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6 results for “fitness assay”
Non-additive interaction between genotypes: implications for competitive fitness assays
<p>Competitive fitness assays are widely used in evolutionary biology and typically rely on a reference strain to compare different focal genotypes. This approach implicitly relies on the absence of interaction between the competing genotypes. In other words, the performance of the reference strain must not depend on the competitor. This report scrutinized this assumption by competing diverged <em>Drosophila simulans</em> populations against a common reference strain. We detected strong evidence for interaction between the competing genotypes: 1) Frequency-dependent selection was common with opposite effects in genetically diverged populations. 2) Temporal heterogeneity of fitness estimates, which can be partially attributed to a competitor-specific delay in the eclosion of the reference strain. We propose that this inconsistent behavior of the reference strain can be considered a specific case of a genotype x environment interaction. Focal populations could modify the environment of the reference strain, either indirectly by altering the microbiome composition and food availability or directly by genotype-specific cannibalism. Our results provide new insights into the interaction of diverged genotypes and have important implications for the interpretation of competitive fitness assays.</p>
Learning protein fitness models from evolutionary and assay-labeled data
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Growth rate assays reveal fitness consequences of β-lactamases
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Experimental assay of a fitness landscape on a macroevolutionary scale
GEO Series GSE99990. Saccharomyces cerevisiae. 24 samples. Type: Genome variation profiling by high throughput sequencing.
Clonal Competition Assays Identify Fitness Signatures in Cancer Progression and Resistance in Multiple Myeloma
GEO Series GSE247219. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Fitness assay of Candida albicans strains grown in vitro or in vivo in a mouse model of gastrointestinal colonization
GEO Series GSE67215. Candida albicans. 12 samples. Type: Other.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.