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5 results for “immunosensor”
Eectrochemical immunosensor for the quantification of S100B at clinically relevant levels using a cysteamine modified surface
<p>Datasets analyzed during the work titled "An electrochemical immunosensor for the quantification of S100B at clinically relevant levels using a cysteamine modified surface".</p>
Reduced Graphene Oxide Electrolyte-Gated Transistor Immunosensor with Highly Selective Multiparametric Detection of Anti-Drug Antibodies
<p>Dataset for the publication: </p> <p>Sensi, M., de Oliveira, R. F., Berto, M., Palmieri, M., Ruini, E., Livio, P. A., Conti, A., Pinti, M., Salvarani, C., Cossarizza, A., Cabot, J. M., Ricart, J., Casalini, S., González-García, M. B., Fanjul-Bolado, P., Bortolotti, C. A., Samorì, P., Biscarini, F., Reduced Graphene Oxide Electrolyte-Gated Transistor Immunosensor with Highly Selective Multiparametric Detection of Anti-Drug Antibodies. <em>Adv. Mater.</em> 2023, 2211352. <a href="https://doi.org/10.1002/adma.202211352">https://doi.org/10.1002/adma.202211352</a></p> <p>Transfer curves measured with different analytes (used for Figure 3 in the results and discussion section of the publication). In every file are reported the gate-source voltages (V<sub>GS</sub>) and the average drain-source currents (I<sub>DS</sub>) after exposure of the gate to ATI (Transfer_ATI-dataset), ATI+TNFa(Transfer_ATI+TNFa-dataset), TNFa(Transfer_TNFa-dataset) at specific concentration. Transfer_control is the dataset for the control experiments, without the probe on gate.</p> <p>EIS (EIS-functionalization-dataset) dataset has been used for the functionalization in figure 2b. In the the file are reported the frequency, the real and the imaginary impedance for each functionalization step (in specific tabs Au, SAM, IFX+ETA). Transfer (Transfer-functionalization-dataset) dataset used for the functionalization in figure 2c. In the the file are reported the V<sub>GS</sub> and the I<sub>DS </sub>for each functionalization step (in specific tabs Au, SAM, IFX+ETA).</p>
Dataset for the article "Structural and Functional Insights into Oxidized and Hydrogenated HPHT Nanodiamonds for Cortisol Immunosensor Applications".
<p>Dataset for the article "Structural and Functional Insights into Oxidized and Hydrogenated HPHT Nanodiamonds for Cortisol Immunosensor Applications</p> <p>Chakavak Esmaeili1, Štěpán Stehlík2, Martin Krejci3, Bohuslav Rezek1</p> <p>1 Faculty of Electrical Engineering, CTU in Prague, Technicka 2, 16627 Prague, Czech Republic</p> <p>2 Institute of Physics of the Czech Academy of Sciences, Cukrovarnická 10, 162 00 Prague, Czech Republic</p> <p>3 FHNW University of Applied Sciences and Arts Northwestern Switzerland School of Engineering Klosterzelgstrasse 2<br>CH-5210 Windisch</p> <p> </p> <p>Fig 1A. SEM images of (a) the carbon bare electrode (b) before and (c) after rinsing of 3 µg HPHT-O<br>Fig 1B. SEM image of (a) the carbon bare electrode (b) before and (c) after rinsing of 3 µg HPHT-H<br>Fig 1C. SEM micrographs of (a) bare carbon electrode, (b) SPE/HPHT-O, (c) SPE/HPHT-O/APTES, (d) SPE/HPHT-O/APTES/EDC NHS, (e) SPE/HPHT-O/APTES/EDC NHS/Ab, (f) SPE/HPHT-O/APTES/EDC NHS/Ab/BSA, (g) SPE/HPHT-O/APTES/EDC NHS/Ab/BSA/Ag (with original magnification 2.00KX (up) and 15.00KX (down) at 5 kV)<br>Fig 2. The preparation and immobilization step of the cortisol fabrication based on electrochemical immunosensor <br>Fig 3. Functionalization step. a) CV and b) DPV results of (1) carbon bare electrode, (2) electrode/HPHT-O, (3) electrode/HPHT-O/APTES, (4) electrode/HPHT-O/APTES/EDC