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6,818 results for “inhibition”
How ovarian hormones influence the behaviroal activation and inhibition system through the dopamine pathway
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Response inhibition and selective attention in adults and children with and without ADHD
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The exercise paradox: Avoiding physical inactivity stimuli requires higher response inhibition
<p><strong>Dataset related to the paper on Response inhibition to physical inactivity stimuli using go/no-go tasks. </strong></p> <p>This dataset includes:</p> <p><strong>1) A codebook (including the name of the main variables)</strong></p> <p>--> "code_book_Go_noGo_Miller.xlsx"</p> <p><strong>2) Raw data of the behavioral outcomes (i.e., reaction times) of the affective go/no-go task</strong></p> <p>--> "corrected.behavioral.data.csv"</p> <p>--> "correct_Order.csv"</p> <p><strong>3) Self-reported data </strong></p> <p>--> "Self_report_data.csv"</p> <p><strong>3) EEG data </strong></p> <p>--> "gng_data"</p> <p><strong>5) R script for the data management (i.e., from the raw data to data ready to be analyzed)</strong></p> <p>--> "Data_management_Self_report_go_no_go_Miller.R" for the self-reported data (return the file: "Data_SR_final.RData")</p> <p>--> "Data_management_behav_go_no_go_Miller.R" for the behavioral outcomes (return the file: "Data_GNG_behav.RData")</p> <p>--> Data ready to be analyzed "Data_GNG_final_all.RData"</p> <p><strong>6) Eprime script for the affective go/no-go task ("Go_no_go_task.zip")</strong></p> <p>--> Images depicting physical activity and physical inactivity stimuli were kindly Share by Kullmann et al. (2014)</p> <p><strong>7) R script for the models tested</strong></p> <p><strong>--> "</strong>Models_GoNogo_Miller_VZenodo.R" for behavioral data</p> <p>--> "Models_EEG_GoNogo.R" for EEG data</p>
Diffraction images used to solve the structures published in the article "Contribution of Shape and Charge to the Inhibition of a Family GH99 endo-α-1,2-Mannanase"
<p>Raw diffraction images used for generating the structures published in the article "Contribution of Shape and Charge to the Inhibition of a Family GH99 endo-α-1,2-Mannanase" (available <a href="https://doi.org/10.1021/jacs.6b10075">here</a>). Full single-crystal datasets are published. The software used for the processing of each dataset is listed in their respective PDB entries.</p> <p> </p> <p>If you find this useful, please contact me at <a href="mailto:lukasz.sobala@hirszfeld.pl">lukasz.sobala@hirszfeld.pl</a>, I am just interested in how these data are used!</p>
Inhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis "
<table> <tbody> <tr> <td> <p>Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disease characterized by excessive extracellular matrix (ECM) deposition. Current IPF therapies slow disease progression but do not stop or reverse it. The (myo)fibroblasts are thought to be the main cellular contributors to excessive ECM production in IPF. Here we report that fibrotic AT2 cells regulate production and crosslinking of ECM via the co-transcriptional activator YAP. YAP leads to increase expression of Lysyloxidase (LOX) and subsequent LOX mediated crosslinking by fibrotic AT2 cells. Pharmacological YAP inhibition reverses fibrotic AT2 cell reprogramming and LOX expression in experimental lung fibrosis <span>in vivo</span><span> and in human fibrotic </span><span>tissue ex vivo</span><span>. We thus identify YAP-TEAD/LOX inhibition in AT2 cells as a promising potential new therapy for IPF patients.<span> </span></span></p> <p><span><span>In</span></span></p> </td> </tr> </tbody> </table>
Dataset: Relation of pest insect-killing and soilborne pathogen-inhibition abilities to species diversification in environmental Pseudomonas protegens
<p>This dataset is related to "<em>Relation of pest insect-killing and soilborne pathogen-inhibition abilities to species diversification in environmental Pseudomonas protegens</em>" and contains all the data obtained from insect experiments and plant-pathogen inhibition assays, as well as the code used for phylogenetic and Biolog anaylsis. </p>
PsPM-FSS7B: Inhibiting human aversive memory by transcranial theta-burst stimulation to primary sensory cortex
<p>This dataset includes skin conductance response (SCR), electromygoram (EMG), and pupil size response (PSR) measurements. Also included are CS and US information, keypress responses, keypress response times and key correctness. The dataset contains data from 68 healthy unmedicated participants (34 females) participating in a classical (Pavlovian) discriminant delay fear conditioning task. Simple and complex CS are deliverd to the intermediate phalanges of the index and middle fingers of the nondominant hand. Simple stimulis are stimulations to either index or middle finger, complex stimulis are stimulations of different temporal structure to both index and middle fingers. CS intensity is set to a perceivable but not unpleasant level. US is a train of electric square pulses delivered with a constant current stimulator (Digitimer DS7A, Digitimer, Welwyn Garden City, UK) on participants' dominant forearm through a pin-cathode/ring-anode configuration. SOA betwen the CS and US is 3.5 s. The ITI is randomly determined on each trial to be 7, 9, or 11 s. The study included fear acquisition (day 1), recall and retest sessions (day 2). Participants are divided into experimental and control groups, where experimental group received continuous theta-burst stimulation on primary somatosensory cortex contralateral to the CS hand immediately prior to fear acquisition, and control group received the same stimulation to the primary somatosensory cortex ipsilateral to the CS hand. For SCR data from the acquisition session, there are 62 datasets (28 experimental, 34 control), and for PSR, 37 datasets (20 experimental, 17 control). For EMG data from the recall session, there are 52 datasets (25 experimental, 27 control). For SCR data from the retest session, there are 56 datasets (27 experimental, 39 control), and for PSR, 42 datasets (22 experimental, 20 control). </p>
