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838 results for “immunosuppression”
Data from Time since liver transplantation and immunosuppression withdrawal outcomes: a systematic review with individual patient data meta-analysis
<p>This record provides one CSV file containing anonymized individual patient data (IPD) of pre-withdrawal times (in days) of liver transplant recipients that underwent immunosuppression (IS) withdrawal. Collection and publication of anonymized data was approved by the Ethics Committee Northwest and Central Switzerland. Patients of 15 primary studies are stratified by successfully reaching the state of IS-free operational tolerance (OT) or by developing signs of immunological rejection (non-OT).</p>
Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade
<p>RAW FCS files for the manuscript:</p> <p>"Post-injury immunosuppression and secondary infections are caused by an AIM2 inflammasome-driven signaling cascade"</p> <p> </p>
Integrative spatial omics reveals distinct tumor-promoting multicellular niches and immunosuppressive mechanisms in African American and European American patients with TNBC (Spatial Transcriptomic 10X Visium portion)
<p>Racial disparities in triple-negative breast cancer (TNBC) outcomes have been reported. However, the biological mechanisms underlying these disparities remain unclear. We integrated imaging mass cytometry and spatial transcriptomics, to characterize the tumor microenvironment (TME) of African American (AA) and European American (EA) patients with TNBC. The TME in AA patients was characterized by interactions between endothelial cells, macrophages, and mesenchymal-like cells, which were associated with poor patient survival. In contrast, the EA TNBC-associated niche is enriched in T-cells and neutrophils suggestive of an exhaustion and suppression of otherwise active T cell responses. Ligand-receptor and pathway analyses of race-associated niches found AA TNBC to be “immune cold” and hence immunotherapy resistant tumors, and EA TNBC as ‘inflamed’ tumors that evolved a distinctive immunosuppressive mechanism. Our study revealed the presence of racially distinct tumor-promoting and immunosuppressive microenvironments in AA and EA patients with TNBC, which may explain the poor clinical outcomes.</p> <p> </p> <p>This dataset contains the 10X Visium Spatial Transcriptomic data of TNBC patients. There are two cohorts.</p> <p> </p> <p><strong>Baylor Scott and White (BSW) cohort</strong>: <strong>10x.visium.tar.gz</strong>, containing 10 patients with TNBC from Baylor Scott and White affiliated Hospital. </p> <p>Each sample is made of Space Ranger processed spot-separated gene expression data (processed to HDF5 AnnData file). There are also H&E images, and spot coordinate files available. </p> <p> </p> <p>For <strong>Georgia validation cohort</strong>, 400 genes used for validation of ESG signatures (associated with BA-Community 1 and WA-Community-1) were obtained and provided by Ritu Aneja's lab. These 400 genes' spot-based expression data across Black and White TNBC patients are provided. See file <strong>georgia.validation.visium.tar.gz</strong>. Expression was normalized by total counts per spot, followed by log-normalization by Giotto.</p> <p> </p> <p>As well in our paper, we integrated a published racial TNBC cohort for deriving some of initial results in the paper. This refers to the Bassiouni et al (Cancer Research) paper in Carpten's group. <strong>GSM_giotto_processed.tar.gz</strong> refers to this dataset, which we deposit here. The data were normalized by Giotto using standard procedure.</p>
