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298 results for “melanocytes”
MELAN-A EXPRESSION RELATED TO APOPTOSIS OF MELANOCYTES IN SEGMENTAL AND NONSEGMENTAL VITILIGO
<p><strong>Abstract</strong></p> <p><strong>Background: </strong>Vitiligo is a progressive depigmentation of the skin with unclear etiology. Cell-mediated immunity has been suggested to play an important role in the pathogenesis of vitiligo’s progression. Melan-A has a high affinity for specific CD8+ T cells and is one of the critical markers for detecting damage to melanocytes. </p> <p><strong>Aim: </strong>Our study aims to demonstrate the differences of Melan-A expression associated with apoptosis of melanocytes in patients with segmental vitiligo (SV) and those with non-segmental vitiligo (NSV). </p> <p><strong>Methods:</strong> The subjects consisted of 64 patients diagnosed with vitiligo, of whom 33 were with NSV and 31 with SV. Skin biopsy and direct immunofluorescence were used to examine Melan-A, and the TUNEL method was performed to examine melanocyte apoptosis in both groups. Group comparisons were conducted using appropriate statistical methods. </p> <p><strong>Results: </strong>Melan-A expression was significantly higher in the NSV group than in the SV group, and there was a significant difference between two groups (p = 0.001). The median of melanocyte apoptosis in the NSV group was relatively higher than in the SV group, and a significant difference was found between the two groups (p = 0.001). The Spearman’s rank correlation test between Melan-A expression and melanocyte apoptosis in the NSV group was 0.767 (76.7%) and showed a significant relationship (p <0.05). The same test in the SV group was 0.583 (58.3%) and showed a significant relationship (p <0.05). In both groups, the higher the Melan-A expression, the higher the melanocyte apoptosis. </p> <p><strong>Conclusion:</strong> Melan-A expression and melanocyte apoptosis are correlated. The higher Melan-A expression and melanocyte apoptosis in NSV indicates more severe vitiligo disease compared to SV. </p>
Spatial profiling of benign and malignant melanocytic tumors via RNA-SMI (CosMx)
<p>Melanoma clinical outcomes emerge from incompletely understood genetic mechanisms operating within the tumor and its microenvironment. Here, we utilized single-cell RNA-based spatial molecular imaging (RNA-SMI) in patient-derived archival tumors to reveal clinically relevant markers of malignancy progression and prognosis. We examined spatial gene expression of 203,472 cells inside benign and malignant melanocytic neoplasms, including melanocytic nevi, primary invasive and metastatic melanomas. Algorithmic cell clustering paired with intratumoral comparative 2D-analyses visualized synergistic, spatial gene signatures linking cellular proliferation, metabolism, and malignancy, validated by protein expression. Metastatic niches included upregulation of CDK2 and FABP5, which independently predicted poor clinical outcome in 473 melanoma patients via Cox regression analysis. More generally, our work demonstrates a framework for applying single-cell RNA-SMI technology toward identifying gene regulatory landscapes pertinent to cancer progression and patient survival.</p>
Collected Colorimetric Microscopy (C-Microscopy) Images of Melanocytes and Melanoma 3D Spheroids Irradiated with Different Type of Proton Beam as Used in Proton Radiotherapy
<p>Collected Colorimetric Microscopy (C-Microscopy) images, color calibrated (D65 illuminant), of melanocytes and melanoma 3D spheroids, irradiated with different type of proton beam as used in proton radiotherapy.<br> <br>The data are supplement to:</p> <p>Martyna Durak-Kozica, Ewa Stępień, Jan Swakoń, Benedykt R. Jany, Kamil Kawoń, Damian Wróbel, Sebastian Kusyk, Małgorzata Grzesiak, Katarzyna Knapczyk-Stwora, Andrzej Wróbel, Joanna Chwiejand Paweł Moskal, Short-term response of melanoma spheroids and melanocytes to FLASH proton therapy - colorimetric and FTIR microscopy study, Pol J Med Phys Eng 2024;30(4):263-268 (2024) <a href="https://doi.org/10.2478/pjmpe-2024-0031">https://doi.org/10.2478/pjmpe-2024-0031</a></p> <p> </p> <p><br>HEMA-Spheroids-C-Microscopy.zip - melanocytes 3D spheroids, (C-Microscopy) images, color calibrated (D65 illuminant), image width 435.87 microns</p> <p><br>WM-Spheroids-C-Microscopy.zip - melanoma 3D spheroids, (C-Microscopy) images, color calibrated (D65 illuminant), image width 1089.68 microns</p> <p><br>WM-Spheroids-Texture-C-Microscopy.zip - surface texture of melanoma 3D spheroids, (C-Microscopy) images, color calibrated (D65 illuminant), image width 108.97 microns</p> <p> </p> <p>Proton Beam Radiotherapy Irradiation Conditions:</p> <p>C - Control</p> <p>CC - Control minus 7days</p> <p>LP - conventional proton radiotherapy (CONV) final dose 3Gy (dose rate about 0.140 Gy/s)</p> <p>F - FLASH proton radiotherapy final dose 3Gy (dose rate >60 Gy/s)</p> <p>F20 - FLASH proton radiotherapy final dose 20Gy (dose rate >60 Gy/s)</p> <p>F40 - FLASH proton radiotherapy final dose 40Gy (dose rate >60 Gy/s)</p> <p> </p> <p><br>The details about Colorimetric Microscopy (C-Microscopy) approach could be found in:</p> <p>Benedykt R. Jany, Quantifying Colors at Micrometer Scale by Colorimetric Microscopy (C-Microscopy) Approach, Micron 176, 103557 (2024) <a href="https://doi.org/10.1016/j.micron.2023.103557">https://doi.org/10.1016/j.micron.2023.103557</a></p>
Evaluating the Efficacy of the Melanocyte Keratinocyte Transplantation Procedure in the Treatment of Vitiligo
ClinicalTrials.gov study NCT04374435. IPD Sharing: NO. Countries: 1. Publications: 2.
