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173
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ShareScore release 0.9.0
Dataset results
173 results for “hypogonadism”
Testosterone Therapy and Bone Quality in Men With Diabetes and Hypogonadism
ClinicalTrials.gov study NCT03887936. IPD Sharing: NO. Countries: 1. Publications: 10.
A Study to Evaluate the Effect of Testosterone Replacement Therapy (TRT) on the Incidence of Major Adverse Cardiovascular Events (MACE) and Efficacy Measures in Hypogonadal Men
ClinicalTrials.gov study NCT03518034. IPD Sharing: NO. Countries: 2. Publications: 6.
Treatment of Sexual Dysfunction in Hypogonadal Men With Epilepsy With Testosterone and Either Anastrozole or Placebo
ClinicalTrials.gov study NCT00179517. IPD Sharing: NO. Countries: 1. Publications: 1.
Aromatase Inhibitors and Weight Loss in Severely Obese Hypogonadal Male Veterans (Pilot)
ClinicalTrials.gov study NCT02959853. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Anastrozole Administration in Elderly Hypogonadal Men
ClinicalTrials.gov study NCT00136695. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Normalization of Morning Testosterone Levels in Men With Secondary Hypogonadism
ClinicalTrials.gov study NCT01270841. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Ambulatory Blood Pressure Monitoring in Oral Testosterone Undecanoate (TU, LPCN 1021) Treated Hypogonadal Men
ClinicalTrials.gov study NCT03868059. IPD Sharing: NO. Countries: 1. Publications: 1.
Pharmacokinetic Study of Oral Testosterone (T) Ester Formulations in Hypogonadal Men
ClinicalTrials.gov study NCT00695110. IPD Sharing: NO. Countries: 1. Publications: 1.
Open-label, Follow-up Study of Oral Testosterone Undecanoate in Hypogonadal Men
ClinicalTrials.gov study NCT01699178. IPD Sharing: NO. Countries: 2. Publications: 1.
Safety and Efficacy of BGS649 in Male Obese Subjects With Hypogonadotropic Hypogonadism
ClinicalTrials.gov study NCT02730169. IPD Sharing: NO. Countries: 4. Publications: 1.
Follicle Stimulating Hormone (FSH) to Improve Testicular Development in Men With Hypogonadism
ClinicalTrials.gov study NCT00064987. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Safety and Efficacy Trial of Oral Testosterone Undecanoate (TU) in Hypogonadal Men
ClinicalTrials.gov study NCT01403116. IPD Sharing: NO. Countries: 2. Publications: 1.
A Comparison of Side Effects in Hypogonadal Men Treated With Natesto Versus Testosterone Injections
ClinicalTrials.gov study NCT04439799. IPD Sharing: NO. Countries: 1. Publications: 12.
Subcutaneous Testosterone Enanthate Safety in Adult Men Diagnosed With Hypogonadism
ClinicalTrials.gov study NCT02504541. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy and Safety of Oral Testosterone Undecanoate in Hypogonadal Men
ClinicalTrials.gov study NCT03198728. IPD Sharing: NO. Countries: 1. Publications: 1.
Ambulatory Blood Pressure Monitoring (ABPM) Extension Study of Oral Testosterone Undecanoate in Hypogonadal Men
ClinicalTrials.gov study NCT04467697. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study of the Effect of Topical Testosterone Replacement Therapy on Blood Pressure in Adult Male Participants With Hypogonadism
ClinicalTrials.gov study NCT04274894. IPD Sharing: YES. Countries: 1. Publications: 1.
Safety and Efficacy of Intranasal TBS-1 Treatment of Male Hypogonadism
ClinicalTrials.gov study NCT01446042. IPD Sharing: Not stated. Countries: 1. Publications: 1.
GnRH deficient patients with congenital hypogonadotropic hypogonadism: Novel genetic findings in ANOS1, RNF216, WDR11, FGFR1, CHD7 and POLR3A genes
<p><b>Background: </b>Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic disease caused by Gonadotropin-Releasing Hormone (GnRH) deficiency. So far a limited number of variants in several genes have been associated with the pathogenesis of the disease. In this original research and review manuscript the retrospective analysis of known variants in <i>ANOS1</i> (<i>KAL1)</i>, <i>RNF216</i>,<i> WDR11</i>,<i> FGFR1</i>,<i> CHD7</i> and <i>POLR3A</i> genes is described, along with novel variants identified in patients with CHH by the present study.</p> <p><b>Methods:</b> Seven GnRH deficient unrelated Cypriot patients underwent whole exome sequencing (WES) by Next Generation Sequencing (NGS). The identified novel variants were initially examined by <i>in silico </i>computational algorithms and structural analysis of their predicted pathogenicity at the protein level was confirmed.</p> <p><b>Results:</b> In four nonrelated GnRH males, a novel X-linked pathogenic variant in <i>ANOS1 </i>gene, two novel autosomal dominant (AD) probably pathogenic variants in <i>WDR11 </i>and <i>FGFR1 </i>genes and one rare AD probably pathogenic variant in <i>CHD7</i> gene were identified. A rare autosomal recessive (AR) variant in the <i>SRA1</i> gene was identified in homozygosity in a female patient, whilst two other male patients were also respectively found to carry novel or previously reported rare pathogenic variants in more than one genes; <i>FGFR1</i>/<i>POLR3A </i>and <i>SRA1/RNF216</i>.</p> <p><b>Conclusion: </b>This report embraces the description of novel and previously reported rare pathogenic variants in a series of genes known to be implicated in the biological development of CHH. Notably, patients with CHH can harbor pathogenic rare variants in more than one gene which raises the hypothesis of locus-locus interactions providing evidence for digenic inheritance. The identification of such aberrations by NGS can be very informative for the management and future planning of these patients.</p>
The Effects of Semaglutide vs Testosterone Replacement Therapy on Functional Hypogonadism and Sperm Quality in Men With Type 2 Diabetes Mellitus and Obesity
ClinicalTrials.gov study NCT06489457. IPD Sharing: NO. Countries: 1. Publications: 1.
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