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115 results for “fibrinogen;”
Fibrinogen-like globe domain of human Tenascin-C (hFBG-C); A Target Enabling Package
<p>Chronic activation of the innate immune system by the damage-associated molecular pattern FBG-C (C-terminal fibrinogen-like globe domain of Tenascin-C) contributes to a variety of inflammatory diseases including arthritis, systemic sclerosis, and cancer. This TEP summarizes the first reported efforts to develop small-molecule FBG-C binders, with the aim to disrupt FBG-C-mediated pro-inflammatory protein-protein interactions (PPIs). We present the soluble expression of disulphide-containing human FBG-C (hFBG-C) in <em>E. coli</em>, the novel structure of hFBG-C, and preliminary chemical matter against hFBG-C derived from a crystallographic fragment screen. Finally, we introduce two robustly validated cellular assays, in either immortalized monocytes or primary human macrophages, which provide a route to development of small molecules which inhibit hFBG-C-activated inflammation.</p>
Fibrinogen depletion coagulopathy predicts major bleeding after thrombolysis for ischemic stroke: a multicentre study
<p>Dataset from "Fibrinogen depletion coagulopathy predicts major bleeding after thrombolysis for ischemic stroke: a multicentre study", Romoli & Vandelli et al., Stroke 2022</p>
Рис. 2. Варианты преΑсказанной Αоменной структуры патогенраспознающих моΛекуΛ гемоцитов моΛΛюсков Planorbarius corneus. a — фибриногенпоΑобные беΛки, b — гаΛектины, c — F-Λектины. УсΛовные обозначения и сокращения, зΑесь и ΑаΛее: горизонтаΛьные красные поΛоски — сигнаΛьный пептиΑ, горизонтаΛьные розовые — обΛасть низкой сΛожности, вертикаΛьные синие поΛоски — трансмембранная обΛасть, FBG — фибриногеновый Αомен, FTP — Αомен фукоΛектина, EGF — Αомен эпиΑермаΛьного фактора роста, EGF_CA — каΛьцийсвязывающий EGF-поΑобный Αомен, PAN_AP — APPLE-поΑобный Αомен, SCAN — обΛасть, богатая Λейцином, GLECT — гаΛактозосвязывающий Λектин, CLECT — Λектин C-типа, Gal-bind — гаΛактозиΑ–связывающий Λектин, ML — MD-2- поΑробный Αомен распознавания ΛипиΑов Fig. 2. Variants of the predicted domain structure of pattern recognition molecules from hemocytes of Planorbarius corneus molluscs. a — fibrinogen-related proteins, b — galectins, c — F-lectins. Symbols and abbreviations (here and further): horizontal red stripes — signal peptide, horizontal pink stripes — a low complexity region, vertical blue stripes — transmembrane region, FBG — fibrinogen-related domain, FTP — fucolectin domain, EGF — epidermal growth factor-like domain, EGF_CA — calcium-binding EGF-like domain, PAN_AP — APPLE-like domain, SCAN — leucine rich region, Apple — APPLE domain, GLECT — galactose-binding lectin, CLECT — C-type lectin, Gal-bind — galactoside-binding lectin, ML — MD-2-related lipid-recognition domain in Pathogen recognition molecules from hemocytes of Planorbarius corneus molluscs (Planorbidae, Pulmonata)
Рис. 2. Варианты преΑсказанной Αоменной структуры патогенраспознающих моΛекуΛ гемоцитов моΛΛюсков Planorbarius corneus. a — фибриногенпоΑобные беΛки, b — гаΛектины, c — F-Λектины. УсΛовные обозначения и сокращения, зΑесь и ΑаΛее: горизонтаΛьные красные поΛоски — сигнаΛьный пептиΑ, горизонтаΛьные розовые — обΛасть низкой сΛожности, вертикаΛьные синие поΛоски — трансмембранная обΛасть, FBG — фибриногеновый Αомен, FTP — Αомен фукоΛектина, EGF — Αомен эпиΑермаΛьного фактора роста, EGF_CA — каΛьцийсвязывающий EGF-поΑобный Αомен, PAN_AP — APPLE-поΑобный Αомен, SCAN — обΛасть, богатая Λейцином, GLECT — гаΛактозосвязывающий Λектин, CLECT — Λектин C-типа, Gal-bind — гаΛактозиΑ–связывающий Λектин, ML — MD-2- поΑробный Αомен распознавания ΛипиΑов Fig. 2. Variants of the predicted domain structure of pattern recognition molecules from hemocytes of Planorbarius corneus molluscs. a — fibrinogen-related proteins, b — galectins, c — F-lectins. Symbols and abbreviations (here and further): horizontal red stripes — signal peptide, horizontal pink stripes — a low complexity region, vertical blue stripes — transmembrane region, FBG — fibrinogen-related domain, FTP — fucolectin domain, EGF — epidermal growth factor-like domain, EGF_CA — calcium-binding EGF-like domain, PAN_AP — APPLE-like domain, SCAN — leucine rich region, Apple — APPLE domain, GLECT — galactose-binding lectin, CLECT — C-type lectin, Gal-bind — galactoside-binding lectin, ML — MD-2-related lipid-recognition domain
In Vivo Effects of Fibrinogen Concentrate (FC) Versus Cryoprecipitate on the Neonatal Fibrin Network Structure After Cardiopulmonary Bypass (CPB)
ClinicalTrials.gov study NCT03932240. IPD Sharing: YES. Countries: 1. Publications: 1.
