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125 results for “limb development”
Fig.ç18.A mblyops surugensis sp. nov., holotype, female (NSMT-Cr 21364). A, rst thoracopodal endopod (le); B, second thoracopod (le); C, third thoracopod (le); D, distal part of endopod of the same limb (le); E, sixth thoracopod with rudimentary oostegite; F, eighth thoracopod with developed oostegite. in The Genus Amblyops (Crustacea: Mysida: Mysidae: Erythropinae) from East Asia and Australia, with Descriptions of Ten New Species
Fig.ç18.A mblyops surugensis sp. nov., holotype, female (NSMT-Cr 21364). A, rst thoracopodal endopod (le); B, second thoracopod (le); C, third thoracopod (le); D, distal part of endopod of the same limb (le); E, sixth thoracopod with rudimentary oostegite; F, eighth thoracopod with developed oostegite.
Fig.ç16.A mblyops sagamiensis sp. nov., A–E, I, allotype, male (NSMT-Cr 21362); F, H, holotype, female (NSMT-Cr 21361); G, J, paratype, female with partially developed marsupium (NSMT-Cr 21363). A, third pleopod (le); B, fourth pleopod (le); C, pseudobranchial lobe on the same limb (le); D, distal part of exopod of the same limb (le), E, h pleopod (right), F, G, uropod and telson (dorsal); H, I, proximal part of uropodal endopod (le, ventral); J, posterior part of telson (dorsal). in The Genus Amblyops (Crustacea: Mysida: Mysidae: Erythropinae) from East Asia and Australia, with Descriptions of Ten New Species
Fig.ç16.A mblyops sagamiensis sp. nov., A–E, I, allotype, male (NSMT-Cr 21362); F, H, holotype, female (NSMT-Cr 21361); G, J, paratype, female with partially developed marsupium (NSMT-Cr 21363). A, third pleopod (le); B, fourth pleopod (le); C, pseudobranchial lobe on the same limb (le); D, distal part of exopod of the same limb (le), E, h pleopod (right), F, G, uropod and telson (dorsal); H, I, proximal part of uropodal endopod (le, ventral); J, posterior part of telson (dorsal).
Supplementary information for 'Distinct gene expression dynamics in developing and regenerating crustacean limbs', by Sinigaglia et al.
<p>Supplementary data and code for the manuscript <em>'Distinct gene expression dynamics in developing and regenerating crustacean limbs'</em>, by Sinigaglia et al.</p>
ATACSeq fastq files associated with the manuscript entitled 'Interspecies transcriptome analyses identify genes that control the development and evolution of limb skeletal proportion'
<p>This next-generation sequencing dataset is associated with the research manuscript entitled ‘<em>Interspecies transcriptome analyses identify genes that control the development and evolution of limb skeletal proportion</em>’ (https://www.biorxiv.org/content/10.1101/754002v2).</p> <p>The zipped folder ‘<strong>Zenodo_Saxena_etal_2021_ATACSeq_FastqFiles</strong>’ contains raw/unprocessed ATACSeq Fatsq read files for postnatal day 5 (P5) mouse (Mus) and jerboa (Jac) cartilage samples (Metatarsal = MT; Radius/Ulna = RU).</p> <p>> The <strong>Jac_P5</strong> subfolder contains paired-end reads (R1 and R2) for three jerboa metatarsals (MT1-3) and radius/ulna (RU1-3) biological replicates.</p> <p>> The <strong>Mus_P5</strong> subfolder contains paired-end reads (R1 and R2) for two mouse metatarsals (MT1-2) and radius/ulna (RU1-2) biological replicates.</p>
Anuran limbs reflect microhabitat and distal, later-developing bones are more evolutionarily labile
Tetrapod limbs have been used as a model system to investigate how selective pressures and constraints shape morphological evolution. Anurans have had many independent transitions to various microhabitats, allowing us to dissect how these factors influence limb morphology. Furthermore, anurans provide a unique system to test the generality of developmental constraints proposed in mammals, namely that later-developing limb bones are under less constraint and show more variation. We used micro-computed tomography scans of 236 species from 52 of 55 families, geometric morphometrics, and modern phylogenetic comparative methods to examine how limb bones are related to microhabitat, phylogeny, allometry, and developmental timing. Although there was significant phylogenetic signal, anuran limb shape showed a relationship with microhabitat and to a lesser extent, body size. We found that distal bones had higher evolutionary rates than proximal bones, providing evidence that developmental constraints are reduced in later-developing bones. Distal bones also showed increased selection related to allometry and microhabitat, providing an additional explanation for higher evolutionary rates. By looking at the evolution of limb shape across a diverse clade, we demonstrated that multiple factors have shaped anuran limbs and that greater evolutionary lability in later-developing limb bones is likely a general trend among tetrapods.
