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37 results for “inosine”
Source data for the kinetic assays in publication "Deciphering the allosteric regulation of mycobacterial inosine-5′-monophosphate dehydrogenase"
<p>Datasets of enzyme kinetics related to the publication "Deciphering the allosteric regulation of mycobacterial inosine-5′-monophosphate dehydrogenase", published in <em>Nature Communications</em> with DOI: https://doi.org/10.1038/s41467-024-50933-6 </p> <p>Individual files contain raw kinetic reaction data of the mycobacterial IMPDHs (wild type and mutant forms <em>Mycobacterium smegmatis</em> or wild type <em>Mycobacterium tuberculosis</em>) as a function of IMP, NAD+, GTP, ATP, ppGpp and Mg2+ concentration.</p> <p>Individual data sets are presented as time data points of the absorbance at 340 nm in an Excel file with a linked Graphpad graphical link. Detailed experimental conditions are available in the related publication.</p>
Source data for the HDX-MS experiments in publication "Deciphering the allosteric regulation of mycobacterial inosine-5′-monophosphate dehydrogenase"
<p>Dataset of HDX-MS experiments related to the publication "Deciphering the allosteric regulation of mycobacterial inosine-5′-monophosphate dehydrogenase", published in Nature Communications with DOI: https://doi.org/10.1038/s41467-024-50933-6 </p> <p>The differential HDX-MS experiments compare the apo and ligand-bound states of IMPDH from Mycobacterium smegmatis.</p> <p>A description of the dataset is provided in the attached README file: IMPDH_HDX-MS_README.txt.</p> <p>Detailed experimental conditions are available in the related publication.</p>
Arabidopsis TRM5 encodes a nuclear-localised bifunctional tRNA guanine and inosine-N1-methyltransferase that is important for growth
<p>Modified nucleosides in tRNAs are critical for protein translation. N<sup>1</sup>-methylguanosine-37 and N<sup>1</sup>-methylinosine-37 in tRNAs, both located at the 3’-adjacent to the anticodon, are formed by Trm5. Here we describe <em>Arabidopsis thaliana AtTRM5</em> (At3g56120) as a Trm5 ortholog. <em>Attrm5</em> mutant plants have overall slower growth as observed by slower leaf initiation rate, delayed flowering and reduced primary root length. In <em>Attrm5</em> mutants, mRNAs of flowering time genes are less abundant and correlated with delayed flowering. We show that <em>AtTRM5</em> complements the yeast <em>trm5</em> mutant, and <em>in vitro</em> methylates tRNA guanosine-37 to produce N<sup>1</sup>-methylguanosine (m<sup>1</sup>G). We also show <em>in vitro</em> that AtTRM5 methylates tRNA inosine-37 to produce N<sup>1</sup>-methylinosine (m<sup>1</sup>I) and in <em>Attrm5</em> mutant plants, we show a reduction of both N<sup>1</sup>-methylguanosine and N<sup>1</sup>-methylinosine. We also show that AtTRM5 is localized to the nucleus in plant cells. Proteomics data showed that photosynthetic protein abundance is affected in <em>Attrm5</em> mutant plants. Finally, we show tRNA-Ala aminoacylation is not affected in <em>Attrm5</em> mutants. However the abundance of tRNA-Ala and tRNA-Asp 5’ half cleavage products are deduced. Our findings highlight the bifunctionality of AtTRM5 and the importance of the post-transcriptional tRNA modifications m<sup>1</sup>G and m<sup>1</sup>I at tRNA position 37 in general plant growth and development.</p>
A Phase Ib Trial of Combined Febuxostat and Inosine Therapy in Patients With Parkinson's Disease
ClinicalTrials.gov study NCT07170475. IPD Sharing: YES. Countries: 1. Publications: 4.
A Pilot Study of Inosine in Amyotrophic Lateral Sclerosis (ALS)
ClinicalTrials.gov study NCT02288091. IPD Sharing: NO. Countries: 1. Publications: 3.
A Food-Drug Interaction Study of Serum Urate After Oral Inosine
ClinicalTrials.gov study NCT02614469. IPD Sharing: NO. Countries: 1. Publications: 5.
Data from: Antibody production relies on the tRNA inosine wobble modification to meet biased codon demand
Open the record for dataset details and reuse information.
Treatment of Multiple Sclerosis Using Over the Counter Inosine
ClinicalTrials.gov study NCT00067327. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Gut Microbial Metabolites Inosine Combined With PD-1/PD-L1 Inhibitor for Patients With Malignant Advanced Solid Tumors
ClinicalTrials.gov study NCT05809336. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Protein-Protein Interaction Underlies the Molecular Basis for Substrate Recognition by an Adenosine to Inosine RNA Editing Enzyme
GEO Series GSE112367. Caenorhabditis elegans. 12 samples. Type: Expression profiling by high throughput sequencing; Other.
ADAT2/3 complex-deposited tRNA inosines drives oncogenic transformation
GEO Series GSE234132. Homo sapiens. 9 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Differential effects of inosine monophosphate dehydrogenase (IMPDH/GuaB) inhibition in Acinetobacter baumannii and Escherichia coli
GEO Series GSE275261. Acinetobacter baumannii; Escherichia coli. 24 samples. Type: Expression profiling by high throughput sequencing.
Adenosine to Inosine RNA editing level in mouse lungs from Adar1 K999N mutants or hypoxia-exposed mice
GEO Series GSE281540. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic Remodeling of the Spinal Cord-Injured Bladder and Its Modulation by Inosine Treatment
GEO Series GSE294930. Rattus norvegicus. 18 samples. Type: Expression profiling by high throughput sequencing.
Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation
GEO Series GSE60217. Homo sapiens. 38 samples. Type: Expression profiling by high throughput sequencing.
Adenosine to Inosine RNA editing level in ADAR1-deficient or hypoxia-exposed human pulmonary artery endothelial cells
GEO Series GSE281541. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Inosine enhances mitochondria respiration to promote cancer survival under starvation
GEO Series GSE225643. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Inosine Induces Stemness Features in HA-CAR-T cells and Enhances Potency [RNA-seq]
GEO Series GSE250442. Homo sapiens. 33 samples. Type: Expression profiling by high throughput sequencing.
RNA modifications, alternative splicing and circular RNA landscape in the mouse brain: inosine and beyond
GEO Series GSE275035. Mus musculus. 27 samples. Type: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing.
Inosine monophosphate and inosine differentially regulate endotoxemia and bacterial sepsis
GEO Series GSE183880. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.