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Cortical myelin measured by the T1w/T2w ratio in individuals with depressive disorders and healthy controls
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Smartphone sensor data (accelerometer, virtual keyboard) collected in-the-wild by Parkinson's Disease patients and Healthy Controls
<p>For detailed description of the dataset see the relevant <a href="https://www.nature.com/articles/s41598-020-78418-8">journal article</a>.</p> <p>Python code for model inference and training is available <a href="https://github.com/alpapado/deep_pd">here</a>.</p> <p> </p> <p><strong>DESCRIPTION</strong></p> <p>The dataset contains accelerometer recodings and keyboard typing data contributed by Parkinson's Disease patients and Healthy Controls. Accelerometer data consists of acceleration values recorded during phone calls and typing data consist of virtual keyboard press and release timestamps. The dataset is divided into two parts: the first part, called SData, contains data from a small, medically evaluated, set of users, while the second part, called GData, contains recordings from a large body of users with self-reported PD labels.</p> <p>The dataset is organized into 5 pickle files:</p> <p>1. <strong>imu_sdata.pickle</strong>: Contains the tri-axial accelerometer recordings for the SData part of the dataset in the form of a list of python dictionaries, one for each participating subject. Accelerometer data have been pre-processed to a sampling frequency of 100Hz and come segmented into non-overlapping 5 second windows. Hence, a segment's dimension will be 500 x 3 samples.</p> <p>Sample Python code for accessing the acceleration data of a subject</p> <pre><code class="language-python">sdata = pickle.load(open('imu_sdata.pickle', 'rb')) subject_list = list(sdata.keys()) ## Data for first subject subject_data = sdata[subject_list[0]] # subject_data is a list of length 4 ## The actual data is in the last element of the list acc_segments = subject_data[-1] num_acc_sessions_for_subject = len(acc_segments) acc_segments_for_first_session = acc_segments[0] acc_segments_for_second_session = acc_segments[1] # ..etc In: print(acc_segments_for_first_session.shape) Out: (3, 500, 3) ## The first accelerometer session for this subject consists of 3 five-second segments. In: print(acc_segments_for_second_session.shape) Out: (8, 500, 3) ## The second accelerometer session for this subject consists of 8 five-second segments.</code></pre> <p>2. <strong>imu_gdata.pickle</strong>: Same layout as imu_sdata.pickle but with data ffrom GData subjects.</p> <p>3. <strong>typing_sdata.pickle</strong>: This files contains the typing data originating from the SData part of the dataset. It is a list of dictionaries with one entry per subject. The typing data are given in the form of concatenated hold time (the time elapsed between press and release of the virtual key) and flight time (the time between releasing a key and press the next) histograms, computed over 10ms bins in the range of [0, 1]s for hold time and [0, 4]s for flight time (an additional bin that contains the values in the (1, +oo) and (4, +oo) intervals is also used). So, the total length of the concatenated histogram is 1000/10 + 1 + 4000/10 + 1 = 502.</p> <p>Sample Python code for accessing the typing data of a subject:</p> <pre><code class="language-python">sdata = pickle.load(open('typing_sdata.pickle', 'rb')) subject_list = list(sdata.keys()) ## Data for first subject subject_data = sdata[subject_list[0]] ## The actual data is in the first element of the list typing_histograms = subject_data[0] num_typing_sessions_for_subject = len(typing_histograms) typing_hist_for_first_session = typing_histograms[0] typing_hist_for_second_session = typing_histograms[1] # ..etc In: print(typing_hist_for_first_session.shape) Out: (502, ) ht_hist = typing_hist_for_first_session[:101] # Hold time histogram of the session ft_hist = typing_hist_for_first_session[101:] # Flight time histogram of the session</code></pre> <p>4. <strong>typing_gdata.pickle</strong>: Same layout as typing_sdata.pickle but with data from GData subjects.</p> <p>5. <strong>subject_metadata.pickle</strong>: A list of dictionaries with one entry per subject containing demographic information. The relevant demographic fields have the following interpretation:<br> 'age': Year of birth,<br> 'gender_id': 0 indicates male, 1 indicates female<br> 'healthstatus_id': 0 indicates PD patient, 1 indicates Healthy with PD family history, 2 indicates Healthy without PD family history</p> <p>In the case of SData subjects, there is also symptom UPDRS scores from one or two medical examinations. These are ncoded in the fields med_eval_1 and med_eval_2.</p> <p> </p> <p><strong>ETHICS & FUNDING</strong></p> <p>The study during which the present dataset was collected is a multi-center study approved in each country available (for more info visit: <a href="http://www.i-prognosis.eu/?page_id=3606">http://www.i-prognosis.eu/?page_id=3606</a>). Informed consent, including permission for third-party access to pseudo-anonymised data, was obtained from all subjects prior to their engagement with the study. The work has received funding from the European Union's Horizon 2020 research and innovation programme under Grant Agreement No 690494 - i-PROGNOSIS: Intelligent Parkinson early detection guiding novel supportive interventions (<a href="http://www.i-prognosis.eu/">i-prognosis.eu</a>).</p> <p> </p> <p><strong>CORRESPONDANCE</strong></p> <p>Any inquiries regarding this dataset should be adressed to:</p> <p>Mr. Alexandros Papadopoulos (Electrical & Computer Engineer, PhD candidate)</p> <p>Multimedia Understanding Groupmug<br> Department of Electrical & Computer Engineering<br> Aristotle University of Thessaloniki<br> University Campus, Building C, 3rd floor<br> Thessaloniki, Greece, GR54124</p> <p>Tel: +30 2310 996359, 996365 <br> Fax: +30 2310 996398<br> E-mail: alpapado@mug.ee.auth.gr</p> <p> </p> <p><br> </p> <p> </p>
