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113 results for “hsp90”
Dataset underlying the study "Enhanced Susceptibility to Tomato Chlorosis Virus (ToCV) in Hsp90- and Sgt1-Silenced Plants: Insights from Gene Expression Dynamics"
<p>This dataset is underlying the scientific publication titled "Enhanced Susceptibility to Tomato Chlorosis Virus (ToCV) in Hsp90- and Sgt1-Silenced Plants: Insights from Gene Expression Dynamics", published in the <a href="https://www.mdpi.com/1999-4915/15/12/2370">Viruses</a> journal. </p><p>The dataset includes a time-course transcriptome analysis using RNA-seq of naïve (no whitefly and no virus), mock (non-viruliferous whiteflies) and ToCV (ToCV_viruliferous whiteflies)-treated tomato samples at 2, 7, and 14 days post-infection (dpi) and viral small RNAs derived from Tomato plants infected with ToCV at 14 dpi. The dataset provided here has been deposited in full by the authors in the European Nucleotide Archive (ENA) at EMBL-EBI under accession number PRJEB67704 (<a href="https://www.ebi.ac.uk/ena/browser/view/PRJEB67704"><strong>https://www.ebi.ac.uk/ena/browser/view/PRJEB67704</strong></a><br><br>The provided information in the dataset are further discussed and interpreted in detail, as well as their subsequent results, in the scientific publication.</p><p>This research was conducted within the VIRTIGATION project, which is part of the EU Open Research Data pilot. This project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No. 101000570.</p>
Sampled ΔH/Δλ and ΔH data from ABFE calculations of 18 ligands bound to HSP90
<p>Supplementary Information: "Evaluating the use of absolute binding free energy in the fragment optimization process"</p> <p>Included are the ABFE raw free energy samples for multiple replicates (labelled by `run` number) of 18 ligands bound to HSP90. These ligands are originally detailed by Murray et al. (https://doi.org/10.1021/jm100059d).</p> <p>All samples are provided as a set of `.xvg` files as generated by GROMACS 2021 (https://doi.org/10.5281/zenodo.5849961). The `.xvg` files are labelled as dhdl.N.xvg where N represents the λ state the free energy values were sampled from. The `.xvg` files contain both ΔH/Δλ and ΔH values, please see the header of each files for more information.</p> <p>Samples detailing the partial decoupling of the ligand from the protein-ligand complex are contained within the `complex` folder. These consist of an orientational restraint addition step (found within the `restraints-xvg` folders), charge annihilation step (found within the `coul-xvg` folders), and Van der Waals decoupling step (found within the `vdw-xvg` folders).</p> <p>Samples detailing the partial decoupling of the ligand from solvent are contained within the `ligand` folder and consist of a charge annihilation step (found within the individual `coul-xvg` folders) and a Van der Waals decoupling step (found within the individual `vdw-xvg` folders).</p>
Fig. 2 in Molecular cloning of heat shock protein gene HSP90 and effects of abamectin and double-stranded RNA on its expression in Panonychus citri (Trombidiformes: Tetranychidae)
Fig. 2. Alignment of HSP90 amino acid sequence of P. citri McGregor and its homologus amino acid sequences from other species (Frankliniella occidentalis, Trialeurodes vaporariorum, Pteromalus puparum, Tetranychus cinabarinus).
Expression analysis of targeted genes Sgt1 (A) and Hsp90 (B) in tomato plants subjected to virus-induced gene silencing using Tobacco rattle virus (TRV) vector.
<p><strong>Figure S1</strong>. Expression analysis of targeted genes Sgt1 (A) and Hsp90 (B) in tomato plants subjected to virus-induced gene silencing using Tobacco rattle virus (TRV) vector. (A) Relative expression levels of Sgt1 analyzed by Reverse Transcription-quantitative Polymerase Chain Reaction (RT-qPCR) in tomato plants infected with TRV vector alone (TRV2), TRV carrying Sgt1 silencing constructs (TRV-Sgt1), and mock-inoculated (Mock). Transcript levels were normalized using tomato genes encoding elongation factor 1-α and SAND as internal references, with Mock as the calibrator. (B) Relative expression levels of Hsp90 analyzed by RT-qPCR in tomato plants infected with TRV2, TRV-Hsp90, and Mock. Gene expression levels were normalized using the same reference genes as in (A). (C) Quantification of the relative accumulation of TRV RNA in plants infected with TRV2 and in silenced plants (TRV-Sgt1 and TRV-Hsp90). The expression levels were normalized using tomato genes for elongation factor 1-α and SAND, with TRV2 as the calibrator. All samples were collected at 19 dpi to anticipate the observed decline. Error bars represent standard errors of five biological replicates, and an asterisk indicates a significant difference, as determined by one-way ANOVA with P < 0.05</p>
Extended conformational states dominate the Hsp90 chaperone dynamics
<p>aMD and cgMD simulation trajectories for publication "Extended conformational states dominate the Hsp90 chaperone dynamics"<br> Jussupow et al. doi: 10.1016/j.jbc.2022.102101</p>
Synergistic activity of Hsp90 inhibitors and anticancer agents in pancreatic cancer cell cultures (raw data)
<p>This data set includes raw data supporting the paper "<strong>Synergistic activity of Hsp90 inhibitors and anticancer agents in pancreatic cancer cell cultures</strong>".</p> <p><strong>The files include the following data</strong>:</p> <p>1. MTT assay results used for calculation of <strong><em>EC</em><sub>50</sub> values</strong> of tested compounds and their combinations in cancer cells;</p> <p>2. The data used for calculating <strong>combination index</strong> in order to evaluate synergistic activity;</p> <p>3. The raw data from compound activity evaluation in <strong>3D tumor spheroid assay</strong>;</p> <p>4. The data from <strong>compound and hyperthermia </strong>effect evaluation in cancer cells.</p>
Hsp90 Inhibitor AUY922 and Erlotinib Hydrochloride in Treating Patients With Stage IIIB-IV Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT01259089. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Research Note: Possible influence of thermal selection on patterns of HSP70 and HSP90 gene polymorphisms in Thai indigenous and local chicken breeds and red junglefowls
Open the record for dataset details and reuse information.
