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ShareScore release 0.9.0
Dataset results
33 results for “inhibitory receptors”
Dataset for: All-atom simulations reveal the intricacies of signal transduction upon binding of HLA-E ligand to the transmembrane inhibitory CD94/NKG2A receptor
<p>This dataset contains relevant structures, input and other files that are associated with our article "<em>All-atom simulations reveal the intricacies of signal transduction upon binding of HLA-E ligand to the transmembrane inhibitory CD94/NKG2A receptor", available at https://pubs.acs.org/doi/full/10.1021/acs.jcim.3c00249</em></p>
The co-inhibitory receptor TIGIT promotes tissue protective functions in T cells
<p>TIGIT KO and wild-type mouse T cells were sorted and collected from the lung and spleen in steady state and LCMV conditions. Briefly, cells were sorted into three sub-populations and subsequently pooled for scRNAseq. The individual subpopulations were CD3+/CD8+, CD3+/CD4+/Foxp3-, and CD3+/CD4+/Foxp3+.</p> <p>tigit-full-dataset.rds: contains the full processed dataset ~198645 cells and 25906 genes formatted as a Seurat (v5) object. </p> <p>Alternatively, the raw data plus the associated metadata can be loaded with the following 3 files:</p> <p>tigit-raw-counts.mtx.gz: A sparse count matrix used in the Seurat object above. The matrix was stored as a matrix market format and was subsequently gzipped. The matrix is expected to have 198645 cells and 25906 features.</p> <p>cell-metadata.csv: Cell metadata found in the seu@meta.data slot of the Seurat object.</p> <p>gene-metadata.csv: gene metadata of the scRNAseq experiment as found in the seu@assays$RNA@meta.features slot of the Seurat object.</p> <p> </p>
Data for: Excitatory and inhibitory D-serine binding to the NMDA receptor
<p>N-methyl-D-aspartate receptors (NMDARs) uniquely require binding of two different neurotransmitter agonists for synaptic transmission. D-serine and glycine bind to one subunit, GluN1, while glutamate binds to the other, GluN2. These agonists bind to the receptor's bi-lobed ligand-binding domains (LBDs), which close around the agonist during receptor activation. To better understand the unexplored mechanisms by which D-serine contributes to receptor activation, we performed multi-microsecond molecular dynamics simulations of the GluN1/GluN2A LBD dimer with free D-serine and glutamate agonists. Surprisingly, we observed D-serine binding to both GluN1 and GluN2A LBDs, suggesting that D-serine competes with glutamate for binding to GluN2A. This mechanism is confirmed by our electrophysiology experiments, which show that D-serine is indeed inhibitory at high concentrations. Although free energy calculations indicate that D-serine stabilizes the closed GluN2A LBD, its inhibitory behavior suggests that it either does not remain bound long enough or does not generate sufficient force for ion channel gating. We developed a workflow using pathway similarity analysis to identify groups of residues working together to promote binding. These conformation-dependent pathways were not significantly impacted by the presence of N-linked glycans, which act primarily by interacting with the LBD bottom lobe to stabilize the closed LBD.</p>
Data for: Excitatory and inhibitory D-serine binding to the NMDA receptor
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Data from: Human blood and mucosal regulatory T cells express activation markers and inhibitory receptors in inflammatory bowel disease
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Targeting of the CD161 Inhibitory Receptor Enhances Bone Marrow-Resident Memory CD8+ T Cell-mediated Immunity Against Multiple Myeloma [CART RNA-seq]
GEO Series GSE285163. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
The lectin Siglec-G functions as an inhibitory receptor in CD8+ T cell and can be targeted to enhance therapeutic antitumor immunity.
GEO Series GSE255336. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Siglec-E is a Critical Inhibitory Receptor Controlling APC Activation and T Cell-Mediated Transplant Rejection
GEO Series GSE271770. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Claudins interact with LILRB immune inhibitory receptors to promote myeloid immunosuppression in cancer
GEO Series GSE316655. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
TLR 4 Signaling Inhibitory Pathway Induced by Green Tea Polyphenol Epigallocatechin-3-Gallate through 67-kDa Laminin Receptor
GEO Series GSE21320. Mus musculus. 24 samples. Type: Expression profiling by array.
Oncostatin M (OSM) and Leukemia Inhibitory factor (LIF) treatment of osteoblasts via LIF and OSM receptors
GEO Series GSE83418. Mus musculus. 48 samples. Type: Expression profiling by array.
IL-27 and TCR stimulation promote T cell expression of multiple inhibitory receptors
GEO Series GSE124222. Mus musculus. 6 samples. Type: Expression profiling by array.
The inhibitory receptor Siglec-G controls the severity of chronic lymphocytic leukemia
GEO Series GSE227678. Mus musculus. 121 samples. Type: Expression profiling by high throughput sequencing.
Targeting of the CD161 Inhibitory Receptor Enhances Bone Marrow-Resident Memory CD8+ T Cell-mediated Immunity Against Multiple Myeloma [CART scRNA-seq]
GEO Series GSE285164. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Leukemia inhibitory factor via the toll-like receptor 5 signaling pathway involves aggravation of cachexia induced by human gastric cancer-derived 85As2 cells in rats
GEO Series GSE113110. Homo sapiens. 6 samples. Type: Expression profiling by array.
Metabolic exhaustion of T cells in chronic infection is mediated by inhibitory receptor PD-1 and T cell receptor dependent transcription factor IRF4
GEO Series GSE84820. Mus musculus. 37 samples. Type: Expression profiling by high throughput sequencing.
Expression of the Inhibitory Receptors on Lymphocytes T Cells After Lung Cancer Surgery.
ClinicalTrials.gov study NCT03549546. IPD Sharing: NO. Countries: 1. Publications: 0.
Inhibitory Receptors in Eosinophils of Atopic Subjects
ClinicalTrials.gov study NCT01489293. IPD Sharing: Not stated. Countries: 1. Publications: 0.
iPSC-derived cells lack immune tolerance to autologous NK-cells due to imbalance in ligands for activating and inhibitory NK-cell receptors
GEO Series GSE212796. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Targeting of the CD161 Inhibitory Receptor Enhances Bone Marrow-Resident Memory CD8+ T Cell-mediated Immunity Against Multiple Myeloma [Mice RNA-seq]
GEO Series GSE285162. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.