Study to Test Genetic Alterations Among Different Dermoscopic Types of Melanocytic Nevi.
ClinicalTrials.gov study NCT00422448. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Spatial profiling of benign and malignant melanocytic tumors via RNA-SMI (CosMx)
Open the record for dataset details and reuse information.
Melanocyte Transplantation for Patients With Stable Vitiligo.
ClinicalTrials.gov study NCT01701648. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Immunohistochemical Expression Patterns of microRNA Processing Enzyme Dicer in Cutaneous Malignant Melanoma, Benign and Dysplastic Melanocytic Naevi
ClinicalTrials.gov study NCT00862914. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Role of Melanocyte in Basal Cell Carcinoma
ClinicalTrials.gov study NCT02576769. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Autologous Transplantation of Melanocytes for Treatment of Vitiligo Skin
ClinicalTrials.gov study NCT00631865. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Dermoscopic Monitoring of Pediatric Melanocytic Nevi Regarding Pattern and Diameter Changes
ClinicalTrials.gov study NCT05463510. IPD Sharing: NO. Countries: 1. Publications: 3.
The Mechanism of Melanocyte Self-Assembly on Biomaterials and the Functional Analysis
ClinicalTrials.gov study NCT00509314. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Clinical, Radiological, Histologic and Molecular Features of a Cohort of Melanocytic Tumors of the Central Nervous System
ClinicalTrials.gov study NCT05984108. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Reflectance Confocal Microscopy and Molecular Correlation in Atypical Melanocytic Lesions
ClinicalTrials.gov study NCT07277920. IPD Sharing: Not stated. Countries: 1. Publications: 10.
SMAD4 Methylation and Expression Levels in Non-melanocytic Skin Cancers; SMAD4 Protein Positivity
ClinicalTrials.gov study NCT04759261. IPD Sharing: Not stated. Countries: 1. Publications: 1.
miRNA Machinery in Melanoma, Melanoma Metastases and Benign Melanocytic Naevi
ClinicalTrials.gov study NCT01444560. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Changes in melanocyte RNA and DNA methylation favor pheomelanin synthesis and may avoid systemic oxidative stress after dietary cysteine supplementation in birds
Cysteine plays essential biological roles, but excessive amounts produce cellular oxidative stress. Cysteine metabolism is mainly mediated by the enzymes cysteine dioxygenase and γ-glutamylcysteine synthetase, respectively coded by the genes CDO1 and GCLC. Here we test a new hypothesis posing that the synthesis of the pigment pheomelanin also contributes to cysteine homeostasis in melanocytes, where cysteine can enter the pheomelanogenesis pathway. We conducted a experiment in the Eurasian nuthatch Sitta europaea, a bird producing large amounts of pheomelanin for feather pigmentation, to investigate if melanocytes show epigenetic lability under exposure to excess cysteine. We increased systemic cysteine levels in nuthatches by supplementing them with dietary cysteine during growth. This caused in feather melanocytes the downregulation of genes involved in intracellular cysteine metabolism (GCLC), cysteine transport to the cytosol from the extracellular medium (Slc7a11) and from melanosomes (CTNS), and regulation of tyrosinase activity (MC1R and ASIP). These changes were mediated by increases in DNA m5C in all genes excepting Slc7a11, which experienced RNA m6A depletion. Birds supplemented with cysteine synthesized more pheomelanin than controls, but did not suffer higher systemic oxidative stress. These results suggest that excess cysteine activates an epigenetic mechanism that favors pheomelanin synthesis and may protect from oxidative stress.
Random Sample from Keratinocytes, Fibroblasts and Melanocytes
<p>From the ftp genboree.org. Subsample of publicly available data.</p>
Distinct melanocyte subpopulations defined by stochastic expression of proliferation or maturation programs enable a rapid and sustainable pigmentation response
Open the record for dataset details and reuse information.
Evaluation of Human Melanocytes After the Use of PRP Versus Fractional CO2 Laser in Vitiligo
ClinicalTrials.gov study NCT04320160. IPD Sharing: Not stated. Countries: 0. Publications: 13.
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OpenNeuro
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