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Dataset results
518 results for “human relations”
A Curated Gene and Biological System Annotation of Adverse Outcome Pathways Related to Human Health
<p>Adverse Outcome Pathways (AOPs) are multi-scale models of biological mechanisms connecting molecular initiating events to adverse outcomes through measurable key events. AOPs can guide the use and development of new approach methodologies (NAMs) aimed at reducing animal experimentation in chemical safety assessment. Here, we present a comprehensive molecular annotation of AOPs relevant to human health to embed the AOP framework into molecular data interpretation, which supports the development and application of novel AOP-based approaches in biomedical research.</p> <p>Please cite the following publication alongside this Zenodo entry when using the data:</p> <p>Saarimäki, L.A., Fratello, M., Pavel, A. <em>et al.</em> A curated gene and biological system annotation of adverse outcome pathways related to human health. <em>Sci Data</em> <strong>10</strong>, 409 (2023). https://doi.org/10.1038/s41597-023-02321-w</p>
Human TWIK-related Acid-Sensitive K+ Channel 1 (TASK1): A Target Enabling Package
<p>The TWIK related acid-sensitive K<sup>+</sup> channel 1 (<a href="https://www.ncbi.nlm.nih.gov/gene/3777">TASK-1</a>) belongs to the family of two-pore domain potassium (K<sub>2P</sub>) channels. It regulates resting membrane potential and is expressed in cardiomyocytes, neurons and vascular smooth muscle cells. Loss of function mutations in TASK-1 lead to primary pulmonary hypertension type 4 (PPH4) which is often fatal in mid-life (1). We have produced TASK-1 and determined structures of this protein alone and in complex with two highly potent inhibitors, BAY 1000493 and BAY 2341237, with EC<sub>50</sub> values of 9.5 nM and 7.6 nM, respectively. We have used a two-electrode voltage clamp assay to measure the effect of mutations in TASK-1 and the effect of inhibitors. The native structure of TASK-1 also allowed us to map the six known disease mutations leading to PPH4.</p>
Data and scripts related to: Rapid coordination of effective learning by the human hippocampus
<p>This data set contains intracranial EEG data (ASCII format), eye-tracking data from an EyeLink 1000 remote system (edf format), behavioral data, and MATLAB code to reproduce the analyses reported in the manuscript, “Rapid coordination of effective learning by the human hippocampus” published in <em>Science Advances.</em></p> <p>The file <strong>KragelEtal21_SciAdv.zip</strong> contains the raw data divided into folders according to content type, for each of the six participants in the study, and the MATLAB code necessary to reproduce all analyses. MATLAB live scripts provide examples of how to reproduce the main analyses reported in the manuscript.</p> <p>External datasets:</p> <p>In addition to the dataset provided here, three open-access datasets are analyzed in the manuscript.</p> <p> - The <a href="http://figrim.mit.edu/">FIGRIM Dataset</a> contains eye-tracking data during a continuous recognition task.</p> <p> - Two additional eye-tracking datasets during free viewing of repeated scenes are provided in “<a href="https://datadryad.org/stash/dataset/doi:10.5061/dryad.9pf75">An extensive dataset of eye movements during viewing of complex images</a>,” namely the Memory I and Memory II datasets.</p> <p>To reproduce region of interest analyses outside of the hippocampus, both the seven-network cortical parcellation developed by <a href="https://surfer.nmr.mgh.harvard.edu/fswiki/CorticalParcellation_Yeo2011">Yeo, Krienen et al.</a>, and the <a href="https://identifiers.org/neurovault.image:1702">Harvard-Oxford cortical atlas</a> are required.</p> <p>Stimuli:</p> <p>The scenes used in this study are part of <a href="https://cocodataset.org">Microsoft COCO</a>. Scenes were selected from the 2017 Train images. Image identifiers are maintained.</p> <p>Salience model:</p> <p>To reproduce analyses that consider the visual salience of each scene, DeepGaze II model predictions for each stimulus are required. Tensorflow models and a Jupyter notebook demonstrating their use are available for <a href="https://deepgaze.bethgelab.org/">download</a>.</p> <p>Software dependencies:</p> <p>The code in this project was developed using MATLAB r2017b. The following external packages are required for code execution. Some external packages are included in the repository.</p> <p>- fieldtrip (<a href="https://github.com/fieldtrip/fieldtrip">https://github.com/fieldtrip/fieldtrip</a>)<br> - spm12 (<a href="https://github.com/spm/spm12">https://github.com/spm/spm12</a>)<br> - BOSC (<a href="https://doi.org/10.1016/j.neuroimage.2010.08.064">https://doi.org/10.1016/j.neuroimage.2010.08.064</a>)<br> - Edf2Mat (<a href="https://github.com/uzh/edf-converter">https://github.com/uzh/edf-converter</a>)<br> - boundedline (<a href="https://github.com/kakearney/boundedline-pkg">https://github.com/kakearney/boundedline-pkg</a>)<br> - export_fig (https://github.com/altmany/export_fig)</p> <p>License:</p> <p>The included code is free software: you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation, either version 3 of the License, or any later version. See the file COPYING for more details. The release of this software includes functions from other toolboxes that are covered under their respective licenses.</p>
