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803 results for “hippocampal”
Hippocampal-neocortical interactions sharpen over time for predictive actions
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Abrupt hippocampal remapping signals resolution of memory interference.
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Human hippocampal replay during rest prioritizes weakly learned information and predicts memory performance
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Semi-automated Quantitative Morphometric Analysis of E18 Rat Hippocampal Neurons from 0.5 to 6 Days In Vitro
<p>This is the dataset presented in "Semi-automated quantitatve evaluation of neuron developmental morphology <em>in vitro</em> using the change-point test" by AS Liao, W Cui, VS Webster-Wood, and YJ Zhang (submitted to Neuroinformatics 2022).</p>
Data related to: Hippocampal ripples and their coordinated dialogue with the default mode network during recent and remote recollection, Norman et al. (2021)
<p>This dataset contains intra-cranial EEG recordings and analysis code related to the paper: "Hippocampal ripples and their coordinated dialogue with the default mode network during recent and remote recollection" by Norman et al. (https://doi.org/10.1016/j.neuron.2021.06.020)<br> The study investigates the role of hippocampal ripples in the human brain during retrieval of recent and remote autobiographical memories and semantic facts. The intracranial recordings underwent standard preprocessing as described in the paper and were stored in EEGLAB datasets. The analysis code that accompanies the dataset implements the main analyses described in the paper.</p> <p>The dataset includes the following zip files:</p> <ul> <li>iEEG data and main analysis code: <ul> <li>“Norman_et_al_2021_iEEG_data_and_code_1.zip" </li> <li>“Norman_et_al_2021_iEEG_data_and_code_2.zip" </li> </ul> </li> <li>Patients' anatomical data: <ul> <li>“Norman_et_al_2021_Freesurfer.zip”</li> </ul> </li> <li>Additional toolboxes (developed by others): <ul> <li>“MATLAB_toolboxes.zip”</li> </ul> </li> </ul> <p>The code is written primarily in Matlab (version R2018b) and runs on a desktop computer with a 3.4Ghz Intel Core i7-6700 CPU with 64GB RAM. Matlab's Signal Processing Toolbox is required, as well as EEGLAB, Unfold toolbox, and several other open-source toolboxes.</p>
Sparsification of AP firing in adult-born hippocampal granule cells via voltage-dependent alpha5-GABAA receptors
<p>The ZIP file consists of folders, containing RAW data used for analysis and used to prepare the Figures 1-6 of the paper published in Cell Reports 2021, with the title mentioned above.</p> <p>All recordings were made from acute hippocampal brain slices, obtained from adult C57BL6 mice. Whole-cell voltage-clamp and current-clamp recordings of mature and adult-born young hippocampal granule cells were performed as outlined in methods and recordings were digitized using a power1401 interface from CED (Cambridge Electronic Design, UK), and saved to file using the CFS library support from CED. The contents of the different files is described in File_Description.pdf.</p>
Hippocampal hub neurons maintain distinct connectivity throughout their lifetime
<p>The temporal embryonic origins of cortical GABA neurons are critical for their specialization. In the neonatal hippocampus, GABA cells born the earliest (ebGABAs) operate as ‘hubs’ by orchestrating population synchrony. However, their adult fate remains largely unknown. To fill this gap, we have examined CA1 ebGABAs using a combination of electrophysiology, neurochemical analysis, optogenetic connectivity mapping as well as ex vivo and in vivo calcium imaging. We show that CA1 ebGABAs not only operate as hubs during development, but also maintain distinct morpho-physiological and connectivity profiles, including a bias for long-range targets and local excitatory inputs. In vivo, ebGABAs are activated during locomotion, correlate with CA1 cell assemblies and display high functional connectivity. Hence, ebGABAs are specified from birth to ensure unique functions throughout their lifetime. In the adult brain, this may take the form of a long-range hub role through the coordination of cell assemblies across distant regions.</p>
Data from: Whole-brain spatial organization of hippocampal single-neuron projectomes
<p>Mapping hippocampal single-neuron projections is essential for understanding brain-wide circuit organization and diverse functions of the hippocampus, a brain structure underlying episodic memory and cognition. Here, we reconstructed 10,100 single-neuron projectomes of the mouse hippocampus, identified rostral and caudal axon pathways that preferentially innervated cortical vs. subcortical areas, and classified 43 projectome subtypes with distinct axon targeting patterns. Notably, the soma locations along hippocampal longitudinal and transverse axes determined the number of their target areas and the spatial distribution and complexity of their axon arbors within the targets. We defined selective hippocampal subdomains based on spatial transcriptomic profiles and found that many projectome subtypes were enriched in specific subdomains. Next, we defined the wiring diagram for hippocampal neurons exclusively projecting to hippocampal formation (HPF) and those projecting to both intra- and extra-HPF targets with coordinated projection strengths. Furthermore, bi-hemispheric projecting hippocampal neurons generally projected to one pair of homologous targets with ipsilateral preference. These organization principles of single-neuron projectomes provide a structural basis for understanding diverse but coordinated functions of hippocampal neurons.</p>
Hippocampal CA1 pyramidal cell membrane voltage recorded in response to noise stimuli at two temperatures.
