Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
52
datasets available to search
ShareScore release 0.9.0
Dataset results
52 results for “medium spiny neurons”
Data from: No evidence for sex differences in the electrophysiological properties and excitatory synaptic input onto nucleus accumbens shell medium spiny neurons
<p>Sex differences exist in how the brain regulates motivated behavior and reward, both in normal and pathological contexts. Investigations into the underlying neural mechanisms have targeted the striatal brain regions, including the dorsal striatum and nucleus accumbens core and shell. These investigations yield accumulating evidence of sexually different electrophysiological properties, excitatory synaptic input, and sensitivity to neuromodulator/hormone action in select striatal regions both before and after puberty. It is unknown whether the electrical properties of neurons in the nucleus accumbens shell differ by sex and whether sex differences in excitatory synaptic input are present before puberty. To test the hypothesis that these properties differ by sex, we performed whole-cell patch-clamp recordings on male and female medium spiny neurons (MSNs) in acute brain slices obtained from prepubertal rat nucleus accumbens shell. We analyzed passive and active electrophysiological properties, and miniature EPSCs (mEPSCs). No sex differences were detected; this includes those properties, such as intrinsic excitability, action potential after hyperpolarization, threshold, and mEPSC frequency, that have been found to differ by sex in other striatal regions and/or developmental periods. These findings indicate that, unlike other striatal brain regions, the electrophysiological properties of nucleus accumbens shell MSNs do not differ by sex. Overall, it appears that sex differences in striatal function, including motivated behavior and reward, are likely mediated by other factors and striatal regions.</p>
Data from: No evidence for sex differences in the electrophysiological properties and excitatory synaptic input onto nucleus accumbens shell medium spiny neurons
Open the record for dataset details and reuse information.
Data from: Structural and functional features of medium spiny neurons in the BACHDΔN17 mouse model of Huntington’s disease
Open the record for dataset details and reuse information.
Medium spiny neuron electrophysiological properties across male rats and female rats in different estrous cycle phases in the nucleus accumbens core: Excitatory synaptic input, action potential, and intrinsic properties
<p>This dataset presents electrophysiological properties from whole-cell patch clamped nucleus accumbens core medium spiny neurons from male rats and female rats recorded in different estrous cycle phases. Excitatory synaptic input, action potential, and intrinsic properties are presented in an analyzed format, as well as the original electrophysiological recordings of each neuron. These data were originally presented across two different papers (Proaño et al., 2018, 2020) and further analyzed in an additional paper (Long et al., 2024), all of which are cited below. These data were key for establishing that nucleus accumbens neuron electrical function changed across the estrous cycle in response to its associated hormones, programming a phase-dependent sex difference in adulthood. This finding provided a new framework for understanding how biological sex and hormone cyclicity regulate the neurons implicated in motivated behaviors and related functions and disorders.</p>
Medium spiny neuron electrophysiological properties across male rats and female rats in different estrous cycle phases in the nucleus accumbens core: Excitatory synaptic input, action potential, and intrinsic properties
Open the record for dataset details and reuse information.
Transcriptomic Characterization Reveals Disrupted Medium Spiny Neuron Trajectories in Huntington's Disease and Possible Therapeutic Avenues [Bulk RNA-seq treated with Cerulenin]
GEO Series GSE232647. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
H3K4me3 ChIP-Seq profiles of control and huntington's disease iPSC-derived medium spiny neuron-like cells
GEO Series GSE144493. Homo sapiens. 17 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Gene-targeted, CREB-mediated induction of ∆FosB controls distinct downstream transcriptional patterns within D1 and D2 medium spiny neurons
GEO Series GSE176132. Mus musculus. 88 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide maps of chromatin state in medium spiny neurons in the striatum of adult mice
GEO Series GSE84244. Mus musculus. 5 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Zfhx3 is required for the differentiation of late born D1-type medium spiny neurons
GEO Series GSE127976. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Single cell RNA Sequencing of control and huntington's disease iPSC-derived medium spiny neuron-like cells
GEO Series GSE144477. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic Characterization Reveals Disrupted Medium Spiny Neuron Trajectories in Huntington's Disease and Possible Therapeutic Avenues [bulk RNA-seq]
GEO Series GSE232646. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Human Pluripotent Stem Cell-derived Medium Spiny Neurons (hMSNs) Exhibit Acute and Chronic Responses to Dopamine
GEO Series GSE195492. Homo sapiens. 60 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Gene expression profiling of FACS-purified striatal medium spiny neurons in Huntington's disease model mouse
GEO Series GSE113928. Mus musculus. 8 samples. Type: Expression profiling by array.
Translatome analysis of dorsal striatum D1-medium spiny neurons (D1-MSNs) lacking the TrkB receptor in mice.
GEO Series GSE146274. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
A guide to single-cell transcriptomics in adult rodent brain: the medium spiny neuron transcriptome revisited
GEO Series GSE112177. Mus musculus. 80 samples. Type: Expression profiling by high throughput sequencing.
Biology and Bias in Cell Type-Specific RNAseq of Nucleus Accumbens Medium Spiny Neurons
GEO Series GSE121199. Mus musculus. 49 samples. Type: Expression profiling by high throughput sequencing.
Adult nucleus accumbens single-nucleus RNA-seq dataset for "Distinct subpopulations of D1 medium spiny neurons exhibit unique transcriptional responsiveness to cocaine"
GEO Series GSE222418. Rattus norvegicus. 4 samples. Type: Expression profiling by high throughput sequencing.
Construction of human 3D striato nigral circuitoids to recapitulate medium spiny neuronal projection defects in Huntington disease
GEO Series GSE251684. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Transposable elements are dynamically expressed within medium spiny neurons and associated with molecular and behavioral adaptations to cocaine
GEO Series GSE296397. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.