Immunosuppression and senescence in dung beetles exposed to ivermectin
<p><span>Immunosuppression and premature senescence are main risks of exposure to toxic compounds that might define individual longevity and the fate of natural animal populations. However, these sublethal effects have not been studied in insects that are of fundamental importance for human economy and well-being such as dung beetles. We exposed adult dung beetles <em>Euoniticellus intermedius</em> to ivermectin, a commonly used antiparasitic drug in cattle that is excreted in dung, and measured immune activity through phenoloxidase (PO) and its zymogen, prophenoloxidase (proPO), in males and females of different ages. We predicted that both ivermectin exposure and age would reduce immune activity, with the negative effect of ivermectin being more pronounced in older individuals, revealing immunosenescence. Despite PO and proPO activities decreased with age and ivermectin exposure, ivermectin effects on these immune mechanisms were mainly constant across ages, revealing that immunosenescence is not an effect of ivermectin exposure. Whereas males suffered a reduction in PO and proPO with ivermectin and age, female proPO was not affected by ivermectin or age. This potentially reveals a strategy of self-care adopted by females to prioritize immune function when facing stressful conditions. Among sublethal effects caused by ivermectin in dung beetles, immunosuppression might be a main physiological driver of population declines in non-target beneficial fauna from contaminated environments.</span></p>
Transcriptomic profiling of clobetasol propionate-induced immunosuppression in challenged zebrafish embryos
<p>We have conducted an immune challenge experiment on 48h zebrafish embryos, which were previously treated with the immunosuppressive drug clobetasol propionate (CP). The embryos' immune system was challenged by injection of a mix of different pathogen associated molecular patterns (PAMPs). RNA sequencing was performed in order to detect altered molcular expression levels induced by CP, PAMPs and a combination of both. The data was published in <a href="https://doi.org/10.1016/j.ecoenv.2022.113346" target="_blank" rel="noopener">Essfeld <em>et al.</em> 2022</a>.</p> <p>The uploaded data archive (<a href="https://www.7-zip.org/">7-zip</a> compressed) consists of three major data types:<br>1. MultiQC reports from raw RNA-Seq read processing and QC (50bp SR)<br>2. Result tables from differential gene expression analysis (DGEA) with DESEq2<br>3. Result tables from Overrespresentation Analysis (ORA) with clusterProfiler</p> <p>Gene count normalization and DGEA was conducted with DESeq2 (<a href="https://genomebiology.biomedcentral.com/articles/10.1186/s13059-014-0550-8">Love et al., 2014</a>, DOI 10.1186/s13059-014-0550-8) . Three biological replicates per condition, exposure treatments were compared with respect to the control group in a pairwise fashion, applying Wald’s t-test. P values were corrected for multiple testing with independent hypothesis weighting (IHW) (<a href="https://www.nature.com/articles/nmeth.3885">Ignatiadis et al., 2016</a>, DOI 