Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
5
datasets available to search
ShareScore release 0.9.0
Dataset results
5 results for “hippocampal mossy fiber”
Recruitment of release sites underlies chemical presynaptic potentiation at hippocampal mossy fiber boutons
<p>The MFB_cLTP_Data zip folder contains the data from the publication by Orlando M, Dvorzhak A, Bruentgens F, Maglione M, Rost BR, Sigrist SJ, Breustedt J, and Schmitz D. "Recruitment of release sites underlies chemical presynaptic potentiation at hippocampal mossy fiber <em>boutons" </em>that is under revision at PLOS Biology. </p> <p>Each file corresponds to a figure in the paper. The folder contains data from two photon live glutamate imaging, STED microscopy, electron microscopy of murine hippocampal mossy fiber boutons and autaptic neuron electrophysiology. We compared boutons in control conditions (CTRL) with boutons at wich chemical potentiation was induced by the application of 50 µM Forskolin for 15 minutes (FSK).</p>
Synaptopodin regulates denervation-induced plasticity at hippocampal mossy fiber synapses
<p>Neurological diseases can lead to the denervation of brain regions caused by demyelination, traumatic injury or cell death. The molecular and structural mechanisms underlying lesion-induced reorganization of denervated brain regions, however, are a matter of ongoing investigation. In order to address this issue, we performed an entorhinal cortex lesion (ECL) in mouse organotypic entorhino-hippocampal tissue cultures of both sexes and studied denervation-induced plasticity of mossy fiber synapses, which connect dentate granule cells (dGCs) with CA3 pyramidal cells (CA3-PCs) and play important roles in learning and memory formation. Partial denervation caused a strengthening of excitatory neurotransmission in dGCs, CA3-PCs and their direct synaptic connections, as revealed by paired recordings (dGC-to-CA3-PC). These functional changes were accompanied by ultrastructural reorganization of mossy fiber synapses, which regularly contain the plasticity-regulating protein synaptopodin and the spine apparatus organelle. We demonstrate that the spine apparatus organelle and synaptopodin are related to ribosomes in close proximity to synaptic sites and unravel a synaptopodin-related transcriptome. Notably, synaptopodin-deficient tissue preparations that lack the spine apparatus organelle failed to express lesion-induced synaptic adjustments. Hence, synaptopodin and the spine apparatus organelle play a crucial role in regulating lesion-induced synaptic plasticity at hippocampal mossy fiber synapses.</p>
Synaptopodin regulates denervation-induced plasticity at hippocampal mossy fiber synapses
Open the record for dataset details and reuse information.
Synaptopodin regulates denervation-induced plasticity at hippocampal mossy fiber synapses
GEO Series GSE216509. Mus musculus. 63 samples. Type: Expression profiling by high throughput sequencing; Other.
Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2
GEO Series GSE161619. Mus musculus. 304 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.