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ShareScore release 0.9.0
Dataset results
24 results for “gadoxetate”
Rat gadoxetate MRI signal dataset for the IMI-WP2-TRISTAN Six Test Compounds study
<p>Dataset to accompany the manuscript "Use of In Vivo Imaging and Physiologically-Based Kinetic Modelling to Predict Hepatic Transporter Mediated Drug–Drug Interactions in Rats" by Nicola Melillo, Daniel Scotcher, J. Gerry Kenna, Claudia Green, Catherine D. G. Hines, Iina Laitinen, Paul D. Hockings, Kayode Ogungbenro, Ebony R. Gunwhy, Steven Sourbron, John C. Waterton, Gunnar Schuetz, and Aleksandra Galetin (referred to as the 'Six Test Compounds' study).</p> <p><strong>data.zip</strong></p> <p>After extracting the contents within the data.zip folder, the MRI signal data acquired in this study are provided in csv format and can be found inside the <code>data/SixTestCompounds/01_signals</code> subfolder. Each csv file contains the liver and spleen region of interest (ROI) time curve data for a single rat at a specific site and day, after administration of the test compound of interest.</p> <p>The corresponding filename for each file is formatted as a string containing study descriptors (metadata) separated by underscores, i.e., filename = <code>compound_site_RatNumber_dayNumber_dataType</code>, e.g., <code>Asunaprevir_E_Rat2_2_Signals</code>.</p> <p><strong>results.zip</strong></p> <p>The results and figures relating to this manuscript were created using the outputs contained in <code>results/SixTestCompounds/2022-09-01</code>.</p> <p><code>01_model_ouputs</code> contains all outputs generated as a result of the tracer kinetic model fitting. Within this, plotted signal time curves for each acquistion per rat may be found in <code>figures/per_rat</code>, while average deltaR1 curves per drug may be found in <code>figures/per_drug</code>. All estimated parameter variables from the fitting are stored in <code>all_parameters.csv</code>. The folder <code>relaxation_rates_and_signals</code> contains the fitted MRI signal data in a similar format to the original csv data in <code>data/01_signals</code>. Additional columns have been included showing the MRI signals converted to R1.</p> <p><code>02_effect_sizes</code> contains results of the statistical analysis performed on the tracer kinetic modelling output. This is summarised in tabular format in <code>effect_sizes.csv</code>, while graphical distributions are provided within the <code>figures/</code> folder. <code>fit_errors.txt</code> contains an ID list for any computational fitting errors found during quality control of the tracer kinetic modelling.</p>
Rat gadoxetate MRI signal dataset for the IMI-WP2-TRISTAN Reproducibility study
<p>Dataset to accompany the manuscript "Assessment of hepatic transporter function in rats using dynamic gadoxetate-enhanced MRI: A reproducibility study" by Ebony R. Gunwhy, Catherine D. G. Hines, Claudia Green, Iina Laitinen, Sirisha Tadimalla, Paul D. Hockings, Gunnar Schütz, J. Gerry Kenna, Steven Sourbron, and John C. Waterton (referred to as the 'Reproducibility' study).</p> <p><strong>data.zip</strong></p> <p>After extracting the contents within the data.zip folder, the MRI signal data acquired in this study are provided in csv format and can be found inside the <code>data/Reproducibility/01_signals</code> subfolder. Each csv file contains the liver and spleen region of interest (ROI) time curve data for a single rat from a specific substudy and day, after administration of the test compound of interest.</p> <p>The corresponding filename for each file is formatted as a string containing study descriptors (metadata) separated by underscores, i.e., filename = <code>substudy_</code><code>compound_site_RatNumber_dayNumber_dataType</code>, e.g., <code>1_Rifampicin_D_Rat5_2_Signals</code>.</p> <p><strong>results.zip</strong></p> <p>The results and figures relating to this manuscript were created using the outputs contained in <code>results/Reproducibility/2023-04-17</code>.</p> <p><code>01_model_ouputs</code> contains all outputs generated as a result of the tracer kinetic model fitting. Within this, plotted signal time curves for each acquistion per rat may be found in <code>figures/per_rat</code>, while average deltaR1 curves per substudy may be found in <code>figures/per_substudy</code>. All estimated parameter variables from the fitting are stored in <code>all_parameters.csv</code>. The folder <code>relaxation_rates_and_signals</code> contains the fitted MRI signal data in a similar format to the original csv data in <code>data/01_signals</code>. Additional columns have been included showing the MRI signals converted to R1. <code>fit_errors.txt</code> contains an ID list for any computational fitting errors found during quality control of the tracer kinetic modelling.</p> <p><code>02_analyses</code> contains results of the statistical analysis performed on the tracer kinetic modelling output. These are summarised in tabular csv format within the <code>repeatability/ </code>and <code>reproducibility/</code> folders, while graphical distributions are provided within the <code>figures/</code> folder. Summary results for benchmark values and from the mixed ANOVA are also provided in <code>benchmarks.csv </code>and<code> mixed_anova.csv</code>, respectively. Please see the manuscript for further details on these results.</p>
Gadoxetic Acid-MRI Versus Ultrasonography for the Surveillance of Hepatocellular Carcinoma in High-risk Patients
ClinicalTrials.gov study NCT01446666. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Gadoxetate Enhanced Imaging Study to Detect Prostate Cancer
ClinicalTrials.gov study NCT01867424. IPD Sharing: NO. Countries: 1. Publications: 3.
