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136 results for “hyperpolarization”
NMR data for "Rapid and simple 13C-hyperpolarization by 1H dissolution dynamic nuclear polarization followed by an in-line magnetic field inversion"
<p>Liquid-state and solid-state NMR data for "Rapid and simple 13C-hyperpolarization by 1H dissolution dynamic nuclear polarization followed by an in-line magnetic field inversion".</p> <p>The data enclosed are NMR data generated by the software Topspin by Burker Biospin. The experiments are dDNP runs that come in two parts: a solid-state and a liquid-state part.</p> <ul> <li>Experiments from 1 to 9 are reference experiments used to quantify polarization in other experiments</li> <li>Experiments 11-19, 21-29, 31-39, ... 61-69 correspond to 6 dDNP runs performed a different samples from the same batch. The numbers correspond between solid and liquid-state datasets</li> </ul> <p>The codes used to analyze the data are available at in a next upload.</p> <p>Refer to the main text of the paper and its supplementary material at 10.26434/chemrxiv-2023-6gd0l for more information.</p>
Human Hyperpolarization Activated Cyclic Nucleotide Gated Ion Channel 4 (HCN4); A Target Enabling Package
<p>HCN4 is one of four hyperpolarisation activated cyclic nucleotide gated ion channels. It is responsible for the pacemaker or funny (If) current in the heart and is required for maintenance of a stable heartbeat. Mutations in HCN4 lead to a number of arrhythmias. HCN4 is the target for the angina drug ivabradine, which reduces HCN4 activity. However, ivabradine is non-selective, affecting all of the four HCN channels. HCN4 is a close homologue of HCN2, which is a target for neuropathic and inflammatory pain treatment. We have solved the structure of HCN4 both in complex with cyclic AMP and without nucleotide. Comparison of our HCN4 structure with that of the related HCN1 channel (86% identity) allows us to suggest ways to design selectivity for small molecule inhibitors between these closely related channels. </p>
Primary data: Signal enhancement of hyperpolarized 15N sites in solution — increase in solid-state polarization at 3.35 T and prolongation of relaxation in deuterated water mixtures
<p>Primary data for DOI: 10.1002/nbm.4787</p> <p>NMR in Biomedicine. 2022;e4787</p> <p>Title: Signal enhancement of hyperpolarized 15N sites in solution—increase in solid-state polarization at 3.35 T and prolongation of relaxation in deuterated water mixtures</p> <p>Authors: Ayelet Gamliel, David Shaul, J. Moshe Gomori, Rachel Katz-Brull</p> <p>Description:</p> <p>These primary datasets contain data presented in the above publication and consist of:</p> <p>1. 15N-NMR spectra in solutions</p> <p>2. 13C polarization buildup data in solid-state</p> <p>3. 13C microwave profiles in solid state</p> <p>Please consult the Archive Guide.</p>
Data from: Theta oscillations coincide with sustained hyperpolarization in CA3 pyramidal cells, underlying decreased firing
<p>Brain-state fluctuations modulate membrane potential dynamics of neurons, influencing the functional repertoire of the network. Pyramidal cells (PCs) in hippocampal CA3 are necessary for rapid memory encoding, preferentially occurring during exploratory behavior in the high-arousal theta state. However, the relationship between the membrane potential dynamics of CA3 PCs and theta has not been explored. Here, we characterize the changes in the membrane potential of PCs in relation to theta using electrophysiological recordings in awake mice. During theta, most PCs behave in a stereotypical manner, consistently hyperpolarizing time-locked to the duration of theta. Additionally, PCs display lower membrane potential variance and reduced firing rate. In contrast, during large irregular activity, a low-arousal state, PCs show heterogeneous changes in membrane potential. This suggests coordinated hyperpolarization of PCs during theta, possibly caused by increased inhibition. This could lead to higher signal-to-noise ratio in the small population of PCs active during theta as observed in ensemble recordings.</p>
1H Hyperpolarization of Solutions by Overhauser Dynamic Nuclear Polarization with 13C-1H Polarization Transfer
<p>The dataset here contains the raw data used for the publication 10.1021/acs.jpclett.2c01956</p> <p>There are two folders and one readme file. NMR data in JCAMP or Topspin are in these two folders and are organised according to the figure or table mentioned in the publication. For details, please refer to the readme file. </p>
Data for: Solvent effects in hyperpolarization of 15N nuclei in [15N3]metronidazole and [15N3]nimorazole antibiotics via SABRE-SHEATH
<p>Raw 15N and 1H NMR spectra for the article which is under revision at the time posting this dataset.</p> <p>These results are also available as preprint at https://doi.org/10.26434/chemrxiv-2024-6pg8b</p> <p>15N NMR spectra were acquired using SpinSolve Expert Software (Magritek)</p> <p>1H NMR spectra were acquired using TopSpin (Bruker)</p>
Maximizing Relayed 1H Hyperpolarization Transfer by Slow-Fast MAS NMR Spectroscopy
<p>NMR raw data, matlab scripts, and data related to publication: https://doi.org/10.1021/acs.jpca.4c02452.</p> <p>The raw data content is described in the README files provided within the folders.</p>
Data from: Theta oscillations coincide with sustained hyperpolarization in CA3 pyramidal cells, underlying decreased firing
Open the record for dataset details and reuse information.
