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ShareScore release 0.7.1
Dataset results
21 results for “lipid biomarkers”
Concentrations of methane, sulfate and lipid biomarkers and carbon isotope values oof lipids in the sediments from the outer Laptev Sea
<p>The dataset contains the concentrations of methane, sulfate and microbial lipid biomarkers, and the carbon isotope composition of lipids in the sediment collected from the SWERUS-C3 expedition in 2014. The core sediment samples were from stations 13, 14 and 23 in the outer Laptev Sea. The field investigation reveals it is a methane seep area. </p>
mselensky/Selensky2021_LavaBeds_Lithoautotrophy: Stable Carbon Isotope Depletions in Lipid Biomarkers Suggest Subsurface Carbon Fixation in Lava Caves
<p>Data and R script repository for the manuscript "Stable Carbon Isotope Depletions in Lipid Biomarkers Suggest Subsurface Carbon Fixation in Lava Caves" (Selensky et al. 2021)</p>
APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population
<p>In post-industrial settings, <i>APOE4</i> is associated with increased cardiovascular and neurological disease risk. However, the majority of human evolutionary history occurred in environments with higher pathogenic diversity and low cardiovascular risk. We hypothesize that in high-pathogen and energy-limited contexts, the <i>APOE4</i> allele confers benefits by reducing innate inflammation when uninfected, while maintaining higher lipid levels that buffer costs of immune activation during infection. Among Tsimane forager-farmers of Bolivia (N=1266), <i>APOE4</i> is associated with 30% lower C-reactive protein, and higher total cholesterol and oxidized-LDL. Blood lipids were either not associated, or negatively associated with inflammatory biomarkers, except for associations of oxidized-LDL and inflammation which were limited to high BMI adults. Further, <i>APOE4</i> carriers maintain higher levels of total and LDL cholesterol at low BMIs. These results suggest the relationship between <i>APOE4</i> and lipids may be beneficial for pathogen-driven immune responses, and unlikely to increase cardiovascular risk in an active subsistence population.</p>
Data for: Lipid biomarkers recording marine microbial community structure changes through the Frasnian‐Famennian mass extinction event
<p>This dataset contains data for a research article published on Geobiology. The article is entitled " <span class="Dummy">Lipid biomarkers recording marine microbial community structure changes through the </span><span class="fc">Frasnian‐Famennian</span><span class="Dummy"> mass extinction event</span>". <span class="Dummy"><span class="Dummy">This study aims to reconstruct changes in the marine microbial community structure through the Late Devonian Frasnian‐Famennian (F‐F) transition. We performed a multiproxy investigation on a drill core of the Upper Devonian New Albany Shale from the Illinois Basin (western Kentucky, USA). </span><span class="Dummy">Detailed information regarding the data collection, analysis, and interpretation can be found in the </span></span><span class="Dummy"><span class="Dummy">following paper:<br></span></span></p> <p class="MsoNormal">Chen J., Hogancamp<sup> </sup>N., Lu<sup> </sup>M., Ikejiri T., Malina N., Ojeda<sup> </sup>A., Sun Y., Lu Y. 2023. Lipid Biomarkers Recording Marine Microbial Community Structure Changes Through the Frasnian‐Famennian Mass Extinction Event. Geobiology <a href="https://doi.org/10.1111/gbi.12568"><span>https://doi.org/10.1111/gbi.12568</span></a></p>
Quantification of multiple environmental controls on lipid biomarkers in common marine diatoms and dinoflagellates
<p>In the monocultures of two algal species, i.e., <em>Phaeodactylum tricornutum</em> (Bacillariophyceae; strain MACC/B254) and <em>Prorocentrum minimum</em> (Dinophyceae; strain HYESL63), we investigated responses of lipid biomarkers (sterols and fatty acids (FAs)) to different temperatures (12, 18 and 24℃), nitrogen and phosphorus concentrations and their molar ratios (N:P ratios) of 10:1, 24:1 and 63:1.</p> <p>Algal cells were counted daily with an improved Neubauer hemacytometer (Glaswarenfabrik Karl Hecht GmbH) under a microscope (Olympus CX41). To analyze particulate organic carbon (POC), sterols and FAs, algal cells at steady-state conditions were harvested on pre-combusted GF/F filters (Whatman) after filtering 15-30 mL of cultures depending on cell density in the culture flask and the parameters to be determined. Samples were kept at − 80℃ after filtration.