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3 results for “glutathione-s-transferase”
Arabidopsis Glutathione-S-Transferases GSTF11 and GSTU20 function in Aliphatic Glucosinolate Biosynthesis
<p>GSH conjugation with intermediates is required for the biosynthesis of glucosinolate (GSL) by serving as a sulfur supply. Glutathione-S-transferases (GSTs) primarily work on GSH conjugation, suggesting their involvement in GSL metabolism. Although several GSTs, including GSTF11 and GSTU20, have been recently postulated to act in GSL biosynthesis, molecular evidence is lacking. Here, we demonstrated that <i>GSTF11</i> and <i>GSTU20</i> play nonredundant, although partially overlapping, roles in aliphatic GSL biosynthesis. In addition, <i>GSTU20</i> plays a more important role than<i> GSTF11</i>, which is manifested by the greater loss of aliphatic GSLs associated with <i>GSTU20</i> mutant and a greater number of differentially expressed genes in <i>GSTU20</i> mutant compared to <i>GSTF11</i> mutant. Moreover, a double mutation leads to a greater aggregate loss of aliphatic GSLs, suggesting that <i>GSTU20</i> and <i>GSTF11</i> may function in GSL biosynthesis in a dosage-dependent manner. Together, our results provide direct evidence that <i>GSTU20</i> and <i>GSTF11</i> are critically involved in aliphatic GSL biosynthesis, filling the knowledge gap that has been speculated in recent decades.</p>
Arabidopsis Glutathione-S-Transferases GSTF11 and GSTU20 function in Aliphatic Glucosinolate Biosynthesis
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Glutathione-S-transferase theta 2 (GSTT2) modulates the tumor microenvironment and the response to BCG immunotherapy in a murine orthotopic model of bladder cancer
GEO Series GSE281932. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.