<p>Electrophysiological recording of the membrane voltage (whole-cell patch-clamp) of three hippocampal CA1 pyramidal cells. Cells are stimulated with a current step chosen to ensure a firing rate around 5-10Hz (amplitude of the current step is given in the filenames) and a noise stimulus with zero mean (Ornstein-Uhlenbeck process with 4ms timescale). Each CSV file contains three columns, the timepoints (saved at 10000Hz), the noise stimulus, and the voltage trace recorded in response to the given noise stimulus. Voltages are recorded at low temperatures (around 32 degrees Celsius) and at high temperatures (around 37 degrees Celsius for cell 1, around 40 degrees Celsius for cells 2 and 3), exact temperatures are given in the filenames. The file metadata.csv contains additional information.</p>
Correlative microscopy of rat cultured hippocampal pyramidal cell from 40x confocal imaging to super-resolution 93x 3D STED of dendritic spines
<p>This dataset contain multi-scale image of rat hippocampal pyramidal cell related to our paper "<em>From tissues to segmentation: a modular framework for multi-scale neuron isolation</em>" by Cauzzo et al. <strong>Nature Comm (2024).</strong></p>
BRAIN Journal-Suicide: Neurochemical Approaches-Figure 2. Hippocampal BDNF and NGF levels of suicide subjects and normal controls
<p>Among the suicidal victims BDNF and NGF levels were significantly reduced in the<br> hippocampus compared to normal control subjects (tBDNF =5.43; df=18; p<0.001; tNGF =6.13; df=18;<br> p<0.001 Figure 2). Such observations clearly indicate the relation of chronic mental depression and<br> hippocampal neurotrophin levels.</p>
Data from: Integrating pheromonal and spatial information in the amygdalo-hippocampal network. Villafranca-Faus et al. 2021
<p>The local field potential (LFP) of the dorsal hippocampus (CA1) and cortical amygdala (PMCo) of mice, under head-fix recording and inmersed on a virtual environtmernt.</p> <p><strong>Paper Abstract</strong>: <br> Vomeronasal information is critical in mice for territorial behavior. Consequently, learning the territorial spatial structure should incorporate the vomeronasal signals indicating individual identity into the hippocampal cognitive map. In this work we show in mice that navigating a virtual environment induces synchronic activity, with causality in both directionalities, between the vomeronasal amygdala and the dorsal CA1 of the hippocampus in the theta frequency range. The detection of urine stimuli induces synaptic plasticity in the vomeronasal pathway and the dorsal hippocampus, even in animals with experimentally induced anosmia. In the dorsal hippocampus, this plasticity is associated with the overexpression of pAKT and pGSK3β. An amygdalo-entorhino-hippocampal circuit likely underlies this effect of pheromonal information on hippocampal learning. This circuit likely constitutes the neural substrate of territorial behavior in mice, and it allows the integration of social and spatial information.</p>
Silencing of hippocampal synaptic transmission impairs spatial reward search on a head-fixed tactile treadmill task
<p>Publication data</p> <p>This repository contains the raw data files for the following manuscript:</p> <p>Title: Silencing of hippocampal synaptic transmission impairs spatial reward search on a head-fixed tactile treadmill task<br> Authors: Jake T. Jordan and J. Tiago Gonçalves<br> Pre-print in bioRxiv. doi:10.1101/2021.09.03.458092 (2021)</p> <p>A summary of all experimental groups and data tables and included as two Excel (.xlsx) files: DREADDs_Cued.xlsl and DREADDs_Spatial.xlsl, these correspond to figures 2 and 3 of the publication, respectively.</p> <p>The raw data files were acquired as described in Jordan et al. (2021a) doi:10.1016/j.xpro.2021.100770 <br> Software code for data acquisition and interpretation is available at doi:10.5281/zenodo.5196612</p>
Dataset for manuscript "Prefrontal stimulation as a tool to disrupt hippocampal and striatal reactivations underlying fast motor memory consolidation"
<p>Dataset containing the source data corresponding to figures and tables in the manuscript "Prefrontal stimulation as a tool to disrupt hippocampal and striatal reactivations underlying fast motor memory consolidation", as well as raw behavioral and MEP data and the corresponding analysis scripts.</p>
Data from: Topography of inputs into the hippocampal formation of a food-caching bird
