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196 results for “folate”
Implication of Folate Deficiency in CYP2U1 loss of function
<p>Hereditary spastic paraplegias are heterogeneous neurodegenerative disorders. Understanding of their pathogenic mechanisms remains sparse and therapeutic options are lacking. We characterized a mouse model lacking the Cyp2u1 gene, loss of which is known to be involved in a complex form of these diseases in Humans. We showed that this model partially recapitulated the clinical and biochemical phenotypes of patients. Using electron microscopy, lipidomic, and proteomic studies, we identified vitamin B2 as a substrate of the CYP2U1 enzyme, as well as coenzyme Q, neopterin, and interferon-alpha levels as putative biomarkers in mouse and in fluids obtained from the largest series of CYP2U1- mutated patients reported so far. We also confirmed brain calcifications as a potential biomarker in patients. Our results suggest that CYP2U1 deficiency disrupts mitochondrial function and impacts proper neurodevelopment, which could be prevented by folate supplementation in our mouse model, followed by a neurodegenerative process altering multiple neuronal and extra neuronal tissues.</p>
Fig. 2 in Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer
Fig. 2 Effect of probenecid (PBN) on the activity of PM, MTX, and TMX. Y axis represents the percentage decrease in IC50 in the presence of PBN. One hundred percent (100%) represents the IC50 in the absence of PBN. In the absence of PBN, the MTX, TMX, and PM IC50 values were 30, 7, and 1,200 nM, respectively
Ariaal MDD-W, folate & homocysteine data
<p>This file (Ariaal_MDDW&HCY) contains data for a journal article manuscript entitled, "Protective effects of diversified diets for dietary folate adequacy and serum homocysteine level in breastfeeding mothers amid historic drought." by Fujita, Asthana, and Wamwere-Njoroge. This manuscript is under review for publication as of May, 2024. The variables and data are found under the Data tab, and the data coding information under the code & info tab. Please contact Masako Fujita (ORCID 0000-0001-9173-6678, E-mail masakof@msu.edu) for questions regarding the data.</p> <p><strong>Condition for data use</strong>: Please cite DOI (DOI: 10.5281/zenodo.7897424) for this data file and the article, and acknowledge the support from the grant agencies listed below:</p> <p><em>Data source/article:</em></p> <p>Fujita M. 2023. Ariaal MDD-W, folate & homocysteine data. DOI: 10.5281/zenodo.7897424.</p> <p>Fujita M, Ashana A, Wamwere-Njorge G. [Year] Protective effects of minimally diversified diets for folate nutrition among breastfeeding mothers amid historic drought. [Journal name, article DOI].</p> <p><em>Grant support:</em></p> <p> National Science Foundation (BCS-0622358, BCS-1638167)</p> <p> Wenner Gren Foundation (Gr. 7460, Gr. 9278)</p> <p> Provost Undergraduate Research Initiative Grant, Michigan State University </p>
Fig. 1 in Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer
Fig. 1 Chemical structures of folic acid and of the antifolate drugs we analyzed
Folate Receptor Alpha Peptide Vaccine With GM-CSF Versus GM-CSF Alone in Patients With Platinum Sensitive Ovarian Cancer
ClinicalTrials.gov study NCT02978222. IPD Sharing: NO. Countries: 1. Publications: 1.
Study of Mirvetuximab Soravtansine in Combination With Bevacizumab, Carboplatin, Pegylated Liposomal Doxorubicin, Pembrolizumab, or Bevacizumab + Carboplatin in Participants With Folate Receptor Alpha
ClinicalTrials.gov study NCT02606305. IPD Sharing: Not stated. Countries: 4. Publications: 0.
Phase 2 Study of OTL38 for Intra-operative Imaging of Folate Receptor-alpha Positive Ovarian Cancer
ClinicalTrials.gov study NCT02317705. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Folate Supplementation in Schizophrenia
ClinicalTrials.gov study NCT00249288. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Vitamin B12 and Folate Administration on Homocysteine Concentrations After Nitrous Oxide Anesthesia
ClinicalTrials.gov study NCT00901394. IPD Sharing: NO. Countries: 1. Publications: 3.
