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102 results for “immune priming”
Self-adjuvanting Nanovaccines Boost Lung-resident CD4+ T Cell Immune Responses in BCG-primed mice
<p>The "readcount_genename.xls" file and "fpkm_genename.xls" file contain gene expression data for genes (gene list is detailed in "gene.xls") in the panel. All data were obtained from bone marrow derived dendritic cells from WT C57BL/6 mice treated with KFE8 nanofibers or mock. All RNA sequencing and subsequent processing was performed by Novogene Corporation.</p> <p>The remaining .xls files contain the differential expression analysis for KFE8 nanofiber treatment at four hours compared with mock (NF4vsC4) or KFE8 nanofiber treatment at sixteen hours compared with mock (NF16vsC16).</p> <p>The "pathway analysis Rcode.R" file contains the code used to generate Reactome pathway analysis for both time points. </p> <p>The "NF16 volc Rcode.R" file contains the code used to generate a volcano plot for the 16 hour time point. </p>
Parasite resistance and parasite tolerance: insights into transgenerational immune priming in an invertebrate host
<p>Parasites impose different selection regimes on their hosts, which respond by increasing their resistance and/or tolerance. Parental challenge with parasites can enhance the immune response of their offspring, a phenomenon documented in invertebrates and termed transgenerational immune priming. We exposed two parental generations of the model organism <em>Daphnia magna</em> to the horizontally-transmitted parasitic yeast <em>Metschnikowia bicuspidata</em>, and recorded resistance- and tolerance-related traits in the offspring generation. We hypothesized that parentally-primed offspring will increase either their resistance or their tolerance to the parasite. Our susceptibility assays revealed no impact of parental exposure on offspring resistance. Nonetheless, different fitness-related traits, which are indicative of tolerance, were altered. Specifically, maternal priming increased offspring production and decreased survival. Grandmaternal priming positively affected age at first reproduction and negatively affected brood size at first reproduction. Interestingly, both maternal and grandmaternal priming significantly reduced within-host parasite proliferation. Nevertheless, <em>Daphnia </em>primed for two consecutive generations had no competitive advantage in comparison to unprimed ones, implying additive maternal and grandmaternal effects. Our findings do not support evidence of transgenerational immune priming from bacterial infections in the same host species, thus emphasizing that transgenerational immune responses may not be consistent even within the same host species.</p>
Immunization of Children Previously Primed With GSK Pneumococcal Vaccine GSK1024850A and of Unprimed Children in Mali
ClinicalTrials.gov study NCT00985465. IPD Sharing: YES. Countries: 1. Publications: 2.
Immunization of Children Previously Primed With GSK Pneumococcal Vaccine GSK1024850A and of Unprimed Children in Nigeria
ClinicalTrials.gov study NCT01153893. IPD Sharing: YES. Countries: 1. Publications: 1.
Data from: Pathogen susceptibility and fitness costs explain variation in immune priming across natural populations of flour beetles
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Data for: Parent-specific transgenerational immune priming enhances offspring defense – unless heat stress negates it all
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Parasite resistance and parasite tolerance: insights into transgenerational immune priming in an invertebrate host
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Trans-generational viral transmission and immune priming are dose-dependent
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Data from: Does immune priming in Galleria mellonella reveal plastic mechanisms for survival?
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'Disease-smart outcrossing can enhance individual fitness and increase survival via immune priming against pathogens: new approaches to strengthen genetic rescue efforts
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Data from: Senescence in immune priming and attractiveness in a beetle
Age-related decline in immune activity is referred to as immunosenescence and has been observed for both the adaptive immune response of vertebrates and the innate immune system of invertebrates. Since maintaining a basic level of immune defence and mounting an immune response is costly, optimal investment in immune function should vary over a wide range of individual states such as the individual's age. In this study we tested whether the immune response and immunological priming within individuals become less efficient with age using mealworm beetles, Tenebrio molitor, as a model organism. We also tested whether aging and immunological priming affected the odours produced by males. We found that young males of T.molitor were capable of mounting an immune response a sterile nylon monofilament implant with the potential to exhibit a simple form of immune memory through mechanisms of immune priming. Older males did not increase their immune response to a second immune challenge, which negatively affected their sexual attractiveness and remaining life span. Our results indicate that the immune system of older males in T.molitor is less effective, suggesting complex evolutionary trade-offs between ageing, immune response and sexual attractiveness.
