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45 results for “genotoxic stress”
Data from: The CST complex facilitates cell survival under oxidative genotoxic stress
<p><span>Genomic DNA is constantly exposed to a variety of genotoxic stresses, and it is crucial for organisms to be equipped with mechanisms for repairing the damaged genome. Previously, it was demonstrated that the mammalian CST (CTC1-STN1-TEN1) complex, which was originally identified as a single-stranded DNA-binding trimeric protein complex essential for telomere maintenance, is required for survival in response to hydroxyurea (HU), which induces DNA replication fork stalling. It is still unclear, however, how the CST complex is involved in the repair of diverse types of DNA damage induced by oxidizing agents such as H<sub>2</sub>O<sub>2</sub>.</span></p> <p><em><span>STN1</span></em><span> knockdown (KD) sensitized HeLa cells to high doses of H<sub>2</sub>O<sub>2</sub>. While H<sub>2</sub>O<sub>2</sub>-induced DNA strand breaks throughout the cell cycle, <em>STN1</em> KD cells were as resistant as control cells to H<sub>2</sub>O<sub>2</sub> treatment when challenged in the G1 phase of the cell cycle, but they were sensitive when exposed to H<sub>2</sub>O<sub>2</sub> in S/G2/M phase. <em>STN1</em> KD cells showed a failure of DNA synthesis and RAD51 foci formation upon H<sub>2</sub>O<sub>2</sub> treatment. Chemical inhibition of RAD51 in sh<em>STN1</em> cells did not exacerbate the sensitivity to H<sub>2</sub>O<sub>2</sub>, implying that the CST complex and RAD51 act in the same pathway. Collectively, our results suggest that the CST complex is required for maintaining genomic stability in response to oxidative DNA damage, possibly through RAD51-dependent DNA repair/protection mechanisms.</span></p>
Data from: The CST complex facilitates cell survival under oxidative genotoxic stress
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SETBP1 accumulation induces P53 inhibition and genotoxic stress in neural progenitors underlying neurodegeneration in Schinzel-Giedion syndrome
GEO Series GSE171266. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
p53-Dependent Induction of P2X7 on Hematopoietic Stem and Progenitor Cells Regulates Hematopoietic Response to Genotoxic Stress [ChIP-seq]
GEO Series GSE171694. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Identification of microRNAs dysregulated in cellular senescence driven by endogenous genotoxic stress
GEO Series GSE48417. Mus musculus. 16 samples. Type: Non-coding RNA profiling by array.
p53-Dependent Induction of P2X7 on Hematopoietic Stem and Progenitor Cells Regulates Hematopoietic Response to Genotoxic Stress
GEO Series GSE171697. Mus musculus. 16 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
RGG motif-containing Scd6/LSM14A proteins regulate the translation of specific mRNAs in response to hydroxyurea-induced genotoxic stress
GEO Series GSE274294. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Toxin-antitoxin deletions in Legionella pneumophila reveal unusual cell death and contact-dependent survival responses during genotoxic stress [Lp_growth_phase_RNAseq]
GEO Series GSE278702. Legionella pneumophila. 8 samples. Type: Expression profiling by high throughput sequencing.
Analysis of transcriptomic responses of genotoxic stress in human HepaRG hepatocarcinoma cells
GEO Series GSE146549. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
CRTC2 couples genotoxic stress and plasma cell differentiation in the germinal center
GEO Series GSE23171. Homo sapiens. 20 samples. Type: Expression profiling by array; Genome binding/occupancy profiling by genome tiling array.
p53-Dependent Induction of P2X7 on Hematopoietic Stem and Progenitor Cells Regulates Hematopoietic Response to Genotoxic Stress [RNA-seq]
GEO Series GSE171691. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
The Effects of miR-526b, miR655 and COX-2 Overexpression on Oxidative and Genotoxic Stress in MCF7 Breast Cancer Cells
GEO Series GSE295502. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
Genome wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress
GEO Series GSE56640. Homo sapiens. 25 samples. Type: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing.
Genomic localization of Cockayne syndrom B protein upon genotoxic stresses
GEO Series GSE50925. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo [DNAse-Seq]
GEO Series GSE71177. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner
GEO Series GSE209742. Mus musculus. 2557 samples. Type: Expression profiling by high throughput sequencing.
Genome wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress [ChIP-Seq]
GEO Series GSE56674. Homo sapiens. 13 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage
GEO Series GSE144510. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide analysis of p53 transcriptional programs in B cells upon exposure to genotoxic stress in vivo [RNA-Seq]
GEO Series GSE71176. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress
GEO Series GSE14283. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.