Assessment of the Pharmacodynamic Effect on Plasma Folate and Red Blood Cell Folate and Comparison of the Folate Metabolites During the 24 Weeks of Treatment (Yasmin + Metafolin Versus Yasmin + Folic
ClinicalTrials.gov study NCT01258660. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy and Safety Study for an Oral Contraceptive Containing Folate
ClinicalTrials.gov study NCT00468481. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A Study of Mirvetuximab Soravtansine in Platinum-Resistant, Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression
ClinicalTrials.gov study NCT04296890. IPD Sharing: Not stated. Countries: 11. Publications: 3.
OTL38 for Intra-operative Imaging of Folate Receptor Positive Ovarian Cancer
ClinicalTrials.gov study NCT03180307. IPD Sharing: NO. Countries: 2. Publications: 1.
A Study of Mirvetuximab Soravtansine vs. Investigator's Choice of Chemotherapy in Women With Folate Receptor (FR) Alpha Positive Advanced Epithelial Ovarian Cancer (EOC), Primary Peritoneal or Fallopi
ClinicalTrials.gov study NCT02631876. IPD Sharing: Not stated. Countries: 13. Publications: 1.
Data from: Development of folate receptor targeting chimeras for cancer selective degradation of extracellular proteins
Open the record for dataset details and reuse information.
Fig. 4 in Biochemical and molecular insights of PGPR application for the augmentation of carotenoids, tocopherols, and folate in the foliage of Moringa oleifera
Fig. 4. HPLC Chromatograms of 1–5,6,7,8 tetrahydro folic acid (THF) in Control and 937b- B. subtilis IN937b treated M. oleifera foliage.
Fig. 3 in Biochemical and molecular insights of PGPR application for the augmentation of carotenoids, tocopherols, and folate in the foliage of Moringa oleifera
Fig. 3. HPLC Chromatograms of 1- Violaxanthin, 2- Lutein, 3- Chl b, 4-Chl a, 5- β-carotene in control and GBO3- B. subtilis GB03 treated M. oleifera foliage.
Fig. 5 in Biochemical and molecular insights of PGPR application for the augmentation of carotenoids, tocopherols, and folate in the foliage of Moringa oleifera
Fig. 5. Differential expression of mRNA levels of γ-tocopherol methyltransferase (γ-TMT), phytoene synthase (PSY), phytoene desaturase (PDS), lycopene β-cyclase (LBC) and dihydrofolate reductase thymidylate (DHFR-TS) in M. oleifera foliage after treatment with GB03-B. subtilis GB03, T4-B. pumilus T4, COM1- Combination 1, COM2- Combination 2, COM3-Combination 3. Experiments were repeated three times, each with three replicates. Columns without a common lowercase letter indicate significantly different values among treatments based on Tukey's test (P value ≤ 0.05).
Fig. 2 in Biochemical and molecular insights of PGPR application for the augmentation of carotenoids, tocopherols, and folate in the foliage of Moringa oleifera
Fig. 2. HPLC Chromatograms of 1- δ-tocopherol, 2- γ-tocopherol and 3- α-tocopherol in control, 937a- B. amyloliquefaciens IN937a and SE34- B. pumilus SE34 treated M. oleifera foliage.
Fig. 1. M. oleifera treated with 1 in Biochemical and molecular insights of PGPR application for the augmentation of carotenoids, tocopherols, and folate in the foliage of Moringa oleifera
Fig. 1. M. oleifera treated with 1) B. amyloliquefaciens IN937a, 2) B. subtilis IN937b, 3) Brevibacillus brevis IPC 11, 4) B. subtilis GB03, 5) B. pumilus INR7, 6) B. pumilus SE34, 7) B. pumilus T4, 8) P. fluorescens UOM14 shown compared to control.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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