10.1038/nmeth.3885 ) after Benjamini-Hochberg (BH). To improve the signal to statistical noise ratio, the obtained log<sub>2</sub>-fold change (lfc) values were shrunk with the apeglm method described by Zhu and colleagues (<a href="https://academic.oup.com/bioinformatics/article/35/12/2084/5159452?login=true">2019</a>, DOI 10.1093/bioinformatics/bty895 ) before DGEA result tables were subjected to ORA via clusterProfiler (<a href="https://www.liebertpub.com/doi/10.1089/omi.2011.0118">Yu et al., 2012</a>, DOI 10.1089/omi.2011.0118).</p> <p>The ArrayExpress accession number E-MTAB-11092, provides access to the raw and DESeq2 normalized gene count matrices upon which these analysis were performed. Genes were annotated through the biomaRt package (<a href="https://www.nature.com/articles/nprot.2009.97.pdf?origin=ppub">Durinck et al., 2009</a>, DOI 10.1038/nprot.2009.97 ) in R (<a href="https://www.r-project.org/">R Core Team 2021</a>).</p>
Dataset related to article "Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression"
<p>This record contains raw data related to article “Complement activation promoted by the lectin pathway mediates C3aR-dependent sarcoma progression and immunosuppression"</p> <p>Complement has emerged as a component of tumor promoting inflammation. We conducted a systematic assessment of the role of complement activation and effector pathways in sarcomas. <em>C3</em> <sup>-/-</sup>, <em>MBL1/2</em> <sup>-/-</sup> and <em>C4</em> <sup>-/-</sup> mice showed reduced susceptibility to 3-methylcholanthrene sarcomagenesis and transplanted sarcomas, whereas C1q and factor B deficiency had marginal effects. Complement 3a receptor (C3aR), but not C5aR1 and C5aR2, deficiency mirrored the phenotype of <em>C3</em> <sup>-/-</sup> mice. C3 and C3aR deficiency were associated with reduced accumulation and functional skewing of tumor-associated macrophages, increased T cell activation and response to anti-PD-1 therapy. Transcriptional profiling of sarcoma infiltrating macrophages and monocytes revealed the enrichment of MHC II-dependent antigen presentation pathway in C3-deficient cells. In patients, C3aR expression correlated with a macrophage population signature and C3 deficiency-associated signatures predicted better clinical outcome. These results suggest that the lectin pathway and C3a/C3aR axis are key components of complement and macrophage-mediated sarcoma promotion and immunosuppression.</p>
Single-cell and spatial transcriptomics delineate molecular traits and immunosuppressive landscape during histological progression of lung adenocarcinoma
<p>Two specimens of lung adenocarcinoma, each corresponding to the lepidic and solid histologic patterns as confirmed through histologic scrutiny, were procured in accordance with standard surgical protocols. These specimens underwent a process of formalin fixation and were subsequently encapsulated within paraffin-embedded tissue blocks. The specimens were then sectioned and subjected to hematoxylin and eosin (H&E) staining to facilitate subsequent imaging at a resolution of 40x (equivalent to 0.25 micron/pixel) via the use of Aperio GT450 scanners. The tissue slides were then conveyed to the Genomics core, where following the decoverslipping of the tissue, the Visium CytAssist device was employed to transfer transcriptomic probes from the original glass slides to capture areas on Visium slides measuring 11mm x 11mm. Comprehensive transcriptomic profiling was achieved post mRNA permeabilization, through poly(A) capture and probe hybridization. The resultant libraries were sequenced utilizing the Illumina Novaseq 6000, using paired-end sequencing with a read length of 150 base pairs.</p>