NHS, at pH 7.0, containing 250 mM KCl and 5 mM K3[Fe(CN)6] and 5 mM K4[Fe(CN)6], Scan rate 0.1Vs−1<br>Fig 4. Sensing steps. a) CV and b) DPV results for (4) electrode/HPHT-O/APTES/EDC NHS, (5) electrode/HPHT-O/APTES/EDC NHS/Ab, (6) electrode/HPHT-O/APTES/EDC NHS/Ab/BSA, and (7) electrode/HPHT-O/APTES/EDC NHS/Ab/BSA/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/s<br>Fig 5. a) CV and b) DPV results for (1) carbon bare electrode, (2) electrode/HPHT-O, (3) electrode/HPHT-O/APTES, (4) electrode/HPHT-O/APTES/Ab, (5) electrode/HPHT-O/APTES/Ab/BSA, and (6) electrode/HPHT-O/APTES /Ab/BSA/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/s<br>Fig 6. a) CV and b) DPV results for (1) carbon bare electrode, (2) electrode/HPHT-O, (3) electrode/HPHT-O/EDC NHS, (4) electrode/HPHT-O/ EDC NHS /Ab, (5) electrode/HPHT-O/ EDC NHS /Ab/BSA, and (6) electrode/HPHT-O/ EDC NHS /Ab/BSA/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/s<br>Fig 7. a) CV and b) DPV results of (1) carbon bare electrode, (2) electrode/HPHT-H, (3) electrode/HPHT-H/APTES, (4) electrode/HPHT-H/APTES/EDC NHS, (5) electrode/HPHT-H/APTES/EDC NHS/Ab, (6) electrode/HPHT-H/APTES/EDC NHS/Ab/BSA, and (7) electrode/HPHT-H/APTES/EDC NHS/Ab/BSA/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/s<br>Fig 8. Variation of the immunosensor response against the cortisol concentrations in the range of 1.0 ng to 0.5 ng/mL at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/s<br>Fig 9. Interference study involving progesterone (2430 pg/ml), β-oestradiol (32 pg/ml), cortisone (28.6 nM), and corticosterone (3.94 nM) with respect to cortisol (1 ng/mL)</p> <p><br>Fig S1. Optical images obtained for (a) before and (b) after rinsing of 3.0µg HPHT-H<br>Fig S2. Optical images obtained for (a) bare carbon electrode, (b) HPHT-O, (c) HPHT-O/APTES, (d) HPHT-O/APTES/EDC NHS, (e) HPHT-O/APTES/EDC NHS /Ab, (f) HPHT-O/APTES/EDC NHS /Ab/BSA, (g) HPHT-O/APTES/EDC NHS /Ab/BSA/Ag<br>Fig S3. a) CV and b) DPV results of (1) carbon bare electrode, (2) electrode/HPHT-H, (3) electrode/HPHT-H/APTES, (4) electrode/HPHT-H/APTES/Ab, (5) electrode/HPHT-H/APTES/ Ab/BSA, and (6) electrode/HPHT-H/APTES/Ab/BSA/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/S<br>Fig S4. a) CV and b) DPV results of (1) carbon bare electrode, (2) electrode/HPHT-H, (3) electrode/HPHT-H/EDC NHS, (4) electrode/HPHT-H/EDC NHS/Ab, (5) electrode/HPHT-H/EDC NHS/ Ab/BSA, and (6) electrode/HPHT-H/EDC NHS/Ab/BSA/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/S<br>Fig S5. a) CV and b) DPV results of (1) carbon bare electrode, (2) electrode/APTES, (3) electrode/APTES/EDC NHS, (4) electrode/APTES/EDC NHS/Ab, (5) electrode/APTES/EDC NHS/Ab /BSA, and (6) electrode/APTES/EDC NHS/Ab/Ag in the presence of 1 ng/mL cortisol at pH 7.0, in a solution containing 250 mM KCl, 5 mM K₃[Fe(CN)₆], and 5 mM K₄[Fe(CN)₆], with a scan rate of 0.1 V/S</p> <p> </p> <p><br>Table 1. Summary of the DPV electrochemical performance of the HPHT-O modified electrode using APTES and EDC-NHS as crosslinkers in cortisol immunosensor detection<br>Table 2. Summary of the DPV electrochemical performance of the HPHT-O modified electrode utilizing APTES without EDC-NHS as a crosslinker in cortisol immunosensor detection.<br>Table 3. Summary of the DPV electrochemical performance of the HPHT-O modified electrode utilizing EDC-NHS without APTES as a crosslinker in cortisol immunosensor detection<br>Table 4. Determination of cortisol in artificial human saliva.</p>
Clinical Trails of Photoelectrochemical Immunosensor for Early Diagnosis of Acute Myocardial Infarction
