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81 results for “focal epilepsy”
Data: Focal to bilateral tonic-clonic seizures are associated with widespread network abnormality in temporal lobe epilepsy
<p>We make available all the brain network data, and metadata of 83 patients and 29 healthy controls included in our study.</p> <p>Nishant Sinha, Natalie Peternell, Gabrielle M. Schroeder, Jane de Tisi, Sjoerd B. Vos, Gavin P. Winston, John S. Duncan, Yujiang Wang, and Peter N. Taylor "<em>Focal to bilateral tonic-clonic seizures are associated with widespread network abnormality in temporal lobe epilepsy.</em>" Epilepsia 2021 <em>doi:10.1111/epi.16819</em>.</p> <p>Methodological details on MRI acquisition and data processing are provided in our manuscript. We request users to kindly cite our article and data appropriately.</p>
Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adults With Drug-resistant Epilepsy
ClinicalTrials.gov study NCT03373383. IPD Sharing: YES. Countries: 19. Publications: 2.
Treatment of Difficult to Control Focal Epilepsy With Repetitive Transcranial Magnetic Stimulation (rTMS)
ClinicalTrials.gov study NCT01745952. IPD Sharing: NO. Countries: 1. Publications: 13.
A Study to Test the Efficacy and Safety of Padsevonil as Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsy
ClinicalTrials.gov study NCT03739840. IPD Sharing: YES. Countries: 28. Publications: 1.
Phase 2 Efficacy, Safety, and Tolerability Study of Natalizumab in Focal Epilepsy
ClinicalTrials.gov study NCT03283371. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study to Evaluate XEN1101 as Adjunctive Therapy in Focal Epilepsy
ClinicalTrials.gov study NCT03796962. IPD Sharing: Not stated. Countries: 9. Publications: 1.
Arterial Spin Labeling MRI Focal Abnormalities in Refractory Epilepsy
ClinicalTrials.gov study NCT01772654. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Supplementary code and visualisations for "Seizure pathways change on circadian and slower timescales in individual patients with focal epilepsy"
<p>MATLAB code and workspaces for reproducing the main results and figures of the paper "Seizure pathways change on circadian and slower timescales in individual patients with focal epilepsy." Additional supplementary visualisations for all patients are also provided as PDFs. </p> <p>The paper preprint is available on bioRxiv: https://www.biorxiv.org/content/10.1101/661371v2</p>
Does Levetiracetam and Carbamazepine Impact the Autonomic Activity of Children With Self-limiting Focal Epilepsy?
ClinicalTrials.gov study NCT06138847. IPD Sharing: NO. Countries: 1. Publications: 2.
Neurophysiologically Based Brain State Tracking and Modulation in Focal Epilepsy
ClinicalTrials.gov study NCT03946618. IPD Sharing: NO. Countries: 1. Publications: 1.
Genetic and Electrophysiologic Study in Focal Drug-resistant Epilepsies
ClinicalTrials.gov study NCT02890641. IPD Sharing: Not stated. Countries: 1. Publications: 9.
High-resolution Multi-parametric Magnetic Resonance Imaging for Focal Epilepsy
ClinicalTrials.gov study NCT06550726. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
Impact of Thermocoagulation During Invasive EEG Monitoring in Children With Focal Drug-resistant Epilepsies
ClinicalTrials.gov study NCT02886650. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Induced Pluripotent Stem Cell Derived Exosomes Nasal Drops for the Treatment of Refractory Focal Epilepsy
ClinicalTrials.gov study NCT05886205. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Thermographic Examination of Skin Temperatures in Individuals With Focal Onset Epilepsy
ClinicalTrials.gov study NCT01373190. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Transcranial Magnetic Stimulation (rTMS) for Refractory Focal Epilepsy
ClinicalTrials.gov study NCT06681480. IPD Sharing: NO. Countries: 1. Publications: 6.
The Impact of Focused Ultrasound Thalamotomy of the Anterior Nucleus for Focal-Onset Epilepsy on Anxiety
ClinicalTrials.gov study NCT05032105. IPD Sharing: NO. Countries: 1. Publications: 22.
A Pilot Study: Focused Ultrasound Thalamotomy for the Prevention of Secondary Generalization in Focal Onset Epilepsy
ClinicalTrials.gov study NCT03417297. IPD Sharing: NO. Countries: 1. Publications: 1.
Data from: Differential temperature sensitivity of synaptic and firing processes in a neural mass model of epileptic discharges explains heterogeneous response of experimental epilepsy to focal brain cooling
Experiments with drug-induced epilepsy in rat brains and epileptic human brain region reveal that focal cooling can suppress epileptic discharges without affecting the brain's normal neurological function. Findings suggest a viable treatment for intractable epilepsy cases via an implantable cooling device. However, precise mechanisms by which cooling suppresses epileptic discharges are still not clearly understood. Cooling experiments in vitro presented evidence of reduction in neurotransmitter release from presynaptic terminals and loss of dendritic spines at post-synaptic terminals offering a possible synaptic mechanism. We show that termination of epileptic discharges is possible by introducing a homogeneous temperature factor in a neural mass model which attenuates the post-synaptic impulse responses of the neuronal populations. This result however may be expected since such attenuation leads to reduced post-synaptic potential and when the effect on inhibitory interneurons is less than on excitatory interneurons, frequency of firing of pyramidal cells is consequently reduced. While this is observed in cooling experiments in vitro, experiments in vivo exhibit persistent discharges during cooling but suppressed in magnitude. This leads us to conjecture that reduction in the frequency of discharges may be compensated through intrinsic excitability mechanisms. Such compensatory mechanism is modelled using a reciprocal temperature factor in the firing response function in the neural mass model. We demonstrate that the complete model can reproduce attenuation of both magnitude and frequency of epileptic discharges during cooling. The compensatory mechanism suggests that cooling lowers the average and the variance of the distribution of threshold potential of firing across the population. Bifurcation study with respect to the temperature parameters of the model reveals how heterogeneous response of epileptic discharges to cooling (termination or suppression only) is exhibited. Possibility of differential temperature effects on post-synaptic potential generation of different populations is also explored.
Forecasting seizure risk in adults with focal epilepsy: a development and validation study - Data
<p><strong>Data for the article 'Forecasting seizure risk in adults with focal epilepsy: a development and validation study'</strong></p> <p>Includes deidentified individual data in the form of interictal epileptiform activity counts and electrographic seizures for the 18 patients in the development cohort.</p>
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