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Dataset results
77 results for “improvement potential”
Improving the Efficiency of Variationally Enhanced Sampling with Wavelet-Based Bias Potentials
<p>Archive with data supporting the paper "Improving the Efficiency of Variationally Enhanced Sampling with Wavelet-Based Bias Potentials" and the related PhD thesis by B. Pampel</p>
Raw Data for the article: Changes in the Transcriptome Profiles of Human Amnion-Derived Mesenchymal Stromal/Stem Cells Induced by Three-Dimensional Culture: A Potential Priming Strategy to Improve Their Properties
<p>Mesenchymal stromal/stem cells (MSCs) are believed to function in vivo as a homeostatic tool that shows therapeutic properties for tissue repair/regeneration. Conventionally, these cells are expanded in two-dimensional (2D) cultures, and, in that case, MSCs undergo genotypic/phenotypic changes resulting in a loss of their therapeutic capabilities. Moreover, several clinical trials using MSCs have shown controversial results with moderate/insufficient therapeutic responses. Different priming methods were tested to improve MSC effects, and three-dimensional (3D) culturing techniques were also examined. MSC spheroids display increased therapeutic properties, and, in this context, it is crucial to understand molecular changes underlying spheroid generation. To address these limitations, we performed RNA-seq on human amnion-derived MSCs (hAMSCs) cultured in both 2D and 3D conditions and examined the transcriptome changes associated with hAMSC spheroid formation. We found a large number of 3D culture-sensitive genes and identified selected genes related to 3D hAMSC therapeutic effects. In particular, we observed that these genes can regulate proliferation/differentiation, as well as immunomodulatory and angiogenic processes. We validated RNA-seq results by qRT-PCR and methylome analysis and investigation of secreted factors. Overall, our results showed that hAMSC spheroid culture represents a promising approach to cell-based therapy that could significantly impact hAMSC application in the field of regenerative medicine.</p>
Fig. 1 in Microbial Respiration of Organic Carbon in Freshwater Microcosms: The Potential for Improved Estimation of Microbial CO Emission from Organically Enriched Freshwater Ecosystems
Fig. 1. Densities (ordinate) of ciliates (N × 104 L–1) black bars, and densities of bacteria (N × 109 ml–1) grey bars; for Experiment One and Experiment Two with carbon-enriched (E) and control (C) preparations (abscissa).
Figure 2 in Neuroprotective potential of lignan-rich fraction of Piper cubeba L. by improving antioxidant capacity in the rat's brain
Figure 2. LF Chromatogram (a) and the mass spectrum of presumed (b) Hinokinin, (c) Cubebin, (d) Yatein by UPLC-MS.
Figure 3 in Neuroprotective potential of lignan-rich fraction of Piper cubeba L. by improving antioxidant capacity in the rat's brain
Figure 3. Antioxidant activities on rat's brain based on activities of lipid peroxidation inhibition (a), SOD (b) and CAT (c) activities, and NO concentration (d) of lignan-rich fraction of P.cubeba 200 mg/kg (LF-200), 400 mg/kg (LF-400), Vitamin C 200 mg/kg (Vit-C), and normal control (N). The results are present as the mean ± SEM, asignificantly different compared to the N group (p<0.01), bsignificantly different compared to the N group (p<0.05).
Selective sweeps identification in distinct groups of cultivated rye (Secale cereale L.) germplasm provides potential candidate genes for crop improvement
<p><strong>Background</strong></p> <p>During domestication and subsequent improvement, plants were subjected to intensive positive selection for desirable traits. Identification of selection targets is important with respect to the future targeted broadening of diversity in breeding programmes. Rye (<em>Secale</em> <em>cereale</em> L.) is a cereal that is closely related to wheat, and it is an important crop in Central, Eastern and Northern Europe. The aim of the study was (i) to identify diverse groups of rye accessions based on high-density, genome-wide analysis of genetic diversity within a set of 478 rye accessions, covering a full spectrum of diversity within the genus, from wild accessions to inbred lines used in hybrid breeding, and (ii) to identify selective sweeps in the established groups of cultivated rye germplasm and putative candidate genes targeted by selection. <strong> </strong></p> <p><strong>Results</strong></p> <p>Population structure and genetic diversity analyses based on high-quality SNP (DArTseq) markers revealed the presence of three complexes in the <em>Secale</em> genus: <em>S. sylvestre, S. strictum </em>and<em> S. cereale/vavilovii</em>, a relatively narrow diversity of <em>S. sylvestre</em>, very high diversity of <em>S. strictum</em>, and signatures of strong positive selection in <em>S. vavilovii</em>. Within cultivated ryes, we detected the presence of genetic clusters and the influence of improvement status on the clustering. Rye landraces represent a reservoir of variation for breeding, and especially a distinct group of landraces from Turkey should be of special interest as a source of untapped variation. Selective sweep detection in cultivated accessions identified 133 outlier positions within 13 sweep regions and 170 putative candidate genes related, among others, to response to various environmental stimuli (such as pathogens, drought, cold), plant fertility and reproduction (pollen sperm cell differentiation, pollen maturation, pollen tube growth), and plant growth and biomass production.</p> <p><strong>Conclusions</strong></p> <p>Our study provides valuable information for efficient management of rye germplasm collections, which can help to ensure proper safeguarding of their genetic potential and provides numerous novel candidate genes targeted by selection in cultivated rye for further functional characterisation and allelic diversity studies.</p>
