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61 results for “intravenous thrombolysis”
Association of Serum Biomarkers with Early Neurological Improvement after Intravenous Thrombolysis in Ischemic Stroke
<p><strong>Background:</strong> Early neurological improvement (ENI) after intravenous thrombolysis is associated with favorable outcome, but associated serum biomarkers were not fully determined. We aimed to investigate the issue in a prospective cohort.</p> <p><strong>Methods:</strong> In INTRECIS study, five centers were designed to consecutively collect the blood sample from enrolled patients. Enrolled patients with ENI and without ENI were matched by propensity score matching with the ratio of 1:1. Preset 49 biomarkers were measured through protein microarray analysis. Enrichment of Gene Ontology and pathway, and protein-protein interaction network were analyzed in the identified biomarkers.</p> <p><strong>Results:</strong> Of 358 patients, 19 occurred ENI, who were assigned as ENI group, while 19 matched patients without ENI were assigned as Non ENI group. A total of nine biomarkers were found different, among which levels of chemokine (C-C motif) ligand (CCL)-23, chemokine (C-X-C motif) ligand (CXCL)-12, insulin-like growth factor binding protein (IGFBP)-6, interleukin (IL)-5, lymphatic vessel endothelial hyaluronan receptor (LYVE)-1, plasminogen activator inhibitor (PAI)-1, platelet-derived growth factor (PDGF)-AA, suppression of tumorigenicity (ST)-2, and tumor necrosis factor (TNF)-α were higher in ENI group, compared with those in Non ENI group.</p> <p><strong>Conclusions:</strong> Our finding found that serum levels of CCL-23, CXCL-12, IGFBP-6, IL-5, LYVE-1, PAI-1, PDGF-AA, ST-2, and TNF-α at admission were associated with post-thrombolytic ENI in ischemic stroke. The role of these biomarkers warrant further investigation.</p>
Safety of Intravenous Thrombolysis for Wake-up Stroke
ClinicalTrials.gov study NCT01183533. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Intravenous Thrombolysis With Alteplase in MRI-Selected Patients
ClinicalTrials.gov study NCT01282242. IPD Sharing: NO. Countries: 1. Publications: 2.
Safety and Efficacy of Remote Ischemic Conditioning Combined With Intravenous Thrombolysis for Acute Ischemic Stroke
ClinicalTrials.gov study NCT04980625. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical Research of Intravenous Thrombolysis for Ischemic Stroke in Northeast of China
ClinicalTrials.gov study NCT05028868. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Early Reperfusion Therapy With Intravenous Thrombolysis for Recovery of VISION in Acute Central Retinal Artery Occlusion
ClinicalTrials.gov study NCT04965038. IPD Sharing: NO. Countries: 1. Publications: 1.
Intravenous Thrombolysis Combined With Tirofiban in Acute Ischemic Stroke
ClinicalTrials.gov study NCT07290751. IPD Sharing: NO. Countries: 1. Publications: 10.
Early Antiplatelet Administration After Intravenous Thrombolysis for Acute Ischemic Stroke (TREND-IVT)
ClinicalTrials.gov study NCT06548971. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Rescue Stenting in the Severe Atherosclerotic Stenosis After the Failure of Intravenous Thrombolysis
ClinicalTrials.gov study NCT05666388. IPD Sharing: NO. Countries: 1. Publications: 4.
Tirofiban for the Prevention of Early Neurological Deterioration After Intravenous Thrombolysis in Acute Ischemic Stroke
ClinicalTrials.gov study NCT06587347. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Rescue Stenting and Intravenous Thrombolysis in Patients with Large Vessel Ischemic Stroke
ClinicalTrials.gov study NCT06727006. IPD Sharing: YES. Countries: 1. Publications: 12.
Advancing Stroke Safety and Efficacy Through Early Tirofiban Administration After Intravenous Thrombolysis (ASSET-IT)
ClinicalTrials.gov study NCT06134622. IPD Sharing: NO. Countries: 1. Publications: 2.
Ginkgolide With Intravenous Alteplase Thrombolysis in Acute Ischemic Stroke Neurological Improving Trial
ClinicalTrials.gov study NCT03772847. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Intravenous Thrombolysis Registry for Chinese Ischemic Stroke Within 4.5 h Onset
ClinicalTrials.gov study NCT02854592. IPD Sharing: NO. Countries: 1. Publications: 8.
Efficacy and Safety of Intravenous Thrombolysis in Branch Atheromatous Disease
ClinicalTrials.gov study NCT07299994. IPD Sharing: YES. Countries: 3. Publications: 16.
Intravenous Thrombolysis With rhTNK-tPA for Acute Non-large Vessel Occlusion in Extended Time Window
ClinicalTrials.gov study NCT05752916. IPD Sharing: NO. Countries: 1. Publications: 1.
Early Tirofiban Administration After Intravenous Thrombolysis in Acute Ischemic Stroke
ClinicalTrials.gov study NCT06045156. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Ticagrelor With Aspirin Dual Antiplatelet Therapy Combined With Intravenous Thrombolysis for Ischemic Stroke
ClinicalTrials.gov study NCT06316570. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Dual IntraVenous Thrombolysis Approach (DIVA) in Patients With Medium-vessel-occlusion Strokes: a Retrospective Study
ClinicalTrials.gov study NCT05809921. IPD Sharing: NO. Countries: 1. Publications: 1.
Tirofiban Plus Intravenous Thrombolysis in Acute Anterior Choroidal Infarction or Paramedian Pontine Infarction
ClinicalTrials.gov study NCT05733507. IPD Sharing: NO. Countries: 1. Publications: 1.
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