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33 results for “mechanosensation”
Nonlinear mechanosensation in fiber networks
<p>Dataset corresponding to the underlying numerical and experimental data of the research article "Nonlinear mechanosensation in fiber networks". </p> <p>This repository contains four folders containing the data used to produced the figures shown in the article:<br>- EXPERIMENTS.zip : microrheology measurements in biopolymer networks<br>- MACRO.zip : macroscopic loading of disordered fiber networks (simulations results)<br>- MICRO.zip : local probing of disordered fiber networks (simulations results)<br>- Spatial-NL.zip : local probing of disordered fiber networks, with records of the networks spatial deformations (simulations results)<br>The README.txt document provides a detailed description of the content, including files naming convention and data description.</p> <div> <div> <div> <p>We would like to acknowledge that this project has received funding (E.B. and C.P.B.) from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Grant Agreement No. 891217 and the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - Project ID 201269156 - SFB 1032 (Project B12). P.R. is supported by France 2030, the French National Research Agency (ANR-16-CONV-0001) and the Excellence Initiative of Aix-Marseille University - A*MIDEX. M.G. and H.Y. acknowledge support from NIH Grant No. 1R01G140108.</p> </div> </div> </div>
Pectoral fin kinematics and motor patterns are shaped by fin ray mechanosensation during steady swimming in Scarus quoyi
<div class="page"> <div class="layoutArea"> <div class="column"> <p>For many species of fish, rhythmic movement of the pectoral fins, or forelimbs, drives locomotion. In terrestrial vertebrates, normal limb- based rhythmic gaits require ongoing modulation with limb mechanosensors. Given the complexity of the fluid environment and dexterity of fish swimming through it, we hypothesize that mechanosensory modulation is also critical to normal fin-based swimming. Here, we examined the role of sensory feedback from the pectoral fin rays and membrane on the neuromuscular control and kinematics of pectoral fin-based locomotion. Pectoral fin kinematics and electromyograms of the six major fin muscles of the parrotfish, Scarus quoyi, a high-performance pectoral fin swimmer, were recorded during steady swimming before and after bilateral transection of the sensory nerves extending into the rays and surrounding membrane. Alternating activity of antagonistic muscles was observed and drove the fin in a figure-of-eight fin stroke trajectory before and after nerve transection. After bilateral transections, pectoral fin rhythmicity remained the same or increased. Differences in fin kinematics with the loss of sensory feedback also included fin kinematics with a significantly more inclined stroke plane angle, an increased angular velocity and fin beat frequency, and a transition to the body-caudal fin gait at lower speeds. After transection, muscles were active over a larger proportion of the fin stroke, with overlapping activation of antagonistic muscles rarely observed in the trials of intact fish. The increased overlap of antagonistic muscle activity might stiffen the fin system in order to enhance control and stability in the absence of sensory feedback from the fin rays. These results indicate that fin ray sensation is not necessary to generate the underlying rhythm of fin movement, but contributes to the specification of pectoral fin motor pattern and movement during rhythmic swimming.</p> <p> </p> </div> </div> </div>
Data from: To hatch and hatch not: Rejecting the hypothesis that heterochrony in vestibular mechanosensing explains poor escape-hatching success of Agalychnis spurrelli in snake attacks compared with its congener A. callidryas
<p>Phyllomedusid treefrogs hatch prematurely to escape egg predation, but escape success varies among species. During spontaneous hatching of <em>Agalychnis</em> <em>spurrelli</em>, snake attacks elicited 55% less escape-hatching than did attacks on less developed <em>A. callidryas</em>. <em>Agalychnis</em> <em>callidryas</em> use their vestibular system and, secondarily, their lateral line to sense physical disturbances that cue hatching. Since <em>A. spurrelli </em>develop faster, we hypothesized that heterochronic shifts in the onset timing of vestibular mechanosensory function, relative to hatching ability, might explain their lower escape response to mechanosensory cues. To test this, we compared the onset timing of hypoxia- and mechanosensory-cued hatching (MCH) and vestibular mechanosensory function in developmental series of <em>A. spurrelli</em> and <em>A. callidryas</em> embryos. Across species, most sibships began responding to each cue at the same developmental stage. MCH onset in A. spurrelli was associated with vestibular function onset, as indicated by measurements of the vestibulo-ocular reflex (VOR). Indeed, the first <em>A. spurrelli</em> embryos to show MCH had VOR amplitudes similar to those previously found for <em>A. callidryas</em> at the onset of MCH. These results indicate that low escape-hatching success in <em>A. spurrelli</em> is not caused by a relative delay in the onset of vestibular mechanosensory function, rejecting our initial hypothesis; the developmental timing of vestibular mechanosensing and its role in predator-induced hatching appears conserved. Our observations of both higher escape success of larger clutches in snake attacks and hatching complications in flooded A. spurrelli suggest, instead, that differences in egg capsule and clutch structure may contribute to species differences in escape-hatching success.</p>
Piezo2 and perineal mechanosensation are essential for sexual function
<p>Despite the potential importance of genital mechanosensation for sexual reproduction little is known about how perineal touch influences mating. Here we explored how mechanosensation affords exquisite awareness of the genitals and controls reproduction in mice and humans. Using genetic strategies and in vivo functional imaging, we demonstrated that the mechanosensitive ion channel Piezo2 is necessary for behavioral sensitivity to perineal touch. Notably, Piezo2-function is needed for triggering a touch-evoked erection reflex and successful mating in both male and female mice. Humans with complete loss of PIEZO2 function have genital hyposensitivity and experience no direct pleasure from gentle touch or vibration. Together, our results explain how perineal mechanoreceptors detect the gentlest of stimuli and trigger physiologically important sexual responses, providing a platform for exploring the sensory basis of sexual pleasure and its relationship to affective touch.</p>