Long-term nitrogen fertilization inhibits carbon and nitrogen loss during late stage fungal necromass decomposition depending on necromass chemistry
Fungal necromass is increasingly recognized as a key component of in soil carbon (C) and nitrogen (N) cycling. However, how C and N loss from fungal necromass during decomposition are impacted by global change factors such as anthropogenic N addition and changes to soil C supply (e.g. via changing root exudation and rhizosphere priming) remains unclear and understudied relative to plant tissues. To address these gaps, we conducted a year-long decomposition experiment with four species of fungal necromass incubated across four forested sites in plots that had received inorganic N and/or labile C fertilization for decades in Minnesota, USA. We found that necromass chemistry was the primary driver of C and N loss from fungal necromass as well as response to fertilization. Specifically, N addition suppressed late-stage decomposition, but this effect was weaker in melanin-rich necromass, contrary to the hypothesis based on plant litter dynamics that N addition should suppress decomposition of more complex organic molecules. Labile C addition had no effect on either the early or late stages of necromass decomposition. Nitrogen release from necromass also varied among species, with N-poor necromass having lower N release after controlling for differences in mass loss via regression. The relatively minor effects of N fertilization on the proportion of initial necromass N released suggests that N demand by decomposers is the primary control on N loss during fungal necromass decomposition. Together, our results stress the importance of the afterlife effects of fungal chemical composition to forest soil C and N cycles. Further, they demonstrate that C and N release from this critical pool can be reduced by ongoing anthropogenic N addition.
Sunburned plankton: Ultraviolet radiation inhibition of phytoplankton photosynthesis in the Community Earth System Model version 2
<p>Climate model output for paper describing CESM2-UVphyto.</p>
Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson's
<h3><strong>ABSTRACT</strong></h3> <p>Ca<sup>2+</sup> entry into nigrostriatal dopamine (DA) neurons and axons via L-type voltage-gated Ca<sup>2+</sup> channels (LTCCs) contributes respectively to pacemaker activity and DA release, and has long been thought to contribute to vulnerability to degeneration in Parkinson’s disease. LTCC function is greater in DA axons and neurons from substantia nigra pars compacta than from ventral tegmental area, but this is not explained by channel expression level. We tested the hypothesis that LTCC-control of DA release is governed rather by local mechanisms, focussing on candidate biological factors known to operate differently between types of DA neurons and/or be associated with their differing vulnerability to parkinsonism, including biological sex, α-synuclein, DA transporters (DATs), and calbindin-D28k (Calb1). We detected evoked DA release <em>ex vivo </em>in mouse striatal slices using fast-scan cyclic voltammetry, and assessed LTCC support of DA release by detecting the inhibition of DA release by the LTCC inhibitors isradipine or CP8. Using genetic knockouts or pharmacological manipulations we identified that striatal LTCC support of DA release depended on multiple intersecting factors, in a regionally and sexually divergent manner. LTCC function was promoted by factors associated with Parkinsonian risk, including male sex, α-synuclein, DAT, and a dorsolateral co-ordinate, but limited by factors associated with protection i.e. female sex, glucocerebrosidase activity, Calb1, and ventromedial co-ordinate. Together, these data show that LTCC function in DA axons, and isradipine effect, are locally governed and suggest they vary in a manner that in turn might impact on, or reflect, the cellular stress that leads to parkinsonian degeneration.</p> <p> </p> <h3><strong>FILE DESCRIPTIONS</strong></h3> <p>This repository contains the following files:</p> <ul> <li>Key Resources Table (.xlsx) - Table containing details on key lab materials (antibodies, mouse lines, and software), and the persistent identifiers for protocols and code used and generated in this study. </li> <li>Source Data (.xlsx) - Excel spreadsheet containing all tabular datasets plotted in Main Figures 1 to 5 (.xlsx).</li> <li>R_Scritps (.R) - Custom written R scripts to perform a classification tree analysis.</li> </ul>
Data Set related to Synaptic inhibition in the lateral habenula shapes reward anticipation.
