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Dataset results
24 results for “human serum albumin”
Serum albumin domain structures in human blood serum by mass spectrometry and computational biology
<p>Contact prediction data generated by EPC-map used in the paper "Serum Albumin Domain Structures in Human Blood Serum by Mass Spectrometry and Computational Biology" by Rappsilber et al.</p>
Binding constants of clinical drugs and other organic ligands with human and mammalian serum albumins
<p>The dataset contains literature values of the experimental equilibrium binding constants of drugs and some other organic ligands with human and mammalian (predominantly bovine) serum albumins. There are 1755 records gathered from 346 original literature sources describing the albumin affinity of 324 different substances. The data were extracted from both articles and existing protein binding databases applying strict data selection rules in order to exclude the values influenced by the third-party compounds. For each experiment with a particular ligand–albumin system found in literature we provide (if possible) the following details: albumin source organism, ligand chemical name, canonical SMILES, InChIKey, the binding (either association <em>K<sub>a</sub></em> or dissociation <em>K<sub>d</sub></em>) constant value in molarity-based scale, temperature in K, albumin and ligand concentrations, buffer pH, composition, and concentration, experimental method, model used for the binding constant calculation, DOI or link to the source paper. For the results obtained using independent binding sites model, the average number of binding sites <em>n</em> is also provided. If two different types of binding sites were suggested, we put the second site-specific binding constant <em>K<sub>a2</sub></em> or <em>K<sub>d2</sub></em> and the number of the second-type sites<em> </em> <em>n</em><sub>2</sub> into separate columns. For some systems, the enthalpies of binding have also been determined either from the temperature dependence of the binding constant or using direct calorimetric measurements. Their values are also given in the respective column. The dataset can be used as the reference one, for the development of predictive models to calculate the binding constants, and for the choice of the experimental setup in the future albumin binding studies.</p>
Neonicotinoid trapping by the FA1 site of human serum albumin
<p><strong>Leboffe_et_al_docking_simulations:</strong> Input and output files derived from the docking simulations described in the manuscript "Neonicotinoid trapping by the FA1 site of human serum albumin" by Leboffe et al. More informations are given in the "README.txt" file.</p>
Human Serum Albumin Adductome as an Instant Dosimeter of the Potential Internal Exposure of PM2 .5
<p>This dataset contains observations and indicators for PM2.5 potential internal exposure (PIE) evaluation. The dataset including three csv files:</p> <ol> <li> Surface Plasmon Resonance (SPR) technology monitoring data of human serun albumin (HSA) -water soluble organic molecule( WSOM) interaction</li> <li>HSA-WSOM adductome abundance</li> <li>ADMET evaluation for major contributors</li> </ol> <p> </p> <p> </p>
Data from: Identification and mapping of linear antibody epitopes in human serum albumin using high-density peptide arrays
We have recently developed a high-density photolithographic, peptide array technology with a theoretical upper limit of 2 million different peptides per array of 2 cm2. Here, we have used this to perform complete and exhaustive analyses of linear B cell epitopes of a medium sized protein target using human serum albumin (HSA) as an example. All possible overlapping 15-mers from HSA were synthesized and probed with a commercially available polyclonal rabbit anti-HSA antibody preparation. To allow for identification of even the weakest epitopes and at the same time perform a detailed characterization of key residues involved in antibody binding, the array also included complete single substitution scans (i.e. including each of the 20 common amino acids) at each position of each 15-mer peptide. As specificity controls, all possible 15-mer peptides from bovine serum albumin (BSA) and from rabbit serum albumin (RSA) were included as well. The resulting layout contained more than 200.000 peptide fields and could be synthesized in a single array on a microscope slide. More than 20 linear epitope candidates were identified and characterized at high resolution i.e. identifying which amino acids in which positions were needed, or not needed, for antibody interaction. As expected, moderate cross-reaction with some peptides in BSA was identified whereas no cross-reaction was observed with peptides from RSA. We conclude that high-density peptide microarrays are a very powerful methodology to identify and characterize linear antibody epitopes, and should advance detailed description of individual specificities at the single antibody level as well as serologic analysis at the proteome-wide level.