PheKnowLator Human Disease KG Benchmarks: Class-Standard Relations-OWL (v2.0.0 - January 2021)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Class-Standard Relations-OWL</i></p><p><strong>Build Date: </strong>January 25, 2021</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/January-25%2C-2021">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Instance-Inverse Relations-OWLNETS (v2.0.0 - May 2020)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Instance-InverseRelations-OWLNETS</i></p><p><strong>Build Date: </strong>May 10, 2020</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-10%2C-2020">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Instance-Standard Relations-OWLNETS (v2.0.0 - January 2021)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Instance-Standard Relations-OWLNETS</i></p><p><strong>Build Date: </strong>January 25, 2021</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/January-25%2C-2021">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Instance-Inverse Relations-OWLNETS (v2.0.0 - January 2021)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Instance-Inverse Relations-OWLNETS</i></p><p><strong>Build Date: </strong>January 25, 2021</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/January-25%2C-2021">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Instance-Standard Relations-OWL (v2.0.0 - May 2020)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Instance-StandardRelations-OWL</i></p><p><strong>Build Date: </strong>May 10, 2020</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-10%2C-2020">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Instance-Standard Relations-OWLNETS (v2.0.0 - May 2020)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Instance-StandardRelations-OWLNETS</i></p><p><strong>Build Date: </strong>May 10, 2020</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-10%2C-2020">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Instance-Inverse Relations-OWL (v2.0.0 - May 2020)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Instance-InverseRelations-OWL</i></p><p><strong>Build Date: </strong>May 10, 2020</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-10%2C-2020">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Class-Inverse Relations-OWL (v2.0.0 - January 2021)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Class-Inverse Relations-OWL</i></p><p><strong>Build Date: </strong>January 25, 2021</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/January-25%2C-2021">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Class-Inverse Relations-OWLNETS (v2.0.0 - May 2020)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Class-InverseRelations-OWLNETS</i></p><p><strong>Build Date: </strong>May 10, 2020</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-10%2C-2020">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Class-Standard Relations-OWLNETS (v2.0.0 - January 2021)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Class-Standard Relations-OWLNETS</i></p><p><strong>Build Date: </strong>January 25, 2021</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/January-25%2C-2021">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Class-Inverse Relations-OWLNETS (v2.0.0 - January 2021)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Class-Inverse Relations-OWLNETS</i></p><p><strong>Build Date: </strong>January 25, 2021</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/January-25%2C-2021">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Instance-Inverse Relations-OWL (v2.0.0 - January 2021)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Instance-Inverse Relations-OWL</i></p><p><strong>Build Date: </strong>January 25, 2021</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/January-25%2C-2021">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Class-Inverse Relations-OWL (v2.0.0 - May 2020)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Class-InverseRelations-OWL</i></p><p><strong>Build Date: </strong>May 10, 2020</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-10%2C-2020">here</a>.</li></ul>
PheKnowLator Human Disease KG Benchmarks: Class-Standard Relations-OWLNETS (v2.0.0 - May 2020)
<p><strong>PKT Human Disease Knowledge Graph Benchmark Builds (v2.0.0)</strong></p><p><strong>Build Type: </strong><i>Class-Standard Relations-OWLNETS</i></p><p><strong>Build Date: </strong>May 10, 2020</p><p> </p><h3><strong>Important Build Information</strong></h3><p>The benchmarks were originally built and stored using Google Cloud Platform (GCP) resources. For details and a complete description of this process, can be found on GitHub (<a href="https://github.com/callahantiff/PheKnowLator/tree/master/builds#readme">here</a>). Note that we have developed an archive for the builds on Zenodo. While the original GCP resources contained all associated files, due to the file size upload limits associated with each archive, we have limited the uploaded files to the KGs, associated metadata, and log files. The list of resources, including their URLs, and date of download, can all be found in the associated logs.</p><p>Details on each of the files generated by the build process can be found in the file associated with this directory (<a href="https://zenodo.org/records/10065431/files/PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx?download=1">PheKnowLator_HumanDiseaseKG_Output_FileInformation.xlsx</a>).</p><p> </p><p>🚨 <strong>AVAILABLE FILES </strong>🚨 </p><ul><li>Available KG benchmark files are zipped and listed below.</li><li>For additional details on what each file contains, please see the associated Wiki page 👉 <a href="https://github.com/callahantiff/PheKnowLator/wiki/May-10%2C-2020">here</a>.</li></ul>
TF-Marker: A comprehensive manually curated database for transcription factors and related markers in specific cell and tissue types in human.