resting state fMRI of 17 idiopathic epileptic dogs and 20 healthy control dogs
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IMU data captured unobtrusively and in-the-wild by Parkinson's disease patients and healthy controls
<p><strong>DATASET</strong></p> <p>The dataset contains IMU signals captured in-the-wild via the accelerometer sensor embedded in modern smartphones, for the purpose of detecting tremorous episodes, related to Parkinson's Disease (PD). A group of 31 PD patients and 14 Healthy controls contributed accelerometer data using their personal smartphones, for a period spanning many months.Tri-axial acceleration values were recorded automatically whenevera phone call was realized. The recording lasted for 75 seconds at the most. Each phone call thus resulted in one recorded accelerometer signal, also referred to as session. Each subject contributed a different amount of sessions depending on the number of phone calls they realized during the data collection period as well as their participation time (they were free to drop-out at any time). A detailed description of the capturing process as well as analysis results, can be found in the related research article.</p> <p>The data is presented as a list of python dictionaries, stored in a pickle file. Each dictionary in the list, corresponds to one subject and containes the following fields:</p> <p>1. subject_id: scalar<br> A numerical value that uniquely identifies the subject.</p> <p>2. subject_sessions: list of numpy.array<br> A list of numpy arrays of shape (N, 4) that contains the tri-axial accelerometer sessions that the subject contributed. N denotes the total length of the session in samples (which varies from session to session) Column 0 of the array contains the timestamps of the accelerometer samples. Columns 1-3 contain the acceleration values across the x,y,z directions.</p> <p>3. session_datetimes: list of datetime objects <br> A list of datetime objects that denote the capturing date and time of the corresponding entries in the subject_sessions field.</p> <p>4. annotation: dict<br> A dictionary containing the following tremor-related annotation values:<br> * updrs16: scalar int<br> The value related to tremor as described in item 16 of the part II of the MDS-UPDRS scale, as reported by the subject.</p> <p>* updrs20_right: scalar int in range [0, 4]<br> The value related to rest tremor in the right hand as described in item 20 of the part III of the MDS-UPDRS scale, as reported by the attending neurologist.</p> <p>* updrs20_left: scalar int in range [0, 4]<br> Same as above but for left hand.</p> <p>* updrs21_right: scalar int in range [0, 4]<br> The value related to action/postural tremor in the right hand as described in item 21 of the part III of the MDS-UPDRS scale, as reported by the attending neurologist.</p> <p>* updrs21_left: scalar int in range [0, 4]<br> Same as above but for left hand.</p> <p>* sp_expert: scalar int in range [0, 1]<br> A binary tremor annotation created by a group of signal processing experts, upon visually examining the contributed signals in both time and frequency domain and taking into consideration the UDPRS scores of each subject. This was necessary due to the intermittent nature of tremor, as well as a number of considerations related to the in-the-wild nature of the data capturing process. For more details, we refer the reader to the dataset description in the related research article.<br> A '1' value indicates that the subject has tremor.<br> A '0' value indicates that the subject doesn't have tremor.</p> <p>* pd_status: scalar int in range [0, 1]<br> A '1' value indicates that the subject is a PD patient.<br> A '0' value indicates that the subject is a Healthy Control</p> <p>Note: Each annotation value refers to the subject as a whole, and not in any one session.<br> </p> <p><strong>ETHICS & FUNDING</strong></p> <p>The study during which the present dataset was collected is a multi-center study approved in each country available (for more info visit: <a href="http://www.i-prognosis.eu/?page_id=3606">http://www.i-prognosis.eu/?page_id=3606</a>). Informed consent, including permission for third-party access to pseudo-anonymised data, was obtained from all subjects prior to their engagement with the study. The work has received funding from the European Union's Horizon 2020 research and innovation programme under Grant Agreement No 690494 - i-PROGNOSIS: Intelligent Parkinson early detection guiding novel supportive interventions (<a href="http://www.i-prognosis.eu/">i-prognosis.eu</a>).</p> <p> </p> <p><strong>CORRESPONDANCE</strong></p> <p>Any inquiries regarding this dataset should be adressed to:</p> <p>Mr. Alexandros Papadopoulos (Electrical & Computer Engineer, PhD candidate)</p> <p>Multimedia Understanding Groupmug<br> Department of Electrical & Computer Engineering<br> Aristotle University of Thessaloniki<br> University Campus, Building C, 3rd floor<br> Thessaloniki, Greece, GR54124</p> <p>Tel: +30 2310 996359, 996365 <br> Fax: +30 2310 996398<br> E-mail: alpapado@mug.ee.auth.gr</p> <p> </p> <p><strong>LICENSE</strong></p> <p>This is an open access dataset, licensed under Creative Commons Attribution 4.0 International (<a href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</a>).</p> <p> </p> <p><strong>WARRANTY</strong></p> <p>This dataset comes without any warranty. Administrators of this dataset can not be held accountable for any damage (physical, financial or otherwise) caused by the use of this dataset. </p>