<p>The lateral habenula (LHb) supports learning processes enabling the prediction of upcoming rewards. While reward-related stimuli decrease the activity of LHb neurons, whether this anchors on synaptic inhibition to guide reward-driven behaviors remains poorly understood. Here, we combine in vivo two-photon calcium imaging with Pavlovian conditioning in mice and report that anticipatory licking emerges along with decreases in cue-evoked calcium signals in individual LHb neurons. In vivo multiunit recordings and pharmacology reveal that the cue-evoked reduction in LHb neuronal firing relies on GABA<sub>A</sub>-receptor activation. In parallel, we observe a postsynaptic potentiation of GABA<sub>A</sub>-receptor-mediated inhibition, but not excitation, onto LHb neurons together with the establishment of anticipatory licking. Finally, strengthening or weakening postsynaptic inhibition with optogenetics and GABA<sub>A</sub>-receptor manipulations enhances or reduces anticipatory licking, respectively. Hence, synaptic inhibition in the LHb shapes reward anticipation.</p>
Validation data for a Microwave Exposure Prototype for In Vitro Growth Inhibition of Plasmodium falciparum
<p>The dataset presented in this article revolves around the validation of an innovative irradiation device designed for <em>in vitro</em> malaria tests. The motivation stems from the escalating need for new malaria treatments due to the high mortality rates, the absence of an effective vaccine, and rising antimalarial drug resistance. The theoretical background for generating this data is based on prior studies indicating that microwave exposure can non-thermally kill malaria parasites by interacting with hemozoin crystals within infected erythrocytes, a process in which healthy cells remain unaffected, probably due to the absence of these crystals. This dataset aims to provide a thorough validation of the device's biological and electrical efficacy, by providing models to simulate various parameters such as the magnetic and electric field strength, and experimentally validate the biological effects on parasite viability under controlled microwave exposure. This contribution is pivotal for advancing research in electromagnetic therapy as a potential treatment for malaria, providing a foundational dataset for future experimental and theoretical work.</p>
Data associated with "Microbiota-derived metabolites inhibit Salmonella virulent subpopulation development by acting on single-cell behaviors"
<p>Data used for the publication Microbiota-derived metabolites inihibit Salmonella virulent subpopulation development by acting on single-cell behaviors. </p> <p> </p> <p>all_hi_2307202.csv Single-cell quantifications of Salmonella SPI-1 reporter cells grown in the presence of SCFAs.</p> <p>all_no_2307202.csv Single-cell quantifications of Salmonella SPI-1 reporter cells grown in the absence of SCFAs.</p> <p>odmeasurements.csv OD measurements of plate-reader assays of Salmonella SPI-1 reporter cells and controls grown in a range of SCFA conditions. </p> <p>gfpmeasurements.csv GFP measurements of plate-reader assays of Salmonella SPI-1 reporter cells and controls grown in a range of SCFA conditions. </p>
Data and Code: Decreased spinal inhibition leads to undiversified locomotor patterns
<p>Data and Code belonging to the article 'Increased spinal excitation causes decreased locomotor complexity'.<br>Available as preprint at: <a href="https://www.biorxiv.org/content/10.1101/2022.04.21.489087v2">https://www.biorxiv.org/content/10.1101/2022.04.21.489087v2</a></p> <p><strong>Included files</strong><br>CODE: </p> <p>- runExampleNet.m: this trains and tests an example network and plots the network outputs. The settings for the signal and the network can all be changed in this file.</p> <p>- runMFT.m: this runs the meanfield theory analysis for various levels of Imbalance and g_tot</p> <p>- createSignal.m: function to create the test and train signals, called from runExampleNet.m</p> <p>- ESN_EI.m: function for the <em>echo state network</em> with distinct excitatory and inhibitory populations, called from runExampleNet.m</p> <p>- getNPG.m: function to get parameter values for the desired imbalances and overall parameter levels</p> <p>DATA: <br>Myonardo (a 3D musculoskeletal model) output for walking slowly (XXX=WalkingI), walking fast (XXX=WalkingII) and running (XXX=Running), used in createSignal.</p> <p>Each folder contains:</p> <p>- XXX.qtm: File with the labelled qualisys data </p> <p>- XXX.mat: File with the recorded kinetic ('force') and kinematic ('trajectories') data </p> <p>- modelOutput.mat: the relevant outputs of the myonardo simulation, used to create the signals in createSignal: </p> <p>- includes: time, right heel marker, muscle length, muscle velocity and muscle activation</p> <p>- musclenames.mat: file indicating which column corresponds to what muscle, necessary for signal creation in createSignal.</p> <p> </p> <p>Upon request, the model simulations results can be shared (several GB). Contact: mdegraaf@uni-muenster.de</p> <p> </p>
