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20 results for “locomotor adaptation”
Locomotor Adaptation Training to Prevent Mobility Disability: Dataset
<p>Data for 3 groups of older adults at risk of mobility disability (1: control, 2: traditional treadmill intervention, 3: split-belt treadmill intervention) were collected at 2 timepoints 1) prior (PRE) and 2) following (POST) a 16-week intervention study. </p> <p>5 dimensions of mobility disability were assessed:</p> <p>1. Cognitive Function</p> <p>To include - Mini Mental-State Exam score (MMSE), Trail making test part A (TrailsA), Trail making test part B (TrailsB), and the difference between trail making test A & B (TMT)</p> <p>2. Clinical Function</p> <p>To include - Short Physical Performance Battery score (SPPB), Dynamic Gait Index (DGI), Timed Up-and-Go performance (TUG)</p> <p>3. Spatiotemporal Gait Parameters</p> <p>To include - self-selected walking speed, cadence, stride length, stride time, step width, stance time (as % gait cycle), and standard deviations of each of these variables.</p> <p>4. Kinetic Gait Parameters</p> <p>To include - Peak plantarflexion moment, peak eccentric plantarflexor power, and peak concentric hip flexor power.</p> <p>5. Cardiovascular Fitness </p> <p>To include - maximal oxygen uptake (VO2max), heart rate (HR), ratings of perceived exertion (RPE), and gait efficiency</p> <p> </p> <p>Data set displayed in first sheet ("Data"), description of codes provided in the second sheet ("Codes").</p>
Data from: A proprioceptive feedback circuit drives C. elegans locomotor adaptation through dopamine signaling
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Data from: Understanding mechanisms of generalization following locomotor adaptation
<p>Our nervous system has the remarkable ability to adapt our gait to accommodate changes in our body or surroundings. However, our adapted walking patterns often generalize only partially (or not at all) between different contexts. Here, we sought to understand how the nervous system generalizes adapted gait patterns from one context to another. Through a series of split-belt treadmill walking experiments, we evaluated different mechanistic hypotheses (i.e., the mechanism specific, credit assignment, and slow switching hypotheses) to explain the partial generalization of adapted gait patterns from split-belt treadmill to overground walking. In support of the credit assignment hypothesis, our experiments revealed the central finding that adaptation involves 1) the recalibration of forward models of our body that generalize to overground walking, and 2) models of the treadmill that do not generalize.</p>
Data from: Understanding mechanisms of generalization following locomotor adaptation
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Data for: Exploration-based learning of a stabilizing controller predicts locomotor adaptation
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Data from: Selection towards different adaptive optima drove the early diversification of locomotor phenotypes in the radiation of Neotropical geophagine cichlids
Background: Simpson envisaged a conceptual model of adaptive radiation in which lineages diversify into "adaptive zones" within a broad adaptive landscape. However only a handful of studies have actually investigated the adaptive landscape and its implication for our interpretation of the underlying mechanisms of phenotypic evolution. In fishes the evolution of locomotor phenotypes may represent an important dimension of ecomorphological diversification during an adaptive radiation given its implications for feeding and habitat use. Neotropical geophagine cichlids represent a newly identified adaptive radiation and provide a useful system for studying patterns of locomotor diversification and the implications of selective constraints on phenotypic divergence in general. Results: We use multivariate ordination models of phenotypic evolution and posterior predictive approaches to investigate the adaptive landscape and test for evidence of early diversification of locomotor phenotypes in Geophagini. The evolution of locomotor phenotypes was characterized by divergent selection towards two distinct adaptive peaks and the early divergence of modern morphological disparity. Evolutionary models and posterior predictive approaches favoured constant-rate divergent selection over decreasing rates of phenotypic evolution as the underlying process driving the early divergence of locomotor phenotypes. Conclusions: The influence of multiple adaptive peaks on the divergence of locomotor attributes in Geophagini is compatible with the expectations of an ecologically-driven adaptive radiation. This study confirms that the diversification of locomotor morphology represents an important dimension of phenotypic evolution in the geophagine adaptive radiation. It also suggests that the commonly observed early burst of phenotypic evolution during adaptive radiations is best explained by a model that incorporates divergent selection deep in the phylogeny.