The CAD WALK Healthy Controls Dataset
<p>This dataset contains the raw dynamic plantar pressure measurements of 55 healthy Dutch individuals collected at Sint Maartenskliniek, Nijmegen. For each individual, 24 dynamic plantar pressure measurements were collected from both feet. Also collected are walking speeds for each plantar pressure measurements, and demographic information of all individuals measured (age, height, weight, shoe size, sex, handedness, leg dominance).</p> <p>For more information, please see the Readme.pdf file accompanying this dataset.</p>
Keystroke timing and pressure data captured during touchscreen typing by early Parkinson's disease patients and healthy controls
<p><strong>DATASET</strong></p> <p>The present dataset comprises keystroke timing and pressure data that correspond to short text excerpts typed by early Parkinson’s disease (PD) patients (n=18) and healthy controls (n=15) on a common touchscreen-equipped smartphone (LG Nexus 5X with a screen of 5.2 inches in diagonal and a resolution of 1080 × 1920 pixels, running native Android 7.0). Subjects were asked to transcribe up to 11 short text excerpts, with the initial one being 200 characters-long and common for all subjects, while the rest were 40-115 characters-long, pseudorandomly drawn from the fairy tale 'The Little Prince'. Data were recorded using a custom Android Operating System input method (keyboard), developed for the purposes of the study. Additional details on exepriment design, material and methods can be found in the related research article mentioned below. </p> <p>Data consist of sequences of raw press and release timestamps (in milliseconds), as well as of values of normalized pressure (0.000-1.000) applied to initiate keystrokes, corresponding to the consecutive keys tapped during the transcription of each text excerpt. Data included in the 'Data' folder are organised in sub-folders per subject. Each sub-folder contains a number of .txt files with each one corresponding to a text excerpt typed by the particular subject. Files are named using the format S##_TEX##.txt, with S## denoting the subject's coded ID and TEX## the serial number of the transcribed text excerpt. For all subjects, file S##_TEX01.txt corresponds to the initial and common 200 characters-long text excerpt. Each file contains the sequences of raw key press/release timestamps (Tp#, Tp#) and normalized pressure (NP#), applied to initiate each keystroke, in the following format:</p> <p>{<br> Press, Tp1, Release, Tr1, NP1<br> Press, Tp2, Release, Tr2, NP2<br> .<br> .<br> . <br> Press, Tpn, Release, Trn, NPn<br> }</p> <p>where 1,2,...,n denote the serial index of the key tapped during typing.</p> <p><em>Note:</em> Out of 33 subjects, 32 managed to transcribe 8 to 11 text excerpts, while the remaining one (Subject ID: 16) typed only 5. Ten subjects (Subject IDs: 6, 14, 16, 17, 25, 27, 29, 31, 32, 33) did not manage to type the initial 200 characters-long excerpt in its entirety.</p> <p>The dataset also includes a record, in Microsoft Excel format (Demographics_Clinical_Characteristics.xlsx), of the demographic and clinical characteristics (with respect to PD) of subjects. Entries of the Excel file are linked to subjects' sub-folders and individual keystroke data text files via the coded ID of the subject.</p> <p>Demographic characteristics included:</p> <p>Age; Gender; Education level; Years of smartphone usage; Dominant hand<sup>1</sup></p> <p>Clinical characteristics included:</p> <p>Group (PD, Control); Years from diagnosis; Hoehn-Yahr disease stage; Most affected side<sup>2</sup>; Levodopa Equivalent Daily Dose; UPDRS_III<sup>3</sup> total score; UPDRS_III Item 21 Tremor-Right hand; UPDRS_III Item 21 Tremor-Left hand; UPDRS_III Item 22 Rigidity-Right hand; UPDRS_III Item 22 Rigidity-Left hand; UPDRS_III Item 23 Finger taps-Right hand; UPDRS_III Item 23 Finger taps-Left hand; UPDRS_III Item 31 Body bradykinesia/ Hypokinesia</p> <p><sup>1</sup>Dominant hand: (Relating to handedness) the operant hand generally used for performing fine motor-skills tasks.<br> <sup>2</sup>Most affected body side by Parkinson's disease<br> <sup>3</sup>UPDRS_III: Unified Parkinson's Disease Rating Scale Part III (Motor section)</p> <p> </p> <p><strong>RELATED RESEARCH</strong></p> <p>This dataset was originally used and described in the OPEN ACCESS publication: </p> <p>[1] Iakovakis, D., Hadjidimitriou, S., Charisis, V., Bostantzopoulou, S., Katsarou, Z., & Hadjileontiadis, L. J. (2018). Touchscreen typing-pattern analysis for detecting fine motor skills decline in early-stage Parkinson’s disease. Scientific reports, 8(1), 7663. <a href="http://doi.org/10.1038/s41598-018-25999-0">https://doi.org/10.1038/s41598-018-25999-0</a> </p> <p>All documents and papers that report on research that uses this dataset will acknowledge this by citing the above publication.</p> <p> </p> <p><strong>ETHICS & FUNDING</strong></p> <p>The study during which the present dataset was collected was approved by the Aristotle University of Thessaloniki Bioethics Committee of Medical School (approval no. 359/3.4.17), Thessaloniki, Greece. Informed consent, including permission for third-party access to pseudo-anonymised data, was obtained from all subjects prior to their engagement with the study. The work has received funding from the European Union's Horizon 2020 research and innovation programme under Grant Agreement No 690494 - i-PROGNOSIS: Intelligent Parkinson early detection guiding novel supportive interventions (<a href="http://www.i-prognosis.eu">i-prognosis.eu</a>).