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72 results for “immune marker”
Normalized and batch-corrected concentration of 43 immune markers from 248 subjects with stress-related mental disorders and 36 healthy controls
<h1>Abstract</h1> <p>In a subset of patients with mental disorders, such as depression, low-grade inflammation and altered immune marker concentrations are observed. However, these immune alterations are often assessed by only one data type and small markers panels. Here, we used a transdiagnostic approach and combined data from two cohorts to define subgroups of depression symptoms across the diagnostic spectrum through a large-scale multi-omics clustering approach in 237 individuals. The method incorporated age, body mass index (BMI), 43 plasma immune markers and RNA-seq data from peripheral mononuclear blood cells (PBMCs). Our initial clustering revealed four clusters, including two immune-related depression symptom clusters characterized by elevated BMI, higher depression severity and elevated levels of immune markers such as interleukin-1 receptor antagonist (IL-1RA), C-reactive protein (CRP) and C-C motif chemokine 2 (CCL2 or MCP-1). In contrast, the RNA-seq data mostly differentiated a cluster with low depression severity, enriched in brain related gene sets. This cluster was also distinguished by electrocardiography data, while structural imaging data revealed differences in ventricle volumes across the clusters. Incorporating predicted cell type proportions into the clustering resulted in three clusters, with one showing elevated immune marker concentrations. The cell type proportion and genes related to cell types were most pronounced in an intermediate depression symptoms cluster, suggesting that RNA-seq and immune markers measure different aspects of immune dysregulation. Lastly, we found a dysregulation of the SERPINF1/VEGF-A pathway that was specific to dendritic cells by integrating immune marker and RNA-seq data. This shows the advantages of combining different data modalities and highlights possible markers for further stratification research of depression symptoms.</p> <h1>Methods</h1> <p>The normalized and batch-corrected concentration of 43 immune markers from 237 subjects with stress-related mental disorders and 36 healthy controls was determined in plasma. This data was used in the initial analysis. Additionally, the same measurements are provided for 11 subjects with stress-related mental disorders used in a replication analysis.</p> <p>- blood was collected in the morning under fasted conditions and plasma stored at -80°C until further processing<br>- samples were randomized into 96 well plates<br>- immune marker concentration was measured with the Meso Scale Diagnostics V-PLEX Human Biomarker 54-Plex Kit and the MESO QuickPlex SQ 120 imager according to the manufacturer's instructions<br>- additionally, high-sensitivity C-reactive protein (Tecan Group Ltd.), cortisol (Tecan Group Ltd.), interleukin (IL)-6 (Thermo Fisher Scientific), IL-6 soluble receptor (Thermo Fisher Scientific) and IL-13 (Thermo Fisher Scientific) was measured via ELISA according to the manufacturer's instructions<br>- values below the detection limit in markers measured with ELISA were set to zero and values above the detection limit to the upper limit<br>- the data was quantile-normalized (values were ranked and mapped to the quantiles of a standard normal distribution)<br>- the normalized concentration was corrected for the biobank storage position (batch_variable) via a linear model and the residuals reported as the concentration</p> <p>The following markers were measured:<br>fibroblast growth factor 2 (FGF2 or bFGF), cortisol, C-C motif chemokine 11 (CCL11 or eotaxin), CCL26 (eotaxin-3), vascular endothelial growth factor receptor 1 (VEGFR1 or Flt-1), hsCRP, intercellular adhesion molecule (ICAM)-1, interferon (IFN)-gamma, IL-1alpha, IL-1 receptor antagonist (IL-1RA), IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-17B, IL-2, IL-27, IL-31, IL-5, IL-6 high sensitivity (IL-6HS), IL-7, IL-8HS, C-X-C motif chemokine 10 (CXCL10 or IP-10), CCL2 (MCP-1), CCL13 (MCP-4), CCL22 (MDC), CCL3 (MIP-1alpha), CCL4 (MIP-1beta), placental growth factor (PlGF), serum amyloid A (SAA), sIL-6R, CCL17 (TARC), angiopoietin-1 receptor (Tie-2), tumor necrosis factor (TNF or TNF-alpha), lymphotoxin-alpha (LT-alpha or TNF-beta), thymic stromal lymphopoietin (TSLP), vascular cell adhesion protein 1 (VCAM-1), vascular endothelial growth factor (VEGF)-A-HS, VEGF-C, VEGF-D</p> <p>The data is provided as a tab separated file.</p>
Multi OIT to Test Immune Markers After Minimum Maintenance Dose
ClinicalTrials.gov study NCT03181009. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Immune and Genomic Markers in ALK+ NSCLC
ClinicalTrials.gov study NCT04881916. IPD Sharing: YES. Countries: 1. Publications: 1.