Figure 2 from: Abarova S, Stoitchkova K, Tzonev S, Argirova M, Yancheva D, Anastassova N, Tenchov B (2024) Spectroscopic and thermodynamic characterization of the interaction of a new synthesized antitumor drug candidate 2H4MBBH with human serum albumin. Pharmacia 71: 1-5. https://doi.org/10.3897/pharmacia.71.e112385
Figure 2 Fluorescence titration curve of HSA (4 µM) with the 2H4MBBH in saline at 15 °C and 25 °C. Different curves correspond to 2H4MBBH concentrations of 0, 10, 20, 30, 40, 50 µM, respectively.
Figure 3 from: Abarova S, Stoitchkova K, Tzonev S, Argirova M, Yancheva D, Anastassova N, Tenchov B (2024) Spectroscopic and thermodynamic characterization of the interaction of a new synthesized antitumor drug candidate 2H4MBBH with human serum albumin. Pharmacia 71: 1-5. https://doi.org/10.3897/pharmacia.71.e112385
Figure 3 Stern-Volmer plots for quenching of different 2H4MBBH concentrations (10–50 µM) to HSA (4 µM) in saline at 15 and 25 °C.
Dataset: Modification of Gradient HPLC Method for Determination of Small Molecules' Affinity to Human Serum Albumin under Column Safety Conditions: Robustness and Chemometrics Study
<p>Dataset for publication.</p> <p> </p>
Short-term Survival of Subjects With Acute-on-chronic Liver Failure After Plasma Exchange With Human Serum Albumin 5%
ClinicalTrials.gov study NCT03702920. IPD Sharing: NO. Countries: 10. Publications: 0.
Data from: Spectroscopic and molecular docking studies reveal binding characteristics of nazartinib (EGF816) to human serum albumin
Open the record for dataset details and reuse information.
Data from: Identification and mapping of linear antibody epitopes in human serum albumin using high-density peptide arrays
Open the record for dataset details and reuse information.
Pleural fluid and Human Serum albumin modulate the behavior of a hypervirulent and Multidrug-resistant (MDR) Acinetobacter baumannii representative strain
GEO Series GSE167117. Acinetobacter baumannii. 12 samples. Type: Expression profiling by high throughput sequencing.
Figure 4 from: Abarova S, Stoitchkova K, Tzonev S, Argirova M, Yancheva D, Anastassova N, Tenchov B (2024) Spectroscopic and thermodynamic characterization of the interaction of a new synthesized antitumor drug candidate 2H4MBBH with human serum albumin. Pharmacia 71: 1-5. https://doi.org/10.3897/pharmacia.71.e112385
Figure 4 Modified Stern-Volmer plots for 2H4MBBH-HSA complexes at 15 and 25 °C.
Figure 1 from: Abarova S, Stoitchkova K, Tzonev S, Argirova M, Yancheva D, Anastassova N, Tenchov B (2024) Spectroscopic and thermodynamic characterization of the interaction of a new synthesized antitumor drug candidate 2H4MBBH with human serum albumin. Pharmacia 71: 1-5. https://doi.org/10.3897/pharmacia.71.e112385
Figure 1 Synthesis of 2-(2-hydroxy-4-methoxybenzylidene)-1-(1H-benzimidazol-2-yl)hydrazine.
Optimization of Therapeutic Human Serum Albumin Infusion in Selected Critically Ill Patients
ClinicalTrials.gov study NCT02755155. IPD Sharing: NO. Countries: 1. Publications: 0.
Sibling Oocyte Study of Medium for In Vitro Fertilization/Intracytoplasmic Sperm Injection (IVF/ICSI) With no Human Serum Albumine
ClinicalTrials.gov study NCT00541892. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Phase II/III of Recombinant Human Serum Albumin
ClinicalTrials.gov study NCT05858853. IPD Sharing: NO. Countries: 1. Publications: 0.
Study on the Role of Human Serum Albumin in Large Acute Ischemic Stroke of Anterior Circulation After Thrombectomy
ClinicalTrials.gov study NCT06629116. IPD Sharing: NO. Countries: 1. Publications: 0.
Recombinant Human Serum Albumin in Patients With Liver Cirrhosis and Ascites Subjects
ClinicalTrials.gov study NCT05249374. IPD Sharing: NO. Countries: 1. Publications: 0.
Recombinant Human Serum Albumin in Healthy Subjects
ClinicalTrials.gov study NCT05179265. IPD Sharing: NO. Countries: 1. Publications: 0.
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