</p> <p> </p> <p><strong>CORRESPONDANCE</strong></p> <p>Any inquiries regarding this dataset should be adressed to:</p> <p>Mr. Dimitrios Iakovakis (Electrical & Computer Engineer, PhD candidate)</p> <p>Signal Processing & Biomedical Technology Unit<br> Department of Electrical & Computer Engineering<br> Aristotle University of Thessaloniki<br> University Campus, Building D, 6th floor<br> Thessaloniki, Greece, GR54124</p> <p>Tel: +30 2310 996319<br> Fax: +30 2310 996312<br> E-mail: dimiiako12@gmail.com</p> <p> </p> <p><strong>LICENSE</strong></p> <p>This is an open access dataset, licensed under Creative Commons Attribution 4.0 International (<a href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</a>).</p> <p> </p> <p><strong>WARRANTY</strong></p> <p>This dataset comes without any warranty. Administrators of this dataset can not be held accountable for any damage (physical, financial or otherwise) caused by the use of this dataset. </p>
Functional Brain Networks of Picture Naming in Broca's Aphasia and Healthy Controls
<p>The data were from the picture-naming task with MEG scanning. </p> <p>Brain networks of ".net" format: Each network has 776 regions that were derived by subdividing USCBrain Atlas. Phase-locking values (PLV) were calculated between the 776 regions in a gamma-band of 30-45Hz. PLVs were normalized (z-PLVs) by using the mean and standard deviation of the 200-ms pre-stimulus baseline. The edges were weighted by z-PLVs. </p> <p>Vector files of ".vec" format: Each file contains activations, viz., amplitude, of regions. There are two types of amplitude. One is the estimated electric density in a physical unit of picoampere. Another is the z-score of amplitude calculated through comparison with a baseline of –200 ms.</p> <p>We provided both the group-averaged files (named as b999 for the Broca group and c999 for the control group) and the individuals' files (b1 to b5 for the Broca's aphasia and c1 to c5 for the control persons).</p> <p>We also provided two ".clu" files. One is the partition file of eight functional modules in two hemispheres. Another is the partition file of two hemispheres. </p> <p>The .net, .vec., and .clu files can be imported to Pajek for further interpretations and visualizations. </p> <p> </p>
The Relationship between Vitamin D Status, Intake and Exercise Performance in UK University-level Athletes and Healthy Inactive Controls
<p>The potential ergogenic effects of vitamin D (vitD) in high performing athletes has received considerable attention in the literature and media. However, little is known about non-supplemented university athletes and students residing at a higher latitude. This study aimed to investigate the effects of vitD (biochemical status and dietary intake) on exercise performance in UK university athletes and sedentary students. Physically healthy male and female university students and athletes from the University of Surrey (51.2ºN) were recruited between January and March (2018) to take part in this study. A total of 50 participants (n= 24 males, n= 26 females) were included, 34 (n=18 male, n=16 female) were university athletes competing in a variety of sports. </p> <p>Fasted serum vitD status and sunlight exposure were assessed using LC-MS/MS and dosimetry, respectively. Body composition was measured through the use of a dual-energy x-ray absorptiometry (DEXA) whole body scan (Hologic QDR, Hologic inc. USA). Muscular strength of the upper and lower body was assessed using dominant arm handgrip and knee extensor dynamometry (KE) of the non-dominant leg. Countermovement jump (CMJ) and aerobic fitness were measured using an Optojump and VO<sub>2max</sub> test using a stationery cycle ergometer, respectively.</p>
CSV files and R script: writing process data of typed picture description by 15 cognitively impaired patients and 15 healthy controls
<p>Writing process data of 15 cognitively impaired patients and 15 age- and gender-matched healthy controls were obtained. Each of them completed two typed picture description tasks that were logged with Inputlog, a keystroke logging tool. Variables included time on task; number of characters, pauses and Pause-bursts per minute; proportion of pause time; duration of Pause-bursts; and pause time between words. For pause time between words, also the effect of pauses preceeding specific word categories was analyzed.</p> <p>The data were used to explore if the observation of writing behavior can assist in the screening and follow-up of mild cognitive impairment (MCI) and mild dementia due to Alzheimer’s disease (AD). This data set contains the CSV files that were used for the analyses and the corresponding R script.</p>
Normalized and batch-corrected concentration of 43 immune markers from 248 subjects with stress-related mental disorders and 36 healthy controls