Dataset from: Limb development in skeletally-immature large-sized dogs: a radiographic study
<p>Dataset from the publication: "Limb development in skeletally-immature large-sized dogs: a radiographic study", published in PLoS ONE, 2021.</p> <p>Despite the extreme morphological variability of the canine species, data on limb development are limited and the time windows for the appearance of the limb ossification centres (OCs) reported in veterinary textbooks, considered universally valid for all dogs, are based on dated studies. The aim of this study was to acquire up-to-date information regarding the arm, forearm and leg bone development in skeletally-immature large-sized dogs from 6 weeks to 16 weeks of age. Nine litters of 5 large-sized breeds (Boxer, German Shepherd, Labrador Retriever, Saarloos Wolfdog, White Swiss Shepherd Dog) were included, for a total of 54 dogs, which were subject to clinical and radiographic examination on a bi-weekly basis. The appearance of 18 limb OCs was recorded and 14 radiographic measurements were performed; their relationship with age and body weight was investigated and any breed differences were analysed.</p>
RNASeq fastq files associated with the manuscript entitled 'Interspecies transcriptome analyses identify genes that control the development and evolution of limb skeletal proportion'
<p>This next-generation sequencing dataset is associated with the research manuscript entitled ‘<em>Interspecies transcriptome analyses identify genes that control the development and evolution of limb skeletal proportion</em>’ (https://www.biorxiv.org/content/10.1101/754002v2).</p> <p>The folder ‘<strong>Zenodo_Saxena_etal_2021_RNASeq_FastqFiles</strong>’ contains raw/unprocessed RNASeq Fatsq read files for postnatal day 5 (P5) mouse (Mus) and jerboa (Jac) cartilage samples (Metatarsal = MT; Radius/Ulna = RU).</p> <p>> The <strong>Jac_P5</strong> subfolder contains single-end reads (R1) for five jerboa metatarsals (MT1-5) and radius/ulna (RU1-5) biological replicates. Jac_MT1-3 and Jac_RU1-3 were used in the primary differential expression analysis (n=3). Jac_MT4-5 and Jac_RU4-5 were used for independent validation (n=2) of the the primary analysis. </p> <p>> The <strong>Mus_P5</strong> subfolder contains single-end reads (R1) for five mouse metatarsals (MT1-5) and radius/ulna (RU1-5) biological replicates. Mus_MT1-3 and Mus_RU1,3 & 4 were used in the primary differential expression analysis (n=3). Mus_MT4-5 and Mus_RU4 & 5 were used for independent validation (n=2) of the the primary analysis. </p>
Development of Adaptive Vacuum Suspension to Improve Prosthetic Fit and Residual Limb Health
ClinicalTrials.gov study NCT03927404. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Development of limb bone laminarity in the homing pigeon (Columba livia)
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Data from: Relaxed selection in evolution of genes regulating limb development gives clue to variation in forelimb morphology of cetaceans and other mammals
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Anuran limbs reflect microhabitat and distal, later-developing bones are more evolutionarily labile
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Raw data for "Preclinical upper- limb neurorobotic platform to assess, rehabilitate and develop therapies"
<p>Source data for all figures. Tabulated data underlying the data points in all plots of each individual figure.</p>
Developing an in-depth understanding of the prevalence, risk factors and treatment recommendations for phantom limb pain, and patient-generated care priorities for people who have undergone lower limb amputations.