Relapsed multiple myeloma demonstrates distinct patterns of immune microenvironment and malignant cell-mediated immunosuppression
<p> </p> <table> <tbody> <tr> <td>rowID</td> <td>filename</td> <td>date</td> <td>batch</td> <td>group</td> <td>ID</td> </tr> <tr> <td>1</td> <td>20200121_bm003696_RMM_tx_01.FCS</td> <td>20200121</td> <td>1</td> <td>RMM</td> <td>bm003696</td> </tr> <tr> <td>2</td> <td>20200121_bm054122_DRMM_tx_01.FCS</td> <td>20200121</td> <td>1</td> <td>DRMM</td> <td>bm054122</td> </tr> <tr> <td>3</td> <td>20200121_bm054496_RMM_tx_02.FCS</td> <td>20200121</td> <td>1</td> <td>RMM</td> <td>bm054496</td> </tr> <tr> <td>4</td> <td>20200121_bm059645_NDMM_tx_01.FCS</td> <td>20200121</td> <td>1</td> <td>NDMM</td> <td>bm059645</td> </tr> <tr> <td>5</td> <td>20200121_bm060791_NDMM_tx_01.FCS</td> <td>20200121</td> <td>1</td> <td>NDMM</td> <td>bm060791</td> </tr> <tr> <td>6</td> <td>20200121_bm064862_DRMM_tx_01.FCS</td> <td>20200121</td> <td>1</td> <td>DRMM</td> <td>bm064862</td> </tr> <tr> <td>7</td> <td>20200121_REF2_tx_01.FCS</td> <td>20200121</td> <td>1</td> <td>REF</td> <td>REF2</td> </tr> <tr> <td>8</td> <td>20200124_BM038232_RMM_TAX_01.FCS</td> <td>20200124</td> <td>2</td> <td>RMM</td> <td>BM038232</td> </tr> <tr> <td>9</td> <td>20200124_BM051757_NDMM_TAX_01.FCS</td> <td>20200124</td> <td>2</td> <td>NDMM</td> <td>BM051757</td> </tr> <tr> <td>10</td> <td>20200124_BM052673_DRMM_TAX_01.FCS</td> <td>20200124</td> <td>2</td> <td>DRMM</td> <td>BM052673</td> </tr> <tr> <td>11</td> <td>20200124_BM053393_NDMM_TAX_01.FCS</td> <td>20200124</td> <td>2</td> <td>NDMM</td> <td>BM053393</td> </tr> <tr> <td>12</td> <td>20200124_BM053570_RMM_TAX_01.FCS</td> <td>20200124</td> <td>2</td> <td>RMM</td> <td>BM053570</td> </tr> <tr> <td>13</td> <td>20200124_BM059775_DRMM_TAX_01.FCS</td> <td>20200124</td> <td>2</td> <td>DRMM</td> <td>BM059775</td> </tr> <tr> <td>14</td> <td>20200124_REF2_TAX_01.FCS</td> <td>20200124</td> <td>2</td> <td>REF</td> <td>REF2</td> </tr> <tr> <td>15</td> <td>20200128_3-1-BM060915-DRMM_TX_01.FCS</td> <td>20200128</td> <td>3</td> <td>DRMM</td> <td>BM060915</td> </tr> <tr> <td>16</td> <td>20200128_3-2-BM064896-DRMM_TX_01.FCS</td> <td>20200128</td> <td>3</td> <td>DRMM</td> <td>BM064896</td> </tr> <tr> <td>17</td> <td>20200128_3-3-BM059424-NDMM_TX_01.FCS</td> <td>20200128</td> <td>3</td> <td>NDMM</td> <td>BM059424</td> </tr> <tr> <td>18</td> <td>20200128_3-4-BM059429-NDMM_TX_02.FCS</td> <td>20200128</td> <td>3</td> <td>NDMM</td> <td>BM059429</td> </tr> <tr> <td>19</td> <td>20200128_3-5-BM043778-RMM_TX_01.FCS</td> <td>20200128</td> <td>3</td> <td>RMM</td> <td>BM043778</td> </tr> <tr> <td>20</td> <td>20200128_3-6-BM008007-RMM_TX_01.FCS</td> <td>20200128</td> <td>3</td> <td>RMM</td> <td>BM008007</td> </tr> <tr> <td>21</td> <td>20200129_3-7-ref2_tax_01.FCS</td> <td>20200129</td> <td>3</td> <td>REF</td> <td>REF2</td> </tr> <tr> <td>22</td> <td>20200204_5-1_BM054866-DRMM-Tx_01.FCS</td> <td>20200204</td> <td>5</td> <td>DRMM</td> <td>BM054866</td> </tr> <tr> <td>23</td> <td>20200204_5-2_BM065069-DRMM-Tx_01.FCS</td> <td>20200204</td> <td>5</td> <td>