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144 results for “genetic modifiers”
Fig. 2 in Genetically modified maize resistant to corn earworm (Lepidoptera: Noctuidae) in Sinaloa, Mexico
Fig. 2. Percentage of corn ears ear damaged by Helicoverpa zea in Agrisure® VipteraTM 3111, AgrisureTM 3000 GT, and their respective isolines at El Dorado, Culiacan, and Navolato (Sinaloa, Mexico). 2012. Genetically modified hybrids and their respective isolines followed by the same letter do not differ significantly (LSD; P> 0.05). ic = insecticide control
Fig. 1 in Genetically modified maize resistant to corn earworm (Lepidoptera: Noctuidae) in Sinaloa, Mexico
Fig. 1. Percentage of corn ears damaged by Helicoverpa zea in AgrisureTM 3000 GT, Agrisure® VipteraTM 3110, and their respective isolines at Oso Viejo, Culiacan (Sinaloa, Mexico) during 2011.Genetically modified hybrids and their respective isolines followed by the same letter do not differ significantly (LSD; P> 0.05). ic = insecticide control.
Fig. 1 in Effect of genetically modified Bt maize in an artificial diet on the survival of Cydia pomonella (Lepidoptera: Tortricidae)
Fig. 1. Probit response on log Bt concentration of Cydia pomonella larvae reared on a diet containing maize where the responses were: (A) larval mortality Y = 2.980 + 1.27(X); (B) delayed larval development, Y = 3.789 + 1.886(X) for experiment 1 and Y = 2.840 + 1.886(X) for experiment 2; (C) larvae leaving the diet, Y = 3.595 + 0.681(X); (D) total response or response A + B + C, Y = 4.133 + 2.344(X) for experiment 1 and Y = 3.592 + 2.344(X) for experiment 2. Y is the probit response and X is the log Bt concentration.
Figure 2 in Scientific Opinion on a notification (reference C/NL/09/02) for the placing on the market of the genetically modified carnation IFD-26407-2 with a modified colour, for import of cut flowers for ornamental use, under Part C of Directive 2001/18/EC from Florigene
Figure 2. - Neobythites bimarginatus. Pelvic-fin length and horizontal eye diameter showing negative allometric growth.
Figure 1 in Scientific Opinion on a notification (reference C/NL/09/02) for the placing on the market of the genetically modified carnation IFD-26407-2 with a modified colour, for import of cut flowers for ornamental use, under Part C of Directive 2001/18/EC from Florigene
Figure 1. - Neobythites bimarginatus Fourmanoir & Rivaton, 1979. SAIAB 189024, SL 122 mm. From off Madagascar (photo M. Krag, ZMUC).
The relative strength of selection on modifiers of genetic architecture under migration load
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Genome-wide association results from: Transcriptomic stratification of late-onset Alzheimer's cases reveals novel genetic modifiers of disease pathology
<p>Late-Onset Alzheimer's disease (LOAD) is a common, complex genetic disorder well-known for its heterogeneous pathology. The genetic heterogeneity underlying common, complex diseases poses a major challenge for targeted therapies and the identification of novel disease-associated variants. Case-control approaches are often limited to examining a specific outcome in a group of heterogenous patients with different clinical characteristics. Here, we developed a novel approach to define relevant transcriptomic endophenotypes and stratify decedents based on molecular profiles in three independent human LOAD cohorts. By integrating post-mortem brain gene co-expression data from 2114 human samples with LOAD, we developed a novel quantitative, composite phenotype that can better account for the heterogeneity in genetic architecture underlying the disease. We used iterative weighted gene co-expression network analysis (WGCNA) to reduce data dimensionality and to isolate gene sets that are highly co-expressed within disease subtypes and represent specific molecular pathways. We then performed single variant association testing using whole genome-sequencing data for the novel composite phenotype in order to identify genetic loci that contribute to disease heterogeneity. Distinct LOAD subtypes were identified for all three study cohorts (two in ROSMAP, three in Mayo Clinic, and two in Mount Sinai Brain Bank). Single variant association analysis identified a genome-wide significant variant in <i>TMEM106B</i> (p-value < 5´10<sup>-8</sup>, rs1990620<sup><span><span>G</span></span></sup>) in the ROSMAP cohort that confers protection from the inflammatory LOAD subtype. Taken together,<b> </b>our novel approach can be used to stratify LOAD into distinct molecular subtypes based on affected disease pathways.</p>
Dataset: T-DNA characterization of genetically modified 3-R-gene late blight resistant potato events with a novel procedure utilizing the Samplix Xdrop® Enrichment Technology
<p>Before commercialization of genetically modified crops, the events carrying the novel DNA must be thoroughly evaluated for agronomic, nutritional, and molecular characteristics. Over the years, Polymerase Chain Reaction-based methods, Southern blot, and short-read sequencing techniques have been utilized for collecting molecular characterization data. Multiple genomic applications are necessary to determine the insert location, flanking sequence analysis, characterization of the inserted DNA, and determination of any interruption of native genes. These techniques are time-consuming and labor-intensive, making it difficult to characterize multiple events. Current advances in sequencing technologies are enabling whole genomic sequencing of modified crops to obtain full molecular characterization. However, in polyploids, such as the tetraploid potato, it is a challenge to obtain whole genomic sequencing coverage that meets regulatory approval of the genetic modification. Here we describe an alternative to labor-intensive applications with a novel procedure using Samplix Xdrop® enrichment technology and next-generation Nanopore sequencing technology to more efficiently characterize the T-DNA insertions of four genetically modified potato events developed by the Feed the Future Global Biotech Potato Partnership: DIA_MSU_UB015, DIA_MSU_UB255, GRA_MSU_UG234 and GRA_MSU_UG265 (derived from regionally important varieties Diamant and Granola). Using the Xdrop® /Nanopore technique, we obtained a very high sequence read coverage within the T-DNA and junction regions. In three of the four events, we were able to use the data to confirm single T-DNA insertions, identify insert locations, identify flanking sequences, and characterize the inserted T-DNA. We further used the characterization data to identify native gene interruption and confirm the stability of the T-DNA across clonal cycles. These results demonstrate the functionality of using the Xdrop® /Nanopore technique for T-DNA characterization. This research will contribute to meeting regulatory safety and regulatory approval requirements for commercialization with small shareholder farmers in target countries within our partnership.</p>
