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41 results for “gestational exposures”
Gestational Cd exposure in the CD-1 mouse induces sex-specific hepatic insulin insensitivity, obesity and metabolic syndrome in adult female offspring
<p>There is compelling evidence that developmental exposure to some toxic metals increases risk for obesity and obesity-related morbidity including cardiovascular disease and type 2 diabetes in adults. To explore the hypothesis that developmental Cd exposure increased risk of obesity later in life, male and female CD-1 mice were maternally exposed to 500 ppb CdCl<sub>2</sub> in drinking water during a human gestational equivalent period (GD0 - PND10). Hallmark indicators of metabolic disruption, hepatic steatosis, and metabolic syndrome were evaluated prior to birth through adulthood. Blood Cd levels in dams were similar to those observed in human pregnancy cohorts. There were no observed impacts of exposure on dams or pregnancy-related outcomes. Results of glucose and insulin tolerance testing revealed that Cd-exposure impaired glucose homeostasis in young adult offspring. Exposure-related increases in circulating triglycerides and hepatic steatosis were apparent only in females. By PND120, Cd-exposed females had become 30% heavier with 700% more perigonadal fat than unexposed control females. There was no evidence of dyslipidemia, steatosis, increased weight gain, nor increased adiposity in Cd-exposed male offspring. Hepatic transcriptome analysis at PND1, PND21, and PND42 revealed evidence for female-specific increases in oxidative stress and mitochondrial dysfunction with significant early disruption of retinoic acid signaling and altered insulin receptor signaling consistent with hepatic insulin sensitivity in adult females. The observed steatosis and metabolic syndrome-like phenotypes resulting from exposure to 500 ppb CdCl<sub>2</sub> during the pre- and perinatal period of development equivalent to human gestation indicate that Cd acts developmentally as a sex-specific delayed obesogen.</p>
Gestational Cd exposure in the CD-1 mouse induces sex-specific hepatic insulin insensitivity, obesity and metabolic syndrome in adult female offspring
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Topological Overlap Matrices for DNA Methylation data of Gestational Diabetes Cohort with BMI and Exposure Status
<p>DNA methylation in placenta was measured with the Infinium HumanMethylation450 BeadChip (Illumina, Inc) microarray, in a sample of 28 women, 20 of whom had a gestational diabetes (GD)-affected pregnancy and 8 who did not. We used GD status as our exposure variable, assuming that this has widespread effects on DNA methylation and on its correlation patterns. Our response, Y, is the standardized body mass index (BMI) in the offspring at the age of 5. For the 10,000 most variable probes, we provide 3 topological overlap matrices (TOM), which are used in our analysis (note that each of the following TOM matrices are a 10,000 by 10,000 symmetric matrix with row names and column names corresponding to the CpG probe IDs:</p> <ol> <li>TOM_Methylation_All_10k.rds: based on all 28 subjects, </li> <li>TOM_Methylation_E0_10k.rds: based on the 8 subjects without a GD-affected pregnancy</li> <li>TOM_Methylation_E1_10k.rds: based on the 20 subjects with a GD-affected pregnancy </li> </ol> <p>The BMI (phenotype) and GD status (exposure) are given in the following dataset:</p> <ol> <li>BMI_and_Exposure_Status.rds: 28 x 2 matrix of the phenotype and exposure. each row is a subject.</li> </ol> <p>Using our ECLUST method (preprint available at http://sahirbhatnagar.com/slides/manuscript1_SB_v4.pdf), we derive 77 clusters, and here we provide the 1st principal component of each cluster:</p> <ol> <li>Cluster_Summary_1stPC.rds: 28 x 77 matrix, where each row is a subject, in the same order as the BMI_and_Exposure_Status.rds data</li> <li>Cluster_CpGs_names.rds: a list of length 77, where each element of the list contains the list of CpG probe IDs contained in each of the clusters</li> </ol> <p>To read in the data use the readRDS function, e.g.:</p> <p>TOM_All <- readRDS(file = "TOM_Methylation_All_10k.rds")</p>
Gestational and Peri-conceptional Exposure to Intra-nasal Instilled Air Pollutants Epigenetically Perturb Metabolic, Placental and Embryonic Phenotypes
