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94 results for “histone deacetylase inhibitors”
Selective Estrogen Receptor Modulators to Enhance the Efficacy of Viral Reactivation With Histone Deacetylase Inhibitors
ClinicalTrials.gov study NCT03382834. IPD Sharing: YES. Countries: 2. Publications: 1.
Effect of the histone deacetylase inhibitor Trichostatin A on facial development in cichlid fishes
<p>A central question in biology is the molecular origins of phenotypic diversity. While genetic changes are key to the genotype-phenotype relationship, alterations to chromatin structure and the physical packaging of histone proteins may also be important drivers of vertebrate divergence. We investigate the impact of such an epigenetic mechanism, histone acetylation, within a textbook example of an adaptive radiation. Cichlids of Lake Malawi have adapted diverse craniofacial structures, and here we investigate how histone acetylation influences morphological variation in these fishes. Specifically, we assessed the effect of inhibiting histone deacetylation using the drug trichostatin A (TSA) on developing facial structures. We examined this during three critical developmental windows in two cichlid species with alternate adult morphologies. Exposure to TSA during neural crest cell (NCC) migration and as post-migratory NCCs proliferate into the pharyngeal arches resulted in significant changes in lateral and ventral shape in <em>Maylandia</em>, but not in <em>Tropheops</em>. This included an overall shortening of the head, widening of the lower jaw, and steeper craniofacial profile, all of which are paedomorphic morphologies. In contrast, treatment with TSA during early chondrogenesis did not result in significant morphological changes in either species. Together, these data suggest a sensitivity to epigenetic alterations that are both time- and species-dependent. We find that morphologies are due to non-autonomous or potentially indirect effects on NCC development, including in part a global developmental delay. Our research bolsters the understanding that proper histone acetylation is essential for early craniofacial development and identifies a species-specific robustness to developmental change. Overall, this study demonstrates how epigenetic regulation may play an important role in both generating and buffering morphological variation.</p>
Dietary Histone Deacetylase Inhibitors (HDAC)
ClinicalTrials.gov study NCT01543074. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Exploratory Evaluation of AR-42 Histone Deacetylase Inhibitor in the Treatment of Vestibular Schwannoma and Meningioma
ClinicalTrials.gov study NCT02282917. IPD Sharing: NO. Countries: 1. Publications: 2.
Effect of the histone deacetylase inhibitor Trichostatin A on facial development in cichlid fishes
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Fig. 6 in Sesquiterpenes with diverse skeletons from histone deacetylase inhibitor modified cultures of the basidiomycete Cyathus stercoreus (Schwein.) De Toni HFG134
Fig. 6. (A) The four possible stereoisomers of 9. (B), (C) The comparisons of the experimental CD and calculated ECD of 9.
Study of Vorinostat (MK0683), an Histone Deacetylase (HDAC) Inhibitor in Combination With Bortezomib in Patients With Relapsed or Refractory Multiple Myeloma (MK-0683-095)
ClinicalTrials.gov study NCT00773838. IPD Sharing: YES. Countries: 0. Publications: 1.
A Dose Escalation Study of the Histone Deacetylase Inhibitor (HDACi) JNJ 26481585 in Combination With VELCADE (Bortezomib) and Dexamethasone for Patients With Relapsed Multiple Myeloma
ClinicalTrials.gov study NCT01464112. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study to Evaluate the Safety and Effect of HIVconsv Vaccines in Combination With Histone Deacetylase Inhibitor Romidepsin on the Viral Rebound Kinetic After Treatment Interruption in Early Treated HIV
ClinicalTrials.gov study NCT02616874. IPD Sharing: Not stated. Countries: 1. Publications: 1.
An Investigational Study of a Histone Deacetylase (HDAC) Inhibitor Plus Targretin in Cutaneous T-Cell Lymphoma Patients (0683-016)(TERMINATED)
ClinicalTrials.gov study NCT00127101. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Fig. 3 in Sesquiterpenes with diverse skeletons from histone deacetylase inhibitor modified cultures of the basidiomycete Cyathus stercoreus (Schwein.) De Toni HFG134
Fig. 3. ECD and NMR of 1 and 2.
Fig. 2. Key 2D in Sesquiterpenes with diverse skeletons from histone deacetylase inhibitor modified cultures of the basidiomycete Cyathus stercoreus (Schwein.) De Toni HFG134
Fig. 2. Key 2D NMR correlations of compounds 1–9.
Fig. 1 in Sesquiterpenes with diverse skeletons from histone deacetylase inhibitor modified cultures of the basidiomycete Cyathus stercoreus (Schwein.) De Toni HFG134
Fig. 1. The chemical structures of compounds 1–13.
Trial of the Histone-Deacetylase Inhibitor ITF2357 Followed by Mechlorethamine in Relapsed/Refractory Hodgkin's Lymphoma
ClinicalTrials.gov study NCT00792467. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Histone Deacetylase Inhibitor LBH589 in Addition to Corticosteroids in Patients With Acute Graft Versus Host Disease (GVHD)
ClinicalTrials.gov study NCT01111526. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Phase I of Histone Deacetylase (HDAC) Inhibitor Panobinostat With Ipilimumab With Unresectable III/IV Melanoma
ClinicalTrials.gov study NCT02032810. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Experience modulates the effects of histone deacetylase inhibitors on gene and protein expression in the hippocampus: Impaired plasticity in aging
GEO Series GSE172109. Rattus norvegicus. 84 samples. Type: Expression profiling by array.
A Multi-loop, Double-cube Microarray Design Applied to Prostate Cancer Cell Lines with Variable Sensitivity to Histone Deacetylase Inhibitors
GEO Series GSE34452. Homo sapiens. 22 samples. Type: Expression profiling by array.
Histone deacetylase inhibitors in alveolar rhabdomyosarcoma
GEO Series GSE115698. Homo sapiens; Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
H3K9K14ac ChIP-chip in lung cancer cells treated with histone deacetylase inhibitor
GEO Series GSE20304. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by genome tiling array.
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.