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3 results for “hypoglycemia-induced”
Hypoglycemia-induced electrocardiogram changes in a rodent model of type 1 diabetes
<p>Retrospective data was obtained from studies conducted by Reno et al. Adult male Sprague-Dawley rats (weight, 250–300 g; Charles River Laboratories, Malvern, PA) were housed individually in temperature- and light-controlled environments and fed ad libitum a standard chow diet and water. Rats underwent surgery for carotid artery and jugular vein cannulation as previously described. ECG leads were also placed subcutaneously during surgery. One wire was placed over the lower left rib cage and one was placed over the right supraclavicular fossa. A reference wire was placed over the back. Two days after cannulation, one set of rats received intraperitoneal injections of streptozotocin (65 mg/kg; Sigma, St. Louis, MO) to induce diabetes (n = 37). A second group of rats received sodium citrate buffer and acted as a control, non-diabetic group (n = 54). Blood glucose was measured from the tail vein with a glucometer (Ascensia Contour; Bayer HealthCare, Mishawaka, IN) to ensure diabetes. Rats were diabetic for two weeks prior to the hypoglycemic clamp. Overnight fasted, awake, unrestrained non-diabetic and diabetic rats underwent hyperinsulinemic (0.2 units ⋅ kg−1 ⋅ min−1; Humulin R), severe hypoglycemic (10–15 mg/dL) single step clamps with continuous ECGs for 3 hours, as previously described ECGs were recorded every millisecond (ms) using PowerLab 26T software (LabChart; ADInstruments, Colorado Springs, CO). Arterial blood was used to determine glucose levels during the clamp with a glucometer (Ascensia Contour BG monitors; Bayer Healthcare Mishawaka, IN) every 15-minutes.</p> <p> </p> <p>Reno CM, Daphna-Iken D, Chen YS, VanderWeele J, Jethi K, Fisher SJ. Severe hypoglycemia-induced lethal cardiac arrhythmias are mediated by sympathoadrenal activation. Diabetes. 2013;62(10):3570-81.</p> <p> </p> <p>Reno CM, VanderWeele J, Bayles J, Litvin M, Skinner A, Jordan A, et al. Severe Hypoglycemia-Induced Fatal Cardiac Arrhythmias Are Augmented by Diabetes and Attenuated by Recurrent Hypoglycemia. Diabetes. 2017;66(12):3091-7.</p> <p> </p> <p> </p> <p> </p>
Vitamin C and Liraglutide Effects on Hypoglycemia-induced Oxidative Stress, Inflammation and Endothelial Dysfunction in Type 1 Diabetes.
ClinicalTrials.gov study NCT02109315. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Development of Agents to Diminish the Risk of Hypoglycemia-induced Brain Injury in Type 1 Diabetes
ClinicalTrials.gov study NCT03356457. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.