DRMM</td> <td>BM065069</td> </tr> <tr> <td>24</td> <td>20200204_5-3_BM035491-NDMM-Tx_01.FCS</td> <td>20200204</td> <td>5</td> <td>NDMM</td> <td>BM035491</td> </tr> <tr> <td>25</td> <td>20200204_5-4_BM0333015-NDMM-Tx_01.FCS</td> <td>20200204</td> <td>5</td> <td>NDMM</td> <td>BM0333015</td> </tr> <tr> <td>26</td> <td>20200204_5-5_BM0052990-RMM-Tx_01.FCS</td> <td>20200204</td> <td>5</td> <td>RMM</td> <td>BM0052990</td> </tr> <tr> <td>27</td> <td>20200204_5-5_BM0052990-RMM-Tx_02.FCS</td> <td>20200204</td> <td>5</td> <td>RMM</td> <td>BM0052990</td> </tr> <tr> <td>28</td> <td>20200204_5-5_BM052990-RMM-Tx_02.FCS</td> <td>20200204</td> <td>5</td> <td>RMM</td> <td>BM052990</td> </tr> <tr> <td>29</td> <td>20200204_5-6_BM052692-RMM-Tx_02.FCS</td> <td>20200204</td> <td>5</td> <td>RMM</td> <td>BM052692</td> </tr> <tr> <td>30</td> <td>20200204_5-7 -Ref2-Tx_01.FCS</td> <td>20200204</td> <td>5</td> <td>REF</td> <td>REF2</td> </tr> <tr> <td>31</td> <td>20200207_6-1_BM063515_DRMM_Tax_01.FCS</td> <td>20200207</td> <td>6</td> <td>DRMM</td> <td>BM063515</td> </tr> <tr> <td>32</td> <td>20200207_6-2_BM054226_DRMM_Tax_01.FCS</td> <td>20200207</td> <td>6</td> <td>DRMM</td> <td>BM054226</td> </tr> <tr> <td>33</td> <td>20200207_6-3_BM008346_NDMM_Tax_01.FCS</td> <td>20200207</td> <td>6</td> <td>NDMM</td> <td>BM008346</td> </tr> <tr> <td>34</td> <td>20200207_6-4_BM008718_NDMM_Tax_01.FCS</td> <td>20200207</td> <td>6</td> <td>NDMM</td> <td>BM008718</td> </tr> <tr> <td>35</td> <td>20200207_6-5_BM052764_RMM_Tax_01.FCS</td> <td>20200207</td> <td>6</td> <td>RMM</td> <td>BM052764</td> </tr> <tr> <td>36</td> <td>20200207_6-6_Ref2_Tax_01.FCS</td> <td>20200207</td> <td>6</td> <td>REF</td> <td>REF2</td> </tr> <tr> <td>37</td> <td>20200211_7-1_BM061912_DRMM_TAX_01.FCS</td> <td>20200211</td> <td>7</td> <td>DRMM</td> <td>BM061912</td> </tr> <tr> <td>38</td> <td>20200211_7-2_BM059328_DRMM_TAX_01.FCS</td> <td>20200211</td> <td>7</td> <td>DRMM</td> <td>BM059328</td> </tr> <tr> <td>39</td> <td>20200211_7-3_BM065082_DRMM_TAX_01.FCS</td> <td>20200211</td> <td>7</td> <td>DRMM</td> <td>BM065082</td> </tr> <tr> <td>40</td> <td>20200211_7-4_BM008353_DRMM_TAX_01.FCS</td> <td>20200211</td> <td>7</td> <td>DRMM</td> <td>BM008353</td> </tr> <tr> <td>41</td> <td>20200211_Ref2_Tax_02.FCS</td> <td>20200211</td> <td>7</td> <td>REF</td> <td>REF2</td> </tr> <tr> <td>42</td> <td>20200214_4-1_BM062618_DRMM_Tax_01.FCS</td> <td>20200214</td> <td>4</td> <td>DRMM</td> <td>BM062618</td> </tr> <tr> <td>43</td> <td>20200214_4-2_BM062255_DRMM_Tax_01.FCS</td> <td>20200214</td> <td>4</td> <td>DRMM</td> <td>BM062255</td> </tr> <tr> <td>44</td> <td>20200214_4-3_BM032596_NDMM_Tax_01.FCS</td> <td>20200214</td> <td>4</td> <td>NDMM</td> <td>BM032596</td> </tr> <tr> <td>45</td> <td>20200214_4-4_BM047845_NDMM_Tax_01.FCS</td> <td>20200214</td> <td>4</td> <td>NDMM</td> <td>BM047845</td> </tr> <tr> <td>46</td> <td>20200214_4-5_BM042666_RMM_Tax_01.FCS</td> <td>20200214</td> <td>4</td> <td>RMM</td> <td>BM042666</td> </tr> <tr> <td>47</td> <td>20200214_4-6_Ref2_Tax_01.FCS</td> <td>20200214</td> <td>4</td> <td>REF</td> <td>REF2</td> </tr> </tbody> </table> <p> </p> <p>*files with row ID #26 and #27 need to be concatenated since they represent the same sample acquired over 2 files</p>
Adalimumab vs. Conventional Immunosuppression for Uveitis Trial
ClinicalTrials.gov study NCT03828019. IPD Sharing: YES. Countries: 3. Publications: 1.