<p>Here, we developed the TF-Marker database (TF-Marker, http://bio.liclab.net/TF-Marker/) which is committed to a comprehensive manual curation of TFs and related markers with experimental evidence in specific cell and tissue types in human. Currently, through reviewing <strong>2,091</strong> published literature, we have manually classified TFs and related markers into five types according to their functions: 1) <strong>TF</strong>: TFs, which regulate the expression of markers; 2) <strong>T Marker</strong>: markers, which are regulated by TFs (TF and T Marker pairs can identify cell types more specifically); 3) <strong>I Marker</strong>: markers, which influence the activity of TFs (I Markers can also influence the development of specific cells and tissues); 4) <strong>TFMarker</strong>: TFs, which play roles as markers (TFMarkers are cell/tissue-specific TFs used as cell markers in biology experiments); and 5) <strong>TF Pmarker</strong>: TFs, which play roles as potential markers. By curating thousands of published literature, <strong>5,905</strong> entries including <strong>1,316</strong> TFs, <strong>1,092</strong> T Markers, <strong>473</strong> I Markers, <strong>1,600</strong> TFMarkers and <strong>1,424</strong> TF Pmarkers, were annotated in <strong>383</strong> cell types and <strong>95</strong> tissue types in human. Moreover, TF-Marker divided markers into disease markers and tissue/cell-specific markers. TF-Marker is an elaborate database, which provides TFs and related markers supported by experimental evidence. We believe TF-Marker will provide strong support for research into cell/tissue-specific TFs and related markers.</p>
Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis
<p>Genetic studies have identified ≥240 loci associated with risk of type 2 diabetes (T2D), yet most of these loci lie in non-coding regions, masking the underlying molecular mechanisms. Recent studies investigating mRNA expression in human pancreatic islets have yielded important insights into the molecular drivers of normal islet function and T2D pathophysiology. However, similar studies investigating microRNA (miRNA) expression remain limited. Here, we present data from 63 individuals, the largest sequencing-based analysis of miRNA expression in human islets to date. We characterize the genetic regulation of miRNA expression by decomposing the expression of highly heritable miRNAs into <em>cis</em>- and <em>trans</em>-acting genetic components and mapping <em>cis</em>-acting loci associated with miRNA expression (miRNA-eQTLs). We find (i) 84 heritable miRNAs, primarily regulated by <em>trans</em>-acting genetic effects, and (ii) 5 miRNA-eQTLs. We also use several different strategies to identify T2D-associated miRNAs. First, we colocalize miRNA-eQTLs with genetic loci associated with T2D and multiple glycemic traits, identifying one miRNA, miR-1908, that shares genetic signals for blood glucose and glycated hemoglobin (HbA1c). Next, we intersect miRNA seed regions and predicted target sites with credible set SNPs associated with T2D and glycemic traits and find 32 miRNAs that may have altered binding and function due to disrupted seed regions. Finally, we perform differential expression analysis and identify 14 miRNAs associated with T2D status—including miR-187-3p, miR-21-5p, miR-668, and miR-199b-5p—and 4 miRNAs associated with a polygenic score for HbA1c levels—miR-216a, miR-25, miR-30a-3p, and miR-30a-5p.</p>
Dataset related to article "NKp46-expressing human gut-resident intraepithelial Vδ1 T cell subpopulation exhibits high antitumor activity against colorectal cancer"
<p>γδ T cells account for a large fraction of human intestinal intraepithelial lymphocytes (IELs) endowed with potent antitumor activities. However, little is known about their origin, phenotype, and clinical relevance in colorectal cancer (CRC). To determine γδ IEL gut specificity, homing, and functions, γδ T cells were purified from human healthy blood, lymph nodes, liver, skin, and intestine, either disease-free, affected by CRC, or generated from thymic precursors. The constitutive expression of NKp46 specifically identifies a subset of cytotoxic Vδ1 T cells representing the largest fraction of gut-resident IELs. The ontogeny and gut-tropism of NKp46+/Vδ1 IELs depends both on distinctive features of Vδ1 thymic precursors and gut-environmental factors. Either the constitutive presence of NKp46 on tissue-resident Vδ1 intestinal IELs or its induced expression on IL-2/IL-15-activated Vδ1 thymocytes are associated with antitumor functions. Higher frequencies of NKp46+/Vδ1 IELs in tumor-free specimens from CRC patients correlate with a lower risk of developing metastatic III/IV disease stages. Additionally, our in vitro settings reproducing CRC tumor microenvironment inhibited the expansion of NKp46+/Vδ1 cells from activated thymic precursors. These results parallel the very low frequencies of NKp46+/Vδ1 IELs able to infiltrate CRC, thus providing insights to either follow-up cancer progression or to develop adoptive cellular therapies.</p> <p> </p> <p>This dataset is created with fcs files form, in order to guarantee the access we attach a pdf information about</p>
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.