="http://www.nuigalway.ie/osw/">Open Scholarship Week 2020</a>. It can also be viewed at <a href="https://www.youtube.com/watch?v=fANpI4xX-lk">https://www.youtube.com/watch?v=fANpI4xX-lk</a> or <a href="https://nuigalway.mediaspace.kaltura.com/media/Open+SynthesisA+Open+Science+in+Evidence+Synthesis/1_rdli41as/121659351">https://nuigalway.mediaspace.kaltura.com/media/Open+SynthesisA+Open+Science+in+Evidence+Synthesis/1_rdli41as/121659351</a></p>
Data for: Ecological impacts of extreme climatic events on terrestrial and freshwater biota in the Arctic: A synthesis of current scientific evidence and opportunities
<p>File contains the results of a literature review on the ecological impacts of extreme climatic events on terrestrial and freshwater biota in the Arctic.</p>
Research Integrity Assessment (RIA) Tool for RCTs in evidence synthesis
<p>The RIA tool, consisting of six domains to assess the research integrity of RCTs included in systematic reviews, is a new transparent option to include the concept of research integrity in evidence synthesis as part of the eligibility screening.</p> <p>Brief summary: Potentially eligible RCTs identified during screening should be assessed for research integrity hierarchically considering domain 1 to 6. Retraction, lack of prospective registration, lack of adequate ethical approval with informed written consent, inconsistencies in the author group and the location of the study, lack of proper randomization, implausible study results should lead to exclusion of a RCT. Concerns with the RCT in any domain put the study in ‘awaiting classification’ and should lead to further investigations. If no concerns appear through all domains or could be clarified, e.g. in correspondence with study authors, the RCT meets criteria for inclusion in the review and can be processed further. In living systematic reviews, included RCTs and RCTs ‘awaiting classification’ must be reassessed for retraction notices.</p>
Search Strategies for the Generic Justification Evidence Synthesis: magnetic resonance guided radiotherapy
<p>The dataset includes the complete, reproducible search strategies for all bibliographic databases searched during this project. The search strategies were designed to answer the following research questions: </p> <p><strong>RQ1.</strong> In patients with cancer requiring radiotherapy, does the choice of image-guided modality (MRgRT versus other) result in a difference in clinical effectiveness?</p> <p><strong>RQ2. </strong>In patients with cancer requiring radiotherapy, does the choice of image-guided modality (MRgRT versus other) result in a difference in potential harms?</p> <p> </p>
APPENDIX H: Evidence Synthesis Form and APPENDIX I: Extracted Associators
<p>APPENDIX H: Evidence Synthesis Form and APPENDIX I: Extracted Associators for Memoryscapes in Recto-spection: Visualizing Avenida, Recto, and Carriedo, Manila as Virtual Memoryscapes through immersive mobile technologies and digital heritage interpretation. Thesis Adviser: Dr. Cathe Desiree S. Nadal, Ph. D.</p>
Soil carbon stocks in sugarcane cultivation: an evidence synthesis associated with land use and management practices
Open the record for dataset details and reuse information.
Peripheral Microglial Process TRAP shows evidence of new protein synthesis at perisynaptic and phagocytic structures
GEO Series GSE161460. Mus musculus. 44 samples. Type: Expression profiling by high throughput sequencing.
Evidence Synthesis: Hypertension Medication Adherence & Intensification
ClinicalTrials.gov study NCT00682968. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Feed restriction, but not L-carnitine infusion, affects the liver transcriptome with an evident and inhibition of energy production and sterol synthesis and increase of gluconeogenesis in mid-lactati
GEO Series GSE43307. Bos taurus. 19 samples. Type: Expression profiling by array.
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