Data and code for "The immune regulation and epidemiological consequences of specific immune priming in Drosophila"
<p>Raw data and R code used to analyse and generate all figures in the above manuscript.</p>
Data for manuscript Trans-generational immune priming against American Foulbrood does not affect the performance of honeybee colonies
<p>Data used in analysis for manuscript Trans-generational immune priming against American Foulbrood does not affect the performance of honeybee colonies</p>
Safety and immunogenicity of heterologous booster immunization with Ad5-nCoV after three-dose priming with inactivated SARS-CoV-2 vaccine in Chinese adults: a randomized, double-blind, parallel-controlled trial
<p>Data on safety and immunity of heterologous booster (fourth dose) after three-dose priming with inactivated SARS-CoV-2 vaccine are limited in Chinese adults. Here, we evaluate the safety and immunogenicity of immunization with Ad5-nCoV in a randomized, double-blind, parallel-controlled phase 4 clinical trial in Zhejiang, China (NCT05373030). Participants aged 18-80 years (100 participants per group) who have administered three doses of inactivated SARS-CoV-2 vaccine ≥ 6-month earlier were enrolled and randomized at 1:1 into two groups, then administered intramuscular Ad5-nCoV or different inactivated SARS-CoV-2 vaccine (CoronaVac or Covilo) respectively. All observed adverse reactions were predictable and manageable. Ad5-nCoV elicited significantly higher RBD-specific IgG levels, with a GMC of 2924.0 on day 14 post-booster, 7.8-fold that of the inactivated vaccine. Pseudovirus-neutralizing antibodies to Omicron BA.4/5 showed a similar pattern, with GMT of 228.9 in the Ad5-nCoV group and 65.5 in the inactivated vaccine group. The Ad5-nCoV booster-maintained a high antibody levels on day 90, with seroconversion of 71.4%, while the inactivated vaccine group was 5.2%, closed to pre-booster levels. In summary, a fourth Ad5-nCoV vaccination following three-dose inactivated SARS-CoV-2 vaccination is immunogenic, tolerable, and more efficient than inactivated SARS-CoV-2 vaccine. Ad5-nCoV elicits a stronger humoral response against Omicron BA.4/5 and maintains antibody levels for longer than homologous boosting.</p>
Heterologous Boost Immunization with an Aerosolised Ad5-nCoV After Two-dose Priming with an Inactivated SARS-CoV-2 Vaccine
ClinicalTrials.gov study NCT05204589. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Heterologous Prime-boost Immunization with an Aerosolised Adenovirus Type-5 Vector-based COVID-19 Vaccine (Ad5-nCoV) After Priming with an Inactivated SARS-CoV-2 Vaccine
ClinicalTrials.gov study NCT05043259. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Safety and Immune Response to a Prime-Boost Vaccination Schedule in HIV-infected Patients
ClinicalTrials.gov study NCT00270465. IPD Sharing: Not stated. Countries: 1. Publications: 4.
HIV PrEP Priming of Immune Effectors
ClinicalTrials.gov study NCT02593409. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Heterologous Boost Immunization with Ad5-nCoV After Three-dose Priming with an Inactivated SARS-CoV-2 Vaccine
ClinicalTrials.gov study NCT05303584. IPD Sharing: NO. Countries: 1. Publications: 2.
Safety of and Immune Response to a Prime-Boost Vaccine Regimen in HIV-Uninfected Vaccine-Naive Adults
ClinicalTrials.gov study NCT00820846. IPD Sharing: Not stated. Countries: 2. Publications: 4.
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.