Selective sweeps identification in distinct groups of cultivated rye (Secale cereale L.) germplasm provides potential candidate genes for crop improvement
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Data of "Investigating the potential for genetic improvement of nitrogen and phosphorus efficiency of in a Swiss Large White pigs population using chemical analysis"
<p>Data for article 'Investigating the Potential for Genetic Improvement of Nitrogen and Phosphorus Efficiency in a Swiss Large White Pig Population using Chemical Analysis' (DOI: 10.1111/JBG.12472). Dataset of 294 Swiss Large White pigs for which phenotypes of nitrogen efficiency, phosphorus efficiency (both determined by chemical analysis of N and P content of empty body and carcass as well as the feed ingested over the experiment phase), average daily gain and gain:feed ratio are available. We also provide the pedigree that was used to estimate genetic parameters in animal models and a description of the variables (metadata).</p>
Data for GMD article: "Towards an improved treatment of cloud-radiation interaction in weather and climate models: exploring the potential of the Tripleclouds method for various cloud types using libRadtran 2.0.4"
<p>Dataset for the publication by Nina Črnivec and Bernhard Mayer: "Towards an improved treatment of cloud-radiation interaction in weather and climate models: exploring the potential of the Tripleclouds method for various cloud types using libRadtran 2.0.4" submitted to Geoscientific Model Development in 2020.</p> <p>The repository contains data for stratocumulus, cirrus and cumulonimbus cloud case studies. It also contains MYSTIC benchmark radiation data (including atmosphering heating rate and net surface flux) for the aforementioned cloud cases. See README for additional information and description of data files.</p>
Data for "Potential of mid-tropospheric water vapor isotopes to improve large-scale circulation and weather predictability"
<p>This contains simulation results of "Potential of mid-tropospheric water vapor isotopes to improve large-scale circulation and weather predictability".</p>
Figure 1 in Neuroprotective potential of lignan-rich fraction of Piper cubeba L. by improving antioxidant capacity in the rat's brain
Figure 1. TLC analysis result of LF showed the presence of cubebin and other lignans.
Underlying data for "Development of a framework of potential adverse effects of interventions to improve critical thinking about health choices: A mixed methods study."
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Supplementary Material to "An improved grand-potential phase-field model of solid-state sintering for many particles"
<p>Supplementary Material to the publication "An improved grand-potential phase-field model of solid-state sintering for many particles" by Seiz, Hierl and Nestler. This contains the pre-study for determining the effective stiffness for the rigid-body velocity calculation and video files showing the 3D evolution of the green body in more detail than possible in the paper itself.</p> <p> </p> <p>slicethru_{start,end}.webm: Moving slices through the 400^3 nm green body at t=0.045ms and t=1.8ms representing the start and end of the simulation respectively. White/transparency indicates the surrounding vapor, with the colourmap showing different grains. Any interfaces are shown as black lines.</p> <p> </p> <p>greenbody_400.webm : Time evolution of the 400^3 nm green body based on the solid-vapor interface. White/transparent indicates the surrounding vapor, with the brownish material indicating the grains.</p> <p> </p> <p>prestudy.zip: Contains the notebook and data used for the pre-study for determining the effective stiffness. A binder is available at</p> <pre>https://mybinder.org/v2/git/https%3A%2F%2Fgit.scc.kit.edu%2Fxt5201%2Fsupplementary-material-for-improved-pf-sintering-model/master?labpath=eval-kvar.ipynb</pre> <p> </p> <p> </p>
Improved methane mitigation potential and modulated methane cycling microbial communities in arable soil by compost addition
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Data from: Extended grain filling has potential to improve yield in grain sorghum
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Data from: Improving properties of chitosan/PVA films using cashew nut Testa extract – potential applications in food packaging
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Consistent variations in personality traits and their potential for genetic improvement in the biocontrol agent Trichogramma evanescens - Data table and code for data analysis
<p>We provide data and code needed to re-do the analyses and figures presented in our preprint <em>Consistent variations in personality traits and their potential for genetic improvement in the biocontrol agent </em>Trichogramma evanescens (DOI : 10.1101/2020.08.21.257881 ):</p> <p>- data table : <em>data_repetition01.xls</em>, with informations about each column in the file <em>data_repetition_info.pdf</em></p> <p>- data table : <em>data_individual01.xls</em>, with informations about each column in the file <em>data_indivdual_info.pdf</em></p> <p><em>- </em>The R code used to do the analyses : <em>Rscript-Consistent variations in personality traits and their potential for genetic improvement in the biocontrol agent Trichogramma evanescens.R</em></p> <p><br> </p> <p> </p> <p> </p> <p> </p>
Data for the manuscript "Improved Initialisation of Optimal Path Calculations Using Stepwise Traversal over the Image Dependent Pair Potential Surface"
<p>Data of all initial and minimum energy paths presented.</p>
Evaluation of Fluid Output Threshold for Safe Chest Tube Removal - A Potential Way to Decrease Length of Stay in Hospital and to Improve Postoperative Care After Lung Surgery?
ClinicalTrials.gov study NCT03093610. IPD Sharing: NO. Countries: 1. Publications: 9.
Cracking the Egg Potential: Improving Young Child Nutrition in Ecuador
ClinicalTrials.gov study NCT02446873. IPD Sharing: Not stated. Countries: 1. Publications: 8.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.