The metabolic representation of ischemia in rat brain slices: A hyperpolarized 13 C magnetic resonance study
<p>This dataset contains primary data for DOI: 10.1002/nbm.4509</p><p>NMR in Biomedicine. 2021; 34(7):e4509</p><p>Title: The metabolic representation of ischemia in rat brain slices: A hyperpolarized 13 C magnetic resonance study </p><p>Authors: David Shaul , Benjamin Grieb, Gal Sapir, Sivaranjan Uppala, Jacob Sosna, J Moshe Gomori, Rachel Katz-Brull</p><p> </p><p>These primary datasets contain data related to the above publication and consist of 31P (thermal equilibrium) and hyperpolarized 13C -NMR spectra. </p><p>Please consult the Archive Guide.</p>
Real-time influence of intracellular acidification and Na+/H+ exchanger inhibition on in-cell pyruvate metabolism in the perfused mouse heart: A 31P-NMR and hyperpolarized 13C-NMR study
<p>This dataset contains primary data for DOI: 10.1002/nbm.4993</p> <p>NMR in Biomedicine. 2023; 10;e4993</p> <p>Title: Real-time influence of intracellular acidification and Na+/H+ exchanger inhibition on in-cell pyruvate metabolism in the perfused mouse heart: A 31P-NMR and hyperpolarized 13C-NMR study</p> <p>Authors: David Shaul, Naama Lev-Cohain, Gal Sapir, Jacob Sosna, J. Moshe Gomori, Leo Joskowicz, Rachel Katz-Brull</p> <p> </p> <p>Description:</p> <p>These primary datasets contains data presented in the above publication and consist of 31P- (at thermal equilibrium) and hyperpolarized 13C-NMR spectra. </p> <p>Please consult the Archive Guide.</p>
DATA - Modern manufacturing enables magnetic field cycling experiments and parahydrogen induced hyperpolarization with a benchtop NMR
<p>Datasets and software for the publication "Modern manufacturing enables magnetic field cycling experiments and parahydrogen induced hyperpolarization with a benchtop NMR"</p>
Chemically induced deceleration of nuclear spin relaxation (CIDER) preserves hyperpolarization
<p>This data corresponds to the following paper:</p> <p>Title: Chemically induced deceleration of nuclear spin relaxation (CIDER) preserves hyperpolarization<br>Journal: Angwandte Chemie<br>Authors: Josh P. Peters, Charbel Assaf, Arne Brahms, Kolja Them, Mirco Gerdsen, Rainer Herges, Jan-Bernd Hövener, Andrey N. Pravdivtsev</p> <p>The data is organized with respect to the subfigures in figure 2 and figure 3 as a whole. Data not shown in figures is placed in Supplement.<br>An overview about the experiments is given in "Experiment overview.xlsx", while the extracted data for each figure is summarized in "Analyzed data.xlsx"<br>A description of acquisition parameters is provided in the "Acquisition parameters.xlsx" file for each dataset.</p>
Yeast solutions and hyperpolarization enable real-time observation of metabolized substrates even at natural abundance
<div>This data corresponds to the following paper:</div> <div> </div> <div>Title: Yeast solutions and hyperpolarization enable real-time observation of metabolized substrates even at natural abundance</div> <div>Journal: Analytical Chemistry</div> <div>Authors: Josh P. Peters, Charbel Assaf, Farhad Haj Mohamad, Eric Beitz, Sanjay Tiwari, Konrad Aden, Jan-Bernd Hövener and Andrey N. Pravdivtsev</div> <div> </div> <div>The data is organized with respect to the subfigures in figure 2 to 6.</div> <div>A description of acquisition parameters is provided in the "Acquisition parameters.xlsx" file for each dataset.</div> <div> </div> <div>Figure 2:</div> <div>- Overview of pyruvate metabolism in yeast cells using hyperpolarized and 13C labeled [1-13C]pyruvate. </div> <div>Hyperpolarized and thermally polarized spectra, if applicable, are included. </div> <div> </div> <div>Figure 3:</div> <div>- Overview of pyruvate metabolism in yeast cells using co-hyperpolarized [1-13C] and [2-13C]pyruvate at an n.a. of 13C. </div> <div>Hyperpolarized and thermally polarized spectra, if applicable, are included.</div> <div> </div> <div>Figure 4:</div> <div>- Overview of fumarate metabolism in yeast cells using hyperpolarized and 13C labeled [1,4-13C2]fumarate</div> <div>Hyperpolarized and thermally polarized spectra, if applicable, are included.</div> <div> </div> <div>Figure 5:</div> <div>- The fitted conversion exchange rate constants as a function of the yeast concentration. </div> <div>Hyperpolarized and thermally polarized spectra, if applicable, are included.</div> <div> </div> <div>Figure 6:</div> <div>- Metabolic data from pyruvate metabolism in yeast depending on the position of the yeast in the NMR tube. We </div> <div>Hyperpolarized and thermally polarized spectra, if applicable, are included.</div> <p> </p>
Live Magnetic Observation of Parahydrogen Hyperpolarization Dynamics
