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21 results for “ionising radiation”
(A) Phase 1 and 2 Non-Ionising Radiation and Frequency Data Files
<p>The data files for all nine locations measured using the tinyUltra Spectrum Analyser (TUSA) . The file names starting with "Location" are data files for Phase 1 and the file names starting with "L" are data files for Phase 2.</p>
TG 111: Factors Governing the Individual Response of Humans to Ionising Radiation
<p>The current system of radiological protection, that aims to avoid tissue reactions (deterministic effects) and minimize risk of stochastic effects (cancers and hereditary effects), through justification and optimisation of practices and limitation of exposures, is based on estimations of risk to a notional average person. The use of an age- and sex-averaged approach is not a reflection of the reality of population structures, but is a pragmatic approach. However, we know that there are variations in radiosensitivity between individuals within the population. The underlying reasons for this variation can be genetic (for example, the radiation-sensitive syndromes such as ataxia telangiectasia and Gorlin syndrome), epigenetic and also environmental or behavioural (for example, the difference in lung cancer risks in smokers and non-smokers). A better understanding of the factors that underlie inter-individual variation in response to radiation, and the magnitude of the variation could impact on the approaches adopted to radiation protection in the occupational, medical and public sectors. One example where this may impact is in radiotherapy for cancer, where severe normal tissue complications can be observed in a sub-set of the individuals treated. Understanding the subpopulations for which such severe complications occur, and the underlying mechanistic basis could inform radiotherapy treatment decision making, improving tumour cure rates while avoiding the severe complications. In 2018, the International Commission on Radiological Protection established a Task Group, TG111 to consider Factors Governing the Individual Response of Humans to Ionising Radiation. The aim of this presentation is to review the current state of knowledge on variation in individual response to radiation and to provide an update on progress with the work of the ICRP Task Group.</p>
Breaking photoswitch activation depth limit using ionising radiation stimuli adapted to clinical application
<p>This deposit gathers the main raw data and custom codes related to the manuscript "Breaking photoswitch activation depth limit using ionising radiation stimuli adapted to clinical application".</p>
Water is a radiation protection agent for ionised pyrrole
<p>Data and scripts for the manuscript with the title: Water is a radiation protection agent for ionised pyrrole</p>
LuBiO3 nanoparticles for attenuation of ionising radiation
<p>Supplementary data for bachelor thesis: ENEDIKOVÁ Alexandra, 2020. <em>LuBiO3 nanoparticles for attenuation of ionizing radiation</em>. Liberec<em>.</em> Bachelor thesis. Technical University of Liberec. Faculty of Mechatronics, Informatics and Interdisciplinary Studies. Supervisor: Jan Grégr.</p> <p>After thorough research three methods of preparing LuBiO3 nano- and microparticles were chosen for preparataion. Afterwards, effectivity of these methods was compared, and products were characterised. Polymer solution was prepared from PVB andnanoparticles, which was then processed by electrospinning. LuBiO3 nanofibers were characterised and tested on X-Ray attenuation effect.</p>
Zenith: A Radiosonde detector for Rapid-Response Ionising Atmospheric Radiation Measurements during Solar Particle Events
<p>Supporting data for journal paper titled "Zenith: A Radiosonde detector for Rapid-Response Ionising Atmospheric Radiation Measurements during Solar Particle Events" published in the AGU journal Space Weather.</p>
Managing Ionising Radiation Risks: The Need for a Broader Context
<p>ICRP is the leading scientific organisation regrouping some of the most recognised RP experts worldwide and has defined for decades the principles and tools to be used by RP professionals. The ICRP has recently embarked on a process to revise its General Recommendations.</p> <p>The Radiological Protection Working Group (RPWG) of the World Nuclear Association, a forum for RP experts in the field of nuclear energy, acknowledges the need to adapt selected parts of the RP system, but recommends considering any reform in a wider context.</p> <p>The overarching aim of the radiological protection is the protection of humans, animals, and the environment from any detrimental health effects due to ionising radiation. Over the years however, the RP community started to understand that the harmful effects of ionising radiation should not be considered in isolation of other types of hazard. As such, the “all-hazard approach” was developed to include all the risks considered for a specific scenario, albeit all too often focused on the local scale only, forgetting the potential implications on the global scale. Climate change originating from anthropomorphic activities is one such risk that is already creating upheaval in our society and is on the move to cause a tremendous impact on our planet in the near future, far more than any small improvement in radiation exposure ever will.</p> <p>The ICRP has the responsibility more than ever to contextualise the realities of our time and to fully understand the potential consequences of any changes or added complexity to our current RP system which may add some small benefits from a health and safety perspective but would penalise nuclear technologies that provide huge benefits to society and an essential tool to reaching carbon neutrality. Consequently, any changes to the current RP system should be subject to a deep impact analysis using a true “all-hazard approach”.</p> <p>The LNT hypothesis, the need for education especially for members of the public towards the risks associated with low doses, the avoidance of over-conservatism, the changes of the system of dose quantities, are some of the many subjects that will need to be very carefully considered bearing in mind the current challenges.</p> <p>Overall, the revision of the general recommendations will need to be simple and practical. The RPWG is willing to collaborate with the ICRP to provide industry input on the practicalities of radiological protection as applied in the nuclear industry.</p>