Prognostic Performance of Preoperative and Follow by Gadoxetic Enhanced MRI in HCC Patients After TACE
ClinicalTrials.gov study NCT05125094. IPD Sharing: NO. Countries: 0. Publications: 2.
Abbreviated MRI Using Gadoxetic Acid Versus CT for Surveillance of Recurrent HCC After Curative Treatment
ClinicalTrials.gov study NCT06537193. IPD Sharing: NO. Countries: 1. Publications: 0.
May the Risk of PHLF be Predicted With Preoperative Liver Gadoxetate MRI
ClinicalTrials.gov study NCT04692259. IPD Sharing: Not stated. Countries: 4. Publications: 11.
Gadoxetate Abbreviated MRI in Metastatic Colorectal Cancer
ClinicalTrials.gov study NCT05314400. IPD Sharing: NO. Countries: 1. Publications: 13.
Development of an Imaging Biomarker for Hepatic Fibrosis Using Gadoxetate Disodium
ClinicalTrials.gov study NCT01783314. IPD Sharing: Not stated. Countries: 1. Publications: 36.
Abbreviated MRI Using Gadoxetic Acid Versus Ultrasonography for Surveillance of Early-stage HCC in Patients at High Risk
ClinicalTrials.gov study NCT06312826. IPD Sharing: NO. Countries: 1. Publications: 1.
Role of FAPI PET/MR Combined With Gadoxetate Disodium in Assessing Hepatic Malignancies
ClinicalTrials.gov study NCT06287411. IPD Sharing: NO. Countries: 1. Publications: 1.
Gadoxetic Acid-enhanced MR Evaluation of Hepatocellular Carcinoma and Dysplastic Nodules in the Cirrhotic Liver
ClinicalTrials.gov study NCT01501240. IPD Sharing: Not stated. Countries: 1. Publications: 3.
The Role of Gadoxetate (Eovist) Enhanced CT in Evaluating Cholangiocarcinoma
ClinicalTrials.gov study NCT01673802. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of Transient Dyspnea During Gadoxetic Acid Enhanced Multiphasic Liver MRI
ClinicalTrials.gov study NCT02395991. IPD Sharing: NO. Countries: 1. Publications: 0.
Magnetic Resonance With Gadoxetic Acid for the Diagnosis of Hepatocellular Carcinoma in Patients With Liver Cirrhosis. Evaluation of Its Impact for the Non-invasive Diagnosis
ClinicalTrials.gov study NCT01575574. IPD Sharing: Not stated. Countries: 1. Publications: 0.
An Observational Study to Learn More About the Impact of Gadoxetate Sodium-Enhanced Magnetic Resonance Imaging (EOB-MRI) When Used to Diagnose the Spread of Cancer From the Pancreas to the Liver in Ja
ClinicalTrials.gov study NCT06106568. IPD Sharing: NO. Countries: 1. Publications: 0.
Added Value of Gadoxetic Acid-enhanced Liver MRI
ClinicalTrials.gov study NCT03045419. IPD Sharing: NO. Countries: 1. Publications: 0.
Gadoxetate Sodium Enhanced MRI as a Biomarker for Aggressive Prostate Cancer
ClinicalTrials.gov study NCT03960788. IPD Sharing: NO. Countries: 1. Publications: 0.
MRI With Gadoxetate Disodium in Measuring Tumors in Patients With Liver Cancer
ClinicalTrials.gov study NCT02578602. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Gadopiclenol vs Gadoxetate MRI for Liver Lesions
ClinicalTrials.gov study NCT06596616. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
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