Data from: Functional capacity of kangaroo rat hindlimbs: adaptations for locomotor performance
Many cursorial and large hopping species are extremely efficient locomotors with various morphological adaptations believed to reduce mechanical demand and improve movement efficiency, including elongated distal limb segments. However, despite having elongated limbs, small hoppers such as desert kangaroo rats (Dipodomys deserti) are less efficient locomotors than their larger counterparts, which may be in part due to avoiding predators through explosive jumping movements. Despite potentially conflicting mechanical demands between the two movements, kangaroo rats are both excellent jumpers and attain high hopping speeds, likely due to a specialized hindlimb musculoskeletal morphology. This study combined experimental dissection data with a static analysis of muscle moment generating capacities using a newly developed musculoskeletal model to characterize kangaroo rat hindlimb musculoskeletal architecture and investigate how morphology has evolved to meet hopping and jumping mechanical demands. Hindlimb morphology appears biased towards generating constant moment arms over large joint ranges of motion in this species, which may balance competing requirements by reducing the need for posture and movement specific excitation patterns. The ankle extensors are a major exception to the strong positive relationship exhibited by most muscles between muscle architecture parameters (e.g. Lfibre) and joint moment arms. These muscles appear suited to meeting the high moments required for jumping: the biarticular nature of the ankle extensors is leveraged to reduce MTU strain and create a four-bar linkage that facilitates proximal force transfer. The kangaroo rat hindlimb provides an interesting case study for understanding how morphology balances the sometimes competing demands of hopping and jumping.
Adaptation of Locomotor Activity in Patients Suffering From Hip OA - Analysis of This Adaptation as a Prognostic Criterion for Future Disease Progression
ClinicalTrials.gov study NCT01907503. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Gait Adaptability: Tracking Locomotor Recovery After Incomplete Spinal Cord Injury
ClinicalTrials.gov study NCT03343132. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Increasing Gait Automaticity in Older Adults by Exploiting Locomotor Adaptation
ClinicalTrials.gov study NCT04934956. IPD Sharing: YES. Countries: 1. Publications: 25.
Augmentation of Locomotor Adaptation Post-Stroke
ClinicalTrials.gov study NCT02892084. IPD Sharing: YES. Countries: 1. Publications: 24.
Data from: Functional capacity of kangaroo rat hindlimbs: adaptations for locomotor performance
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Data from: Selection towards different adaptive optima drove the early diversification of locomotor phenotypes in the radiation of Neotropical geophagine cichlids
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Data from: Adaptive evolution in locomotor performance: how selective pressures and functional relationships produce diversity
Despite the complexity of nature, most comparative studies of phenotypic evolution consider selective pressures in isolation. When competing pressures operate on the same system, it is commonly expected that trade-offs will occur that will limit the evolution of phenotypic diversity, however, it is possible that interactions amongst selective pressures may promote diversity instead. We explored the evolution of locomotor performance in lizards in relation to possible selective pressures using the Ornstein-Uhlenbeck process. Here, we show that a combination of selection based on foraging mode and predator escape is required to explain variation in performance phenotypes. Surprisingly, habitat use contributed little explanatory power. We find that it is possible to evolve very different abilities in performance which were previously thought to be tightly correlated, supporting a growing literature that explores the many-to-one mapping of morphological design. While we generally find the expected trade-off between maximal exertion and speed, this relationship surprisingly disappears when species experience selection for both performance types. We conclude that functional integration need not limit adaptive potential, and that an integrative approach considering multiple major influences on a phenotype allows a more complete understanding of adaptation and the evolution of diversity.
Data from: Bony labyrinth morphometry indicates locomotor adaptations in the squirrel-related clade (Rodentia, Mammalia)
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Data from: Adaptive evolution in locomotor performance: how selective pressures and functional relationships produce diversity
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Locomotor Adaptation Training to Prevent Mobility Disability
ClinicalTrials.gov study NCT02554916. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Walking Rehabilitation After Spinal Cord Injury: Locomotor Training Using Adaptive Robotics
ClinicalTrials.gov study NCT03504826. IPD Sharing: NO. Countries: 1. Publications: 0.
Neurophysiology of Locomotor Adaptation and Freezing of Gait in Parkinson's Disease
ClinicalTrials.gov study NCT06911229. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study on Preliminary Safety and Efficacy of Adaptive DBS Aligned to Locomotor States to Improve Locomotor Functions in Parkinson's Patients
ClinicalTrials.gov study NCT06791902. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.