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23
datasets available to search
ShareScore release 0.9.0
Dataset results
23 results for “forward genetic screen”
Data from: Forward genetic screening for regulators involved in cholesterol synthesis using validation-based insertional mutagenesis
Somatic cell genetics is a powerful approach for unraveling the regulatory mechanism of cholesterol metabolism. However, it is difficult to identify the mutant gene(s) due to cells are usually mutagenized chemically or physically. To identify important genes controlling cholesterol biosynthesis, an unbiased forward genetics approach named validation-based insertional mutagenesis (VBIM) system was used to isolate and characterize the 25-hydroxycholesterol (25-HC)-resistant and SR-12813-resisitant mutants. Here we report that five mutant cell lines were isolated. Among which, four sterol-resistant mutants either contain a truncated NH2-terminal domain of sterol regulatory element-binding protein (SREBP)-2 terminating at amino acids (aa) 400, or harbor an overexpressed SREBP cleavage-activating protein (SCAP). Besides, one SR-12813 resistant mutant was identified to contain a truncated COOH-terminal catalytic domain of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase). This study demonstrates that the VBIM system can be a powerful tool to screen novel regulatory genes in cholesterol biosynthesis.
Data from: Forward chemical genetic screens in Arabidopsis identify genes that influence sensitivity to the phytotoxic compound sulfamethoxazole
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Data from: Forward genetic screening for regulators involved in cholesterol synthesis using validation-based insertional mutagenesis
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Data from: Forward genetic screen of human transposase genomic rearrangements
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Novel cancer gene discovery using a forward genetic screen in RCAS-PDGFB driven gliomas
GEO Series GSE207264. Mus musculus. 78 samples. Type: Other.
A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis [mutant]
GEO Series GSE108353. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Forward genetic screening in engineered colorectal cancer organoids identifies novel regulators of metastasis [crispr gRNA knockout screening 3]
GEO Series GSE263582. Mus musculus. 15 samples. Type: Other.
Forward genetic screening in engineered colorectal cancer organoids identifies novel regulators of metastasis [crispr gRNA knockout screening 2]
GEO Series GSE263581. Mus musculus. 30 samples. Type: Other.
Forward genetic screening in engineered colorectal cancer organoids identifies novel regulators of metastasis
GEO Series GSE237980. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Forward genetic screens in zebrafish identify novel molecular pathways regulating early T cell development
GEO Series GSE77480. Danio rerio. 12 samples. Type: Expression profiling by high throughput sequencing.
Systems-guided forward genetic screen reveals critical role of the replication stress response protein ETAA1 in T cell clonal expansion
GEO Series GSE99144. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis [clonality]
GEO Series GSE108354. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
A Sleeping Beauty Forward Genetic Screen Identifies Genes Promoting Osteosarcoma Development and Metastasis
GEO Series GSE58770. Homo sapiens. 24 samples. Type: Methylation profiling by genome tiling array.
Forward genetic screening in engineered colorectal cancer organoids identifies novel regulators of metastasis [crispr gRNA knockout screening 1]
GEO Series GSE263580. Mus musculus. 33 samples. Type: Other.
A forward genetics screen identifies modifiers of Rocaglate responsiveness
GEO Series GSE167242. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
RNA-sequencing based linkage analysis identifies supt16h as a target gene from a forward genetic screen
GEO Series GSE106342. Danio rerio. 2 samples. Type: Expression profiling by high throughput sequencing.
A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis
GEO Series GSE108355. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Droplet-based genome-wide forward genetic screening of astrocyte-microglia communication mechanisms
GEO Series GSE200457. Mus musculus. 50 samples. Type: Expression profiling by high throughput sequencing.
A forward genetic screen identifies potassium channel essentiality in SHH medulloblastoma maintenance [RNA-seq]
GEO Series GSE277171. Mus musculus. 70 samples. Type: Expression profiling by high throughput sequencing.
A forward genetic screen for modifiers of transgene silencing in the mouse identifies Inhibitor of Growth Family Member 5 (Ing5)
GEO Series GSE76870. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.