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Dataset results
797 results for “infection prevention”
A Niclosamide-releasing hot-melt extruded catheter prevents Staphylococcus aureus experimental biomaterial-associated infection
<p>Biomaterial-associated infections are a major healthcare challenge as they are responsible for high disease burden in critically ill patients. In this study, we have developed drug-eluting antibacterial catheters to prevent catheter-related infections. Niclosamide (NIC), originally an antiparasitic drug, was incorporated into the polymeric matrix of thermoplastic polyurethane (TPU) via solvent casting, and catheters were fabricated using hot-melt extrusion technology. The mechanical and physicochemical properties of TPU polymers loaded with NIC were studied. NIC was released in a sustained manner from the catheters and exhibited <em>in vitro</em> antibacterial activity against <em>Staphylococcus aureus</em> and <em>Staphylococcus epidermidis</em>. Moreover, the antibacterial efficacy of NIC-loaded catheters was validated in an <em>in vivo</em> biomaterial-associated infection mouse model using a methicillin-susceptible and methicillin-resistant strain of <em>S. aureus. </em>The released NIC from the produced catheters reduced bacterial colonization of the catheter as well as of the surrounding tissue. In summary, the NIC-releasing hot-melt extruded catheters prevented implant colonization and reduced the bacterial colonization of peri-catheter tissue by methicillin sensitive as well as resistant <em>S. aureus</em> in a biomaterial-associated infection mouse model and has good prospects for preclinical development.</p>
Suspension of Zinc Oxide Nanoparticles (ZnO-NP) as an Intraoperative Wound Irrigation to Prevent Infection After Fracture Fixation
<p>This was underlying data as part of the article "Suspension of Zinc Oxide Nanoparticles (ZnO-NP) as an Intraoperative Wound Irrigation to Prevent Infection After Fracture Fixation"</p>
Evaluating the Response to Two Antiretroviral Medication Regimens in HIV-Infected Pregnant Women, Who Begin Antiretroviral Therapy Between 20 and 36 Weeks of Pregnancy, for the Prevention of Mother-to
ClinicalTrials.gov study NCT01618305. IPD Sharing: YES. Countries: 7. Publications: 1.
Study of a Single Intramuscular Dose of Nirsevimab in the Prevention of Hospitalizations Due to Respiratory Syncytial Virus (RSV) Infection in Healthy Term and Preterm Infants During the First Year of
ClinicalTrials.gov study NCT05437510. IPD Sharing: YES. Countries: 3. Publications: 2.
Love Infection: A Dramatized Story Intervention (Telenovela/Soap Opera) for HIV Prevention
ClinicalTrials.gov study NCT05358366. IPD Sharing: YES. Countries: 1. Publications: 30.
Data from: Preventing Zika virus infection during pregnancy using a seasonal window of opportunity for conception
It has come to light that Zika virus (ZIKV) infection during pregnancy can result in trans-placental transmission to the fetus along with fetal death, congenital microcephaly and/or Central Nervous System (CNS) malformations. There are projected to be > 9, 200, 000 births annually in countries with ongoing ZIKV transmission. In response to the ZIKV threat, the World Health Organization (WHO) is strategically targeting prevention of infection in pregnant women and funding contraception in epidemic regions. I propose that the damaging effects of ZIKV can be reduced using a seasonal window of opportunity for conception that may minimize maternal exposure. Like other acute viral infections—including the related flavivirus, dengue virus (DENV)—the transmission of ZIKV is anticipated to be seasonal. By seasonally planning pregnancy, this aspect of pathogen ecology can be leveraged to align sensitive periods of gestation with the low-transmission season.
Efficacy of Oral Vancomycin Prophylaxis for Prevention of Recurrent Clostridium Difficile Infection
ClinicalTrials.gov study NCT03462459. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of EVO100 for Prevention of Urogenital Chlamydia Trachomatis and Neisseria Gonorrhoeae Infection
ClinicalTrials.gov study NCT04553068. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Prevention of Infection and Incidence of COVID-19 in Medical Personnel Assisting Patients With New Coronavirus Disease
ClinicalTrials.gov study NCT04405999. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy of Immunization With 4C-MenB in Preventing Experimental Urethral Infection With Neisseria Gonorrhoeae
ClinicalTrials.gov study NCT05294588. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study of Heterologous Vaccine Regimen of Adenovirus Serotype 26 Mosaic4 Human Immunodeficiency Virus(Ad26.Mos4.HIV), Adjuvanted Clade C gp140 and Mosaic gp140 to Prevent HIV-1 Infection Among Cis-ge
ClinicalTrials.gov study NCT03964415. IPD Sharing: YES. Countries: 9. Publications: 1.
Isavuconazole in Preventing Invasive Fungal Infections in Adult Patients With Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome and Neutropenia
ClinicalTrials.gov study NCT03019939. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Evaluating the Safety of Immediate Versus Deferred Isoniazid Preventive Therapy Among HIV-Infected Pregnant Women
ClinicalTrials.gov study NCT01494038. IPD Sharing: Not stated. Countries: 8. Publications: 6.
Prevention of Surgical Site Infections: Effectiveness of Nasal Povidone-Iodine and Nasal Mupirocin
ClinicalTrials.gov study NCT01313182. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Peginterferon Lambda-1a for the Prevention and Treatment of SARS-CoV-2 (COVID-19) Infection
ClinicalTrials.gov study NCT04344600. IPD Sharing: NO. Countries: 1. Publications: 4.
Benefit of a Single Preoperative Dose of Antibiotics for the Prevention of Surgical Site Infections
ClinicalTrials.gov study NCT00801099. IPD Sharing: Not stated. Countries: 1. Publications: 1.
World-wide Randomized Antibiotic Envelope Infection Prevention Trial
ClinicalTrials.gov study NCT02277990. IPD Sharing: Not stated. Countries: 25. Publications: 6.
Nitrofurantoin Administration for the Prevention of Short-Term Catheter Associated Urinary Tract Infection After Pelvic Surgery
ClinicalTrials.gov study NCT03287089. IPD Sharing: NO. Countries: 1. Publications: 21.
Drug Treatment Combined With Drug and Risk Reduction Counseling to Prevent of HIV Infection and Death Among Injection Drug Users
ClinicalTrials.gov study NCT00270257. IPD Sharing: NO. Countries: 2. Publications: 7.
Pulsed UV Xenon Disinfection to Prevent Resistant Healthcare Associated Infection
ClinicalTrials.gov study NCT03349268. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.