</p> <p>POC was determined by an elemental analyzer (Thermo Flash 2000) (Sharp 1974, https://doi.org/10.4319/lo.1974.19.6.0984). Sterols and FAs were analyzed according to the methods in Eglinton et al. (1996 https://doi.org/10.1021/ac9508513), Galy et al. (2011, https://doi.org/10.1016/j.epsl.2011.02.003) and Zhao et al. (2006, https://doi.org/10.1016/j.orggeochem.2005.08.022). The trimethylsilyl ether derivatives of sterols and fatty acid methyl esters (FAMEs) were analyzed in a gas chromatograph (Agilent Technologies 8890A) equipped with a flame ionization detector, and a HP-1 column (50 m, 0.32 mm i.d., 0.17 μm film; Agilent J&W) and a SP-2560 column (100 m, 0.25 mm i.d., 0.20 μm film; Supelco) for sterol and FAME analysis, respectively.</p> <p>The identification of sterols was performed by gas chromatography-mass spectrometry (GC-MS) analysis at 70 eV using an Agilent 7890B GC (HP-5MS column; 30 m, 0.25 mm i.d., 0.25 μm film; Agilent J&W) connected to an Agilent MSD 5977B mass selective detector (ion source temperature 230℃). Sterols were identified be comparison of the mass spectra of their trimethylsilyl ether derivatives to those of published GC-MS values (Lisboa et al. 1982, https://doi.org/10.1016/0305-0491(82)90281-4; Taipale et al. 2016, https://doi.org/10.3389/fpls.2016.00212), based on the molecular ion and prominent ions. The following sterols were identified: brassicasterol/epi-brassicasterol,and dinosterol. FAs were identified with reference to the standard Supelco 37 component FAME mixture. C-normalized (on a per POC basis; μg mg C-1) and per-cell (pg cell-1) contents of sterols and FAs were presented, and FA proportions (% of total fatty acids (TFAs)) were also reported in the dataset.</p>
Lipid Biomarkers for Diabetic Heart Disease
ClinicalTrials.gov study NCT01752842. IPD Sharing: NO. Countries: 1. Publications: 6.
Data for: Lipid biomarkers recording marine microbial community structure changes through the Frasnian‐Famennian mass extinction event
Open the record for dataset details and reuse information.
APOE4 is associated with elevated blood lipids and lower levels of innate immune biomarkers in a tropical Amerindian subsistence population
Open the record for dataset details and reuse information.
Hydrogen Isotope Fingerprinting of Lipid Biomarkers in the Chinese Marginal Seas-Data
<p>Hydrogen isotope data for lipid biomarkers extracted from surface sediments of the Chinese marginal seas. </p>
Lipid Mediators in Colonic Biopsies as Biomarkers of Disease Activity of Inflammatory Bowel Diseases
ClinicalTrials.gov study NCT01990716. IPD Sharing: NO. Countries: 1. Publications: 1.
Lipid Biomarker Study in Men With Dyslipidemia After Simvastatin Treatment (Study MK-0000-140)(COMPLETED)
ClinicalTrials.gov study NCT00935259. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Hydrogen Isotope fingerprinting of lipid biomarkers in the Chinese Marginal Seas
Open the record for dataset details and reuse information.
Analysis of Lipid Biomarkers of Exposure and Host Response
ClinicalTrials.gov study NCT00493831. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Dietary Lipids, Energy Expenditure and Obesity Biomarkers
ClinicalTrials.gov study NCT02656940. IPD Sharing: Not stated. Countries: 0. Publications: 17.
Whole-transcriptome analysis in peripheral blood mononuclear cells from patients with lipid-specific oligoclonal IgM band characterization reveals two circular RNAs and two linear RNAs as biomarkers o
GEO Series GSE159035. Homo sapiens. 8 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Identification of early transcriptome-based biomarkers related to lipid metabolism in peripheral blood mononuclear cells of rats nutritionally programmed for improved metabolic health
GEO Series GSE119955. Rattus norvegicus. 23 samples. Type: Expression profiling by array.
Studying Lipids as Potential Biomarkers in Patients With Fabry Disease
ClinicalTrials.gov study NCT05046379. IPD Sharing: NO. Countries: 1. Publications: 0.
An Experimental Medicine Study to Evaluate Serum Biomarkers of Lipid Metabolism
ClinicalTrials.gov study NCT00847782. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of Leukocyte Immunophenotype and the Lipid Transport System as Predictive Biomarkers of Severe Bacterial Infections
ClinicalTrials.gov study NCT04178915. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Serum Lipid Levels and Other Biomarkers of Cardiovascular Disease in Patients With Psoriasis
ClinicalTrials.gov study NCT01019200. IPD Sharing: YES. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.