Caplacizumab and Immunosuppressive Therapy Without Firstline Therapeutic Plasma Exchange in Adults With Immune-mediated Thrombotic Thrombocytopenic Purpura
ClinicalTrials.gov study NCT05468320. IPD Sharing: YES. Countries: 11. Publications: 1.
Efficacy Regarding Renal Function of Everolimus in Combination With Specific Standard Immunosuppressive Regimen Lung Transplant Recipients
ClinicalTrials.gov study NCT01404325. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Dataset: The TCR repertoire reconstitution in multiple sclerosis: comparing one-shot and continuous immunosuppressive therapies
<p>This dataset, containing TCRbeta-chain data, is the basis for the following publication in Frontiers in Immunology: The TCR repertoire reconstitution in multiple sclerosis: comparing one-shot and continuous immunosuppressive therapies. The file key can be found in the file: file_key.xlsx. Relevant methodological details maybe found in the corresponding publication.</p>
Host aphid immunosuppression by Aphidius ervi venom
<p>Dataset referred to the manuscript: </p> <p><span><span><span><strong>Host aphid immunosuppression by </strong></span></span></span><span><span><span><em><strong>Aphidius</strong></em></span></span></span><span><span><span><strong> </strong></span></span></span><span><span><span><em><strong>ervi</strong></em></span></span></span><span><span><span><strong> venom</strong></span></span></span></p> <p><span><span><strong>Elia Russo</strong></span></span><span><sup><span><strong>1§</strong></span></sup></span><span><span><strong>, Andrea Becchimanzi</strong></span></span><span><sup><span><strong>1,2§</strong></span></sup></span><span><span><strong>, Giulia Magoga</strong></span></span><span><sup><span><strong>1</strong></span></sup></span><span><span><strong>, Matteo Montagna</strong></span></span><span><sup><span><strong>1,2</strong></span></sup></span><span><span><strong>, Ilaria Di Lelio</strong></span></span><span><sup><span><strong>1,2</strong></span></sup></span><span><span><strong>* & Francesco Pennacchio</strong></span></span><span><sup><span><strong>1,2</strong></span></sup></span><span><span><strong>*</strong></span></span></p> <p> </p> <p><sup><span>1</span></sup><span>University of Naples ‘Federico II’ - Department of Agricultural Sciences, Naples, Italy, and </span><sup><span>2</span></sup><span>BAT Center - Interuniversity Center for Studies on Bioinspired Agro-Environmental Technology, University of Naples ‘Federico II’, Naples, Italy</span></p> <p> </p> <p><span><span><strong>bstract </strong></span></span></p> <p><span><span>The host immunosuppression by parasitic wasps is an important component of the host regulation strategy. The venom injected at the oviposition is one of the key-factors involved in this host alteration and, in some parasitoids, its immunosuppressive role is complemented by wasp’s symbionts. Most studies in this research area are related to hosts belonging to Lepidoptera and Diptera, for which a strong immune response is observed, whereas little is known for hemimetabolous host species, characterized by apparently much weaker defense barriers. To fill this research gap, here we focus on the host–parasitoid system </span></span><span><span><em>Acyrthosiphon pisum</em></span></span><span><span> </span></span><span>(Harris) </span><span><span>(Hemiptera: Aphididae) – </span></span><span><span><em>Aphidius ervi</em></span></span><span><span> Haliday (Hymenoptera: Braconidae). We functionally characterized </span></span><span><span>a serine</span></span><span><span> protease homolog (</span></span><span><span><em>Ae</em></span></span><span><span>SPH) protein </span></span><span><span>in vivo, </span></span><span><span>identified in the venom of the aphid endoparasitoid </span></span><span><span><em>A. ervi</em></span></span><span><span>, generating </span></span><span><span><em>Ae</em></span></span><span><span>SPH-depleted female wasps by RNA interference and evaluating their capacity to successfully parasitize the host. Parasitism success rate was negatively affected by </span></span><span><span><em>Ae</em></span></span><span><span>SPH