<p>The entry contains numerical data files, processing code (Wolfram Mathematica) and simulation code (Wolfram Mathematica running the 'SpinDynamica' packages) to generate Figures 1 to 6 of the manuscript titled above, arXiv preprint: <a href="https://arxiv.org/abs/2402.10766">https://arxiv.org/abs/2402.10766</a>. A PDF export of the Mathematica code is also provided.</p> <p><strong>Authors: </strong><a href="https://arxiv.org/search/physics?searchtype=author&query=Eills,+J">James Eills</a>, <a href="https://arxiv.org/search/physics?searchtype=author&query=Mitchell,+M+W">Morgan W. Mitchell</a>, <a href="https://arxiv.org/search/physics?searchtype=author&query=Rius,+I+M">Irene Marco Rius</a>, <a href="https://arxiv.org/search/physics?searchtype=author&query=Tayler,+M+C+D">Michael C. D. Tayler</a></p> <p><strong>Abstract:</strong> Hyperpolarized nuclear spins in molecules exhibit high magnetization that is unachievable by classical polarization techniques, making them widely used as sensors in physics, chemistry, and medicine. The state of a hyperpolarized material, however, is typically only studied indirectly and with partial destruction of magnetization, due to the nature of conventional detection by resonant-pickup nuclear magnetic resonance spectroscopy or imaging. Here we establish atomic magnetometers with sub-pT sensitivity as an use an alternative modality to detect <em>in real time</em> the complex dynamics of hyperpolarized materials without disturbing or interrupting the magnetogenesis process. As an example of dynamics that are impossible to detect in real time by conventional means, we examine parahydrogen-induced 1H and 13C magnetization during adiabatic eigenbasis transformations at μT-field avoided crossings. Continuous but nondestructive magnetometry reveals previously unseen spin dynamics, fidelity limits, and magnetization back-action effects. As a second example, we apply magnetometry to observe the chemical-exchange-driven 13C hyperpolarization of [1-13C]-pyruvate — the most important spin tracer for clinical metabolic imaging. The approach can be readily combined with other high-sensitivity magnetometers and is applicable to a broader range of general observation scenarios involving production, transport and systems interaction of hyperpolarized compounds.</p>
Behavioral control by depolarized and hyperpolarized states of an integrating neuron
<p><span>Coordinated transitions between mutually exclusive motor states are central to behavioral decisions. During locomotion, the nematode <i>Caenorhabditis elegans</i> spontaneously cycles between forward runs, reversals, and turns with complex but predictable dynamics. Here we provide insight into these dynamics by demonstrating how<i> </i>RIM interneurons, which are active during reversals, </span>act in two modes to stabilize both forward runs and reversals. <span>By systematically quantifying the roles of RIM outputs during spontaneous behavior, we </span>show that RIM lengthens reversals when depolarized through glutamate and tyramine neurotransmitters and lengthens forward runs when hyperpolarized through its gap junctions. RIM is not merely silent upon hyperpolarization: RIM <span>gap junctions actively reinforce a hyperpolarized state of the reversal circuit. Additionally, the combined outputs of chemical synapses and gap junctions from RIM regulate forward-to-reversal transitions. Our results indicate that multiple classes of RIM synapses create behavioral inertia during spontaneous locomotion.</span></p>
Hyperpolarized [15N]nitrate as a potential long lived hyperpolarized contrast agent for MRI
<p>Primary data for DOI: <a href="https://doi.org/10.1016/j.jmr.2019.01.001">10.1016/j.jmr.2019.01.001</a></p> <p>Title: Hyperpolarized [<sup>15</sup>N]nitrate as a potential long lived hyperpolarized contrast agent for MRI</p> <p>Authors: Ayelet Gamliel, Sivaranjan Uppala, Gal Sapir, Talia Harris, Atara Nardi-Schreiber, David Shaul, Jacob Sosna, J. Moshe Gomori, Rachel Katz-Brull</p> <p>Description:</p> <p>The primary datasets in this archive contain data presented in the above publication and consist of <sup>15</sup>N-NMR spectra in solutions.</p> <p>Please consult the Archive Guide.</p>
Hyperpolarized Xenon-129 MRI: a New Multi-dimensional Biomarker to Determine Pulmonary Physiologic Responses to COPD Therapeutics
ClinicalTrials.gov study NCT03002389. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Study of the Effect of VX-770 on Hyperpolarized Helium-3 Magnetic Resonance Imaging in Subjects With Cystic Fibrosis and the G551D Mutation
ClinicalTrials.gov study NCT01161537. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Hyperpolarized 13C Pyruvate MRI for Treatment Response Assessment in Pancreatic Ductal Adenocarcinoma
ClinicalTrials.gov study NCT04565327. IPD Sharing: NO. Countries: 1. Publications: 1.
Hyperpolarized Xenon-129 Magnetic Resonance Imaging and Spectroscopy of Brown Fat: Healthy Adult Volunteer Pilot Study
ClinicalTrials.gov study NCT02220426. IPD Sharing: NO. Countries: 1. Publications: 1.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.