<h1>Abstract</h1> <p>In a subset of patients with mental disorders, such as depression, low-grade inflammation and altered immune marker concentrations are observed. However, these immune alterations are often assessed by only one data type and small markers panels. Here, we used a transdiagnostic approach and combined data from two cohorts to define subgroups of depression symptoms across the diagnostic spectrum through a large-scale multi-omics clustering approach in 237 individuals. The method incorporated age, body mass index (BMI), 43 plasma immune markers and RNA-seq data from peripheral mononuclear blood cells (PBMCs). Our initial clustering revealed four clusters, including two immune-related depression symptom clusters characterized by elevated BMI, higher depression severity and elevated levels of immune markers such as interleukin-1 receptor antagonist (IL-1RA), C-reactive protein (CRP) and C-C motif chemokine 2 (CCL2 or MCP-1). In contrast, the RNA-seq data mostly differentiated a cluster with low depression severity, enriched in brain related gene sets. This cluster was also distinguished by electrocardiography data, while structural imaging data revealed differences in ventricle volumes across the clusters. Incorporating predicted cell type proportions into the clustering resulted in three clusters, with one showing elevated immune marker concentrations. The cell type proportion and genes related to cell types were most pronounced in an intermediate depression symptoms cluster, suggesting that RNA-seq and immune markers measure different aspects of immune dysregulation. Lastly, we found a dysregulation of the SERPINF1/VEGF-A pathway that was specific to dendritic cells by integrating immune marker and RNA-seq data. This shows the advantages of combining different data modalities and highlights possible markers for further stratification research of depression symptoms.</p> <h1>Methods</h1> <p>The normalized and batch-corrected concentration of 43 immune markers from 237 subjects with stress-related mental disorders and 36 healthy controls was determined in plasma. This data was used in the initial analysis. Additionally, the same measurements are provided for 11 subjects with stress-related mental disorders used in a replication analysis.</p> <p>- blood was collected in the morning under fasted conditions and plasma stored at -80°C until further processing<br>- samples were randomized into 96 well plates<br>- immune marker concentration was measured with the Meso Scale Diagnostics V-PLEX Human Biomarker 54-Plex Kit and the MESO QuickPlex SQ 120 imager according to the manufacturer's instructions<br>- additionally, high-sensitivity C-reactive protein (Tecan Group Ltd.), cortisol (Tecan Group Ltd.), interleukin (IL)-6 (Thermo Fisher Scientific), IL-6 soluble receptor (Thermo Fisher Scientific) and IL-13 (Thermo Fisher Scientific) was measured via ELISA according to the manufacturer's instructions<br>- values below the detection limit in markers measured with ELISA were set to zero and values above the detection limit to the upper limit<br>- the data was quantile-normalized (values were ranked and mapped to the quantiles of a standard normal distribution)<br>- the normalized concentration was corrected for the biobank storage position (batch_variable) via a linear model and the residuals reported as the concentration</p> <p>The following markers were measured:<br>fibroblast growth factor 2 (FGF2 or bFGF), cortisol, C-C motif chemokine 11 (CCL11 or eotaxin), CCL26 (eotaxin-3), vascular endothelial growth factor receptor 1 (VEGFR1 or Flt-1), hsCRP, intercellular adhesion molecule (ICAM)-1, interferon (IFN)-gamma, IL-1alpha, IL-1 receptor antagonist (IL-1RA), IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17B, IL-2, IL-27, IL-31, IL-5, IL-6 high sensitivity (IL-6HS), IL-7, IL-8HS, C-X-C motif chemokine 10 (CXCL10 or IP-10), CCL2 (MCP-1), CCL13 (MCP-4), CCL22 (MDC), CCL3 (MIP-1alpha), CCL4 (MIP-1beta), placental growth factor (PlGF), serum amyloid A (SAA), sIL-6R, CCL17 (TARC), angiopoietin-1 receptor (Tie-2), tumor necrosis factor (TNF or TNF-alpha), lymphotoxin-alpha (LT-alpha or TNF-beta), thymic stromal lymphopoietin (TSLP), vascular cell adhesion protein 1 (VCAM-1), vascular endothelial growth factor (VEGF)-A-HS, VEGF-C, VEGF-D</p> <p>The data is provided as a tab separated file.</p>
Mobile Device Voice Recordings at King's College London (MDVR-KCL) from both early and advanced Parkinson's disease patients and healthy controls
<p><strong>Dataset description</strong></p> <p>The dataset description will start with describing the local conditions and other metadata, then will continue with describing the recording procedure and annotation methodology. Finally, a brief description of the dataset deployment and publication will be given.</p> <p><strong>Meta Information</strong></p> <p>The dataset was recorded at King's College London (KCL) Hospital, Denmark Hill, Brixton, London SE5 9RS in the period from 26 to 29 September 2017. We used a typical examination room with about ten square meters area and a typical reverberation tome of approx. 500ms to perform the voice recordings. Due to the fact, that the voice recordings are performed in the realistic situation of doing a phone call (i.e. participant holds the phone to the preferred ear and microphone is in direct proximity to the mouth), one can assume that all recordings were performed within the reverberation radius and thus can be considered as “clean”.</p> <p><strong>Recording Procedure</strong></p> <p>We used a Motorola Moto G4 Smartphone as recording device. To perform the voice recordings on the device, we developed a “Toggle Recording App”, which uses the same functionalities as the voice recording module used within the i-PROGNOSIS Smartphone application, but deployed as a standalone android application. This means, that the voice capturing service runs as a standalone background service on the recording device and triggers voice recordings via on- and off-hook signals of the Smartphone. Due to the fact, that we directly record the microphone signal, and not the GSM (“Global System for Mobile Communications”) compressed stream, we end up with high quality recordings with a sample rate of 44.1 kHz and a bit depth of 16 Bit (audio CD quality). The raw, uncompressed data is directly written to the external storage of the Smartphone (SD-card) using the well-known WAVE file format (.wav). We used the following workflow to perform a voice recording:</p> <ul> <li>Ask the participant to relax a bit and then to make a phone call to the test executor (off-hook signal triggered).