<p>The mammalian hippocampal formation (HF) is organized into domains associated with different functions. These differences are driven in part by the pattern of input along the hippocampal long axis, such as visual input to the septal hippocampus and amygdalar input to temporal hippocampus. HF is also organized along the transverse axis, with different patterns of neural activity in the hippocampus and the entorhinal cortex. In some birds, a similar organization has been observed along both of these axes. However, it is not known what role inputs play in this organization. We used retrograde tracing to map inputs into HF of a food-caching bird, the black-capped chickadee. We first compared two locations along the transverse axis: the hippocampus and the dorsolateral hippocampal area (DL), which is analogous to the entorhinal cortex. We found that pallial regions predominantly targeted DL, while some subcortical regions like the lateral hypothalamus (LHy) preferentially targeted the hippocampus. We then examined the hippocampal long axis and found that almost all inputs were topographic along this direction. For example, the anterior hippocampus was preferentially innervated by thalamic regions, while posterior hippocampus received more amygdalar input. Some of the topographies we found bear resemblance to those described in the mammalian brain, revealing a remarkable anatomical similarity of phylogenetically distant animals. More generally, our work establishes the pattern of inputs to HF in chickadees. Some of these patterns may be unique to chickadees, laying the groundwork for studying the anatomical basis of these birds' exceptional hippocampal memory.</p>
Volitional activation of remote place representations with a hippocampal brain‐machine interface
<p><strong>Overview</strong></p> <p>This repository is associated with the following paper: <strong>Lai C, Tanaka S, Harris TD, Lee AK. Volitional activation of remote place representations with a hippocampal brain‐machine interface. Science, 2023 (in press).</strong></p> <p>This dataset demonstrates the ability of animals to activate remote place representations within the hippocampus when they aren't physically present at those locations. Such remote activations serve as a fundamental capability underpinning memory recall, mental simulation/planning, imagination, and reasoning. By employing a hippocampal map-based brain-machine interface (BMI), we designed two specific tasks to test whether animals can intentionally control their hippocampal activity in a flexible, goal-directed, and model-based manner. Our results show that animals can perform both tasks in real-time and in single trials. This dataset provides the neural and behavior data of these two tasks. The details of the tasks and results are described in the paper.</p> <p> </p> <p><strong>Dataset, pre-trained model and code access:</strong></p> <ul> <li> <p>Unzip the <code>data.7z</code> to get a <code>data</code> folder. The <code>data</code> folder contains three subfolders:</p> <ul> <li><strong>1. Running</strong>: This folder has two subfolders: <ul> <li><strong>run_before_jumper</strong>: Contains data files for the Running task performed before the Jumper task.</li> <li><strong>run_before_jedi</strong>: Contains data files for the Running task performed before the Jedi task.</li> </ul> </li> <li><strong>2. Jumper</strong>: Contains data files for the Jumper task.</li> <li><strong>2. Jedi</strong>: Contains data files for the Jedi task.</li> </ul> </li> <li> <p>Unzip the <code>model.7z</code> to get a <code>pretrained_model</code> folder, which contains all 6 pretrained models (<code>pth</code> files) trained using the data from the <code>Running</code> tasks, 3 used in <code>Jumper</code> tasks and 3 used in the <code>Jedi</code> tasks.</p> </li> <li> <p>Unzip the <code>code.7z</code></p> </li> </ul>
Synaptic basis of feature selectivity in hippocampal neurons
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Perirhinal cortex abnormalities impair hippocampal plasticity and learning in Scn2a, Fmr1, and Cdkl5 autism mouse models
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Hippocampal firing fields anchored to a moving object predict homing direction during path-integration-based behavior
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Closed-loop modulation of remote hippocampal representations with neurofeedback
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ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.