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18 results for “high-altitude adaptation”
The combination of high leaf hydraulic safety and water use efficiency allows alpine shrubs to adapt to high-altitude habitats
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Coordinated changes across the O2 transport pathway underlie adaptive increases in thermogenic capacity in high-altitude deer mice
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Data from: Differential high-altitude adaptation and restricted gene flow across a mid-elevation hybrid zone in Andean tit-tyrant flycatchers
The tropical Andes are a global hotspot of avian diversity that is characterized by dramatic elevational shifts in community composition and a preponderance of recently evolved species. Bird habitats in the Andes span a nearly two-fold range of atmospheric pressure that poses challenges for respiration, thermoregulation, water balance, and powered flight, but the extent to which physiological constraints limit species' elevational distributions is poorly understood. We report a previously unknown hybrid zone between recently diverged flycatchers (Aves, Tyrannidae) with partially overlapping elevational ranges. The southern Anairetes reguloides has a broad elevational range (0-4200 m), while the northern Anairetes nigrocristatus is restricted to high elevations (>2200 m). We found hybrids in central Peru at elevations between ~3100-3800 m, with A. nigrocristatus above this elevation and A. reguloides below. We analyzed variation in hematology, heart mass, morphometrics, plumage, and one mitochondrial and three nuclear loci across an elevational transect that encompasses the hybrid zone. Phenotypic traits and genetic markers all showed steep clines across the hybrid zone. Hemoglobin concentration, hematocrit, mean cellular hemoglobin concentration, and relative heart mass each increased at altitude more strongly in A. reguloides than in A. nigrocristatus. These findings suggest that A. nigrocristatus is more resistant than A. reguloides to high-altitude hypoxic respiratory stress. Considering that the ancestor of the genus is suggested to have been restricted to high elevations, A. reguloides may be secondarily adapted to low-altitude. We conclude that differential respiratory specialization on atmospheric pressure combined with competitive exclusion maintains replacement along an elevational contour, despite interbreeding.
Introgression, admixture and selection facilitate genetic adaptation to high-altitude environments in Chinese cattle
<p>Domestication and subsequent selection of cattle to form breeds and biological types that can adapt to different environments partitioned ancestral genetic diversity into distinct modern lineages. Genome-wide selection particularly for adaptation to extreme environments left detectable signatures genome-wide. We used high-density genotype data for 42 cattle breeds and identified the influence of <em>Bos grunniens</em> and <em>Bos javanicus</em> on the formation of Chinese indicine breeds that led to their divergence from India-origin Zebu. We also found evidence for introgression, admixture, and migration in most of the Chinese breeds. Selection signature analyses between high-altitude (>1800m) and low-altitude adapted breeds (<1500m) revealed candidate genes (<em>ACSS2</em>, <em>ALDOC,</em> <em>EPAS1</em>,<em> EGLN1, NUCB2</em>) and pathways that are putatively involved in hypoxia adaptation. Immunohistochemical, real-time PCR and CRISPR/cas9 <em>ACSS2</em>-knockout analyses suggests that the up-regulation of <em>ACSS2</em> expression in the liver promotes the metabolic adaptation of cells to hypoxia via the hypoxia-inducible factor pathway. High altitude adaptation involved the introgression of alleles from high-altitude adapted Yaks into Chinese <em>B. t. taurus </em>prior to their formation into recognized breeds and followed by selection. In addition to selection, adaptation to high altitude environments has been facilitated by admixture and introgression with locally adapted cattle populations.</p>
Introgression, admixture and selection facilitate genetic adaptation to high-altitude environments in Chinese cattle
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Data from: Differential high-altitude adaptation and restricted gene flow across a mid-elevation hybrid zone in Andean tit-tyrant flycatchers
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The draft genome of the blood pheasant (Ithaginis cruentus): phylogeny and high-altitude adaptation
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Data from: Application of a novel haplotype-based scan for local adaptation to study high-altitude adaptation in rhesus macaques
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Population Structure, and Selection Signatures underlying High-Altitude Adaptation Inferred from Genome-Wide Copy Number Variations in Chinese Indigenous Cattle
GEO Series GSE142218. Bos indicus; Bos grunniens; Bos taurus. 355 samples. Type: Genome variation profiling by SNP array.
Transcriptomic analysis provides insights into the high-altitude adaptation in domestic goats
GEO Series GSE66242. Capra hircus. 27 samples. Type: Expression profiling by high throughput sequencing.
Molecular mechanisms in lung tissue of yak provide insights into high-altitude adaptation by transcriptome-wide analysis
GEO Series GSE153963. Bos grunniens; Bos taurus. 22 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Molecular mechanisms in lung tissue of yak provide insights into high-altitude adaptation by transcriptome-wide analysis [miRNA-seq]
GEO Series GSE153962. Bos grunniens; Bos taurus. 11 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Gene Co-Expression Network Analysis Unraveling Transcriptional Regulation of High-altitude Adaptation of Tibetan Pigs
GEO Series GSE84409. Sus scrofa. 8 samples. Type: Expression profiling by array.
Genome Resequencing Identifies Unique Adaptations of Tibetan Chickens to Hypoxia and High-dose Ultraviolet Radiation in High-altitude Environments
GEO Series GSE77166. Gallus gallus. 8 samples. Type: Expression profiling by high throughput sequencing.
Molecular mechanisms in lung tissue of yak provide insights into high-altitude adaptation by transcriptome-wide analysis [RNA-seq]
GEO Series GSE153956. Bos taurus; Bos grunniens. 11 samples. Type: Expression profiling by high throughput sequencing.
Comparative transcriptomic and proteomic analysis provides insight into the key genes involved in high-altitude adaptation in Tibetan pig (RNA-seq)
GEO Series GSE92981. Sus scrofa. 8 samples. Type: Expression profiling by high throughput sequencing.
Comparative transcriptomic analysis provides insights into high-altitude adaptation
GEO Series GSE93855. Capra hircus; Bos taurus; Gallus gallus; Ovis aries; Bos grunniens; Sus scrofa. 138 samples. Type: Expression profiling by high throughput sequencing.
Exploring the mechanisms of high-altitude adaptation in yak based on single-cell transcriptome atlas.
GEO Series GSE266061. Bos taurus; Bos grunniens x Bos taurus; Bos grunniens. 9 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.