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16,678 results for “lung”
Protein structure files for the paper "Multiplexed identification of RAS paralog imbalance as a driver of lung cancer growth" in Nature Cell Biology by Tang et al.
<p>This archive contains models of HRAS, KRAS, and NRAS homo- and heterodimers with various mutations discussed in the paper, "Multiplexed identification of RAS paralog imbalance as a driver of lung cancer growth" in Nature Cell Biology by Tang et al.<br> as well as crystallographic dimers of these proteins as identified by the ProtCAD database, http://dunbrack2.fccc.edu/ProtCAD/Results/PfamArchClusterInfo.aspx?GroupId=8 (cluster 5). Several of the models are shown in Supp. Figure 11b and the crystallographic dimers of RAS that provide evidence for the possible biological relevance of these models are shown in Supp. Figure 11a.</p> <p>The crystallographic dimers were identified by clustering all possible interfaces generated by symmetry operators in crystals of HRAS, KRAS, and NRAS as described in the paper: Xu, Q., Dunbrack, R.L. ProtCID: a data resource for structural information on protein interactions. <em>Nat Commun</em> <strong>11</strong>, 711 (2020). https://doi.org/10.1038/s41467-020-14301-4.</p> <p>The models were created by superposing monomers of HRAS, KRAS, or NRAS onto the alpha4-alpha5 dimer present in the crystal of PDB entry 3k8y. Mutations were made in PyMOL. The structures were relaxed with the FastRelax protocol and the Ref2015 scoring function in the program Rosetta, which uses the backbone-dependent rotamer library of Shapovalov and Dunbrack to repack side chains.</p> <p>The crystallographic dimers are contained in a zipped PyMOL session. The mmCIF format for all the structures is present in a zip file, Tang_et_al_crystallographic_and_modeled_RAS_dimer_ciffiles.zip. The PyMOL session and zip file contains 87 HRAS dimers, 14 KRAS dimers, and 1 NRAS dimer, all having the interface consisting of the alpha4 and alpha5 helices. The PyMOL session also contains the modeled structures. Only Mg ions and GTP/GNP/GDP ligands are shown. Others are present but hidden and may be displayed by PyMOL ("show sticks, het").</p> <p> </p>
RNA datasets to derive predictors for immune checkpoint inhibitor therapy of non-small cell lung cancer
<p>Nanostring nCounter datasets and corresponding clinical data of tumor samples of patients with advanced NSCLC who received anti-PD-1 immuntherapy. Prospectively divided into a discovery and a validation cohort.</p> <p>Please cite the corresponding publication in Annals of Oncology (10.1093/annonc/mdz049)</p>
TomoBreast randomized clinical trial's lung-heart outcomes and mortality through the 2020 COVID-19 pandemic: data and software
<p>Dataset and R script to reproduce the analyses of the manuscript:</p> <p>Vinh-Hung V, Gorobets O, Adriaenssens N, Van Parijs H, Storme G, Verellen D, Nguyen NP, Magne N, De Ridder M.</p> <p><strong>Lung-heart outcomes and mortality through the 2020 COVID-19 pandemic in a prospective cohort of breast cancer radiotherapy patients.</strong></p> <p>Cancers 2022; 14(24):6241. https:// doi.org/10.3390/cancers14246241</p> <p>https://www.mdpi.com/2072-6694/14/24/6241</p> <p>PubMed: PMID: 36551726</p> <p>PMCID: PMC9777311</p> <p>Info on the variables in file "aelq6_public.R"</p> <p>reproduced in "aelq_2_3_readme.txt":</p> <p>"aelq2_base2.txt" = baseline characteristics.</p> <p>"aelq3.txt" = longitudinal maesurements.</p> <p>Variables in "aelq2_base2.txt":</p> <p>"<strong>aelq2_base2.txt</strong>" = baseline characteristics. <br># Age at randomization, years. <br># RTdose: cf TomoBreast papers. <br># 51 Gy = hypofractionated, simultaneous integrated boost<br># 42 Gy = hypofractionated, no boost, mastectomy cases only<br># 50 Gy = conventional, no boost, mastectomy cases only<br># 66 Gy = conventional, sequential boost<br># Weight kg, Height cm, <br># Detection 1=found by screening (senology follow-up/controle)<br># 2=found by symptoms (pain, palpable)<br># 9=unknown<br># Smoker 0= Not smoker<br># 1= Smoker<br># 2=ex-smoker<br># Mastectomy (and other binary coded) 1= yes<br># chemosched 0=none<br># 1= planned after RT (sequential)<br># 2= prior to RT and is finished (sequential)<br># 3= chemo is on-going or is planned to start with RT (concomitant)<br># hormonetherapy 0=no<br># 1=tamoxifen (nolvadex)<br># 2=Femara (Letrozole)<br># 3=zoladex<br># 4=tamoxifen + zoladex<br># Laterality 1,=Right, 2=Left, 3=Bilateral<br># LengthFU: length of follow-up, days from randomization</p> <p>"<strong>aelq3.txt</strong>" = longitudinal maesurements.