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68 results for “lower respiratory tract infection”
Lung microbiome in children with hematological malignancies and lower respiratory tract infections
<p><strong>Background</strong>: Respiratory infectious complications remain a major cause of morbidity and mortality in children with hematological malignancies. Knowledge regarding the lung microbiome in the aforementioned children is limited.</p> <p><strong>Methods</strong>: A prospective cohort was conducted, enrolling 16 children with hematological malignancies complicated with moderate to severe lower respiratory tract infections(LRTIs), versus 21 LRTIs children with age, gender, weight, infection severity matched, with no underlying malignancies, to evaluate the lung microbiome from bronchoalveolar lavage fluid samples in different groups.</p> <p><strong>Results</strong>: Lung microbiome from children with hematological malignancies and LRTIs showed obviously decreased α and β diversity, increased microbial function in infectious disease:bacteria/parasite, drug resistance:antimicrobial and human pathogenesis than the control group, and significantly reduced proportion of <em>Firmicutes</em>, <em>Bacteroidota</em>, <em>Actinobacteriota</em> , increased <em>Proteobacteria</em> at the phylum level, distinctly elevated <em>Parabacteroides</em>, <em>Klebsiella</em>, <em>Grimontia</em>, <em>Escherichia_Shigella</em>, <em>unclassified_Enterobacteriaceae</em> at the genus level than the control group. Besides, it was revealed that α diversity (Shannon), β diversity (Bray Curtis dissimilarity), Proteobacteria at the phylum level, and <em>unclassified_Enterobacteriaceae</em> and <em>Escherichia_Shigella</em> at the genus level were significantly negatively associated with hospitalization course, whereas <em>Firmicutes</em> at the phylum level was established positively correlated with hospitalization course.</p> <p><strong>Conclusions</strong>: Children with hematological malignancies and LRTIs showed obviously decreased α and β diversity, significantly increased function in infectious disease pathogenesis, antimicrobial drug resistance, and unfavorable environment tolerance. Besides, α diversity (Shannon), β diversity (Bray Curtis dissimilarity), <em>Proteobacteria</em> may be used as negatively correlated predictors for hospitalization course in these children whereas <em>Firmicutes</em> is a positively correlated predictor. </p>
Placebo-Controlled Trial of Antibiotic Therapy in Adults With Suspect Lower Respiratory Tract Infection (LRTI) and a Procalcitonin Level
ClinicalTrials.gov study NCT03341273. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Prospective, Epidemiological Study to Assess the Disease Burden of Respiratory Syncytial Virus Associated, Suspected Lower Respiratory Tract Infections in Newborns, From 0 to 2 Years of Age and Risk
ClinicalTrials.gov study NCT01995175. IPD Sharing: NO. Countries: 8. Publications: 3.
An Algorithm to Decide on Antibiotic Prescription in Lower Respiratory Tract Infection in Primary Care
ClinicalTrials.gov study NCT03191071. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Presatovir in Hematopoietic Cell Transplant Recipients With Respiratory Syncytial Virus (RSV) Infection of the Lower Respiratory Tract
ClinicalTrials.gov study NCT02254421. IPD Sharing: Not stated. Countries: 5. Publications: 1.
A Study to Evaluate the Safety and Efficacy of MEDI8897 for the Prevention of Medically Attended Lower Respiratory Tract Infection Due to Respiratory Syncytial Virus in Healthy Late Preterm and Term I
ClinicalTrials.gov study NCT03979313. IPD Sharing: YES. Countries: 31. Publications: 8.
Lung microbiome in children with hematological malignancies and lower respiratory tract infections
Open the record for dataset details and reuse information.
Study on ICU Patients With Nosocomial Lower Respiratory Tract Infections
ClinicalTrials.gov study NCT03183921. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Diagnostic of Lower Respiratory Tract Infection by Lung Ultrasonography in General Practice
ClinicalTrials.gov study NCT04602234. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Point-of-Care Lung Ultrasound for Prognosis in Critically Ill Infants With Acute Lower Respiratory Tract Infection
ClinicalTrials.gov study NCT06425107. IPD Sharing: NO. Countries: 1. Publications: 4.
Treatment of Upper and Lower Respiratory Tract Infections in Young Children Using Probiotic
ClinicalTrials.gov study NCT04122495. IPD Sharing: Not stated. Countries: 1. Publications: 1.
An Observational Study of Cough / Lower Respiratory Tract Infection (LRTI) in Primary Care
ClinicalTrials.gov study NCT00353951. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Evaluating a Host-response Based Diagnostic for Distinguishing Between Bacterial and Viral Etiology in Patients With Lower Respiratory Tract Infection (LRTI)
ClinicalTrials.gov study NCT03011515. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Procalcitonin Guided Antibiotic Therapy and Hospitalisation in Patients With Lower Respiratory Tract Infections: The "ProHOSP" Study
ClinicalTrials.gov study NCT00350987. IPD Sharing: Not stated. Countries: 1. Publications: 7.
The Impact of MeMed BV® on Management of Patients With Suspected Lower Respiratory Tract Infections (LRTI) in the Emergency Department (ED) and Urgent Care Center (UCC) ("JUPITER" TRIAL)
ClinicalTrials.gov study NCT05762302. IPD Sharing: NO. Countries: 2. Publications: 25.
Anti-inflammatory Effects of Macrolide Treatment in Influenza Lower Respiratory Tract Infections
ClinicalTrials.gov study NCT01779570. IPD Sharing: Not stated. Countries: 1. Publications: 12.
Community-Acquired Pneumonia - Study on the Initial Treatment With Antibiotics of Lower Respiratory Tract Infections
ClinicalTrials.gov study NCT01660204. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Pneumococcal Carriage in Patients With Lower Respiratory Tract Infection (LRTI)
ClinicalTrials.gov study NCT01861184. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase II, Randomized, Double-blind, Placebo-controlled Study to Examine the Effects of DAS181 in Immunocompromised Subjects With Lower Respiratory Tract Parainfluenza Infection on Supplemental Oxyge
ClinicalTrials.gov study NCT01644877. IPD Sharing: Not stated. Countries: 1. Publications: 1.
TREATment of Lower Respiratory Tract Infection in Selected Hospitals in Southern Sri Lanka (TREAT-SL): a Stepped-Wedge Cluster Randomized Trial
ClinicalTrials.gov study NCT06331364. IPD Sharing: NO. Countries: 0. Publications: 0.
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