Gene expression profiling of PBL in response to ionising radiation and modeled microgravity
BACKGROUND: Ionizing radiation (IR) can be extremely harmful for human cells since an improper DNA-damage response (DDR) to IR can contribute to carcinogenesis initiation. Perturbations in DDR pathway can originate from alteration in the functionality of the microRNA-mediated gene regulation being microRNAs (miRNAs) small noncoding RNA that act as post-transcriptional regulators of gene expression. In this study we gained insight into the role of miRNAs in the regulation of DDR to IR under microgravity a condition of weightlessness experienced by astronauts during space missions which could have a synergistic action on cells increasing the risk of radiation exposure. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed miRNA expression profile of human peripheral blood lymphocytes (PBL) incubated for 4 and 24 h in normal gravity (1 g) and in modeled microgravity (MMG) during the repair time after irradiation with 0.2 and 2Gy of gamma-rays. Our results show that MMG alters miRNA expression signature of irradiated PBL by decreasing the number of radio-responsive miRNAs. Moreover let-7i* miR-7 miR-7-1* miR-27a miR-144 miR-200a miR-598 miR-650 are deregulated by the combined action of radiation and MMG. Integrated analyses of miRNA and mRNA expression profiles carried out on PBL of the same donors identified significant miRNA-mRNA anti-correlations of DDR pathway. Gene Ontology analysis reports that the biological category of Response to DNA damage is enriched when PBL are incubated in 1 g but not in MMG. Moreover some anti-correlated genes of p53-pathway show a different expression level between 1 g and MMG. Functional validation assays using luciferase reporter constructs confirmed miRNA-mRNA interactions derived from target prediction analyses. CONCLUSIONS/SIGNIFICANCE: On the whole by integrating the transcriptome and microRNome we provide evidence that modeled microgravity can affects the DNA-damage response to IR in human PBL. Overall Design: Gene expression signature was defined in PBL irradiated with gamma-rays (2.0 Gy) and incubated in modeled microgravity (mmg) and in parallel ground conditions (1g) for 24h. Five independent experiments were performed for each donor to address which mRNAs were regulated on IR stress. The level of each transcript was represented as Log2.
Identification of miRNAs involved in cell response to ionising radiation and modeled microgravity
BACKGROUND: Ionizing radiation (IR) can be extremely harmful for human cells since an improper DNA-damage response (DDR) to IR can contribute to carcinogenesis initiation. Perturbations in DDR pathway can originate from alteration in the functionality of the microRNA-mediated gene regulation being microRNAs (miRNAs) small noncoding RNA that act as post-transcriptional regulators of gene expression. In this study we gained insight into the role of miRNAs in the regulation of DDR to IR under microgravity a condition of weightlessness experienced by astronauts during space missions which could have a synergistic action on cells increasing the risk of radiation exposure. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed miRNA expression profile of human peripheral blood lymphocytes (PBL) incubated for 4 and 24 h in normal gravity (1 g) and in modeled microgravity (MMG) during the repair time after irradiation with 0.2 and 2Gy of gamma-rays. Our results show that MMG alters miRNA expression signature of irradiated PBL by decreasing the number of radio-responsive miRNAs. Moreover let-7i* miR-7 miR-7-1* miR-27a miR-144 miR-200a miR-598 miR-650 are deregulated by the combined action of radiation and MMG. Integrated analyses of miRNA and mRNA expression profiles carried out on PBL of the same donors identified significant miRNA-mRNA anti-correlations of DDR pathway. Gene Ontology analysis reports that the biological category of Response to DNA damage is enriched when PBL are incubated in 1 g but not in MMG. Moreover some anti-correlated genes of p53-pathway show a different expression level between 1 g and MMG. Functional validation assays using luciferase reporter constructs confirmed miRNA-mRNA interactions derived from target prediction analyses. CONCLUSIONS/SIGNIFICANCE: On the whole by integrating the transcriptome and microRNome we provide evidence that modeled microgravity can affects the DNA-damage response to IR in human PBL.
Gene expression profiling of PBL in response to ionising radiation and modeled microgravity
GEO Series GSE20173. Homo sapiens. 20 samples. Type: Expression profiling by array.
Analysis of gene co-expression networks in skin cells exposed to different doses of ionising radiation at different time points
GEO Series GSE29344. Homo sapiens. 24 samples. Type: Expression profiling by array.
A system biology approach reveals neuronal and muscles developmental defects after chronic exposure to ionising radiation
GEO Series GSE134634. Danio rerio. 58 samples. Type: Expression profiling by high throughput sequencing.
Craniofacial Imaging With 3D MRI: an Alternative to Ionising Radiation
ClinicalTrials.gov study NCT04695938. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Identification of miRNAs involved in cell response to ionising radiation and modeled microgravity
GEO Series GSE20120. Homo sapiens. 72 samples. Type: Non-coding RNA profiling by array.