Dataset to perform COMBINE analysis using HSP90
<p>AMBER topology (<strong><em>hsp90_amber_topology_files.zip</em></strong>) and coordinate (<strong><em>hsp90_amber_coordinate_files.zip</em></strong>) files for a set of 70 HSP90-inhibitor complexes. In addition, bash scripts and input files to help one to prepare a system for COMBINE analysis and run it.</p>
Dataset: Chromatographic data for publication Exploration and optimisation of structure-activity relationships of newtriazole-based C-terminal Hsp90 inhibitors towards in vivoanticancer potency
<p>Bio-chromoatographic data caming from publication Exploration and optimisation of structure-activity relationships of new triazole-based C-terminal Hsp90 inhibitors towards in vivo anticancer potency</p>
hsp90 alignment in Description of three widespread new Peronospora species parasitising Caryophyllales
Open the record for dataset details and reuse information.
Evolution of the conformational dynamics of the molecular chaperone Hsp90
<p>MD snapshots from: "Evolution of the conformational dynamics of the molecular chaperone Hsp90"</p> <p> </p>
Additional data "Client binding shifts the populations of dynamic Hsp90 conformations through an allosteric network"
<p>Additional data containing chemical shift perturbations and intensity changes of Hsp90 upon client binding, intermolecular PREs, and raw scattering data of Hsp90-client complexes.</p>
Fig. 1. Figure showing the 2D in Geraniol and Citral as potential therapeutic agents targeting the HSP90 activity: An in silico and experimental approach
Fig. 1. Figure showing the 2D structural representation of lemongrass oil components (A–H). Component structures taken from Pubchem database.
Fig. 3 in Geraniol and Citral as potential therapeutic agents targeting the HSP90 activity: An in silico and experimental approach
Fig. 3. Pharmacophores of ligands H-bond interactions with receptor binding amino acid residues of human HSP90-ATPase binding with (A) ADP; (B) Geldanamycin; (C) Geraniol; (D) Citral; (E) Geranyl Acetate; (F) Methyl Eugenol; (G) Myrcene; (H) Elemicin.
Fig. 2 in Geraniol and Citral as potential therapeutic agents targeting the HSP90 activity: An in silico and experimental approach
Fig. 2. Docking scores of all screened ligands with HSP90 protein of humans (A), P. falciparum (B) and S. cerevisiae (C) which are showing the minimum free binding affinity (ΔG = kcal/mol).
Fig. 2 in Diterpenoids from Zhumeria majdae roots as potential heat shock protein 90 (HSP90) modulators
Fig. 2. Comparison of experimental and in silico calculated ECD spectra of compounds 1–3 and 19 in MeOH.
Fig. 3 in Diterpenoids from Zhumeria majdae roots as potential heat shock protein 90 (HSP90) modulators
Fig. 3. Effect of 20 on HSP90α client protein levels in MCF7 cells after treatment with 20 (18 μM) for 48 h. Equal amounts (30 μg) of total protein lysate were separated on SDS-PAGE and client proteins were visualized by Western Blot analysis. α-tubulin and GAPDH were used as loading controls. The blots are representative of three different experiments with similar results. Numbers above each lane represent the densitometric values.
Fig. 4. Binding mode between 20 and the C in Diterpenoids from Zhumeria majdae roots as potential heat shock protein 90 (HSP90) modulators
Fig. 4. Binding mode between 20 and the C-terminal domain of HSP90. The two chains of the protein are colored differently (blue and red). The hydrogen bond is represented with a blue dotted line, the salt bridge with a pink dotted line, and interacting hydrophobic residues are labeled in black with the corresponding chain explicated. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
The Role of HSP90 in Peripheral Vascular Lesions of Diabetic Atherosclerosis
ClinicalTrials.gov study NCT04787770. IPD Sharing: NO. Countries: 1. Publications: 1.
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.