ClinicalTrials.gov study NCT04390490. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A pencil-lead immunosensor for the rapid electrochemical measurement of anti-Diphtheria Toxin antibodies
<p><strong>Figure S1: </strong>Oxidation of the working surface of the PLE. <strong>(A)</strong> Chronoamperogram obtained by the application of +2V for 50 s in a vigorously stirred solution of 0.1M PBS (pH 7.4) using a bare GRA as the working electrode. The initial oxidation in boxed. <strong>(B)</strong> Cyclic voltagram of the first (black) and second (red) cycle showing the improvement by the oxidization of GRA as working electrode. The reference and auxiliary electrodes were Ag/AgCl (3 mol L<sup>-1</sup> KCl) and GRA, respectively.</p> <p><strong>Figure S2: </strong>Influence of surface modification on the performance of PLE. Cyclic voltammetry (CV) recorded in 0.1 mol L<sup>-1</sup> PBS (pH 7.4) alone (dashed line) or with 3 mM Fe[(CN)<sub>6</sub>]<sup>4-</sup> (solid line) for unmodified PLE (A), oxidized graphite (B) and reduced graphite (C). Before and after electrochemical treatment (Reduced graphite), the peak separation decreased from 670 mV to 90 mV. The peak intensity increased 7-fold featuring an electron transfer improvement. The oxidized graphite presented a large capacitive current and poor electron transfer property demonstrated by less defined peaks. In all cases, the scan rate was 100 mV/sec with bare GRA and Ag/AgCl (KCl 3 mol L<sup>-1</sup>) as auxiliary and reference electrodes, respectively.</p> <p> </p> <p><strong>Figure S3: </strong>SWVs were recorded in a mixture of 5 mmol L<sup>−1 </sup>Fe(CN)<sub>6</sub><sup>3−/4−</sup> in 0.1 mol L<sup>−1</sup> KCl in each stage of the GRA surface modification. Bare GRA (<strong>black line</strong>), GRA/biEP (<strong>red line</strong>), and GRA/biEP/BSA (<strong>blue line</strong>). SWV parameters: amplitude of 10 mV, a step of 10 mV, and frequency of 6.3 Hz.</p> <p> </p> <p><strong>Figure S4:</strong> SWVs were recorded in 5 mmol L<sup>−1</sup> of dPho-HQ prepared in 0.1 mol L<sup>−1</sup> Tris-HCl/0.02 mol L<sup>−1</sup> MgCl<sub>2</sub> solution (pH 9.8) after incubating GRA/biEP/BSA in 10<sup>−4</sup> IU mL<sup>−1 </sup>IgG solution to evaluate the device’s reproducibility (<strong>orange line</strong>, n = 5) and stability after 4 (blue line, n = 3) and 28 (black line, n = 3) days of storage at 4 °C. The experiments were performed using different electrodes; in the case of the reproducibility test, they were prepared in the same manner on different days.</p> <p><strong>Figure S5: (I)</strong> Drawing the electrode holder. They were made stacking three sheets of PMMA where A, B, and C are the top view of the top, middle and bottom layers, respectively. 1 – hole for the reference electrode. 2 – Three holes to add PLEs electrodes. 3 –places for nuts, 4 -places for nuts and screws for electrode hold, 5 – places for screws to adjust the holder height. (<strong>II)</strong> Top view of the disassembled electrode holder. A, B and C are the top, middle and bottom layers, respectively. 1 - hole for the reference electrode, 2 - Three holes to place the PLEs. 3 – places for nuts. 4 - Screws to hold the PLEs. 5 - Nuts. 6 - Places to add the screws to height adjust. (<strong>III and IV)</strong> Photo of the (III) dis- and (IV) assembled holder. 4 – Screws to hold the PLEs. 6 – Screws to height adjust. 7 – Reference electrode. 8 – PLEs 9 – microcentrifuge tube or its cap.</p> <p> </p>
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.