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245 results for “gestational diabetes mellitus”
Vitamin B12 deficiency anaemia and gestational diabetes mellitus: a two-sample Mendelian randomization study
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Raw data for the association of genetic variants of ErbB4 gene and gestational diabetes mellitus
<div>Gestational diabetes (GDM) is one of the common complications of female pregnancy, which seriously affects the health of patients and their offspring. So far, the etiology has not yet been fully clarified. To clarify the relationship of Erb-b2 receptor tyrosine kinase 4 (ErbB4) genetic variants and GDM risk in a Chinese population, ErbB4 variants (rs1595064, rs1595065, rs1595066 and rs6719645) were selected and genotyped in 554 GDM cases and 641 healthy controls. The associations between variants and GDM risk were evaluated with the odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). The false-positive reporting probability (FPRP), multi-factor dimension reduction (MDR) and bioinformatics analysis were adopted to confirm the significant associations. A nomogram model was constructed to predict the risk of GDM. Association analysis demonstrated that the rs1595066 genotype performed a protective effect on GDM risk among whole subjects. Meanwhile, stratified analysis showed that rs1595066 was significantly associated with GDM risk in various subgroups, such as age>30.09 years old, pre-pregnancy BMI>22.23 Kg/m<sup>2</sup> ,SBP≤110.08 mmHg, etc. Further, interactions between rs1595066 and DBP (Pinteraction=0.01), FPG (Pinteraction<0.001) and HbA1c (Pinteraction< 0.001) were detected. The FPRP analysis confirmed that association of rs1595066 and GDM risk in subjects of FPG≤4.79 mmol/L (P=0.199) is true at a prior probability of 0.1. The MDR analysis suggested that rs1595066 was the best single locus model, while the 4-loci model was considered the best multiple factors model to predict GDM risk. Functional prediction revealed that rs1595066 may disturb the microRNA binding sites to influence the stability of miRNA-mRNA binding. The predictive nomogram model has a good consistency and acceptable discriminative ability with a diagnosed AUC of 0.813.ErbB4 rs1595066 was significantly associated with GDM risk and underlying mechanism causing GDM may be the interaction of gene-gene, gene-environment and the changes in the regulatory effects of miRNAs on ERBB4 expression. The nomogram model has a good prospect for GDM prediction.</div>
Data from: Genetic susceptibility, Mendelian randomization and nomogram model construction of gestational diabetes mellitus
<p>The dataset contains subjects' basic information, including the Identification number of the test sample, fasting plasma glucose (FPG), oral glucose tolerance test 1h plasma glucose (1hPG), oral glucose tolerance test 2h plasma glucose (2hPG), glycated hemoglobin (HbA1c), Systolic blood pressure (SBP), Diastolic blood pressure (DBP), triglyceride (TG), total cholesterol (TC), High-density lipoprotein cholesterol (HDL-c), Low-density lipoprotein cholesterol (LDL-c), and also involves subjects' genetic variant information used for analysis of the association of functional polymorphisms and GDM. The variables including SBP_M, DBP_M, FPG_M, 1hPG_M, 2hPG_M, HbA1c_M, TG_M represent the mean value of SBP, DBP, FPG, 1hPG, 2hPG, HbA1c, TG, which are used for the stratification analysis. This study has obtained the support from the Ethics Committee of Guilin Medical University. All included subjects signed the informed consent.</p>
RCT Metformin for Reduction of Gestational Diabetes Mellitus Effects
ClinicalTrials.gov study NCT02980276. IPD Sharing: NO. Countries: 1. Publications: 3.
The Effect of Continuous Glucose Monitoring on Glycemic Control in Insulin-requiring Gestational Diabetes Mellitus
ClinicalTrials.gov study NCT02204657. IPD Sharing: NO. Countries: 1. Publications: 11.
Effects of Gestational Diabetes Mellitus on Children
ClinicalTrials.gov study NCT03997396. IPD Sharing: NO. Countries: 1. Publications: 8.
Combined Liraglutide and Metformin Therapy in Women With Previous Gestational Diabetes Mellitus (GDM)
ClinicalTrials.gov study NCT01234649. IPD Sharing: NO. Countries: 1. Publications: 1.