<br># "Nr" = Case ID<br># "Time" in days from origin (origin =date of randomization), <br># if negative =before randomization<br># "KPS" "Weight" <br># "Died" "LocalRec" "Metast" "NewPrim" = binary code, 0=no, 1=yes<br># "fAEBreast" "fAEHeart" "fAELung" "fAEOther" <br># fAE = freedom from breast, heart, lung, other adverse event score<br># "LVEF2" = ejection fraction, %<br># "MacIver" = estimated cardiac strain</p> <p># the following are pulmonary function tests, untransformed units<br># "FVC", "FEV1", "PEF", "VC", "TLC", "RV", "FRC", "Raw", "sRaw", "DLCO",<br># "VA", "PF"</p> <p># "fDY", "fFA", "fPA" = freedom from dyspnea, from fatigue, from pain<br># range 0 to 100 (best)<br># see papers:</p> <p># Van Parijs, H.; Vinh-Hung, V.; Fontaine, C.; Storme, G.; Verschraegen, C.;<br># Nguyen, D.M.; Adriaenssens, N.; Nguyen, N.P.; Gorobets, O.; De Ridder, M.<br># Cardiopulmonary-related patient-reported outcomes in a randomized clinical<br># trial of radiation therapy for breast cancer. BMC Cancer 2021, 21, 1177,<br># doi:10.1186/s12885-021-08916-z.</p> <p># preprint:<br># Van Parijs, H.; Cecilia-Joseph, E.; Gorobets, O.; Storme, G.; <br># Adriaenssens, N.; Heyndrickx, B.; Verschraegen, C.; Nguyen, N.P.;<br># De Ridder, M.; Vinh-Hung, V. Lung-heart toxicity in a randomized <br># clinical trial of hypofractionated image guided radiation therapy for<br># breast cancer. Preprints 2022, 202212, 0214.<br># https://doi.org/10.20944/preprints202212.0214.v1</p> <p># <br># "Year" = year of the observation<br># example: randomized 1/1/2011, measurement done 1/31/2011, time = 30 days,<br># Year =2011<br>#<br> </p>
Spatial immunophenotyping of the tumor microenvironment in non-small cell lung cancer
<p>A dataset with spatial immune cell information on a lung cancer cohort from Uppsala University Hospital, Sweden, with anonymized clinical data. For more information please refer to the 'readme' file and the original study (https://doi.org/10.1016/j.ejca.2023.02.012).</p>
Prediction of repurposed drugs for treating lung injury in COVID-19
<p>These are output files of shared R scripts used in prediction of repurposed drugs for treating lung injury in COVID-19.</p> <p> </p> <p>R scripts are available here: https://doi.org/10.5281/zenodo.3822923</p> <p> </p> <p>Description of files:</p> <p>HCC515_6_data_for_drug.csv #Differential expression of genes in HCC515 cell at 6 h after treatment of ACE2 inhibitor</p> <p>HCC515_24_data_for_drug.csv #Differential expression of genes in HCC515 cell at 24 h after treatment of ACE2 inhibitor</p> <p>COVID19-Lung_data_for_drug.csv #Differential expression of genes in lung tissues with COVID-19</p> <p>HCC515_6_drug.csv #Drugs for HCC515 cell at 6 h after transfection of ACE2 inhibitor</p> <p>HCC515_24_drug.csv #Drugs for HCC515 cell at 24 h after transfection of ACE2 inhibitor</p> <p>COVID19-Lung_drug.csv #Drugs for lung tissuse from COVID-19 patients</p> <p>COL-3_single_treatment_response_data.csv #Differential expression of genes in HCC515 cell at 24h after treatment of COL-3</p> <p>CGP-60474_single_treatment_response_data.csv #Differential expression of genes in HCC515 cell at 24h after treatment of CGP-60474</p>
Identification of biomarkers for the early detection of non-small cell lung cancer: a systematic review and meta-analysis
<p>We sought to identify the best biomarkers for the early diagnosis of LC, using a systematic review of seven databases. We identified 79 articles that focused on the identification and assessment of diagnostic biomarkers and then performed a meta-analysis. This work has been submitted for publication.</p>
MRI Neonatal Lung Segmentation and 3D Morphologic Features
<p>We developed an ensemble of deep convolutional neural networks (2D-UNets) to perform automated neonatal lung segmentation from MRI sequences. A three-dimensional reconstruction is used to calculate MRI features for lung volume, shape, pixel intensity, and surface.</p> <p>In addition, ML Models for severity prediction of Bronchopulmonary Dysplasia (BPD) are implemented as an applied example of the use of MRI lung volumetric features for disease prognosis.</p> <p>This dataset comprises:</p> <ul> <li>Three pretrained 2D-UNet Models for Neonatal MRI Lung Segmentation.</li> <li>Resulting performances and features per MRI-sequence.</li> </ul> <p>See Publication:</p> <p>Automated MRI Lung Segmentation and 3D Morphologic Features for Quantification of Neonatal Lung Disease (2023)</p> <p><a href="https://doi.org/10.1148/ryai.220239">https://doi.org/10.1148/ryai.220239</a></p>
Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma
<p>Code and data for the MS <strong>"Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma"</strong></p>
Minimal data set for: Air-liquid interface exposure of A549 human lung cells to characterize the hazard potential of a gaseous bio-hybrid fuel blend
<p>This minimal data set presents the values behind the means and standard deviation for the publication entitled: "Air-liquid interface exposure of A549 human lung cells to characterize the hazard potential of a gaseous bio-hybrid fuel blend"</p>
Data from: Cubicle design and dairy cow rising and lying down behaviours in free stalls with insufficient lunge space
<p>Original data from: "Cubicle design and dairy cow rising and lying down behaviours in free-stalls with insufficient lunge space" <a title="Persistent link using digital object identifier" href="https://doi.org/10.1016/j.animal.2024.101314" target="_blank" rel="noreferrer noopener"><span><span>https://doi.org/10.1016/j.animal.2024.101314</span></span></a></p>
Multiplexed histology of COVID-19 post-mortem lung samples - CONTROL CASE 1 FOV1
<p><strong>Image-based data set of a post-mortem lung sample from a non-COVID-related pneumonia donor (CONTROL CASE 1, FOV1)</strong></p> <p>Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.</p>
Multiplexed histology of COVID-19 post-mortem lung samples - CONTROL CASE 2 FOV2
<p><strong>Image-based data set of a post-mortem lung sample from a non-COVID-19-related pneumonia donor (CONTROL CASE 2 FOV2)</strong></p> <p>Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.</p>
Multiplexed histology of COVID-19 post-mortem lung samples - CONTROL CASE 2 FOV1
<p><strong>Image-based data set of a post-mortem lung sample from a non-COVID-19-related pneumonia donor (CONTROL CASE 2 FOV1)</strong></p> <p>Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.</p>
Multiplexed histology of COVID-19 post-mortem lung samples - CONTROL CASE 3 FOV2
<p><strong>Image-based data set of a post-mortem lung sample from a non-COVID-19-related pneumonia donor (CONTROL CASE 3 FOV2)</strong></p> <p>Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.</p>
Multiplexed histology of COVID-19 post-mortem lung samples - ACUTE CASE 2 FOV3
<p><strong>Image-based data set of a post-mortem lung sample from a COVID-19 donor (ACUTE CASE 2 FOV3)</strong></p> <p>Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.</p>
Multiplexed histology of COVID-19 post-mortem lung samples - ACUTE CASE 1 FOV2
<p><strong>Image-based data set of a post-mortem lung sample from a COVID-19 donor (ACUTE CASE 1 FOV2)</strong></p> <p>Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.</p>
Multiplexed histology of COVID-19 post-mortem lung samples - CONROL CASE 3 FOV1
<p><strong>Image-based data set of a post-mortem lung sample from a COVID-19 donor (CONTROL CASE 3 FOV1)</strong></p> <p>Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.</p>
Multiplexed histology of COVID-19 post-mortem lung samples - PROLONGED CASE 2 FOV2
<p><strong>Image-based data set of a post-mortem lung sample from a COVID-19 donor (PROLONGED CASE 2 FOV2)</strong></p> <p>Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.</p>
Multiplexed histology of COVID-19 post-mortem lung samples - ACUTE CASE 1 FOV1
<p><strong>Image-based data set of a post-mortem lung sample from a COVID-19 donor (ACUTE CASE 1 FOV1)</strong></p> <p>Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.</p>
Multiplexed histology of COVID-19 post-mortem lung samples - PROLONGED CASE 4 FOV1
<p><strong>Image-based data set of a post-mortem lung sample from a COVID-19 donor (PROLONGED CASE 4 FOV1)</strong></p> <p>Each image shows the same field of view (FOV), sequentially stained with the depicted fluorescence-labelled antibodies, including surface proteins, intracellular proteins and transcription factors. Images contain 2024 x 2024 pixels and are generated using an inverted wide-field fluorescence microscope with a 20x objective, a lateral resolution of 325 nm and an axial resolution above 5 µm. Images have been normalized and intensities adjusted.</p>
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.