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8 results for “glycosidase”
Diffraction images used to solve the structures published in the article "An Epoxide Intermediate in Glycosidase Catalysis"
<p>Raw diffraction images used for generating the structures published in the article "An Epoxide Intermediate in Glycosidase Catalysis" (available <a href="https://doi.org/10.1021/acscentsci.0c00111">here</a>). Full single-crystal datasets, including images that were not used in the final analyses, are published. The software used for the processing of each dataset is listed in their respective PDB entries.</p> <p> </p> <p>If you find this useful, please contact me at <a href="mailto:lukasz.sobala@hirszfeld.pl">lukasz.sobala@hirszfeld.pl</a>, I am just interested in how these data are used!</p>
Data from: A surface acoustic wave (SAW)-based lab-on-chip for the detection of active α-glycosidase
Enzyme detection in liquid samples is a complex laboratory procedure, based on assays that are generally time- and cost-consuming, and require specialized personnel. Surface acoustic wave sensors can be used for this application, overcoming the cited limitations. To give our contribution, in this work we present the bottom-up development of a surface acoustic wave biosensor to detect active α-glycosidase in aqueous solutions. Our device, optimized to work at an ultra-high frequency (around 740 MHz), is functionalized with a newly synthesized probe 7-mercapto-1-eptyl-D-maltoside, bringing one maltoside terminal moiety. The probe is designed ad hoc for this application and tested in-cuvette to analyze the enzymatic conversion kinetics at different times, temperatures and enzyme concentrations. Preliminary data are used to optimize the detection protocol with the SAW device. In around 60 min, the SAW device is able to detect the enzymatic conversion of the maltoside unit into glucose in the presence of the active enzyme. We obtained successful α-glycosidase detection in the concentration range 0.15–150 U/mL, with an increasing signal in the range up to 15 U/mL. We also checked the sensor performance in the presence of an enzyme inhibitor as a control test, with a signal decrease of 80% in the presence of the inhibitor. The results demonstrate the synergic effect of our SAW Lab-on-a-Chip and probe design as a valid alternative to conventional laboratory tests.
Data from: A surface acoustic wave (SAW)-based lab-on-chip for the detection of active α-glycosidase
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Input files and setup for simulations of ancestral and modern glycosidases
<p>Input files, heme parameters, and representative structures from simulations of ancestral glycosidases and the modern glycosidase from the thermophilic <em>Halothermothrix orenii</em>. For details please see the README file provided.</p>
Rosetta GlycanDock results for two GH12 Domains of a Multidomain Glycosidase From a Hyperthermophilic Euryarchaeon
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B-GLUCANCER2 : A Pilot Study Evaluating a New Method for Cancer Detection by Measuring the Activity of Different Glycosidase Enzymes in the Plasma of Patients With a Localized Cancer.
ClinicalTrials.gov study NCT07236177. IPD Sharing: YES. Countries: 1. Publications: 0.
Gene expression profiling of processing glycosidase inhibitors: defining a common gene set produced by processing glycosidase inhibition in human cervical carcinoma HeLa cells
GEO Series GSE40297. Homo sapiens. 4 samples. Type: Expression profiling by array.
Optimization of GAO oxidation and glycosidase digestion for glycoRNA enrichment
GEO Series GSE277697. Homo sapiens. 4 samples. Type: Non-coding RNA profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.