<p><strong>Supplementary Figure legends</strong></p> <p> </p> <p><strong>Figure 1: </strong>Gestational study: Bar plots of plasma metabolites</p> <p> </p> <p><strong>Figure 2:</strong> Gestational study: Bar graph depicting gestational day 19 (GD19) maternal (left) and fetal (right) blood glucose concentrations presented as mean ± SEM. Air pollutant exposed group (AP) versus controls (CON), *p < 0.05 AP versus CON.</p> <p> </p> <p><strong>Figure 3: </strong>Gestational study: <strong>(A)</strong> GO term enrichment analysis of expressed genes between the AP group versus the CON group (n=6 each). Significant enrichment of pathways represented as q-values have been presented in a color-coded key. NES = normalized enrichment score. <strong>(B)</strong> Category cnet plot depicting the linkage of genes and biological concepts (hallmark pathways) as a network illustrating which genes are involved in enriched pathways, and genes that may belong to multiple annotation categories.</p> <p><strong>Figure 4: </strong>Gestational study:<strong> (A) </strong>Representative Western blots of various glucose and lipid transporter proteins and TNFα protein, with vinculin serving as an internal loading control, obtained from CON and AP GD19 placentas<strong>. (B) </strong>Bar plot showing densitometric analysis of Western blots of the various glucose and lipid transporters and TNFα (n=8 for each protein in each group). Data are depicted as Mean ± SEM. While trends are seen, statistical significance was not achieved.</p> <p><strong>Figure 5: </strong>Periconceptional study: <strong>(A)</strong> Bar plots demonstrating fasting blood glucose concentrations (left panel), Glucose tolerance tests (GTTs) (middle panel) and the area under the curves (AUCs) for GTTs (right panel) in non-pregnant (NP), pregnant (P), omega-3 diet exposed (P<em>n-3</em>) pregnant C57/BL6 (BL6) and CD1 pregnant mice are shown. <strong>(B)</strong> Bar plots demonstrating basal fed-state blood glucose concentrations (left panel), Insulin tolerance tests (ITTs) (middle panel) and AUCs for ITTs (right panel) in non-pregnant (NP), pregnant (P), omega-3 diet exposed (P<em>n-3</em>) pregnant C57/BL6 (BL6) and CD1 pregnant mice are shown (n=4-6 each). Data are presented as Mean ± SEM. Significance is shown as <sup>#</sup>compared to BL6-NP, *compared to BL6-P, and <sup>!</sup>compared to BL6-Pn-3 at a p< 0.05.</p> <p><strong>Figure 6: </strong>Periconceptional study:<strong> (A) </strong>Representative Western blots demonstrate various GD19 placental glucose and lipid transporter proteins, with vinculin serving as the internal loading control. <strong>(B) </strong>Bar plots show densitometric analysis of the Western blots of the various glucose and lipid transporters (n=8 for each protein in each group). Data are presented as Mean ± SEM.</p> <p><strong>Figure 7</strong>: Periconceptional study: Category cnet plot depicting the linkage of genes and biological concepts (hallmark pathways) as a network illustrating which genes are involved in enriched pathways, and the genes that may belong to multiple annotation categories between <strong>(A)</strong> AP and CON,<strong> (B)</strong> AP-<em>n-3</em> and AP, <strong>(C) </strong>AP-<em>n-3</em> and CON.</p> <p><strong>Figure 8: </strong>Periconceptional study:<strong> (A)</strong> Bar plots showing coverage of the 5’-hydroxymethylation DNA marks and genomic annotations in GD19 placentas from CON, AP, <em>n-3</em> and AP<em>-n-3</em> experimental groups (n=4 each). <strong>(B)</strong> Pie charts showing the distribution and genomic annotation of differentially methylated regions (DMRs) between the AP and CON groups. Upper panel depicts the distribution of DMRs across CpG-islands and associated regions, while the lower panel depicts the distribution of DMRs around different genomic regions. <strong>(C)</strong> Pie charts showing the distribution and genomic annotation of differentially methylated regions (DMRs) between AP<em>-n-3</em> and CON (left panel), <em>n-3</em> versus CON (middle panel) and AP<em>-n-3</em> versus AP (right panel).</p> <p><strong>Figure 9:</strong> Periconceptional study: <strong>(A-D) </strong>Volcano plots demonstrating the DNA methylation profiles of GD19 placentas from <strong>(A)</strong> AP versus CON, <strong>(B)</strong> AP<em>n-3</em> vs CON, <strong>(C)</strong> <em>n-3</em> vs CON, and <strong>(D)</strong> AP-<em>n-3</em> vs AP groups. Red and blue dots represent hypomethylated and hypermethylated loci respectively (n=4 each group). </p> <p> </p> <p> </p> <p> </p> <p> </p>
Effects of Gestational and Lactational Exposure to Perfluorohexanoic Acid on the cerebellar transcriptome
GEO Series GSE301375. Mus musculus. 34 samples. Type: Expression profiling by high throughput sequencing.