Gestational Diabetes Mellitus Trial (GDM)
ClinicalTrials.gov study NCT00069576. IPD Sharing: Not stated. Countries: 1. Publications: 23.
Dietary Management of Gestational Diabetes Mellitus
ClinicalTrials.gov study NCT05613920. IPD Sharing: NO. Countries: 1. Publications: 5.
Causal inference and risk prediction of gestational diabetes mellitus based on case-control study and Mendel randomization
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Data from: Genetic variants in HLA-DQA1/DQB1 genes modulate the risk of gestational diabetes mellitus in a southern Chinese population
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Raw data for the association of genetic variants of ErbB4 gene and gestational diabetes mellitus
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Data from: Genetic susceptibility, Mendelian randomization and nomogram model construction of gestational diabetes mellitus
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Data from: Association and function analysis of genetic variants and the risk of gestational diabetes mellitus in a southern Chinese population
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Data from: Impact on offspring methylation patterns of maternal gestational diabetes mellitus and intrauterine growth restraint suggest common genes and pathways linked to subsequent type 2 diabetes risk
Size at birth, postnatal weight gain, and adult risk for type 2 diabetes may reflect environmental exposures during developmental plasticity and may be mediated by epigenetics. Both low birth weight (BW), as a marker of fetal growth restraint, and high birth weight (BW), especially after gestational diabetes mellitus (GDM), have been linked to increased risk of adult type 2 diabetes. We assessed DNA methylation patterns using a bead chip in cord blood samples from infants of mothers with GDM (group 1) and infants with prenatal growth restraint indicated by rapid postnatal catch-up growth (group 2), compared with infants with normal postnatal growth (group 3). Seventy-five CpG loci were differentially methylated in groups 1 and 2 compared with the controls (group 3), representing 72 genes, many relevant to growth and diabetes. In replication studies using similar methodology, many of these differentially methylated regions were associated with levels of maternal glucose exposure below that defined by GDM [the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study] or were identified as changes observed after randomized periconceptional nutritional supplementation in a Gambian cohort characterized by maternal deprivation. These studies provide support for the concept that similar epigenetic modifications may underpin different prenatal exposures and potentially increase long-term risk for diseases such as type 2 diabetes.
Raw data for Association of ACE2 gene functional variants with gestational diabetes mellitus risk in a southern Chinese population
<p class="MsoNormal"><span>These data were generated to investigate the association and functional analysis of angiotensin-converting enzyme 2 genetic variants with the pathogenesis of Gestational diabetes mellitus (GDM). This study conducted a case-control study involving 569 GDM patients and 735 healthy pregnant women to explore the associations between candidate variants in the ACE2 gene variants and the pathogenesis of GDM. This study collected clinical samples and data, and used logistic regression, false positive report rate, multi factor dimension reduction, functional analysis and other analysis methods to process the research data. Potential functional ACE2 gene variants (rs2106809 A>G, rs6632677 G>C, and rs2074192 C>T) were selected and genotyped using kompetitive allele-specific PCR. The strength of the associations between the studied genetic variants and the risk of GDM were evaluated using odds ratios (ORs) and corresponding 95% confidence intervals (CIs). </span><span>Finally, ACE2 gene variants are significantly associated with the risk of GDM via gene-gene and gene-environment combination. The rs2074192 C > T affects the splicing of ACE2 gene, which may be a potential mechanism leading to the altered susceptibility of individual female during pregnancy in Guilin to GDM</span></p>
Early Detection of Gestational Diabetes Mellitus in Pregnancy
ClinicalTrials.gov study NCT05388643. IPD Sharing: NO. Countries: 1. Publications: 2.
Randomized Controlled Trial Intervention With New Nordic DIet in Women With GestatiOnal Diabetes Mellitus: iNDIGO
ClinicalTrials.gov study NCT04169243. IPD Sharing: NO. Countries: 1. Publications: 1.
Early Screening for Gestational Diabetes Mellitus in a Low Risk Population
ClinicalTrials.gov study NCT06704035. IPD Sharing: NO. Countries: 1. Publications: 31.
Lifestyle Intervention for Women With Recent Pre-eclampsia or Gestational Diabetes Mellitus ('Mom's Healthy Heart')
ClinicalTrials.gov study NCT03993145. IPD Sharing: NO. Countries: 1. Publications: 1.
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Allen Brain Atlas
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