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64 results for “hepatocytic differentiation”
A novel UPLC-MS metabolomic analysis-based strategy to monitor the course and extent of iPSC differentiation to hepatocytes
<p>ms2 raw data, peak tables generated in Quantitative Analysis Software from Agilent and Matlab functions for QC-SVRC, data clean-up and analysis for the publication with title "Monitoring the differentiation of iPSC to hepatocytes by means of UPLC-MS metabolomics".</p>
Data from: TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation
The functions of the TAF subunits of mammalian TFIID in physiological processes remain poorly characterised. Here we describe a novel function of TAFs in directing genomic occupancy of a transcriptional activator. Using liver-specific inactivation in mice, we show that the TAF4 subunit of TFIID is required for post-natal hepatocyte maturation. TAF4 promotes pre-initiation complex (PIC) formation at post-natal expressed liver function genes and down-regulates a subset of embryonic expressed genes by increased RNA polymerase II pausing. The TAF4-TAF12 heterodimer interacts directly with HNF4A and in vivo TAF4 is necessary to maintain HNF4A-directed embryonic gene expression at post-natal stages and promotes HNF4A occupancy of functional cis-regulatory elements adjacent to the transcription start sites of post-natal expressed genes. Stable HNF4A occupancy of these regulatory elements requires TAF4-dependent PIC formation highlighting that these are mutually dependent events. Local promoter-proximal HNF4A-TFIID interactions therefore act as instructive signals for post-natal hepatocyte differentiation.
Data from: Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells
Differentiation of stem cells to hepatocytes provides an unlimited supply of human hepatocytes and therefore has been vigorously studied. However, to date, the stem cell-derived hepatocytes were suggested to be of immature features. To obtain matured hepatocytes from stem cells, we tested the effect of culturing iPS cell-derived endoderm cells on collagen vitrigel membrane and compared with our previous reported nanofiber matrix. We cultured hiPS cell-derived endoderm cells on a collagen vitrigel membrane and examined the expression profiles, and tested the activity of metabolic enzymes. Gene expression profile analysis of hepatocytic differentiation markers revealed that upon culture on collagen vitrigel membrane, immature markers of AFP decreased, with a concomitant increase in the expression of mature hepatocyte transcription factors and mature hepatocyte markers such as ALB, ASGR1. Mature markers involved in liver functions, such as transporters, cytochrome P450 enzymes, phase II metabolic enzymes were also upregulated. We observed the upregulation of the liver markers for at least 2 weeks. Gene array profiling analysis revealed that hiPS cell-derived hepatocyte-like cells (hiPS-hep) resemble that of the primary hepatocytes. Functions of the CYP enzyme activities were tested in multi-institution and all revealed high CYP1A, CYP2C19, CYP2D6, CYP3A activity, which could be maintained for at least 2 weeks in culture. Taken together, the present approach identified that collagen vitrigel membrane provides a suitable environment for the generation of hepatocytes from hiPS cells that resemble many characteristics of primary human hepatocytes.
Data from: Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells
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Data from: TAF4, a subunit of transcription factor II D, directs promoter occupancy of nuclear receptor HNF4A during post-natal hepatocyte differentiation
Open the record for dataset details and reuse information.
A two-step de-differentiation and maturation of primary human hepatocytes in vitro with efficient metabolic and regenerative capacities
GEO Series GSE261965. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Direct lineage conversion of terminally differentiated hepatocytes to functional neurons
GEO Series GSE30102. Mus musculus. 7 samples. Type: Expression profiling by array.
Developmental modeling of hepatogenesis using obese iPSCs-hepatocyte differentiation uncovers pathological features
GEO Series GSE198391. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
Integrative gene regulatory analysis reveals transcriptional mechanisms required in mature human hepatocytes and during in vitro hepatocyte differentiation (RNA-Seq)
GEO Series GSE182603. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
Inhibiting YAP1 in hepatoblastoma drives therapeutic differentiation of tumor cells to functional hepatocyte-like cells
GEO Series GSE146548. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Stage-specific regulation of the WNT/β-catenin pathway enhances differentiation of hESCs into hepatocytes
GEO Series GSE128102. Homo sapiens. 19 samples. Type: Expression profiling by high throughput sequencing.
Modulation of mitochondrial DNA copy number to induce hepatocytic differentiation of human Amniotic Epithelial cells
GEO Series GSE100688. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
GATA6 is predicted to regulate DNA methylation in an in vitro model of human hepatocyte differentiation (DE CAGE)
GEO Series GSE163328. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing; Other.
GATA6 is predicted to regulate DNA methylation in an in vitro model of human hepatocyte differentiation (DE)
GEO Series GSE163322. Homo sapiens. 6 samples. Type: Methylation profiling by array.
Expression data from purified hepatoblasts and differentiated hepatocytes and cholangiocytes
GEO Series GSE114833. Mus musculus. 3 samples. Type: Expression profiling by array.
GATA6 is predicted to regulate DNA methylation in an in vitro model of human hepatocyte differentiation (HEP)
GEO Series GSE163324. Homo sapiens. 5 samples. Type: Methylation profiling by array.
In vitro differentiation of hepatoblasts into hepatocytes
GEO Series GSE176069. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
DNA methylation during HepaRG hepatocyte differentiation
GEO Series GSE72074. Homo sapiens. 15 samples. Type: Methylation profiling by genome tiling array.
Transcriptomic analysis of Primary duck hepatocyte with differential susceptibility
GEO Series GSE72868. Anas platyrhynchos. 6 samples. Type: Expression profiling by high throughput sequencing.
GATA6 is predicted to regulate DNA methylation in an in vitro model of human hepatocyte differentiation (HEP CAGE)
GEO Series GSE163329. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing; Other.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.