The impact of late gestation circadian disruption, by two weeks of exposure to chronic light dark phase from 5 weeks before expected calving to 3 weeks expected calving, on dairy cattle hepatic and ma
GEO Series GSE168914. Bos taurus. 24 samples. Type: Expression profiling by high throughput sequencing.
Repeated gestational exposure of mice to chlorpyrifos oxon is associated with paraoxonase 1 (PON1)-modulated effects in maternal and fetal tissues
GEO Series GSE58103. Mus musculus. 60 samples. Type: Expression profiling by array.
Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells
GEO Series GSE269983. Homo sapiens. 192 samples. Type: Methylation profiling by genome tiling array.
mRNA and microRNA Transcriptional Profiling of Gestation Day 21 Female Rat Liver and Placenta following Gestation Day 6 - 20 Ketoconazole Exposure
GEO Series GSE200184. Rattus norvegicus. 160 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Gestational and lactational exposure to gossypol alters the testis transcriptome
GEO Series GSE133811. Ovis aries. 18 samples. Type: Expression profiling by high throughput sequencing.
An Adaptive Response through N6-Methyladenosine in Fetal Offspring following Gestational Nano-TiO2 Inhalation Exposure I
GEO Series GSE211479. Mus musculus. 6 samples. Type: Other.
Ancestral gestational exposure to widely used neonicotinoid thiacloprid leads to global DNA methylation alterations in spermatozoa in three generations of male mice [RNA-Seq]
GEO Series GSE235213. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Programmed suppression of oxidative phosphorylation and mitochondrial function by gestational alcohol exposure correlate with global increases in H3K9me2 that do not suppress transcription
GEO Series GSE163300. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Gene expression changes in the fetal rhesus monkey uterus from early to late gestation and the effects of in utero exposure to BPA
GEO Series GSE38421. Macaca mulatta. 17 samples. Type: Expression profiling by array.
Ancestral gestational exposure to widely used neonicotinoid thiacloprid leads to global DNA methylation alterations in spermatozoa in three generations of male mice
GEO Series GSE235215. Mus musculus. 33 samples. Type: Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Histone mark modifications in murine ovary after gestational exposure to chlordecone
GEO Series GSE129897. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Early or Late Gestational Exposure to Maternal Immune Activation Alters Neurodevelopmental Trajectories in Mice: An Integrated Neuroimaging, Behavioral, and Transcriptional Study
GEO Series GSE178403. Mus musculus. 72 samples. Type: Expression profiling by high throughput sequencing.
Gestational Exposure to Air Pollutants Perturbs Metabolic and Placenta-Fetal Phenotype
GEO Series GSE261095. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
DNA methylation profiles in sibling pairs discordant for intrauterine exposure to maternal gestational diabetes
GEO Series GSE102177. Homo sapiens. 36 samples. Type: Methylation profiling by array.
Newborn Sex-specific Transcriptome Signatures and Gestational Exposure to Fine Particles: Findings from the ENVIRONAGE Birth Cohort
GEO Series GSE83393. Homo sapiens. 146 samples. Type: Expression profiling by array.
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Allen Brain Atlas
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