}</li> <li>Ask the participant to read out “The North Wind and the Sun”</li> <li>Depending on the constitution of the participant either ask to read out “Tech. Engin. Computer applications in geography snippet”</li> <li>Start a spontaneous dialog with the participant, the test executor starts asking random questions about places of interest, local traffic, or personal interests if acceptable.</li> <li>Test executor ends call by farewell (on-hook signal triggered).</li> </ul> <p><strong>Annotation Scheme</strong></p> <p>For each HC and PD participant, we labeled the data regarding scores on the Hoehn & Yahr (H&Y), as well as the UPDRS II part 5 and UPDRS III part 18 scale. The voice recordings are labeled in the following scheme:</p> <p>SI_ HS_ HYR_ UPDRS II-5_UPDRS III-18</p> <p>with</p> <ul> <li>SI as subject identification in the form ID<em>NN</em>, <em>N</em> in [0, 9]</li> <li>HS as the health status label (hc or pd accordingly)</li> <li>HYR as the expert assessed H&Y scale rating</li> <li>UPDRS II-5 as the according expert peer-reviewed score</li> <li>UPDRS III-18 as the according expert assessed score</li> </ul> <p>For example, an audio recording with the file name “ID02_pd_1_2_1.wav” represents a recording of the third participant (First participant was anonymized as ID00), which has PD and a H&Y rating of 1, a UPDRS II-5 score of 2 and a UPDRS III-18 score of 1. At this point, it should be noted, that also all healthy controls were evaluated with regard to the introduced scales, because Parkinson's disease and voice degradation correlate, but don't match exactly. This means, that the data set includes one HC participant (ID31) with UPDRS II-5 and III-18 rating of 1, and also includes PD patients with UPDRS II-5 and III-18 ratings of 0. It should be emphasized, that this does not mean the data set includes ambiguous information, but that an expert was not able to hear voice degradation that would end up in a UPDRS rating greater than zero. Machine learning approaches may be able to nevertheless classify correctly, or at least learn to correlate, but not match PD and voice degradation at any time.</p> <p><strong>Appendix</strong></p> <p>North Wind and the Sun (Orthographic Version):</p> <p>“The North Wind and the Sun were disputing which was the stronger, when a traveler came along wrapped in a warm cloak. They agreed that the one who first succeeded in making the traveler take his cloak off should be considered stronger than the other. Then the North Wind blew as hard as he could, but the more he blew the more closely did the traveler fold his cloak around him; and at last the North Wind gave up the attempt. Then the Sun shone out warmly, and immediately the traveler took off his cloak. And so the North Wind was obliged to confess that the Sun was the stronger of the two.”</p> <p>BNC – Tech. Engin. Computer applications in geography snippet:</p> <p>“[...] This is because there is less scattering of blue light as the atmospheric path length and consequently the degree of scattering of the incoming radiation is reduced. For the same reason, the sun appears to be whiter and less orange-coloured as the observer's altitude increases; this is because a greater proportion of the sunlight comes directly to the observer's eye. Figure 5.7 is a schematic representation of the path of electromagnetic energy in the visible spectrum as it travels from the sun to the Earth and back again towards a sensor mounted on an orbiting satellite. The paths of waves representing energy prone to scattering (that is, the shorter wavelengths) as it travels from sun to Earth are shown. To the sensor it appears that all the energy has been reflected from point P on the ground whereas, in fact, it has not, because some has been scattered within the atmosphere and has never reached the ground at all. [...]”</p>
Reaching and grasping objects in depth for people with stereovision deficits and healthy controls.
<p>Decades of research into hand-object interaction and manipulation skills has yielded fundamental insights with applications in robotics and motor learning. Nevertheless, integrating visual function (especially binocular function, important to perceive depth) into this equation is crucial, forming a triangle between vision, reaching, and object manipulation.</p> <p> </p> <p>The ReGraD dataset provides kinematic data during hand-object interaction in monocular and binocular conditions at different depths and monocular/binocular conditions. It comprises two sub-datasets: ReGraD A (two measurements) can determine its test-retest reliability, whilst ReGraD B (one measurement) can characterize individuals with and without visual disorders. ReGraD includes 35 controls and 3 patients with amblyopia aged 6 to 35.</p> <p> </p> <p>The ReGraD dataset may aid to (1) gain insights into hand-object interaction under various eye conditions and depths, (2) assess reliability and reproducibility and (3) examine the effects of groups (control vs. patients) and age, among others. The ReGraD dataset contains raw data that can also be used to develop algorithms for data segmentation and data interpolation in the kinematic field.</p>
Gut microbiome of multiple sclerosis patients and paired household healthy controls reveal associations with disease risk and course
Open the record for dataset details and reuse information.