<p>The file holds data collected for a series of four studies on phantom limb pain. </p>
Multiple sequence alignments and phylogenetic trees from: Co-option of the limb patterning program in cephalopod eye development
<p>Background</p> <p><span>Across the Metazoa, similar genetic programs are found in the development of analogous, independently evolved, morphological features. The functional significance of this reuse and the underlying mechanisms of co-option remain unclear. Cephalopods have evolved a highly acute visual system with a cup shaped retina and a novel refractive lens in the anterior, important for a number of sophisticated behaviors including predation, mating and camouflage. Almost nothing is known about the molecular-genetics of lens development in the cephalopod.</span></p> <p><span>Results</span></p> <p><span>Here we identify the co-option of the canonical bilaterian limb pattering program during cephalopod lens development, a functionally unrelated structure. We show radial expression of transcription factors <i>SP6-9/sp1, Dlx/dll, </i><i>Pbx/exd, Meis/hth, </i>and a <i>Prdl</i> homolog in the squid <i>Doryteuthis pealeii</i>, similar to expression required in <i>Drosophila</i> limb development.<i> </i>We assess the role of Wnt signaling in the cephalopod lens, a positive regulator in the developing <i>Drosophila </i>limb, and find the regulatory relationship reversed, with ectopic Wnt signaling leading to lens loss. </span></p> <p><span>Conclusion</span></p> <p><span>This regulatory divergence suggests that duplication of SP6-9 in cephalopods may mediate the co-option of the limb patterning program. Thus our study suggests that the limb network could perform a more universal developmental function in radial pattering and highlights how canonical genetic programs are repurposed in novel structures.</span></p>
Effect of Femoral and Sciatic Nerve Blocks, Combined with General Anesthesia, in Postoperative Pain Levels and Phantom Limb Pain Development in Patients Undergoing Lower Limb Amputation
ClinicalTrials.gov study NCT06693427. IPD Sharing: UNDECIDED. Countries: 1. Publications: 17.
Multiple sequence alignments and phylogenetic trees from: Co-option of the limb patterning program in cephalopod eye development
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Analysis code and additional data associated with the manuscript entitled 'Interspecies transcriptome analyses identify genes that control the development and evolution of limb skeletal proportion'
<p>This dataset is associated with the research manuscript entitled ‘<em>Interspecies transcriptome analyses identify genes that control the development and evolution of limb skeletal proportion</em>’ (https://www.biorxiv.org/content/10.1101/754002v2).</p> <p>The folder ‘<strong>Zenodo_Saxena_etal_2021_AdditionalData_AnalysisCode</strong>’ contains:</p> <p>> Analysis code used for jerboas-mouse differential RNASeq analysis (<strong>saxena_Interspecies_DESEQ2_analysis.R</strong>).</p> <p>> A folder <strong>Mus_Jac_gtfDir</strong> with two gtf annotation files for 1:1 orthologs in Mouse (musAnno4_1To1Orthologs) and Jerboa (jerboaAnno4_1To1Orthologs) genomes generated with CESAR. This folder also contains two files with mouse or jerboa gene lengths in non-overlapping exons of each gene in the 1:1 orthologous GTF annotations (suffixed "*_exon_lengths_per_gene.txt"). A supporting R library required to run the analysis is provided in this folder (saxena_shared_library_v2.R).</p> <p>>A <strong>STAR_countsDir</strong> folder with STAR generated GeneCounts for mouse and jerboa samples (suffixed "*_SR50"). Subfolders contain metatarsal (MT) and Radius/ulna (RU) STAR Genecounts used in the primary (“*_n=3") and independent validation ("*_n=2") analyses.</p> <p>> A pdf file with <strong>Additional Figures 1 and 2</strong>. Fig 1 shows RNAScope <em>in situs </em>for <em>Galnt17</em> in jerboa and mouse postnatal day 5 cartilages. Fig 2 shows DESeq2 generated MA-plot for jerboa-mouse metatarsal comparisons (n=3).</p> <p>> <strong>Additional Data Tables_1to3</strong> with DESeq2 differential expression results for all of the 17,464 mouse and jerboa orthologs in the primary (n=3, Table1) and independent validation (n=2, Table2) analyses. r-log transformed gene counts for 17,464 mouse and jerboa 1:1 orthologs in metatarsal samples (n=3, Table3).</p>
Data from: The development of integration in marsupial and placental limbs
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Identifying active cis-regulatory elements during the development of the limbs and external genitalia in the mouse and lizard.
GEO Series GSE64055. Mus musculus; Anolis carolinensis. 21 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Clustering of tissue-specific sub-TADs accompanies the regulation of HoxA genes in developing limbs
GEO Series GSE52483. Mus musculus. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.