knockdown and associated with an increased phenoloxidase (PO) cascade activation in aphids, scored by measuring PO enzymatic activity and the expression of</span></span><span><span><em> phenoloxidase activating factor 2</em></span></span><span><span>, a</span></span><span><span> proPO-activating gene upregulated in response to </span></span><span><span><em>A. ervi</em></span></span><span><span> parasitism. Our results indicate that </span></span><span><span><em>Ae</em></span></span><span><span>SPH contributes to parasitism success by inhibiting the melanization response of the host, which is therefore an important component of the defense barriers involved in the parasitoid egg suppression. The undergoing studies on other virulence factors in </span></span><span><span><em>A. ervi</em></span></span><span><span> venom will allow to further characterize the immunosuppression strategy and its possible broader role in the host regulation through its action on aphid symbiont development. </span></span></p>
Immunosuppressive niche engineering at the onset of human colorectal cancer
<p>Dataset used in "Immunosuppressive niche engineering at the onset of human colorectal cancer" by Gatenbee et al. 2022. </p>
The Immunosuppressive Landscape of the Gastric Mucosa under Helicobacter pylori Infection
<p>Helicobacter pylor (H. pylori) infection triggers a complex interplay between adaptive immune responses and immune suppression. However, these combined reactions typically fail to eliminate the infection. The immune suppressive mechanisms underlying H. pylori infection at the single cell level and spatial resolution remain poorly understood. In this study, we performed single-cell RNA sequencing of the gastric mucosa from both H. pylori-infected individuals and uninfected controls. By integrating spatially resolved transcriptomics data, we identified a conserved continuum spanning from normal gastric mucosa to inflammatory regions, intestinal metaplasia, and gastric cancer. We observed spatial microenvironment heterogeneity of gastric mucosa across different pathological stages spanning beyond that previously appreciated in H. pylori infection. Through comparative analysis, We identified several pathways of T cell exhaustion and observed that the presence of exhaustion-like mucosal-associated invariant T (MAIT) cells correlates with an inflammatory environment, increased myeloid cell activity, Th17 cell expansion, and upregulation of cytokine-associated pathways. Additionally, we traced the progression of intestinal metaplasia in epithelial cells, noting the accumulation of lipid-associated enterocytes, which may interact with immune cells and contribute to the immune suppressive microenvironment. Overall, our findings offer new insights into the pathogenic mechanisms of H. pylori and suggest potential avenues for developing novel immunoprophylactic strategies.</p>
Data from: Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors
<p>In this study, we used our modified <span>precision-cut tumor slice assay of tumors treated with CAR T cells <em>in vivo </em></span><span>prior to harvest and harvested at different time-points post-treatment, which can better reflect the behavior of CAR T cells in the TME </span><em>in vivo</em><span>.</span></p>
A Study to Assess the Pharmacokinetics of a Modified-release Tacrolimus Based Immunosuppression Regimen in Stable Kidney Transplant Patients
ClinicalTrials.gov study NCT00282568. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Pilot of Abatacept-based Immunosuppression for Prevention of Acute GvHD During Unrelated Donor HCT
ClinicalTrials.gov study NCT01012492. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Optimum Immunosuppression in Renal Transplant Recipients.New Onset Diabetes After Transplantation
ClinicalTrials.gov study NCT01002339. IPD Sharing: UNDECIDED. Countries: 1. Publications: 11.
A Study of a Modified-Release Tacrolimus Based Immunosuppression Regimen in Stable Pediatric Liver Transplant Patients
ClinicalTrials.gov study NCT00282256. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.