Effects of the Probiotic Visbiome Extra Strength on Gut Microbiome & Immune Activation Markers
ClinicalTrials.gov study NCT02706717. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Colorectal cancer patients-derived immunity-organoid platform unveils cancer-specific tissue markers associated with immunotherapy resistance.
Open the record for dataset details and reuse information.
Effects of Probiotics on Microbial Translocation and Immune Activation Markers in HIV-positive Patients on Combined Antiretroviral Therapy
ClinicalTrials.gov study NCT02164344. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Liver Immune Tolerance Marker Utilization Study
ClinicalTrials.gov study NCT02541916. IPD Sharing: Not stated. Countries: 1. Publications: 1.
REAnimation Low Immune Status Markers
ClinicalTrials.gov study NCT02638779. IPD Sharing: NO. Countries: 1. Publications: 5.
Strength Training Induced Alterations in Markers of Immune Function
ClinicalTrials.gov study NCT01450852. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Signatures of Immune Reprogramming in Anti-CD52 Therapy of MS: Markers for Risk Stratification and Treatment Response
ClinicalTrials.gov study NCT04082260. IPD Sharing: NO. Countries: 1. Publications: 1.
The Impact of a Polyphenol-Rich Supplement on Epigenetic and Cellular Markers of Immune Age
ClinicalTrials.gov study NCT05234203. IPD Sharing: UNDECIDED. Countries: 1. Publications: 15.
Correlation of Metabolic Imaging With Immune Markers in NSCLC Candidate to Immunotherapy.
ClinicalTrials.gov study NCT03563482. IPD Sharing: NO. Countries: 1. Publications: 17.
mSEP: Testing of Physiological and Immune-metabolic Blood Markers for Maternal Sepsis
ClinicalTrials.gov study NCT05023954. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of Lactoferrin at Two Doses vs. Active Control on Markers of Immune Function
ClinicalTrials.gov study NCT06012669. IPD Sharing: NO. Countries: 1. Publications: 1.
Role of FDG PET, Immune and Hypoxic Marker in NSCLC
ClinicalTrials.gov study NCT02519062. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Treatment of Helminth co-Infection: Short-Term Effects on HIV-1 Progression Markers and Immune Activation
ClinicalTrials.gov study NCT00130910. IPD Sharing: Not stated. Countries: 1. Publications: 11.
12-week Exercise Intervention Program Versus Observation in Early Stage Breast Cancer Patients on the Impact on Mental Health, Quality of Life and Immune Markers
ClinicalTrials.gov study NCT03518957. IPD Sharing: NO. Countries: 1. Publications: 2.
Increased immune marker variance in a population of invasive birds
<p>Immunity and parasites have been linked to the success of invasive species. Especially lower parasite burden in invasive populations has been suggested to enable a general downregulation of immune investment (Enemy Release and Evolution of Increased Competitive Ability Hypotheses). Simultaneously, keeping high immune competence towards potentially newly acquired parasites in the invasive range is essential to allow population growth. To investigate the variation of immune effectors of invasive species, we compared the mean and variance of multiple immune effectors in the context of parasite prevalence in an invasive and a native Egyptian goose (Alopochen aegyptiacus) population. Three of ten immune effectors measured showed higher variance in the invasive population. Mean levels were higher in the invasive population for three effectors but lower for eosinophil granulocytes. Parasite prevalence depended on the parasite taxa investigated. We suggest that variation of specific immune effectors, which may be important for invasion success, may lead to higher variance and enable invasive species to reduce the overall physiological cost of immunity while maintaining the ability to efficiently defend against novel parasites encountered.</p>
Prognostic Value of CD Markers in Immune Thrombocytopenic Purpura
ClinicalTrials.gov study NCT04311593. IPD Sharing: Not stated. Countries: 0. Publications: 3.
Immune Markers in Pediatric ITP on Second Line Therapy
ClinicalTrials.gov study NCT06093529. IPD Sharing: UNDECIDED. Countries: 0. Publications: 14.
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Allen Brain Atlas
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Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
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