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45 results for “low dose and low dose rate”
Low dose rate radiation induced secretion of TGF-β3 together with an activator in small extracellular vesicles modifies low dose hyper-radiosensitivity through ALK1 binding
<p>This is a collection of results from all clonogenic assays on T-47D cells used in the manuscript "Low dose rate radiation induced secretion of TGF-β3 together with an activator in small extracellular vesicles modifies low dose hyper-radiosensitivity through ALK1 binding". </p> <p>T-47D cells were subjected to various pretreatments: low dose rate priming (0.1-0.3 Gy/h for 1 hour), small extracellular vesicles from irradiated or control cells, irradiated or control cell conditioned medium, MMP/ADAM inhibitor TAPI-2, recombinant TGF-B3, inhibitors of ALK1, ALK2, ALK5 or TGF-BRII, iNOS inhibitor 1400W, recombinant FKBP4, recombinant MMP14 and combinations of these. All pretreatments except low dose rate priming was administered for 24 hours. </p> <p>After pretreatments, cells were seeded to colonies and irradiated with 220 kV x-rays at a dose rate of 22.5 Gy/h or gamma rays from a Co-60 source at a dose rate of 20-25 Gy/h. </p> <p>Colonies were cultured for 2-3 weeks before fixation and manual counting. </p>
Fig. 1 in Evaluating the use of a low dose fipronil bait in reducing black-tailed prairie dog (Cynomys ludovicianus) fleas at reduced application rates
Fig. 1. Flea prevalence (0.0–1.0) during pre-treatment and post-treatment for (A) captured black-tailed prairie dogs (Cynomys ludovicianus); and (B) active burrows. Vertical bars indicate the 95% confidence intervals (95% CI).
TG 91: Radiation Risk Inference at Low-Dose and Low-Dose Rate Exposure for Radiological Protection Purposes
<p>The detriment-adjusted nominal risk coefficients recommended by ICRP have been based, to a large extent, on data obtained from the atomic bomb survivors in Japan. ICRP introduced a Dose and Dose-Rate Effectiveness Factor (DDREF) of 2 to include in calculations of these risk coefficients for application at the low doses and low-dose rate exposures typical in radiological protection. The DDREF was included to account for the survivors’ single acute exposure, and because a linear quadratic instead of a linear risk to dose response was thought to be the most plausible biological model.</p> <p>This paper summarizes the recent work of ICRP Task Group 91 on this topic. Task Group activities have included reviews of the history of low-dose and low-dose-rate effects, various exposure scenarios and their doses and dose rates, radiation-induced effects at the molecular, cellular, animal, and human level, and biologically-based mechanistic models of carcinogenesis. The Task Group performed a meta-analysis of low-dose-rate epidemiological studies, and re-analyses of published results on radiation-induced effects among animal models and among Japanese atomic bomb survivors.</p>
Low-dose Molecular Breast Imaging: Comparison of Breast Cancer Detection Rate at Initial Screening and Two-year Follow-up
ClinicalTrials.gov study NCT01723124. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Dapagliflozin Plus Low Dose Pioglitazone on Hospitalization Rate in Patients With HF and HFpEF
ClinicalTrials.gov study NCT03794518. IPD Sharing: NO. Countries: 1. Publications: 16.
Potency pReservation In Prostate cAncer Patients Treated With UltraSound-guided Low-dose Rate Brachytherapy
ClinicalTrials.gov study NCT04718987. IPD Sharing: NO. Countries: 1. Publications: 6.
Low Dose Growth Hormone (GH) on Insulin Sensitivity and Cortisol Production Rates
ClinicalTrials.gov study NCT00517062. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Low Rate Fluoroscopy to Reduce Radiation Dose During Coronary Angiography and Intervention
ClinicalTrials.gov study NCT01990924. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Impact of Split Dose of Low-volume Polyethylene Glycol on Adenoma Detection Rate
ClinicalTrials.gov study NCT02178033. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Single Fraction Real-time High-Dose-Rate Brachytherapy in Patients With Low and Intermediate Risk Prostate Cancer
ClinicalTrials.gov study NCT02342054. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Operator Radiation Dose Using Ultra-Low Fluoroscopic Pulse Rate Versus Standard In Performing Coronary Angiography Via Right Radial Artery
ClinicalTrials.gov study NCT07221175. IPD Sharing: YES. Countries: 1. Publications: 2.
Side Effects of Low Dose Rate Brachytherapy and Ultra-hypofractionated Radiotherapy in Low to Intermediate Risk Prostate Cancer
ClinicalTrials.gov study NCT07210502. IPD Sharing: UNDECIDED. Countries: 1. Publications: 6.
Pulsed Low Dose Rate Radiation Therapy for Gastric Cancer Patients With Peritoneal Metastasis
ClinicalTrials.gov study NCT03061162. IPD Sharing: NO. Countries: 1. Publications: 1.
Study of High-Dose-Rate Endorectal Brachytherapy (HDRBT) in the Treatment of Locally Advanced Low Rectal Cancer
ClinicalTrials.gov study NCT01226979. IPD Sharing: NO. Countries: 1. Publications: 0.
Chronic low dose-rate versus acute ionizing radiation induced gene expression in primary derived prostate fibroblasts
Using a novel flood source construct we performed a direct comparison of genome-wide gene expression regulations resulting from exposure of primary human prostate fibroblast cultures to acute (10cGy and 200cGy) and longer-term chronic (1.0-2.45cGy cumulative over 24hr) exposures.
Revealing the increased stress response behavior through transcriptomic analysis of adult zebrafish brain after chronic and low to moderate dose rates of ionizing radiations
GEO Series GSE206573. Danio rerio. 21 samples. Type: Expression profiling by high throughput sequencing.
Microarray analysis of gene expression in the kidneys and testes of mice after low-dose-rate irradiation
GEO Series GSE14290. Mus musculus. 24 samples. Type: Expression profiling by array.
Gene expression in mouse blood following low dose-rate or acute x-ray exposure
GEO Series GSE62623. Mus musculus. 48 samples. Type: Expression profiling by array.
Chronic low dose-rate versus acute ionizing radiation induced gene expression in primary derived prostate fibroblasts
GEO Series GSE52918. Homo sapiens. 32 samples. Type: Expression profiling by array.
Effect of Low-dose-rate Radiation on Cognition and Gene Expression Profiles in Type II Diabetes Mellitus Mouse Model
GEO Series GSE255433. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.