Cardiac cells after mechanical stress, ionising radiation or UV
GEO Series GSE2032. Rattus norvegicus. 35 samples. Type: Expression profiling by array.
(A) Phase 1 and 2 Non-Ionising Radiation and Frequency Data Files
<p>The data files for all nine locations measured using the tinyUltra Spectrum Analyser (TUSA) . The file names starting with "Location" are data files for Phase 1 and the file names starting with "L" are data files for Phase 2.</p> <p> </p>
(1) Phases 1 and 2 Non-Ionising Radiation Levels by Frequency for Each Location
<p>The non-ionising radiation levels as a function of frequency for the nine different locations for Phases 1 and 2 as subplots. The corresponding code is the attached csv file "CODE_A". The data files for the csv file is under domain (A). </p>
Identification of miRNAs involved in cell response to ionising radiation and modeled microgravity
BACKGROUND: Ionizing radiation (IR) can be extremely harmful for human cells since an improper DNA-damage response (DDR) to IR can contribute to carcinogenesis initiation. Perturbations in DDR pathway can originate from alteration in the functionality of the microRNA-mediated gene regulation being microRNAs (miRNAs) small noncoding RNA that act as post-transcriptional regulators of gene expression. In this study we gained insight into the role of miRNAs in the regulation of DDR to IR under microgravity a condition of weightlessness experienced by astronauts during space missions which could have a synergistic action on cells increasing the risk of radiation exposure. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed miRNA expression profile of human peripheral blood lymphocytes (PBL) incubated for 4 and 24 h in normal gravity (1 g) and in modeled microgravity (MMG) during the repair time after irradiation with 0.2 and 2Gy of gamma-rays. Our results show that MMG alters miRNA expression signature of irradiated PBL by decreasing the number of radio-responsive miRNAs. Moreover let-7i* miR-7 miR-7-1* miR-27a miR-144 miR-200a miR-598 miR-650 are deregulated by the combined action of radiation and MMG. Integrated analyses of miRNA and mRNA expression profiles carried out on PBL of the same donors identified significant miRNA-mRNA anti-correlations of DDR pathway. Gene Ontology analysis reports that the biological category of Response to DNA damage is enriched when PBL are incubated in 1 g but not in MMG. Moreover some anti-correlated genes of p53-pathway show a different expression level between 1 g and MMG. Functional validation assays using luciferase reporter constructs confirmed miRNA-mRNA interactions derived from target prediction analyses. CONCLUSIONS/SIGNIFICANCE: On the whole by integrating the transcriptome and microRNome we provide evidence that modeled microgravity can affects the DNA-damage response to IR in human PBL.
Gene expression profiling of PBL in response to ionising radiation and modeled microgravity
BACKGROUND: Ionizing radiation (IR) can be extremely harmful for human cells since an improper DNA-damage response (DDR) to IR can contribute to carcinogenesis initiation. Perturbations in DDR pathway can originate from alteration in the functionality of the microRNA-mediated gene regulation being microRNAs (miRNAs) small noncoding RNA that act as post-transcriptional regulators of gene expression. In this study we gained insight into the role of miRNAs in the regulation of DDR to IR under microgravity a condition of weightlessness experienced by astronauts during space missions which could have a synergistic action on cells increasing the risk of radiation exposure. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed miRNA expression profile of human peripheral blood lymphocytes (PBL) incubated for 4 and 24 h in normal gravity (1 g) and in modeled microgravity (MMG) during the repair time after irradiation with 0.2 and 2Gy of gamma-rays. Our results show that MMG alters miRNA expression signature of irradiated PBL by decreasing the number of radio-responsive miRNAs. Moreover let-7i* miR-7 miR-7-1* miR-27a miR-144 miR-200a miR-598 miR-650 are deregulated by the combined action of radiation and MMG. Integrated analyses of miRNA and mRNA expression profiles carried out on PBL of the same donors identified significant miRNA-mRNA anti-correlations of DDR pathway. Gene Ontology analysis reports that the biological category of Response to DNA damage is enriched when PBL are incubated in 1 g but not in MMG. Moreover some anti-correlated genes of p53-pathway show a different expression level between 1 g and MMG. Functional validation assays using luciferase reporter constructs confirmed miRNA-mRNA interactions derived from target prediction analyses. CONCLUSIONS/SIGNIFICANCE: On the whole by integrating the transcriptome and microRNome we provide evidence that modeled microgravity can affects the DNA-damage response to IR in human PBL. Overall Design: Gene expression signature was defined in PBL irradiated with gamma-rays (2.0 Gy) and incubated in modeled microgravity (mmg) and in parallel ground conditions (1g) for 24h. Five independent experiments were performed for each donor to address which mRNAs were regulated on IR stress. The level of each transcript was represented as Log2.
The molecular and cellular basis of divergent dose-dependent ionising radiation response
GEO Series GSE130066. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing; Other.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.