Data from: Vertically inherited microbiota and environment modifying behaviors conceal genetic variation in dung beetle life history
<p>Diverse organisms actively manipulate their (sym)biotic and physical environment in ways that feedback on their own development. However, the degree to which these processes affect microevolution remains poorly understood. The gazelle dung beetle both physically modifies its ontogenetic environment and structures its biotic interactions through vertical symbiont transmission. By experimentally eliminating i) physical environmental modifications, and ii) the vertical inheritance of microbes, we assess how environment modifying behavior and microbiome transmission shape heritable variation. We found that depriving larvae from symbionts and environment modifying behaviors increased additive genetic variance and heritability for development time but not body size. This suggests that larvae's ability to manipulate their environment has the potential to modify heritable variation and to facilitate the accumulation of cryptic genetic variation. This cryptic variation may become released and selectable when organisms encounter environments that alter the degree to which they can be manipulated. Furthermore, we found heritable variation for the response to the elimination of environmental modifications, indicating that genotypes differ in their dependence on the ability to manipulate their environment. Our findings highlight that the ability of organisms to actively manipulate their environment may affect the potential of populations to evolve when encountering novel, stressful conditions.</p>
Genetic modifiers of Huntington's disease differentially influence motor and cognitive domains
<p class="MsoNormal"><span>Genome-wide association studies (GWAS) of Huntington's disease (HD) have identified six DNA maintenance gene loci (among others) as modifiers and implicated a two step-mechanism of pathogenesis: somatic instability of the causative HTT CAG repeat with subsequent triggering of neuronal damage. The largest studies have been limited to HD individuals with a rater-estimated age at motor onset. To capitalize on the wealth of phenotypic data in several large HD natural history studies, we have performed algorithmic prediction using common motor and cognitive measures to predict age at other disease landmarks as additional phenotypes for GWAS. Combined with imputation using the Trans-Omics for Precision Medicine reference panel, predictions using integrated measures provided objective landmark phenotypes with greater power to detect most modifier loci. Importantly, substantial differences in the relative modifier signal across loci, highlighted by comparing common modifiers at MSH3 and FAN1, revealed that individual modifier effects can act preferentially in the motor or cognitive domains. Individual components of the DNA maintenance modifier mechanisms may therefore act differentially on the neuronal circuits underlying the corresponding clinical measures. In addition, we identified new modifier effects at the PMS1 and PMS2 loci and implicated a potential new locus on chromosome 7. These findings indicate that broadened discovery and characterization of HD genetic modifiers based on additional quantitative or qualitative phenotypes offers not only the promise of in-human validated therapeutic targets, but also a route to dissecting the mechanisms and cell types involved in both the somatic instability and toxicity components of HD pathogenesis.</span></p>
Genetically Modified T-Cell Therapy in Treating Patients With Advanced ROR1+ Malignancies
ClinicalTrials.gov study NCT02706392. IPD Sharing: NO. Countries: 1. Publications: 2.
A Pediatric and Young Adult Trial of Genetically Modified T Cells Directed Against CD19 for Relapsed/Refractory CD19+ Leukemia
ClinicalTrials.gov study NCT02028455. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Genetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma
ClinicalTrials.gov study NCT02208362. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Genetic modifiers of somatic expansion and clinical phenotypes in Huntington’s disease reveal shared and tissue-specific effects
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Data from: Spatial genetic structure of two conifers in a highly human-modified landscape of central Mexico
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Genetic modifiers of Huntington’s disease differentially influence motor and cognitive domains
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Data from: Vertically inherited microbiota and environment modifying behaviors conceal genetic variation in dung beetle life history
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Dataset: T-DNA characterization of genetically modified 3-R-gene late blight resistant potato events with a novel procedure utilizing the Samplix Xdrop® Enrichment Technology
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Genome-wide association results from: Transcriptomic stratification of late-onset Alzheimer’s cases reveals novel genetic modifiers of disease pathology
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<i>MSH3</i> is a genetic modifier of somatic repeat instability in X-linked dystonia parkinsonism
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.