Processed OLINK serum proteomics data MIS-C patients versus healthy controls
<p>This dataset contains processed OLINK serum proteomics data MIS-C patients versus healthy controls. Data was generated by Diorio et al. (Diorio, C., Shraim, R., Vella, L.A. <em>et al.</em> Proteomic profiling of MIS-C patients indicates heterogeneity relating to interferon gamma dysregulation and vascular endothelial dysfunction. <em>Nat Commun</em> <strong>12</strong>, 7222 (2021). https://doi.org/10.1038/s41467-021-27544-6). Processing in format provided here was done by dr. Levi Hoste. This table is used in the MultiNicheNet package (https://github.com/saeyslab/multinichenetr) and mentioned in the updated corresponding manuscript. </p>
Linear vs. non-linear metrics of Autonomic Nervous System: study on healthy volunteers during controlled breathing
<h1>Please cite this article as reference article:</h1> <p>Uryga A, Najda M, Berent I, Mataczyński C, Urbański P, Kasprowicz M, Buchner T. The impact of controlled breathing on autonomic nervous system modulation: analysis using phase-rectified signal averaging, entropy and heart rate variability. Physiol Meas. 2024 Sep 16;45(9). doi: 10.1088/1361-6579/ad7778. </p> <h1>Funding</h1> <p>SONATA 18 UMO-2022/47/D/ST7/00229 National Science Centre, Poland (dataset 2)</p> <p>SONATA-BIS UMO-2013/10/E/ST7/00117 National Science Centre, Poland (dataset 1)</p> <h1>General information</h1> <p>Two datasets were used in this study.</p> <p>The dataset 1 includes 49 healthy volunteers (28 females, 21 males, median age: 23 years, range: 18-31 years) who were measured at the Neuroengineering Laboratory at Wroclaw University of Science and Technology (WUST) between October 2014 and June 2015 (Biomedical Committee Agreement number: KB-170/2014).</p> <p>The dataset 2 includes 21 healthy volunteers (14 females, 7 males, median age: 22 years, range: 18-31 years) who were prospectively measured at WUST between October 2023 and January 2024 (Biomedical Committee Agreement number: KB-179/2023/N).</p> <h1>Signal recordings description</h1> <ul> <li>ABP was measured non-invasively by a servo-controlled plethysmograph (Finometer MIDI, FMS Medical Systems, Amsterdam, The Netherlands in all subjects in dataset 1; CNAP, CNSystems Medizintechnik GmbH, Graz, Austria and Finapres Nova, FMS Medical Systems in dataset 2). The cuff was placed on the middle finger of the left hand and held at the level of the heart.</li> <li>Expired end-tidal CO2 (EtCO2), carbon dioxide (CO2) concentration and respiratory rate (RR) were measured via a nasal cannula using a portable capnography monitor (RespSense™, NONIN, Plymouth, USA)</li> <li>Protocol: after a resting epoch lasted at least 5 minutes, a controlled breathing session was initiated with 5-minute recordings at each of the respiratory rate: 6, 10 or 15 breaths/min (0.1 Hz, 0.17 Hz, and 0.25 Hz, respectively), guided by a digital metronome.</li> </ul> <h1>Data description</h1> <ul> <li>Type of database (database 1/database 2)</li> <li>Type of device used to ABP measurement</li> <li>Metadata including: sex (male M, female F), and age</li> <li>Autonomic Nervous System parameters including:</li> </ul> <p>- <strong>Phase-Rectified Signal Averaging</strong> - a non-linear approach used to quantify the acceleration (AC) and deceleration (DC) capacity of the heart; more details could be found here: <em>Campana L M, Owens R L, Clifford G D, Pittman S D and Malhotra A 2010 Phase-rectified signal averaging as a sensitive index of autonomic changes with aging J Appl Physiol 108 1668–73</em></p> <p>- <strong>Entropy</strong>: multiscale entropy (MSEn), approximate entropy (ApEn), sample entropy (SampEn), and fuzzy entropy (FuzzyEn) functions calculated for R-R intervals, which were implemented in NeuroKit2</p> <ul> <li> <strong>Heart rate variability (HRV) metrics</strong>: In the frequency domain, the Lomb–Scargle periodogram was used to determine the power spectral density of the interval time series in the low-frequency range (LF, 0.04–0.15 Hz) and the high-frequency range (HF, 0.15–0.40 Hz). Additionally, the total power of the HRV signal (TP, 0.04–0.40 Hz) and the ratio between low and high-frequency components (LF/HF) were calculated. In the time domain, the following metrics were determined: the standard deviation of the R-R intervals (SDNN) and the square root of the mean of the squared successive differences between adjacent R-R intervals (RMSSD), mean of the R-R intervals (meanNN), and the proportion of R-R intervals greater than 20 ms or 50 ms, out of the total number of R-R intervals (pNN20 and pNN50, respectively); appropriate functions were implemented in NeuroKit2</li> </ul> <p> </p> <p>Update ------version 2</p> <p>After the revision process, SDNNref was added, defined according to formula presented in paper of Monfredi et al. (Monfredi O, Lyashkov AE, Johnsen AB, et al. Biophysical characterization of the underappreciated and important relationship between heart rate variability and heart rate. Hypertension. 2014 Dec;64(6):1334-43)</p>
Muscle activity, ground reaction forces and pointing performance during postural control tasks in healthy adults
<p>To investigate the muscle coordination during postural control, we recorded muscle activity and postural dynamics in healthy human adults. Fourteen participants performed postural tasks in which postural stability and pointing behaviour was varied. The data set contains electromyography of 36 muscles distributed across the body and ground reaction forces recorded during postural control tasks. A full factorial design was used. Stability was either not challenged or challenged in the anterior-posterior or medial-lateral direction. In addition, participants were asked to either relax their arms or to perform an unimanual or a bimanual pointing task. In the pointing task, participants held a laser pointer and pointed it on a target in front of them. Pointing performance was recorded using a video recording of the laser beam on the target area.</p> <p>InformationData.pdf – Description of data acquisition and file structure<br> EMG.zip – EMG data<br> FP.zip – Force plate data<br> Video.zip – Video feed</p>