Fibrinogen in Haemorrhage of Delivery
ClinicalTrials.gov study NCT02155725. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Prospective Double Blinded Randomized Control Study of the Use of Fibrinogen in High-Risk Cardiac Surgery
ClinicalTrials.gov study NCT01623531. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pharmacokinetic, Efficacy and Safety of BT524 in Patients With Congenital Fibrinogen Deficiency
ClinicalTrials.gov study NCT02065882. IPD Sharing: NO. Countries: 5. Publications: 0.
Adjusted Fibrinogen Replacement Strategy
ClinicalTrials.gov study NCT03444324. IPD Sharing: NO. Countries: 7. Publications: 1.
Human Fibrinogen Concentrate in Pediatric Cardiac Surgery
ClinicalTrials.gov study NCT02822599. IPD Sharing: NO. Countries: 1. Publications: 10.
Comparison of Fibrinogen Concentrate and Cryoprecipitate in Pediatric Cardiac Surgery Patients
ClinicalTrials.gov study NCT04376762. IPD Sharing: NO. Countries: 1. Publications: 6.
Human Fibrinogen - Pharmacokinetics
ClinicalTrials.gov study NCT00496262. IPD Sharing: Not stated. Countries: 2. Publications: 1.
The Effects of Fibrinogen Concentrate Infusion on Blood Loss and Allogeneic Blood Conservation in Scoliosis Surgery
ClinicalTrials.gov study NCT03183479. IPD Sharing: YES. Countries: 1. Publications: 1.
Transfusion of Pathogen Reduced Cryoprecipitated Fibrinogen to Expedite Product Availability in Perioperative Bleeding
ClinicalTrials.gov study NCT05711524. IPD Sharing: NO. Countries: 1. Publications: 10.
Albumin and fibrinogen synthesis rates in advanced chronic liver disease
<p>Supplement data for the research work on "<strong>Albumin and fibrinogen synthesis rates in advanced chronic liver disease".</strong></p> <p>Table S1 and table S2.</p>
Incidence of Trauma Induced Coagulopathy in Patients With Prehospital Administration of Fibrinogen
ClinicalTrials.gov study NCT03572309. IPD Sharing: NO. Countries: 1. Publications: 0.
Influence of Preop Fibrinogen on Blood in Pediatric Cardiac Surgery
ClinicalTrials.gov study NCT05525195. IPD Sharing: NO. Countries: 1. Publications: 20.
Fibrinogen Concentrate (FGTW) in Trauma Patients, Presumed to Bleed (FI in TIC)
ClinicalTrials.gov study NCT01475344. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Early Administration of Fibrinogen in Polytraumatized Patients With Hypofibrinogenemia: a Randomized Feasibility Trial
ClinicalTrials.gov study NCT02864875. IPD Sharing: NO. Countries: 1. Publications: 1.
Pilot Randomized Trial of Fibrinogen in Trauma Haemorrhage
ClinicalTrials.gov study NCT02344069. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Prophylactic Fibrinogen Concentrate In Scoliosis Surgery
ClinicalTrials.gov study NCT05391412. IPD Sharing: NO. Countries: 1. Publications: 2.
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