Mechanical Stretch Inhibition Sensitizes Proprioceptors to Compressive Stresses
<p>A repetitive gait cycle is an archetypical component within the behavioural repertoire of many if not all<br> animals including humans. It originates from mechanical feedback within proprioceptors to adjust the<br> motorprogram during locomotion and thus leads to a periodic orbit in a low dimensional space. Here,<br> we investigate the mechanics, molecules and neurons responsible for proprioception in Caenorhabditis<br> (C.) elegans to gain insight into how mechanosensation shapes the orbital trajectory to a well-defined<br> limit cycle. We used genome editing, force spectroscopy and multiscale modeling and found that<br> alternating tension and compression with the spectrin network of a single proprioceptor encodes<br> body posture and informs TRP-4/NOMPC and TWK-16/TREK2 homologs of mechanosensitive<br> ion channels during locomotion. In contrast to a widely accepted model of proprioceptive ‘stretch’<br> reception, we found that proprioceptors activated locally under compressive stresses in vivo and in<br> vitro, and propose that this property leads to compartmentalized activity within long axons delimited<br> by curvature-dependent mechanical stresses.</p>
PhasAGE Expert Seminar- Inhibition of age-associated genomic instability: emerging strategy to delay cellular senescence and aging
<p>The PhasAGE <strong>Expert Seminars </strong>consist of a series of talks with speakers from PhasAGE partner’s institutions to promote a successful transfer of knowledge about PhasAGE topics – biomolecular phase separation, aging and age-related diseases.</p>
A Competing Compound For Remdesivir and Molnupiravir In Inhibiting RdRp Protein of COVID-19
<p>According to a docking study conducted with the online tool [1][2], the compound Nicotinate mononucleotide with the formula C11H15NO9P+ could inhibit RNA-dependent RNA polymerase (RdRp (RTP site)) protein in COVID-19 coronavirus, with a Score Value of -9.4 (kcal / mol). This is better than the amount for the Remdesivir molecule (-9.2 (kcal / mol)) and after MW correction, it is also better than Molnupiravir, to inhibit the same protein. Since inhibition of this protein plays a key role in the inhibitory function of Remdesivir against COVID-19 virus [3], we can see the Nicotinate mononucleotide compound as an alternative to Remdesivir in inhibiting this coronavirus. Since the molecular weight of Nicotinate mononucleotide (336 g / mol) is approximately half that of Remdesivir (603 g / mol) and Molnupiravir-active-form (499.16 g / mol), it is better in terms of both protein adhesion and absorption capacity. Since the main precursor of Nicotinate mononucleotide, Trigonelline alkaloid, is a naturally occurring plant secondary metabolite, and Nicotinate mononucleotide itself is present in mammalian biomolecular pathways, it is likely to be more available, more cost-effective, and more non-toxic and be better than Remdesivir and Molnupiravir. Please see added data.</p>
Plant community richness and foliar fungicides impact soil Streptomyces inhibition, resistance, and resource use phenotypes
Data associated with "Plant community richness and foliar fungicides impact soil Streptomyces inhibition, resistance, and resource use phenotypes" (DOI: 10.3389/fmicb.2024.1452534). These data include soil resource measurements and various phenotypic measurements of associated Streptomyces isolates/populations. Specifically, these data note population level inhibition phenotypes according to Herr's Assays, isolate level antibiotic resistance phenotypes against 9 standard antibiotics, and isolate level resource use phenotypes quantified with Biolog SF-P2 96 well plates.
Probing the mechanisms by which sub-canopy evergreen shrubs inhibit tree seedling recruitment at the Coweeta Hydrologic Laboratory from 1999 to 2003
Two hundred 2x2 meter plots along transects and traversing 3 understory conditions; rhododendron, kalmia, open. Light conditions will be assessed for each plot and the extreme 50% will be used for experimentation. All plots will be planted to a combination of northern red oak, chestnut oak, red maple, and pitch pine. Inoculated (with mychorrizae) and non-inoculated seedlings will be planted in the plots. Relationships between performance and mychorrizal infection will be determined.
Sedimentation inhibits macroalgal priming on an emergent plant decomposition in the littoral zone of an eutrophic lake, China
<p>These are the original data for the Manuscript "<strong>Sedimentation inhibits macroalgal priming on an emergent plant decomposition in the littoral zone of a eutrophic lake, China</strong>" (MS#2020JG005630) submitted to the Journal of Geophysical Research-Biogeoscience.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.