Labelled and unlabelled hand acceleration data captured unobtrusively from PD patients and Healthy Controls
<p>The dataset contains acceleration signals captured in-the-wild via the IMU sensor embedded in modern smartphones, for the purpose of detecting tremorous episodes, related to Parkinson's Disease (PD). It contains two different groups of subjects:</p> <ul> <li>tremor_sdata.pickle --> A group of 45 subjects that have been subjected to neurological examination (the same dataset as https://zenodo.org/record/3519213)</li> <li>tremor_gdata.pickle --> A group of 454 subjects who just self-reported their PD status</li> </ul> <p>All subjects contributed accelerometer data using their personal smartphones, for a period spanning many months. Tri-axial acceleration values were recorded automatically whenever a phone call was realized. The recording lasted for 75 seconds at the most. Each phone call thus resulted in one recorded accelerometer signal, also referred to as session. Each subject contributed a different amount of sessions depending on the number of phone calls they realized during the data collection period as well as their participation time (they were free to drop-out at any time). A detailed description of the capturing process as well as analysis results, can be found in the related research article.</p> <p>The data is presented as a python dictionary, indexed by the subject ids. Each element of the dictionary is a list with the following significance:</p> <table> <thead> <tr> <th scope="col">Index</th> <th scope="col">Meaning</th> </tr> </thead> <tbody> <tr> <td>0</td> <td>List of np.arrays, Each array contains the power spectral density for an acceleration segment of 5s duration</td> </tr> <tr> <td>1</td> <td>Dictionary, Denotes subject updrs</td> </tr> <tr> <td>2</td> <td>List of str containing a unique identifier of the acceleration session that each segment in the other lists belongs to</td> </tr> <tr> <td>3</td> <td>List of np.arrays, Each array contains the pre-processed acceleration values for a 5s segment</td> </tr> </tbody> </table> <p> </p><p>The subject updrs is represented as dictionary containing the following tremor-related annotation values (FOR THE FIRST GROUP ONLY):<br> * updrs16: scalar int<br> The value related to tremor as described in item 16 of the part II of the MDS-UPDRS scale, as reported by the subject.</p> <p></p> <p>* updrs20_right: scalar int in range [0, 4]<br> The value related to rest tremor in the right hand as described in item 20 of the part III of the MDS-UPDRS scale, as reported by the attending neurologist.</p> <p>* updrs20_left: scalar int in range [0, 4]<br> Same as above but for left hand.</p> <p>* updrs21_right: scalar int in range [0, 4]<br> The value related to action/postural tremor in the right hand as described in item 21 of the part III of the MDS-UPDRS scale, as reported by the attending neurologist.</p> <p>* updrs21_left: scalar int in range [0, 4]<br> Same as above but for left hand.</p> <p>* sp_expert: scalar int in range [0, 1]<br> A binary tremor annotation created by a group of signal processing experts, upon visually examining the contributed signals in both time and frequency domain and taking into consideration the UDPRS scores of each subject. This was necessary due to the intermittent nature of tremor, as well as a number of considerations related to the in-the-wild nature of the data capturing process. For more details, we refer the reader to the dataset description in the related research article.<br> A '1' value indicates that the subject has tremor.<br> A '0' value indicates that the subject doesn't have tremor.</p> <p>* pd_status: scalar int in range [0, 1]<br> A '1' value indicates that the subject is a PD patient.<br> A '0' value indicates that the subject is a Healthy Control</p> <p>Note: Each annotation value refers to the subject as a whole, and not in any one session.</p>
Quantitative susceptibility-based MRI radiomic features in patients with multiple sclerosis and healthy controls
<p>This dataset provides access to radiomic features of brain MR susceptibility-based images (QSM). Specifically, a cohort of 151 subjects, mixed of patients with multiple sclerosis (121) and healthy controls (30) was analysed, studying the Normal Appearing White Matter (NAWM) and NAWM tracts (e.g. corticospinal tract and optic radiation). Robustness analysis of those imaging descriptors can be found in Fiscone et al., <em>Assessing robustness of quantitative susceptibility-based MRI radiomic features in patients with multiple sclerosis. </em></p> <p>In the .zip folder, instructions about the organization of the dataset can be found. Together with the data, the code used to assess the reliability of those features is available. </p>
A Phase 1/2, Randomized, Placebo-controlled, Observer-blinded Trial To Evaluate The Safety, Tolerability, And Immunogenicity Of A Multivalent Group B Streptococcus Vaccine In Healthy Adults 18 To 49 Y
ClinicalTrials.gov study NCT03170609. IPD Sharing: YES. Countries: 1. Publications: 1.
Empowering Healthy Lifestyle Personalised Intervention to Prevent and Control Obesity: The HealthyW8 Project
ClinicalTrials.gov study NCT07011368. IPD Sharing: NO. Countries: 8. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.