Data from: To hatch and hatch not: Rejecting the hypothesis that heterochrony in vestibular mechanosensing explains poor escape-hatching success of Agalychnis spurrelli in snake attacks compared with its congener A. callidryas
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Pectoral fin kinematics and motor patterns are shaped by fin ray mechanosensation during steady swimming in Scarus quoyi
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Piezo2 and perineal mechanosensation are essential for sexual function
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Multimodal mechanosensing enables treefrog embryos to escape egg-predators
<p><span>Mechanosensory-cued hatching (MCH) is widespread, diverse, and improves survival in many animals. From flatworms and insects to frogs and turtles, embryos use mechanosensory cues and signals to inform hatching timing, yet mechanisms mediating mechanosensing <i>in ovo</i> are largely unknown. The arboreal embryos of red-eyed treefrogs, <i>Agalychnis callidryas, </i><span>hatch prematurely to escape predation, cued by physical disturbance in snake attacks. When otoconial organs in the developing vestibular system become functional, this response strengthens, but its earlier occurrence indicates another sensor must contribute. </span>Post-hatching, tadpoles use lateral line neuromasts to detect water motion. We ablated neuromast function with gentamicin to assess their role in <i>A. callidryas</i>' hatching response to disturbance<span>. </span>Prior to vestibular function, this<span> nearly eliminated the hatching response to a complex simulated attack cue, egg-jiggling, revealing that neuromasts mediate early MCH. Vestibular function onset increased hatching, independent of neuromast function, indicating young embryos use multiple mechanosensory systems. MCH increased developmentally. All older embryos hatched in response to egg-jiggling, but neuromast function reduced response latency. In contrast, neuromast ablation had no effect on timing or level of hatching in motion-only vibration playbacks. It appears only a subset of egg-disturbance cues stimulate neuromasts; thus embryos in attacked clutches may receive uni- or multimodal stimuli. <i>A. callidryas</i> embryos have more neuromasts than described for any other species at hatching, suggesting precocious sensory development may facilitate MCH. </span>Our findings provide insight into the behavioral roles of two mechanosensory systems <i>in ovo </i>and open possibilities for exploring sensory perception across taxa in early life stages.</span></p>
Data from: Mechanosensation is evolutionarily tuned to locomotor mechanics
The biomechanics of animal limbs has evolved to meet the functional demands for movement associated with different behaviors and environments. Effective movement relies not only on limb mechanics but also on appropriate mechanosensory feedback. By comparing sensory ability and mechanics within a phylogenetic framework, we show that peripheral mechanosensation has evolved with limb biomechanics, evolutionarily tuning the neuromechanical system to its functional demands. We examined sensory physiology and mechanics of the pectoral fins, forelimb homologs, in the fish family Labridae. Labrid fishes exhibit extraordinary morphological and behavioral diversity and employ pectoral fin-based propulsion with fins ranging in shape from high aspect ratio (AR) wing-like fins to low AR paddle-like fins. Phylogenetic character analysis demonstrates that high AR fins evolved independently multiple times in this group. Four pairs of species were examined; each included a pleseiomorphic low AR and a high AR species. Within each species pair, the high AR species demonstrated significantly stiffer fin rays in comparison to the low AR species. Afferent sensory nerve activity was recorded during fin ray bending. In all cases, afferents of stiffer fins were more sensitive at lower displacement amplitudes demonstrating mechanosensory tuning to fin mechanics, and a consistent pattern of correlated evolution. We suggest that this is a clear example of parallel evolution in a complex neuromechanical system, with a strong link between multiple phenotypic characters: pectoral fin shape, swimming behavior, fin ray stiffness, and mechanosensory sensitivity.
Data from: Mechanosensation is evolutionarily tuned to locomotor mechanics
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Multimodal mechanosensing enables treefrog embryos to escape egg-predators
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Neural Control and Mechanosensation in Spine Muscle
ClinicalTrials.gov study NCT07003802. IPD Sharing: YES. Countries: 1. Publications: 0.
Data from: Simulation of the nodal flow of mutant embryos with small number of cilia: comparison of mechanosensing and vesicle transport hypotheses
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Selective inhibition of matrix mechanosensing in stromal cells attenuates cardiovascular fibrosis
GEO Series GSE291370. Mus musculus; Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Melanocyte differentiation and mechanosensation are differentially modulated by distinct extracellular matrix proteins
GEO Series GSE297747. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Increased sinusoidal pressure impairs liver endothelial mechanosensing pathways uncovering specific plasma biomarkers of portal hypertension.
GEO Series GSE181255. Rattus norvegicus. 6 samples. Type: Expression profiling by high throughput sequencing.
JAG1-NOTCH4 mechanosensing drives atherosclerosis [single-cell RNA-seq]
GEO Series GSE207275. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Aging-associated Decline in Vascular Smooth Muscle Cell Mechanosensation is Mediated by Piezo1 Channel
GEO Series GSE230805. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Microtubule acetylation is required for mechanosensation in Drosophila
GEO Series GSE120305. Drosophila melanogaster. 28 samples. Type: Expression profiling by high throughput sequencing.
Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vascular smooth muscle cell mechanosensation via Piezo1
GEO Series GSE186865. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
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